LOCUS       NM_001081111            6781 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus TATA element modulatory factor 1 (Tmf1), mRNA.
ACCESSION   NM_001081111 XM_132740
VERSION     NM_001081111.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6781)
  AUTHORS   Rahimi,R., Malek,I., Lerrer-Goldshtein,T., Elkis,Y., Shoval,I.,
            Jacob,A., Shpungin,S. and Nir,U.
  TITLE     TMF1 is upregulated by insulin and is required for a sustained
            glucose homeostasis
  JOURNAL   FASEB J 35 (2), e21295 (2021)
   PUBMED   33475194
  REMARK    GeneRIF: TMF1 is upregulated by insulin and is required for a
            sustained glucose homeostasis.
REFERENCE   2  (bases 1 to 6781)
  AUTHORS   Elkis,Y., Bel,S., Rahimi,R., Lerer-Goldstein,T., Levin-Zaidman,S.,
            Babushkin,T., Shpungin,S. and Nir,U.
  TITLE     TMF/ARA160 Governs the Dynamic Spatial Orientation of the Golgi
            Apparatus during Sperm Development
  JOURNAL   PLoS One 10 (12), e0145277 (2015)
   PUBMED   26701263
  REMARK    GeneRIF: The microtubule interacting domain (MIT) domain in TMF,
            along with microtubule integrity, are required for stable
            association of TMF with the Golgi apparatus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6781)
  AUTHORS   Bel,S., Elkis,Y., Elifantz,H., Koren,O., Ben-Hamo,R.,
            Lerer-Goldshtein,T., Rahimi,R., Ben Horin,S., Nyska,A., Shpungin,S.
            and Nir,U.
  TITLE     Reprogrammed and transmissible intestinal microbiota confer
            diminished susceptibility to induced colitis in TMF-/- mice
  JOURNAL   Proc Natl Acad Sci U S A 111 (13), 4964-4969 (2014)
   PUBMED   24639530
  REMARK    GeneRIF: Altered mucus secretion in TMF(-/-) mouse colons is
            accompanied by a reprogrammed intestinal microbiota, leading to a
            transmissible reduced sensitivity to induced colitis.
REFERENCE   4  (bases 1 to 6781)
  AUTHORS   Elkis,Y., Bel,S., Lerer-Goldstein,T., Nyska,A., Creasy,D.M.,
            Shpungin,S. and Nir,U.
  TITLE     Testosterone deficiency accompanied by testicular and epididymal
            abnormalities in TMF(-/-) mice
  JOURNAL   Mol Cell Endocrinol 365 (1), 52-63 (2013)
   PUBMED   23000399
  REMARK    GeneRIF: Data from knockout mice suggest that TMF/ARA160
            participates in control of serum testosterone levels in males, and
            its absence results in major testicular and epididymal defects and
            abnormal spermatogenesis and Leydig cell proliferation.
REFERENCE   5  (bases 1 to 6781)
  AUTHORS   Bel,S., Elkis,Y., Lerer-Goldstein,T., Nyska,A., Shpungin,S. and
            Nir,U.
  TITLE     Loss of TMF/ARA160 protein renders colonic mucus refractory to
            bacterial colonization and diminishes intestinal susceptibility to
            acute colitis
  JOURNAL   J Biol Chem 287 (30), 25631-25639 (2012)
   PUBMED   22553199
  REMARK    GeneRIF: absence of TMF/ARA160 renders the colonic mucus refractory
            to bacterial colonization and the large intestine less susceptible
            to the onset of colitis.
REFERENCE   6  (bases 1 to 6781)
  AUTHORS   Gu,P., Min,J.N., Wang,Y., Huang,C., Peng,T., Chai,W. and Chang,S.
