LOCUS       NM_016712               1242 bp    mRNA    linear   ROD 09-FEB-2024
DEFINITION  Mus musculus tropomodulin 4 (Tmod4), mRNA.
ACCESSION   NM_016712
VERSION     NM_016712.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1242)
  AUTHORS   Gokhin,D.S., Ochala,J., Domenighetti,A.A. and Fowler,V.M.
  TITLE     Tropomodulin 1 directly controls thin filament length in both
            wild-type and tropomodulin 4-deficient skeletal muscle
  JOURNAL   Development 142 (24), 4351-4362 (2015)
   PUBMED   26586224
  REMARK    GeneRIF: RNAi depletion of Tmod1 from either wild-type or
            Tmod4(-/-) muscle fibers leads to thin filament elongation by
            approximately 15%.
REFERENCE   2  (bases 1 to 1242)
  AUTHORS   Gokhin,D.S., Tierney,M.T., Sui,Z., Sacco,A. and Fowler,V.M.
  TITLE     Calpain-mediated proteolysis of tropomodulin isoforms leads to thin
            filament elongation in dystrophic skeletal muscle
  JOURNAL   Mol Biol Cell 25 (6), 852-865 (2014)
   PUBMED   24430868
  REMARK    GeneRIF: Calpain-mediated proteolysis of tropomodulin isoforms
            TMOD1 and TMOD4 leads to thin filament elongation in dystrophic
            skeletal muscle.
REFERENCE   3  (bases 1 to 1242)
  AUTHORS   Sui,Z., Nowak,R.B., Bacconi,A., Kim,N.E., Liu,H., Li,J.,
            Wickrema,A., An,X.L. and Fowler,V.M.
  TITLE     Tropomodulin3-null mice are embryonic lethal with anemia due to
            impaired erythroid terminal differentiation in the fetal liver
  JOURNAL   Blood 123 (5), 758-767 (2014)
   PUBMED   24159174
REFERENCE   4  (bases 1 to 1242)
  AUTHORS   Ochala,J., Gokhin,D.S., Iwamoto,H. and Fowler,V.M.
  TITLE     Pointed-end capping by tropomodulin modulates actomyosin
            crossbridge formation in skeletal muscle fibers
  JOURNAL   FASEB J 28 (1), 408-415 (2014)
   PUBMED   24072783
REFERENCE   5  (bases 1 to 1242)
  AUTHORS   Zhao,X., Huang,Z., Liu,X., Chen,Y., Gong,W., Yu,K., Qin,L., Chen,H.
            and Mo,D.
  TITLE     The switch role of the Tmod4 in the regulation of balanced
            development between myogenesis and adipogenesis
  JOURNAL   Gene 532 (2), 263-271 (2013)
   PUBMED   24036428
REFERENCE   6  (bases 1 to 1242)
  AUTHORS   Richard,A.F., Demignon,J., Sakakibara,I., Pujol,J., Favier,M.,
            Strochlic,L., Le Grand,F., Sgarioto,N., Guernec,A., Schmitt,A.,
            Cagnard,N., Huang,R., Legay,C., Guillet-Deniau,I. and Maire,P.
  TITLE     Genesis of muscle fiber-type diversity during mouse embryogenesis
            relies on Six1 and Six4 gene expression
  JOURNAL   Dev Biol 359 (2), 303-320 (2011)
   PUBMED   21884692
REFERENCE   7  (bases 1 to 1242)
  AUTHORS   Yamashiro,S., Speicher,K.D., Speicher,D.W. and Fowler,V.M.
  TITLE     Mammalian tropomodulins nucleate actin polymerization via their
            actin monomer binding and filament pointed end-capping activities
  JOURNAL   J Biol Chem 285 (43), 33265-33280 (2010)
   PUBMED   20650902
REFERENCE   8  (bases 1 to 1242)
  AUTHORS   Gokhin,D.S., Lewis,R.A., McKeown,C.R., Nowak,R.B., Kim,N.E.,
            Littlefield,R.S., Lieber,R.L. and Fowler,V.M.
  TITLE     Tropomodulin isoforms regulate thin filament pointed-end capping
            and skeletal muscle physiology
  JOURNAL   J Cell Biol 189 (1), 95-109 (2010)
   PUBMED   20368620
  REMARK    GeneRIF: Tmod4 localizes to thin filament pointed ends in
            Tmod1-null embryonic muscle
REFERENCE   9  (bases 1 to 1242)
  AUTHORS   Conley,C.A., Fritz-Six,K.L., Almenar-Queralt,A. and Fowler,V.M.
  TITLE     Leiomodins: larger members of the tropomodulin (Tmod) gene family
  JOURNAL   Genomics 73 (2), 127-139 (2001)
   PUBMED   11318603
REFERENCE   10 (bases 1 to 1242)
  AUTHORS   Cox,P.R. and Zoghbi,H.Y.
  TITLE     Sequencing, expression analysis, and mapping of three unique human
            tropomodulin genes and their mouse orthologs
  JOURNAL   Genomics 63 (1), 97-107 (2000)
   PUBMED   10662549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144408.1 and AC131769.3.
