LOCUS       NM_025655               1427 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Mus musculus transmembrane and immunoglobulin domain containing 1
            (Tmigd1), transcript variant 2, mRNA.
ACCESSION   NM_025655 XM_006533947
VERSION     NM_025655.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1427)
  AUTHORS   Belghasem,M., Yin,W., Lotfollahzadeh,S., Yang,X., Meyer,R.D.,
            Napoleon,M.A., Sellinger,I.E., Vazirani,A., Metrikova,E., Jose,A.,
            Zhebrun,A., Whelan,S.A., Lee,N., Rahimi,N. and Chitalia,V.C.
  TITLE     Tryptophan Metabolites Target Transmembrane and Immunoglobulin
            Domain-Containing 1 Signaling to Augment Renal Tubular Injury
  JOURNAL   Am J Pathol 193 (10), 1501-1516 (2023)
   PUBMED   37676196
REFERENCE   2  (bases 1 to 1427)
  AUTHORS   Zhou,L., Zhu,L., Wu,X., Hu,S., Zhang,S., Ning,M., Yu,J. and Chen,M.
  TITLE     Decreased TMIGD1 aggravates colitis and intestinal barrier
            dysfunction via the BANF1-NF-kappaB pathway in Crohn's disease
  JOURNAL   BMC Med 21 (1), 287 (2023)
   PUBMED   37542259
  REMARK    GeneRIF: Decreased TMIGD1 aggravates colitis and intestinal barrier
            dysfunction via the BANF1-NF-kappaB pathway in Crohn's disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1427)
  AUTHORS   Chang,X., Song,Y.H., Xia,T., He,Z.X., Zhao,S.B., Wang,Z.J., Gu,L.,
            Li,Z.S., Xu,C., Wang,S.L. and Bai,Y.
  TITLE     Macrophage-derived exosomes promote intestinal mucosal barrier
            dysfunction in inflammatory bowel disease by regulating TMIGD1 via
            mircroRNA-223
  JOURNAL   Int Immunopharmacol 121, 110447 (2023)
   PUBMED   37301121
  REMARK    GeneRIF: Macrophage-derived exosomes promote intestinal mucosal
            barrier dysfunction in inflammatory bowel disease by regulating
            TMIGD1 via mircroRNA-223.
REFERENCE   4  (bases 1 to 1427)
  AUTHORS   Hartmann,C., Thuring,E.M., Greune,L., Michels,B.E., Pajonczyk,D.,
            Leussink,S., Brinkmann,F., Glaesner-Ebnet,M., Wardelmann,E.,
            Zobel,T., Schmidt,M.A., Janssen,K.P., Gerke,V. and Ebnet,K.
  TITLE     Intestinal brush border formation requires a TMIGD1-based
            intermicrovillar adhesion complex
  JOURNAL   Sci Signal 15 (751), eabm2449 (2022)
   PUBMED   36099341
  REMARK    GeneRIF: Intestinal brush border formation requires a TMIGD1-based
            intermicrovillar adhesion complex.
REFERENCE   5  (bases 1 to 1427)
  AUTHORS   Rahimi,N., Ho,R.X.Y., Chandler,K.B., De La Cena,K.O.C., Amraei,R.,
            Mitchel,A.J., Engblom,N. and Costello,C.E.
  TITLE     The cell adhesion molecule TMIGD1 binds to moesin and regulates
            tubulin acetylation and cell migration
  JOURNAL   J Biomed Sci 28 (1), 61 (2021)
   PUBMED   34503512
  REMARK    GeneRIF: The cell adhesion molecule TMIGD1 binds to moesin and
            regulates tubulin acetylation and cell migration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1427)
  AUTHORS   Wu,Y., Li,E., Wang,Z., Shen,T., Shen,C., Liu,D., Gao,Q., Li,X. and
            Wei,G.