  TITLE     CTC1 deletion results in defective telomere replication, leading to
            catastrophic telomere loss and stem cell exhaustion
  JOURNAL   EMBO J 31 (10), 2309-2321 (2012)
   PUBMED   22531781
REFERENCE   7  (bases 1 to 6781)
  AUTHORS   Lerer-Goldshtein,T., Bel,S., Shpungin,S., Pery,E., Motro,B.,
            Goldstein,R.S., Bar-Sheshet,S.I., Breitbart,H. and Nir,U.
  TITLE     TMF/ARA160: A key regulator of sperm development
  JOURNAL   Dev Biol 348 (1), 12-21 (2010)
   PUBMED   20691678
  REMARK    GeneRIF: TMF/ARA160 is a key regulator which is essential for the
            onset of key events in the differentiation and maturation of
            mammalian sperm and whose absence severely compromises their
            ability to fertilize ova.
REFERENCE   8  (bases 1 to 6781)
  AUTHORS   Volpe,M., Shpungin,S., Barbi,C., Abrham,G., Malovani,H., Wides,R.
            and Nir,U.
  TITLE     trnp: A conserved mammalian gene encoding a nuclear protein that
            accelerates cell-cycle progression
  JOURNAL   DNA Cell Biol 25 (6), 331-339 (2006)
   PUBMED   16792503
REFERENCE   9  (bases 1 to 6781)
  AUTHORS   Perry,E., Tsruya,R., Levitsky,P., Pomp,O., Taller,M., Weisberg,S.,
            Parris,W., Kulkarni,S., Malovani,H., Pawson,T., Shpungin,S. and
            Nir,U.
  TITLE     TMF/ARA160 is a BC-box-containing protein that mediates the
            degradation of Stat3
  JOURNAL   Oncogene 23 (55), 8908-8919 (2004)
   PUBMED   15467733
  REMARK    GeneRIF: TMF/ARA160 is a BC-box-containing protein that mediates
            the degradation of Stat3
REFERENCE   10 (bases 1 to 6781)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155724.8, AK144898.1, CN456538.1, BQ561257.1, BE627586.1 and
            BQ561256.1.
            
            On Jan 13, 2010 this sequence version replaced NM_001081111.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150931.1, SRR9219379.1799.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC155724.8         65142-65182         c
            42-1624             AK144898.1         2-1584
            1625-1673           CN456538.1         153-201
            1674-1860           CN456538.1         217-403
            1861-2254           BQ561257.1         71-464
            2255-2795           BE627586.1         5-545
            2796-2852           AC155724.8         46301-46357         c
            2853-2954           AC155724.8         44519-44620         c
            2955-3022           AC155724.8         44189-44256         c
            3023-3461           BQ561256.1         1-439               c
            3462-6781           AC155724.8         38008-41327         c
FEATURES             Location/Qualifiers
     source          1..6781
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 44.89 cM"
     gene            1..6781
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /note="TATA element modulatory factor 1"
                     /db_xref="GeneID:232286"
                     /db_xref="MGI:MGI:2684999"
     exon            1..243
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..3377