            
            [WARNING] On Mar 25, 2024 this sequence was replaced by
            NM_016712.5.
            
            On Oct 11, 2017 this sequence version replaced NM_016712.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144535.1, AK144408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1241              AK144408.1         2-1242
            1242-1242           AC131769.3         116464-116464
FEATURES             Location/Qualifiers
     source          1..1242
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..1242
                     /gene="Tmod4"
                     /gene_synonym="MTMOD; Sk-Tmod"
                     /note="tropomodulin 4"
                     /db_xref="GeneID:50874"
                     /db_xref="MGI:MGI:1355285"
     exon            1..65
                     /gene="Tmod4"
                     /gene_synonym="MTMOD; Sk-Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            66..228
                     /gene="Tmod4"
                     /gene_synonym="MTMOD; Sk-Tmod"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1143
                     /gene="Tmod4"
                     /gene_synonym="MTMOD; Sk-Tmod"
                     /note="skeletal muscle tropomodulin"
                     /codon_start=1
                     /product="tropomodulin-4"
                     /protein_id="NP_057921.1"
                     /db_xref="CCDS:CCDS17601.1"
                     /db_xref="GeneID:50874"
                     /db_xref="MGI:MGI:1355285"
                     /translation="MSSYQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENML
                     LPAGLRQRDQTKKSPTGPLDRDALLQYLEQQALEVKERDDLVPYTGEKKGKPFIQPKR
                     EIPAQEQITLEPELEEALSHATDAEMCDIAAILGMYTLMSNKQYYDAICSGEICNTEG
                     ISSVVQPDKYKPVPDEPPNPTNIEEMLKRVRSNDKELEEVNLNNIQDIPIPVLSDLCE
                     AMKTNTYVRSFSLVATKSGDPIANAVADMLRENRSLQSLNIESNFISSTGLMAVLKAV
                     RENATLTELRVDNQRQWPGDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAAHAMTR
                     NNELRRQQKKR"
     exon            229..385
                     /gene="Tmod4"
                     /gene_synonym="MTMOD; Sk-Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            386..502
                     /gene="Tmod4"
                     /gene_synonym="MTMOD; Sk-Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            503..592
                     /gene="Tmod4"
                     /gene_synonym="MTMOD; Sk-Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            593..723
                     /gene="Tmod4"
                     /gene_synonym="MTMOD; Sk-Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            724..831
                     /gene="Tmod4"
                     /gene_synonym="MTMOD; Sk-Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            832..975
                     /gene="Tmod4"
                     /gene_synonym="MTMOD; Sk-Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1120
                     /gene="Tmod4"
                     /gene_synonym="MTMOD; Sk-Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1242
                     /gene="Tmod4"
                     /gene_synonym="MTMOD; Sk-Tmod"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accagactcc tcctgctgac cggacagtgt cccagtagaa cagacggacc aactgacaag
       61 gggaggctgt gagtgtcaca ccgtggggaa ggggtagggg ccaccatgtc atcctatcag
      121 aaggaactgg agaaatacag agacatcgac gaagatgaga tcctaaggac cctgagccct
      181 gaagagctag aacagctgga ctgtgagcta caagaaatgg atcctgagaa catgctcttg
      241 ccagctggcc tgagacaacg tgaccagaca aagaagagtc caacagggcc actggacaga
      301 gatgccctat tgcagtacct ggagcaacag gcgctagaag tcaaagagcg tgatgacttg
      361 gtgccctaca ctggcgagaa gaagggaaaa ccctttattc agcctaagag agaaatccca
      421 gcacaggaac agattacgct ggagcctgag ctggaggaag cgctgtccca tgctacagat
      481 gctgaaatgt gtgacattgc agccatcctg ggcatgtata cactgatgag caacaagcaa
      541 tattatgatg ccatctgcag tggagagatc tgcaacacag aaggcattag cagtgtggta
      601 cagcctgaca agtataagcc agtaccagat gaacctccaa atcccacaaa cattgaggag
      661 atgctaaaga gggtacggag taatgacaaa gagctggagg aggtgaacct caataatatc
      721 caggacatcc caatacctgt gctaagtgac ttgtgtgaag caatgaaaac caatacctat
      781 gtccggagct tcagtctggt ggccacaaag agtggtgacc caatcgccaa tgcggtggct
      841 gacatgttgc gtgagaaccg cagtctccag agcctgaaca ttgagtctaa cttcatcagc
      901 agcacagggc tcatggctgt gctaaaggca gttcgggaaa atgctactct cactgagctc
      961 cgtgtagata accagcgcca gtggcctggt gatgcggtag agatggagat ggccactgtg
     1021 ctagagcagt gtccgtctat tgtccgcttc gggtaccact ttacacaaca aggaccacga
     1081 gctcgggcag cccacgccat gacccggaac aatgagctgc gtcgtcagca aaagaagaga
     1141 taacatcacc cttcctttta ccaacaagag atgagagcct gggacgcaca gatcctcatc
     1201 tctctctcct ttcctgtaaa taaaatccct tttgttcacg cc
//
