LOCUS       NM_021883               2887 bp    mRNA    linear   ROD 26-SEP-2023
DEFINITION  Mus musculus tropomodulin 1 (Tmod1), mRNA.
ACCESSION   NM_021883
VERSION     NM_021883.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2887)
  AUTHORS   Patel T, Hammelman J, Aziz S, Jang S, Closser M, Michaels TL, Blum
            JA, Gifford DK and Wichterle H.
  TITLE     Transcriptional dynamics of murine motor neuron maturation in vivo
            and in vitro
  JOURNAL   Nat Commun 13 (1), 5427 (2022)
   PUBMED   36109497
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2887)
  AUTHORS   Liu X, Xia X, Wang X, Zhou J, Sung LA, Long J, Geng X, Zeng Z and
            Yao W.
  TITLE     Tropomodulin1 Expression Increases Upon Maturation in Dendritic
            Cells and Promotes Their Maturation and Immune Functions
  JOURNAL   Front Immunol 11, 587441 (2021)
   PUBMED   33552047
  REMARK    GeneRIF: Tropomodulin1 Expression Increases Upon Maturation in
            Dendritic Cells and Promotes Their Maturation and Immune Functions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2887)
  AUTHORS   Gao R, Liang X, Cheedipudi S, Cordero J, Jiang X, Zhang Q, Caputo
            L, Gunther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G,
            Chen Y, Braun T, Evans SM, Sun Y and Dobreva G.
  TITLE     Pioneering function of Isl1 in the epigenetic control of
            cardiomyocyte cell fate
  JOURNAL   Cell Res 29 (6), 486-501 (2019)
   PUBMED   31024170
REFERENCE   4  (bases 1 to 2887)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2887)
  AUTHORS   Hu J, Shi Y, Xia M, Liu Z, Zhang R, Luo H, Zhang T, Yang Z and Yuan
            B.
  TITLE     WDR1-regulated actin dynamics is required for outflow tract and
            right ventricle development
  JOURNAL   Dev Biol 438 (2), 124-137 (2018)
   PUBMED   29654745
REFERENCE   6  (bases 1 to 2887)
  AUTHORS   Watakabe A, Kobayashi R and Helfman DM.
  TITLE     N-tropomodulin: a novel isoform of tropomodulin identified as the
            major binding protein to brain tropomyosin
  JOURNAL   J Cell Sci 109 (Pt 9), 2299-2310 (1996)
   PUBMED   8886980
REFERENCE   7  (bases 1 to 2887)
  AUTHORS   Schiaffino S and Reggiani C.
  TITLE     Molecular diversity of myofibrillar proteins: gene regulation and
            functional significance
  JOURNAL   Physiol Rev 76 (2), 371-423 (1996)
   PUBMED   8618961
  REMARK    Review article
REFERENCE   8  (bases 1 to 2887)
  AUTHORS   White RA, Dowler LL, Woo M, Adkison LR, Pal S, Gershon D and Fowler
            VM.
  TITLE     The tropomodulin (Tmod) gene maps to chromosome 4, closely linked
            to Mup1
  JOURNAL   Mamm Genome 6 (5), 332-333 (1995)
   PUBMED   7626883
REFERENCE   9  (bases 1 to 2887)
  AUTHORS   Pilz A, Woodward K, Povey S and Abbott C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   10 (bases 1 to 2887)
  AUTHORS   Ito M, Swanson B, Sussman MA, Kedes L and Lyons G.
  TITLE     Cloning of tropomodulin cDNA and localization of gene transcripts
            during mouse embryogenesis
  JOURNAL   Dev Biol 167 (1), 317-328 (1995)
   PUBMED   7851652
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY127972.1, AK132878.1, BC106850.1, W61665.1, AK137060.1 and
            AW061277.1.
            
            [WARNING] On Oct 16, 2023 this sequence was replaced by
            NM_021883.3.