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /note="TMF; androgen receptor coactivator 160 kDa protein;
                     androgen receptor-associated protein of 160 kDa"
                     /codon_start=1
                     /product="TATA element modulatory factor"
                     /protein_id="NP_001074580.1"
                     /db_xref="CCDS:CCDS39575.1"
                     /db_xref="GeneID:232286"
                     /db_xref="MGI:MGI:2684999"
                     /translation="MSWFNASQLSSFAKQALSQAQKSIDRVLDIQEEEPSAWAEAIPY
                     GEPGISPPVSGGWDTSTWGLNSTSSEPQSPPTASQAITKPVRRTVVDESENFFSAFLS
                     PSDAHTIQKSPVVSKPPSKSQRPEEEVKSSLQESSSPGQSRVSETAEVRDSVCVSGET
                     SAVGTPSPVPEDKHEETAGEESEVKVPTVRLKASENVVNVNTTEDVSTTSTQSLTAET
                     KDMALEPKEQKHEDRQSNTPSPPVSSFSSGTSTTSDIEVLDHESVISESSASSRQETS
                     DAKSSLHLMQTSFQLLSASACPEYSRLDDFQKLNESCCSSDAFERIDSFSVQSLDSRS
                     VSEINSDDELPGKGYALVPIIVSPSTPKTKVVESTEENAEEEEGNETLVAPSEEAELE
                     ESGRSATPVNCDQPDILASPTAGSGGHSASGPATEQCEAVENQPKAPPEKEDVCKTVE
                     FLNEKLEKRETQLLSLSKEKALLEEAYDNLKDEMFRVKEESSSISSLKDEFTQRIAEA
                     EKKVQLACKERDAAKKEMKTIKEELATRLNSSQTADLLKEKDEQIQGLMEEGEKLSKQ
                     QLHNSNIIKKLRAKDKDNENVIAKLNRKAKELEEELQHLRQVLDGKEEVEKQHRENIK
                     KLNSVVERQEKDLGRLQVDMDELEEKSRSTQAALDSAYRELTDLHKANAAKDSEVQEA
                     ALRREMKAKEELSGALEKAQEEARQQQEALVLQVGDLRLALQRAEQAAARKEDYLRHE
                     ISELQQRLQEAENRNQELSQSVSSTARPLLRQIENLQATLGSQTSSWETLEKSLSDRL
                     GESQTLLAAAVERERAATEELLANKIQMSSVESQNTLLRQENSRLQAQLESEKNKLRK
                     LEDENSRYQVELENLKDEYVRTLEESRKEKTLLSSQLEMERMKVEQERKKTIFTQEAL
                     KEKDHKLFSVCSTPTMSRSSSISGVDAAGLQASFLSQDESHDHSFGPMSTSASGSNLY
                     EAVRMGAGSSIIENLQSQLKLREGEISHLQLEISNLEKTRSIMSEELVKLTNQNDELE
                     EKVKEIPKLRVQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDELLRQ
                     RLS"
     exon            244..1442
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1546
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1673
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1779
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1922
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2089
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2246
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2339
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2496
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2689
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2759
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..2852
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2954
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3107
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3233
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..6781
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4231..4236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /note="hexamer: AATAAA"
     regulatory      4240..4245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /note="hexamer: ATTAAA"
