LOCUS       NM_016963               3590 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tropomodulin 3 (Tmod3), transcript variant 1, mRNA.
ACCESSION   NM_016963
VERSION     NM_016963.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3590)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3590)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (bases 1 to 3590)
  AUTHORS   Stobdan,T., Jain,P.P., Xiong,M., Bafna,V., Yuan,J.X. and
            Haddad,G.G.
  TITLE     Heterozygous Tropomodulin 3 mice have improved lung vascularization
            after chronic hypoxia
  JOURNAL   Hum Mol Genet 31 (7), 1130-1140 (2022)
   PUBMED   34718575
  REMARK    GeneRIF: Heterozygous Tropomodulin 3 mice have improved lung
            vascularization after chronic hypoxia.
REFERENCE   4  (bases 1 to 3590)
  AUTHORS   Ghosh,A., Coffin,M., West,R. and Fowler,V.M.
  TITLE     Erythroid differentiation in mouse erythroleukemia cells depends on
            Tmod3-mediated regulation of actin filament assembly into the
            erythroblast membrane skeleton
  JOURNAL   FASEB J 36 (3), e22220 (2022)
   PUBMED   35195928
  REMARK    GeneRIF: Erythroid differentiation in mouse erythroleukemia cells
            depends on Tmod3-mediated regulation of actin filament assembly
            into the erythroblast membrane skeleton.
REFERENCE   5  (bases 1 to 3590)
  AUTHORS   Mattebo,A., Sen,T., Jassinskaja,M., Pimkova,K., Prieto
            Gonzalez-Albo,I., Alattar,A.G., Ramakrishnan,R., Lang,S., Jaras,M.,
            Hansson,J., Soneji,S., Singbrant,S., van den Akker,E. and
            Flygare,J.
  TITLE     Yippee like 4 (Ypel4) is essential for normal mouse red blood cell
            membrane integrity
  JOURNAL   Sci Rep 11 (1), 15898 (2021)
   PUBMED   34354145
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3590)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   7  (bases 1 to 3590)
  AUTHORS   Cox,P.R., Fowler,V., Xu,B., Sweatt,J.D., Paylor,R. and Zoghbi,H.Y.
  TITLE     Mice lacking Tropomodulin-2 show enhanced long-term potentiation,
            hyperactivity, and deficits in learning and memory
  JOURNAL   Mol Cell Neurosci 23 (1), 1-12 (2003)
   PUBMED   12799133
REFERENCE   8  (bases 1 to 3590)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3590)
  AUTHORS   Conley,C.A., Fritz-Six,K.L., Almenar-Queralt,A. and Fowler,V.M.
  TITLE     Leiomodins: larger members of the tropomodulin (Tmod) gene family
  JOURNAL   Genomics 73 (2), 127-139 (2001)
   PUBMED   11318603
REFERENCE   10 (bases 1 to 3590)
  AUTHORS   Cox,P.R. and Zoghbi,H.Y.
  TITLE     Sequencing, expression analysis, and mapping of three unique human
            tropomodulin genes and their mouse orthologs
  JOURNAL   Genomics 63 (1), 97-107 (2000)
   PUBMED   10662549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY067594.1, AF237630.1 and AK147017.1.