  TITLE     TMIGD1 Inhibited Abdominal Adhesion Formation by Alleviating
            Oxidative Stress in the Mitochondria of Peritoneal Mesothelial
            Cells
  JOURNAL   Oxid Med Cell Longev 2021, 9993704 (2021)
   PUBMED   34426761
  REMARK    GeneRIF: TMIGD1 Inhibited Abdominal Adhesion Formation by
            Alleviating Oxidative Stress in the Mitochondria of Peritoneal
            Mesothelial Cells.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1427)
  AUTHORS   De La Cena,K.O.C., Ho,R.X., Amraei,R., Woolf,N., Tashjian,J.Y.,
            Zhao,Q., Richards,S., Walker,J., Huang,J., Chitalia,V.C. and
            Rahimi,N.
  TITLE     Transmembrane and Immunoglobulin Domain Containing 1, a Putative
            Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in
            Colon Cancer Cells
  JOURNAL   Am J Pathol 191 (1), 157-167 (2021)
   PUBMED   33129760
  REMARK    GeneRIF: Transmembrane and Immunoglobulin Domain Containing 1, a
            Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint
            Arrest in Colon Cancer Cells.
REFERENCE   8  (bases 1 to 1427)
  AUTHORS   Arafa,E., Bondzie,P.A., Rezazadeh,K., Meyer,R.D., Hartsough,E.,
            Henderson,J.M., Schwartz,J.H., Chitalia,V. and Rahimi,N.
  TITLE     TMIGD1 is a novel adhesion molecule that protects epithelial cells
            from oxidative cell injury
  JOURNAL   Am J Pathol 185 (10), 2757-2767 (2015)
   PUBMED   26342724
REFERENCE   9  (bases 1 to 1427)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603842.9.
            
            On or before Apr 24, 2020 this sequence version replaced
            XM_006533947.4, NM_025655.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.23161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AL603842.9         199115-199172       c
            59-162              AL603842.9         196685-196788       c
            163-441             AL603842.9         194140-194418       c
            442-720             AL603842.9         191006-191284       c
            721-824             AL603842.9         187254-187357       c
            825-865             AL603842.9         185836-185876       c
            866-1427            AL603842.9         184744-185305       c
FEATURES             Location/Qualifiers
     source          1..1427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.15 cM"
     gene            1..1427
                     /gene="Tmigd1"
                     /gene_synonym="2010002A20Rik; Tmigd"
                     /note="transmembrane and immunoglobulin domain containing
                     1"
                     /db_xref="GeneID:66601"
                     /db_xref="MGI:MGI:1913851"
     exon            1..58
                     /gene="Tmigd1"
                     /gene_synonym="2010002A20Rik; Tmigd"
                     /inference="alignment:Splign:2.1.0"
     exon            59..162
                     /gene="Tmigd1"
                     /gene_synonym="2010002A20Rik; Tmigd"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..869
                     /gene="Tmigd1"
                     /gene_synonym="2010002A20Rik; Tmigd"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; transmembrane and immunoglobulin
                     domain-containing protein 1"
                     /codon_start=1
                     /product="transmembrane and immunoglobulin
                     domain-containing protein 1 isoform 2 precursor"
                     /protein_id="NP_079931.1"
                     /db_xref="CCDS:CCDS25072.1"