     polyA_site      4252
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /note="major polyA site"
     polyA_site      4261
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /note="major polyA site"
     regulatory      5198..5203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /note="hexamer: AATAAA"
     polyA_site      5223
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /note="major polyA site"
     regulatory      5541..5546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /note="hexamer: AATAAA"
     polyA_site      5571
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
     regulatory      5717..5722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
                     /note="hexamer: AATAAA"
     polyA_site      5736
                     /gene="Tmf1"
                     /gene_synonym="7030402D04Rik; Gm153; Tmf1`"
ORIGIN      
        1 gtgcggaagg ctcgcagcgc cgcgcggccg cgggaggcgg tggggccggg gccgccgctg
       61 aggccgccgg agccggccgg agccggcgct gaggaggggc catgagctgg ttcaatgcct
      121 cgcagttgtc cagcttcgcc aagcaggccc tgtcccaggc ccagaagtcc atcgacaggg
      181 tcctggacat ccaggaggag gagccgagcg cctgggccga ggccatcccg tacggcgagc
      241 cgggaataag tccccctgtg agtggaggat gggacacttc aacctgggga ttgaactcaa
      301 caagcagcga acctcagagt cccccaacag cctctcaagc aattacaaag ccagttcgaa
      361 ggactgtagt agatgaatct gaaaatttct tcagtgcctt tctctctccg tcggatgccc
      421 ataccattca gaagagccca gtggtatcaa aacctccatc taaatcccag cggccagagg
      481 aagaagtgaa aagcagctta caagaatcgt catctcctgg ccagtccaga gtttctgaga
      541 cagctgaagt gagagactcc gtgtgtgttt ctggagagac ttcagccgtg ggcactccct
      601 cacctgtacc tgaagacaag catgaagaaa cggcaggtga agagtctgag gtgaaggtgc
      661 ccactgtgag attgaaggcg tctgaaaacg tagttaatgt aaacacaaca gaagatgtat
      721 ctaccacatc cactcagtct ctcacggcag aaacgaagga tatggctttg gaacctaaag
      781 aacaaaaaca cgaagacaga cagagcaaca caccttctcc tcctgttagc tccttctcgt
      841 cgggcacctc caccactagt gacattgaag ttttagatca cgagagtgta atcagtgaga
      901 gctcggccag ttcgaggcaa gagacttcgg atgcaaagtc gagtcttcac ctcatgcaga
      961 cgtcatttca gctcctctct gcgtctgctt gtcccgagta tagccgctta gatgacttcc
     1021 agaagctcaa tgagagttgc tgctcatcgg atgcttttga aagaatagac tcatttagcg
     1081 tgcagtctct agatagccgg agcgtaagtg aaatcaactc agacgacgaa ctgccaggca
     1141 aaggctatgc tttagtaccc ataatagtga gtccttcaac cccaaagact aaagtagtag
     1201 aatctactga agagaatgct gaagaagagg aaggaaacga gacattagtt gcgccgtctg
     1261 aggaagcaga attagaggaa agtggccgaa gtgctactcc agtgaactgt gaccagccag
     1321 atatattggc ttctcccaca gcaggaagtg gcgggcactc tgcctctgga ccggccactg
     1381 agcagtgtga agctgttgaa aaccagccaa aagcaccgcc agagaaagaa gatgtttgca
     1441 agacagttga atttctgaat gagaagctag aaaagaggga gactcagtta ttgtccctta
     1501 gtaaagaaaa ggcacttctg gaggaagcgt atgataacct gaaggatgaa atgttcagag
     1561 taaaagaaga aagtagtagc atttcttccc tgaaagatga atttacccag agaattgcag
     1621 aagcagaaaa gaaagttcaa ctagcctgca aggagagaga tgctgctaag aaggaaatga
     1681 aaaccataaa ggaagaactt gccactagat taaatagtag tcaaactgca gacctgttga
     1741 aggaaaaaga tgaacagatt caaggtttaa tggaagaagg agaaaaactt tcaaagcagc