            
            On Apr 11, 2007 this sequence version replaced NM_021883.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.17171.1,
                                           SRR8865137.1260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               BY127972.1         2-347
            347-755             AK132878.1         180-588
            756-1568            BC106850.1         644-1456
            1569-1747           W61665.1           127-305
            1748-2479           AK137060.1         1-732
            2480-2887           AW061277.1         1-408               c
FEATURES             Location/Qualifiers
     source          1..2887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 24.49 cM"
     gene            1..2887
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /note="tropomodulin 1"
                     /db_xref="GeneID:21916"
                     /db_xref="MGI:MGI:98775"
     exon            1..88
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            89..257
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1217
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /note="erythrocyte tropomodulin"
                     /codon_start=1
                     /product="tropomodulin-1"
                     /protein_id="NP_068683.1"
                     /db_xref="CCDS:CCDS18143.1"
                     /db_xref="GeneID:21916"
                     /db_xref="MGI:MGI:98775"
                     /translation="MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALL
                     PAGLRQKDQTTKAPTGPFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKP
                     MDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALGSSSIVNKEG
                     LNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPELEEVNLNNIRNIPIPTLKAYAE
                     ALKENSYVKKFSIVGTRSNDPVAFALAEMLKVNKVLKTLNVESNFISGAGILRLVEAL
                     PHNTSLVELKIDNQSQPLGNKVEMEIVNMLEKNTTLLKFGYHFTQQGPRLRASNAMMS
                     NNDLVRKRRLADLTGPIIPKCRSGV"
     exon            258..414
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            415..534
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            535..624
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            625..755
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            756..863
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1007
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1152
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..2871
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttcccac ccgcggccgc cagggaactc gccaagcccc gcgttccgct cattgccgcc
       61 gcccgcgctc gcgccacccc gcatcccggt cagcagccag cacagaagtt caggagacaa
      121 agacacagcc tcacacaatg tcctacagac gagagctgga gaaatatcga gacctggatg
      181 aggatgaaat cctgggggcc ctcacagagg aggagctgag gacgctggaa aatgagctag
      241 atgaactaga ccctgataat gcactgctcc ctgcaggcct gaggcagaag gatcagacca
      301 ccaaggcacc cacaggcccc tttaaaagag aggagctttt ggaccacttg gaaaagcaag
      361 cgaaggaatt taaggaccga gaagatctgg ttccctacac aggggagaaa cgaggaaagg
      421 tctgggtccc caagcagaag ccaatggatc ccgtgctgga gagtgtgaca ctggagccag
      481 aactggagga ggccctagca aatgcctcgg atgcagaact gtgtgacatc gcagctatcc
      541 tgggcatgca cacactcatg agcaaccagc agtactacca agccttgggc agcagctcca
      601 tcgtgaacaa ggaggggctc aacagtgtga tcaaacccac acaatacaag cctgtgcctg
      661 atgaagaacc aaattcaaca gacgtagagg aaacgctgga gcgaataaag aacaatgacc
      721 cagaactaga agaggttaat cttaacaaca tccggaatat tcccataccc accctcaagg
      781 catatgcaga agccctgaaa gagaactcct atgtgaagaa gttcagcatc gtggggaccc
      841 gcagcaatga ccctgtggcg tttgcccttg ctgaaatgct gaaagtgaac aaggtgctga
      901 agaccctgaa cgtggagtcc aacttcatct ctggagctgg gatcctgcgc ctggtggaag
      961 ctctccccca caacacttct ctggtcgagc tgaaaatcga taaccagagc caacctttgg
     1021 gcaacaaagt ggaaatggag atcgtgaaca tgttggagaa aaacacaacg ctcctcaaat
     1081 ttggctacca ctttacccag caggggcccc ggctgcgggc atccaacgcc atgatgagca
     1141 acaacgacct tgtgaggaag aggaggctcg cagacctgac ggggcctatt atccccaagt
     1201 gccgcagcgg tgtctagcat gcgaagggaa gcccacgcct aggaactgga cgtgttctac
     1261 cgatgatgcg tgtgccccag tggagcccag gacgaatgct ggcgtggagc tcttgtggct
     1321 cagttctttg tgcactgagg tttaggttaa ctagactgta gtcggacctt ttataaaaca
     1381 tggctaatgt gaagtttttc tttaggcaca gaagttcagt ctggtaatta tttaaacatg
     1441 cagaagccct caagctagcg ggccttgctg cagacagtgt gacactggca gagacggccc
     1501 aggagccccc tggcggccct gctttggggc ctaggtgcac ttacaacatg ggacgcacca
     1561 gcacagagca ctcttcccac ctagtttgga agcgtggtga aacaatcttt tatttccaat
     1621 ttgatcgtag caactcagta aaaagaacac ataatcatga tctgtcaacc cccacttgaa
     1681 actttgacat caagattaaa gctgccaaat tgattccagg atcaaacccc cacccctaag
     1741 aatgaaagac aagccacaga attttctaag agtcagaaag acacaggatt ccttttgcca
     1801 ggtaagataa agagggagaa aaaggcaatg gtgaattttc aagtttcaaa acccaccaca
     1861 ccaggcaaca gacatccttc tgagtgctgt gggaacacct gcggggtact catctgcagt
     1921 cagaaatcat ttcttcttta ttgaattcca acttcatgat ggatgaaaac ttacagccgc
     1981 tgggcagtgg tggcacacgc ctttaatccc agcacttggg aggcagaggc aggcggattt
     2041 ctgagttcga ggccagcctg gtctacagag tgagttccag gacagccagg gctatacaga
     2101 gaaaccctgt ctcgaaaaac caaaaaaaaa aaaaaaagga aaaaaaaaga aaacttacag
     2161 ccacataaaa acatcttcct ataccacagt gggcaatggc ttatgtgaga tcaacaccat
     2221 tgggtgaatt tccagtccac catgcctgtg gtatttagca tggccctgct tacagacacc
     2281 aagtgcctgc ctggtcattt atgagacaaa tcaaatcaca cagagctctt gcctacaaac
     2341 aaagcctcta gaggacagca gagtacagca tcttaatggt aaggaattag gagatcctgg
     2401 ccaaacaaca cacgggatta ctctgaaacc taatcttggt gttcctactg gatttccttt
     2461 tttaacacca tgggagccag taaaaatgtt caaatacact gttcttgtgc cttttaatag
     2521 accacagtgc cagttaaact agtatttttg ttgttttggg gagttatttt ccttagggat
     2581 tcagccaata ttatagtaat gataaggctc aaaagctgtt gagcatagcc agggggcttc
     2641 tgacttaaga gaaagcctgc acaccgaact gtaacagtat ggacagtaca gggtaactag
     2701 aggtggcatc ggggcctcag cactgagtgt ccactgaggc tgcacacggg cccaggagtg
     2761 gcaccaagct gcagggacag ccagccccac tcagcttctc cttgaaacac aactgcagct
     2821 gcattctgca tcactggaaa ctgcaaaata atattaaagc catttggtct aaaaaaaaaa
     2881 aaaaaaa
//