            
            On Jan 10, 2006 this sequence version replaced NM_016963.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147017.1, AK169218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               BY067594.1         2-159
            159-1566            AF237630.1         73-1480
            1567-3590           AK147017.1         1568-3591
FEATURES             Location/Qualifiers
     source          1..3590
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.3 cM"
     gene            1..3590
                     /gene="Tmod3"
                     /gene_synonym="U-Tmod; UTMOD"
                     /note="tropomodulin 3"
                     /db_xref="GeneID:50875"
                     /db_xref="MGI:MGI:1355315"
     exon            1..158
                     /gene="Tmod3"
                     /gene_synonym="U-Tmod; UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            159..325
                     /gene="Tmod3"
                     /gene_synonym="U-Tmod; UTMOD"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1258
                     /gene="Tmod3"
                     /gene_synonym="U-Tmod; UTMOD"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitous tropomodulin; tropomodulin 3; ubiquitous
                     tropomodulin"
                     /codon_start=1
                     /product="tropomodulin-3 isoform 1"
                     /protein_id="NP_058659.1"
                     /db_xref="CCDS:CCDS23344.1"
                     /db_xref="GeneID:50875"
                     /db_xref="MGI:MGI:1355315"
                     /translation="MALPFRKDLGDYKDLDEDELLGKLSESELKQLETVLDDLDPENA
                     LLPAGFRQKNQTSKSATGPFDRERLLSYLEKQALEHKDRDDYVPYTGEKKGKIFIPKQ
                     KPAQTLTEETISLDPELEEALTSASDTELCDLAAILGMHNLIADTPFCDVLGSSNGVN
                     QERFPNVVKGEKILPVFDEPPNPTNVEESLKRIRENDARLVEVNLNNIKNIPIPTLKD
                     FAKTLEANTHVKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALI
                     DALRDNETLMELKIDNQRQQLGTSVELEMAKMLEENTNILKFGYQFTQQGPRTRAANA
                     ITKNNDLVRKRRIEGDHQ"
     exon            326..482
                     /gene="Tmod3"
                     /gene_synonym="U-Tmod; UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            483..605
                     /gene="Tmod3"
                     /gene_synonym="U-Tmod; UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            606..695
                     /gene="Tmod3"
                     /gene_synonym="U-Tmod; UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            696..826
                     /gene="Tmod3"
                     /gene_synonym="U-Tmod; UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            827..934
                     /gene="Tmod3"
                     /gene_synonym="U-Tmod; UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1078
                     /gene="Tmod3"
                     /gene_synonym="U-Tmod; UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1223
                     /gene="Tmod3"
                     /gene_synonym="U-Tmod; UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..3590
                     /gene="Tmod3"
                     /gene_synonym="U-Tmod; UTMOD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3235..3240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmod3"
                     /gene_synonym="U-Tmod; UTMOD"
                     /note="hexamer: AATAAA"
     polyA_site      3258
                     /gene="Tmod3"
                     /gene_synonym="U-Tmod; UTMOD"
                     /note="major polyA site"
ORIGIN      
        1 agtgaagggg aaccagcaat acagacagcg cggtcgggtt taggggcagc tggcgggagg
       61 attcggcaac tccctgaact tgaggcaccg cggagtgtgg gcgccgggaa gagcgattca
      121 aaccttgcgg actgtgcagt gggtcggcgg ccagacagct ataacccgtg gtggaagtag
      181 ccagtgagta ccctgcacca tggcactgcc gttccggaag gacttggggg actacaagga
      241 cctggatgag gacgagctcc ttggcaagct gtccgaatca gagctgaaac agctggagac
      301 tgtcctggat gatcttgacc ccgagaatgc ccttctgcct gcagggtttc ggcagaagaa
