LOCUS       NP_068683                359 aa            linear   ROD 24-SEP-2024
DEFINITION  tropomodulin-1 isoform 1 [Mus musculus].
ACCESSION   NP_068683
VERSION     NP_068683.1
DBSOURCE    REFSEQ: accession NM_021883.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 359)
  AUTHORS   Geng,X., Xia,X., Liang,Z., Li,S., Yue,Z., Zhang,H., Guo,L., Ma,S.,
            Jiang,S., Lian,X., Zhou,J., Sung,L.A., Wang,X. and Yao,W.
  TITLE     Tropomodulin1 exacerbates inflammatory response in macrophages by
            negatively regulating LPS-induced TLR4 endocytosis
  JOURNAL   Cell Mol Life Sci 81 (1), 402 (2024)
   PUBMED   39276234
  REMARK    GeneRIF: Tropomodulin1 exacerbates inflammatory response in
            macrophages by negatively regulating LPS-induced TLR4 endocytosis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 359)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 359)
  AUTHORS   Patel,T., Hammelman,J., Aziz,S., Jang,S., Closser,M.,
            Michaels,T.L., Blum,J.A., Gifford,D.K. and Wichterle,H.
  TITLE     Transcriptional dynamics of murine motor neuron maturation in vivo
            and in vitro
  JOURNAL   Nat Commun 13 (1), 5427 (2022)
   PUBMED   36109497
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 359)
  AUTHORS   Liu,X., Xia,X., Wang,X., Zhou,J., Sung,L.A., Long,J., Geng,X.,
            Zeng,Z. and Yao,W.
  TITLE     Tropomodulin1 Expression Increases Upon Maturation in Dendritic
            Cells and Promotes Their Maturation and Immune Functions
  JOURNAL   Front Immunol 11, 587441 (2021)
   PUBMED   33552047
  REMARK    GeneRIF: Tropomodulin1 Expression Increases Upon Maturation in
            Dendritic Cells and Promotes Their Maturation and Immune Functions.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 359)
  AUTHORS   Gao,R., Liang,X., Cheedipudi,S., Cordero,J., Jiang,X., Zhang,Q.,
            Caputo,L., Gunther,S., Kuenne,C., Ren,Y., Bhattacharya,S., Yuan,X.,
            Barreto,G., Chen,Y., Braun,T., Evans,S.M., Sun,Y. and Dobreva,G.
  TITLE     Pioneering function of Isl1 in the epigenetic control of
            cardiomyocyte cell fate
  JOURNAL   Cell Res 29 (6), 486-501 (2019)
   PUBMED   31024170
REFERENCE   6  (residues 1 to 359)
  AUTHORS   Watakabe,A., Kobayashi,R. and Helfman,D.M.
  TITLE     N-tropomodulin: a novel isoform of tropomodulin identified as the
            major binding protein to brain tropomyosin
  JOURNAL   J Cell Sci 109 (Pt 9), 2299-2310 (1996)
   PUBMED   8886980
REFERENCE   7  (residues 1 to 359)
  AUTHORS   Schiaffino,S. and Reggiani,C.
  TITLE     Molecular diversity of myofibrillar proteins: gene regulation and
            functional significance
  JOURNAL   Physiol Rev 76 (2), 371-423 (1996)
   PUBMED   8618961
  REMARK    Review article
REFERENCE   8  (residues 1 to 359)
  AUTHORS   White,R.A., Dowler,L.L., Woo,M., Adkison,L.R., Pal,S., Gershon,D.
            and Fowler,V.M.
  TITLE     The tropomodulin (Tmod) gene maps to chromosome 4, closely linked
            to Mup1
  JOURNAL   Mamm Genome 6 (5), 332-333 (1995)
   PUBMED   7626883
REFERENCE   9  (residues 1 to 359)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   10 (residues 1 to 359)
  AUTHORS   Ito,M., Swanson,B., Sussman,M.A., Kedes,L. and Lyons,G.
  TITLE     Cloning of tropomodulin cDNA and localization of gene transcripts
            during mouse embryogenesis
  JOURNAL   Dev Biol 167 (1), 317-328 (1995)
   PUBMED   7851652
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732615.15.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784648.879786.1,
                                           SRR9219381.84729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 24.49 cM"
     Protein         1..359
                     /product="tropomodulin-1 isoform 1"
                     /note="erythrocyte tropomodulin"
                     /calculated_mol_wt=40335
     Region          3..143
                     /region_name="Tropomodulin"
                     /note="pfam03250"
                     /db_xref="CDD:460862"
     Region          36..61
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P49813.2)"
     Region          39..138
                     /region_name="Tropomyosin-binding. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P49813.2)"
     Region          <183..314
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     CDS             1..359
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /coded_by="NM_021883.3:130..1209"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS18143.1"
                     /db_xref="GeneID:21916"
                     /db_xref="MGI:MGI:98775"
ORIGIN      
        1 msyrreleky rdldedeilg alteeelrtl eneldeldpd nallpaglrq kdqttkaptg
       61 pfkreelldh lekqakefkd redlvpytge krgkvwvpkq kpmdpvlesv tlepeleeal
      121 anasdaelcd iaailgmhtl msnqqyyqal gsssivnkeg lnsvikptqy kpvpdeepns
      181 tdveetleri knndpeleev nlnnirnipi ptlkayaeal kensyvkkfs ivgtrsndpv
      241 afalaemlkv nkvlktlnve snfisgagil rlvealphnt slvelkidnq sqplgnkvem
      301 eivnmleknt tllkfgyhft qqgprlrasn ammsnndlvr krrladltgp iipkcrsgv
//