     1801 agctgcataa ttccaatatc attaagaaat taagagctaa agataaagac aatgaaaatg
     1861 taattgcaaa gctgaacaga aaagctaagg agctggaaga ggagttacag cacttaagac
     1921 aggtccttga tggcaaagag gaggttgaga aacaacatag agaaaatatt aaaaaactaa
     1981 attctgtggt agaacgccag gagaaagatc ttggccgact tcaggtagac atggatgaac
     2041 ttgaagagaa gagccgaagt actcaggctg ccctagatag tgcgtacaga gaacttaccg
     2101 atcttcacaa agccaatgct gctaaggaca gtgaggtaca ggaagctgct ctgaggcgtg
     2161 agatgaaggc taaagaagaa ctttctgggg cactggagaa ggcccaggaa gaagcccgtc
     2221 agcagcaaga ggcattagtg cttcaggtgg gggacctcag gctagcgctg cagcgggcgg
     2281 agcaagcagc tgccagaaaa gaggattact tacgccatga gatcagtgaa cttcagcaga
     2341 gactccaaga agcagagaat cgaaaccaag agctgagtca aagtgtttca tcaacagcca
     2401 gaccgttgct gcgacagata gaaaacttac aagcaactct ggggtcccag acgtcctcgt
     2461 gggagacact ggagaagagt ctttctgata ggcttggtga atcacagacc ttgttggctg
     2521 cagcagttga aagagaacgt gcagctacag aagaactcct ggccaacaaa atccagatgt
     2581 cttcagtgga gtcacagaat acgttattac gacaggaaaa cagtagactt caggcccagc
     2641 tagagtcaga gaaaaataaa ctaagaaaac tagaggatga aaatagtcgg taccaagttg
     2701 aattagaaaa cctaaaagat gaatatgtaa gaacgcttga agagtcaagg aaagagaaga
     2761 cacttttgag cagtcagtta gaaatggaaa gaatgaaagt tgaacaagaa aggaagaaaa
     2821 ccattttcac tcaagaagca ctaaaagaaa aggaccacaa gctgttttct gtttgtagca
     2881 ctcccaccat gtcacgttcc agctctataa gtggagtcga tgctgcaggg ctgcaagcgt
     2941 ccttcctgtc tcaggatgag tctcatgacc attcatttgg gccgatgtct acatcagcca
     3001 gtggaagcaa cctttatgaa gctgtaagga tgggagctgg atcgagcatt attgaaaatc
     3061 tgcagtctca gctaaagctg agggaaggag aaattagtca tttacagctg gaaattagta
     3121 acctagaaaa aactcgatcc ataatgtccg aagagctagt taaattaaca aatcagaatg
     3181 atgaacttga ggagaaagtg aaagagatac ccaagcttcg agttcagctg cgagatttgg
     3241 atcaaagata caacactatt ctgcagatgt atggagaaaa agcagaagaa gcagaggaac
     3301 ttcgcttgga tcttgaagat gtaaaaaata tgtataaaac tcaaatagat gaacttctaa
     3361 gacaaaggct cagttaactt ctgaagtttg tattcccatc aaactaaatg taaacactta
     3421 atatataaat gcagacttcc aataaattct tttatagaat tagaactggg atttgctgta
     3481 gattgtaaaa aaaatttttt taaatttctt ttctagtata tagtaatatt tgcagttaaa
     3541 ttattttatg taatatttga attttatttt tggaactatt ctttaaaatt ttatttttta
     3601 aagctttttt tttttctttt ttcttttttt tttctttttt ctttttcttt tctttttttt
     3661 tttttttttt tttttttttt tttttttttt tggtgccttg aacagcacag agatttctta
     3721 ctttatccac aggaaaggag actggtgttt tcgtattatt gtggatatat aattaattgt
     3781 atctaatttg tatgtgtttg tacatattga gagatttaca gagtaatgtt aacactgaaa
     3841 ttttgaaatc tttcacactg aaatcttcaa catatttctt aaaaatgttt taaacatttg
     3901 agtaaaaagg ttattaagcc tgtaactact aaattataaa ctaaggattc cctttaaaag
     3961 cagaagtcac actgacatgt ttaaaatgta aagagtaatt taaacttaaa aaatgttctg
     4021 ttttgaaaat ttattccatg tatcttccac aatgaagtgt gaacaaatct agatgctttt
     4081 tgttacttat tcaaagaaag ctataaatat ttaatattaa ctaggcataa ttgggtagtg
     4141 ggaaatgttg cttgtagtaa attgtgatag atactatcag tagcaggtaa ttttgaagta
     4201 ttttactaca ctgttatatg aatctaacaa aataaaatca ttaaaaaatt tactcttaaa
     4261 attagtcaat ttactcttta aaattacttg tttagtttca tataattata tttctgaaca
