LOCUS       NP_057920                351 aa            linear   ROD 11-DEC-2024
DEFINITION  tropomodulin-2 [Mus musculus].
ACCESSION   NP_057920 XP_001480922 XP_001480924 XP_001480928 XP_001480930
VERSION     NP_057920.2
DBSOURCE    REFSEQ: accession NM_016711.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 351)
  AUTHORS   Mitra,A., Deats,S.P., Dickson,P.E., Zhu,J., Gardin,J., Nieman,B.J.,
            Henkelman,R.M., Tsai,N.P., Chesler,E.J., Zhang,Z.W. and Kumar,V.
  TITLE     Tmod2 Is a Regulator of Cocaine Responses through Control of
            Striatal and Cortical Excitability and Drug-Induced Plasticity
  JOURNAL   J Neurosci 44 (18), e1389232024 (2024)
   PUBMED   38508714
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 351)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 351)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (residues 1 to 351)
  AUTHORS   Soulez,M., Saba-El-Leil,M.K., Turgeon,B., Mathien,S., Coulombe,P.,
            Klinger,S., Rousseau,J., Levesque,K. and Meloche,S.
  TITLE     Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3
            in Perinatal Survival and Postnatal Growth Using New Genetically
            Engineered Mouse Models
  JOURNAL   Mol Cell Biol 39 (6), e00527-18 (2019)
   PUBMED   30642949
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 351)
  AUTHORS   Guillaud,L., Gray,K.T., Moroz,N., Pantazis,C., Pate,E. and
            Kostyukova,A.S.
  TITLE     Role of tropomodulin's leucine rich repeat domain in the formation
            of neurite-like processes
  JOURNAL   Biochemistry 53 (16), 2689-2700 (2014)
   PUBMED   24746171
  REMARK    GeneRIF: Role of Tmod2 protein's leucine rich repeat domain in the
            formation of neurite-like processes
REFERENCE   6  (residues 1 to 351)
  AUTHORS   Sui,Z., Nowak,R.B., Bacconi,A., Kim,N.E., Liu,H., Li,J.,
            Wickrema,A., An,X.L. and Fowler,V.M.
  TITLE     Tropomodulin3-null mice are embryonic lethal with anemia due to
            impaired erythroid terminal differentiation in the fetal liver
  JOURNAL   Blood 123 (5), 758-767 (2014)
   PUBMED   24159174
REFERENCE   7  (residues 1 to 351)
  AUTHORS   Coulpier,F., Le Crom,S., Maro,G.S., Manent,J., Giovannini,M.,
            Maciorowski,Z., Fischer,A., Gessler,M., Charnay,P. and Topilko,P.
  TITLE     Novel features of boundary cap cells revealed by the analysis of
            newly identified molecular markers
  JOURNAL   Glia 57 (13), 1450-1457 (2009)
   PUBMED   19243017
REFERENCE   8  (residues 1 to 351)
  AUTHORS   Cox,P.R., Fowler,V., Xu,B., Sweatt,J.D., Paylor,R. and Zoghbi,H.Y.
  TITLE     Mice lacking Tropomodulin-2 show enhanced long-term potentiation,
            hyperactivity, and deficits in learning and memory
  JOURNAL   Mol Cell Neurosci 23 (1), 1-12 (2003)
   PUBMED   12799133
  REMARK    GeneRIF: Tmod2 plays a role in behavior, learning, memory, and
            synaptic plasticity.
REFERENCE   9  (residues 1 to 351)
  AUTHORS   Conley,C.A., Fritz-Six,K.L., Almenar-Queralt,A. and Fowler,V.M.
  TITLE     Leiomodins: larger members of the tropomodulin (Tmod) gene family
  JOURNAL   Genomics 73 (2), 127-139 (2001)
   PUBMED   11318603
REFERENCE   10 (residues 1 to 351)
  AUTHORS   Cox,P.R. and Zoghbi,H.Y.
  TITLE     Sequencing, expression analysis, and mapping of three unique human
            tropomodulin genes and their mouse orthologs
  JOURNAL   Genomics 63 (1), 97-107 (2000)
   PUBMED   10662549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147581.1, AK079077.1 and AC123832.4.
            
            On or before Aug 8, 2008 this sequence version replaced
            XP_001480922.1, XP_001480924.1, XP_001480928.1, XP_001480930.1,
            NP_057920.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.74877.1, AK079077.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.31 cM"
     Protein         1..351
                     /product="tropomodulin-2"
                     /note="neuronal tropomodulin; neural tropomodulin"
                     /calculated_mol_wt=39380
     Region          5..146
                     /region_name="Tropomodulin"
                     /note="pfam03250"
                     /db_xref="CDD:460862"
     Site            25
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P70566; propagated from
                     UniProtKB/Swiss-Prot (Q9JKK7.2)"
     Region          <185..338
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     CDS             1..351
                     /gene="Tmod2"
                     /gene_synonym="N-Tmod; NTMOD"
                     /coded_by="NM_016711.3:370..1425"
                     /db_xref="CCDS:CCDS23345.1"
                     /db_xref="GeneID:50876"
                     /db_xref="MGI:MGI:1355335"
ORIGIN      
        1 malpfqkgle kyknidedel lgklseeelk qlenvlddld pesatlpagf rqkdqtqkaa
       61 tgpfdrehll mylekealeq kdredfvpft gekkgrvfip kekpvetrke ekvtldpele
      121 ealasasdte lydlaavlgv hnllnnpkfd eettngegrk gpvrnvvkge kakpvfeepp
      181 nptnveaslq qmkandpslq evnlnnikni piptlkefak sletnthvkk fslaatrsnd
      241 pvalafaeml kvnktlksln vesnfitgtg ilalvealre ndtlteikid nqrqqlgtav
      301 emeiaqmlee nsrilkfgyq ftkqgprtrv aaaitknndl vrkkrvegdr r
//