                     /db_xref="GeneID:66601"
                     /db_xref="MGI:MGI:1913851"
                     /translation="MVWKITGPLQACQLLLVVLSLPQGRTSSVLTVNGRTENYILDTQ
                     HGVQASLECAVQNHTEDEELLWYREDGIVDLKNGNKINISSVCVSPINESDNGVRFTC
                     KLQRDQTVSVTVVLNVTFPPLLSGNGFQTVEENSDVSLVCNVKSNPQAQMMWYKNNSA
                     LVLEKGRHQIHQTRESFQLSITKVKKSDNGTYSCIASSSLKMETMDFHLLVKDKVFVM
                     PAEPIIAACVVVVLTMAFALFSRRKRIMKLCGKKNDPNSETAL"
     exon            163..441
                     /gene="Tmigd1"
                     /gene_synonym="2010002A20Rik; Tmigd"
                     /inference="alignment:Splign:2.1.0"
     exon            442..720
                     /gene="Tmigd1"
                     /gene_synonym="2010002A20Rik; Tmigd"
                     /inference="alignment:Splign:2.1.0"
     exon            721..824
                     /gene="Tmigd1"
                     /gene_synonym="2010002A20Rik; Tmigd"
                     /inference="alignment:Splign:2.1.0"
     exon            825..865
                     /gene="Tmigd1"
                     /gene_synonym="2010002A20Rik; Tmigd"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1427
                     /gene="Tmigd1"
                     /gene_synonym="2010002A20Rik; Tmigd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1401..1406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmigd1"
                     /gene_synonym="2010002A20Rik; Tmigd"
                     /note="hexamer: AATAAA"
     polyA_site      1420
                     /gene="Tmigd1"
                     /gene_synonym="2010002A20Rik; Tmigd"
                     /note="major polyA site"
ORIGIN      
        1 agggctcctg ggcagaggaa gagctaggtg aggaagtcag ctgctgggag ctcagcagaa
       61 ggtccaacct gcattcatta aagatggtgt ggaagatcac cgggccactg caagcatgcc
      121 agcttctctt agtggtttta tctttgccac aggggagaac aagctctgtt ttaactgtga
      181 atggtagaac tgagaactat attctggaca ctcaacatgg tgtccaagca tctctggaat
      241 gtgctgttca aaaccacacc gaggatgaag aacttctctg gtacagagaa gatggaatag
      301 tagatctgaa aaatggaaac aaaatcaaca tcagttctgt ttgtgtctct cccatcaacg
      361 aaagtgacaa tggagtccgc tttacctgca agctacagcg cgatcagacg gtgtccgtta
      421 cagtagtgct gaacgttacc tttcctcctc ttctaagtgg caatggcttc caaaccgtgg
      481 aggaaaacag cgatgtaagt ttggtttgca acgtgaaatc caaccctcaa gcgcaaatga
      541 tgtggtataa aaacaacagc gccttggttt tagagaaagg ccgtcaccaa atccaccaga
      601 caagggagtc ttttcagttg tccatcacca aagtcaagaa atctgacaat gggacctaca
      661 gctgtattgc cagctcatct ctgaaaatgg agaccatgga cttccacctg cttgttaaag
      721 acaaagtttt tgtcatgccg gcagagccca tcattgctgc ttgtgtcgtg gtcgtcctga
      781 cgatggcttt tgccctgttt tctaggagga aaagaataat gaagctctgt gggaaaaaga
      841 atgacccgaa ttcagaaaca gctctataaa acaaacaaac aaaaaaagcg gagctgccac
      901 ctaacacggg aagagttttg catcaagacc atctcgattt gtataatgtc gtctgtattt
      961 attgccattt ttaaattcac tcctgtcaaa ttgtcagagg ttgtgaagaa gtatttagtt
     1021 aattactaaa cagttgttat gaccaatttg atctacttat ggatctgtgt aatgggcaag
     1081 ggttcagaat agaaagattt tggtaaggtc actcctgaag tatgttaatt atttttcaat
     1141 atattcctag tagatcggta accacttact atttgattta tagttttcta catgggagat
     1201 taactgacat ttggatgctc taaatcagtg cagtaggtga gactcgaagc agagaccaat
     1261 atagaacaat gatgtttcta agatgccagg gagccaataa agatgcaaac tgtctcttgt
     1321 gttcagtgtc atctcattaa tgttttggga ctaaaggagg gaacacctaa tctcagaatg
     1381 taagacattc cttcaagtgg aataaatttt gtaccatgaa gatttta
//