     4321 ttagaaatga atgttttaaa ataatctcca tagcaaaaca gaaaagtaat agaagtacat
     4381 ttaaattggg gattttataa ttttatgtag ttgaaccgtt tttccttgaa ccttcaataa
     4441 acaaaaaaat tgcaatgagt agtagtgtag aataacttta gaatatagtt ttcccctctt
     4501 ccaaatgtca ctttgtttaa aaattagtca ggttgtgttt tagacctgta aaatattttg
     4561 atagattcta ttacttaaaa ttgtttaatt gcttttatca cagtccttct ttattctttt
     4621 gcttcttttg ttcttttgct ttttgtggtt ctggctaagg taaaaaataa tccaaaaata
     4681 tatggaaatt acagaaagag taataaatgt tagagtgtat gctgctgagg ggagcctgct
     4741 ggaatctcac tgtttgactc catgtgtcca ggacgtttgc acgccctgtg agcccctgag
     4801 ccgcctcacc tcagctgttg tgtctactgt aatagtgtgg atgagcttgt gatccggtaa
     4861 tccctttgtt ctttaatggc cccaagtgac aaagccaaat gttagccagg agtgcttcct
     4921 taatggcaag atgaacatcc acattggctg tcttgctgga aattgatagc ttctactgtt
     4981 tcaggcatcc actctgggtc tcaaaactgt cttccccacg agaaggtagg agttcaagta
     5041 aaaaccgtaa attttagtta cattttaaac tctacttcag atcacagctg tgagtagcca
     5101 tcttgcagaa tggagaaatt ttaggggtaa ttcaagtgac cttgttttta tcttgtgttc
     5161 ttgtgtttct gttgtgggaa ctcagatttg tagcacgaat aaatgttctt ttggtgaaag
     5221 taacagtcat aaaattaagt ttttgtattt tagtggtaaa aagcagcctc ataacttttt
     5281 gctagcttta aaatgtttta atattcaggg gcaagatgat aagtctgaca gcaataaata
     5341 catagtgtta aaagagacag gaaacctgaa tttcaaaatt gttggcaagc atttagaact
     5401 ggtagtttgg gaaatgtaaa atacttttta aacaaataat ttgggaatgt ggcagagaaa
     5461 agattttgaa attaaaattt cctgtattct agattttata atatcaacat taaatatttt
     5521 tcttggttct taataacatt aataaaagca gcccacttaa aaatcttaaa atgttttcaa
     5581 cttacttatg tataaaatga catgcaacca tttatatctg cttcatctgt aagtgaatag
     5641 ctgatgttca cactgcttat gttggctaga atatacttag acctttcagt acatttcaag
     5701 ttgataaggg gcactgaata aatttcttgt aaataatcca gtaagtggca gaagacttat
     5761 taagcattgg ttgctcttta attttctttg ttatgtatca ttgaaaatta tctacccata
     5821 tgctagtaga atattctaat gcataaaata gtttgcagtt agatgcttcc attcttgggg
     5881 gagaaaacaa aattcaaaaa acaaaacaaa aaaaaaaacc aaaaaataaa aaacccctca
     5941 gatacttgga attaagaggc ccaggtgttg gaggtgagca cgtggagact gctgctgctg
     6001 ctgggcctct cttgagaaca ctctatagca ttcagcatgt gggatgtacc aaatacacga
     6061 cattgcactt caaaatatgc taagtgtgga tgattactga cttagaaaaa tttttggttt
     6121 ttgtagttaa gtaaatgtaa ggaatattta ggaagtatgt ttcccatcag ttatttcatt
     6181 aattgaaagt ttaatttgaa tgcttattta aaagcacatg attttggcct agagagcact
     6241 tgctgatctt ccagagggcc tgagttcaat tcccagcatc catgtggtgg ctcacaacca
     6301 tctgtatctc cagtcccagg ggatccagca ccctcttctg gtgtcctcag acaccaggca
     6361 cacagtggtg cacaggccta gaagcagaca aaacacccat acacataaag taaataaatg
     6421 ttctagatgc acacaatttg tagttattga aaacaaagcc cccaaattaa ggagaaatgg
     6481 gtgcaaaatg tcttatttta ctactgttta gtattataga catgtatgtt ccagggatca
     6541 tttctcattc tcattacaaa aaagctggtc caagttttct tatccttggc cagttttaaa
     6601 ctaaaaaaaa caaaacaaaa caaaacaaaa caaaaaccaa aaaaccccac aaaaaacagc
     6661 tacatatttt gtaaagggct aagagtatga tttaaactaa aagattgata ttttaattcc
     6721 aaatgaaagg tactgtaaat aagcatgggt ctgatttaaa taaagatttc aaagtctgct
     6781 t
//