      361 ccagacatca aagtctgcca cgggaccctt tgatagagaa cggctccttt cttacctaga
      421 gaagcaagca ttggagcaca aagaccggga cgattatgtg ccctacactg gagagaagaa
      481 agggaaaatt tttatcccca aacagaagcc agcgcagact cttacagaag aaactatatc
      541 cctcgaccca gagttagaag aagctttgac aagtgcttca gacacagagc tgtgcgacct
      601 tgcagctatt cttgggatgc acaatctgat tgcagacaca ccgttctgtg atgtgctggg
      661 aagtagtaac ggtgtcaacc aagagcgttt tcccaatgtg gttaaagggg aaaagattct
      721 tccagtgttt gatgagccac caaatccaac caacgttgaa gagagtttaa agagaattag
      781 ggaaaacgat gcccgtcttg ttgaagttaa tttgaataat ataaaaaata tcccaattcc
      841 aactctaaaa gattttgcaa agactttgga agccaacacg catgtgaaac atttcagtct
      901 cgcggccacc aggagcaatg accccgtggc tgttgctttt gcagatatgc tgaaagtgaa
      961 caaaactttg aagagcttaa atatggagtc caacttcatc acaggcgcag gggttttagc
     1021 actgattgat gctttgagag ataatgagac cctgatggag ctcaagattg acaatcagag
     1081 acagcagttg ggcacctcag tagaattaga aatggccaag atgcttgagg aaaatacaaa
     1141 tatccttaaa tttggatatc agttcacgca gcagggaccc cgaaccaggg cagccaacgc
     1201 gataacgaag aacaatgact tagtgcgcaa gaggcgaatt gaaggagacc accagtaagc
     1261 gcagtgacct ttggaagcct gcagatcacc agaggctcgt gttggtggca gcagatgtaa
     1321 aaattacctg ggtagaaggg aaagactgga aatctttttt aactatatgc attattttcc
     1381 tagcttatta tatttgattt gtaaaatcag tactaggtag tattttgtat ttgtagcatt
     1441 tctactgaga ccagtttaat ttagcttaat tgaatggttt atgatgattt ttaggtaaaa
     1501 atgcagttgt ggaaagtttc agaagtcgtg tatgtaagaa taatttgaat gaacatcttg
     1561 aggaccaata ttttttaaat caaaagggac attgctgact caatattaat gttgctcctt
     1621 atacattaag ggtaaggtgc atggtggttt ccttttttaa aaatccatga atttaggcaa
     1681 aagtatgctt tttccttatt agggaaataa aatgtcggaa ttttgaaagg tggctcagaa
     1741 tccattatat ctacataagc caaagtaggc ctgcagggga cacaacagcc atctgtgtgc
     1801 aggtttctgc acacatctaa tgagtctcag ctgcacgggg ctgggtgtgt atgtctccta
     1861 tagtccttag ctctgtccca ctgcatacct tgttaaacgt atagttataa gtatttttct
     1921 ctgctgtggg cattacagtt ttgtaaaagc taatggataa aaagcatccg agtagagagg
     1981 ttcttttccc cataaaaggc tcttggccaa tactcagtta ttgagagtaa aacagaaaaa
     2041 agaaaggcgc tgttagatgt aggagagttc aaacctgaaa tttgcaaggt ggccatctca
     2101 cggatgagca gtgtccgtca ggaactgacg tgagctagct atggtgggtc actcctacag
     2161 tctgagcagc tgagaaggta ggattgccag acattcaaag tcagtctgaa ctacatagga
     2221 acctccaggt tagcctgggc tacatatgtg agaacctatg tcaggaaaag gaaagaacaa
     2281 acttgttgtc tgatgaggag cgctatatgt gattccatag gtgcaatgta gtactgccta
     2341 aacagttaat cccctccacc gtgttccagc caatcacaaa gactgctgtt cttcagaaac
     2401 ctcattttag tagatgtttc cttcatcttg tttttttttt aactgcatat aataaaaagt
     2461 aatttctgta tcataggtta tctctatcac cttagcgtta gttagaatga gggtttgatc
     2521 tgtacagtgg ggttgggtga ggctgcccac cgatgccctg ctagaggact ttcgtctgta
     2581 tctatgctct gccccatgca gctcctacag gagtggcaga ggcacacaca gcagacagtg
     2641 gagaggaaga aggcccaggg aagcacgaac aagtcgacgg ttgcttaaac catgccagtg
     2701 ctggcctgtg aagtattata caactgaaga aaagacttca tcagtaacga gagtgtgaag
     2761 tcatctgatt gaatagatat cttttaagaa ttataatgga gaacagtgtt taccttgatc
     2821 tttacaagtc tggcacctca ttttggtagc agtattttta aattcctctg agatttttat
     2881 gacatggtaa taaattagga ctttgtaata gttttaattt taagctagag atttttctaa
     2941 accttcaagt tttatgcatg attatctaag agaatattct tcacattttt aaattgccct
     3001 tttaaaaagc cttaaattgc ccattttgta aaactatata ttcatatttg tctcaaatta
     3061 taattttcag tatgtctaca tgaaattgta tacattaaat tcaccattag tagctaatat
     3121 tcatgccttg aaaatagatt tggtgctcta cacttacagc caaaacctac tataagtagg
     3181 tttaaagaat acataaaata cattttccta cggtgcctgt catttcaaag accaaataaa
     3241 cattttgtgt taaacatatt agcagactgt tggtcatttc aaggaggatg tttgtgatcc
     3301 ttaagtggca cgttttcacc aatgaaatga gctgtgtcct ttacaagggg tgcaatcctg
     3361 aaaagttaca tgtaaataga actttaaaaa ttgttttatg ggctggtgag atggcttaga
     3421 gggtaagagt cctgactgct cttctggagg tcctgagttc aaatcccaac aaccacatag
     3481 tggctcacaa ccatccgtaa tgagacctga tgccctcttc tggtgtgtct gaagacagct
     3541 acagtgtact tacatataac aataaataaa tcttttttaa aaaatgtttt
//
