LOCUS       NM_029537               1442 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane protein 98 (Tmem98), mRNA.
ACCESSION   NM_029537 XM_001001766
VERSION     NM_029537.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1442)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1442)
  AUTHORS   Hassall,M.M., Javadiyan,S., Klebe,S., Awadalla,M.S., Sharma,S.,
            Qassim,A., White,M., Thomas,P.Q., Craig,J.E. and Siggs,O.M.
  TITLE     Phenotypic consequences of a nanophthalmos-associated TMEM98
            variant in human and mouse
  JOURNAL   Sci Rep 13 (1), 11017 (2023)
   PUBMED   37419942
  REMARK    GeneRIF: Phenotypic consequences of a nanophthalmos-associated
            TMEM98 variant in human and mouse.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1442)
  AUTHORS   Cross,S.H., Mckie,L., Hurd,T.W., Riley,S., Wills,J., Barnard,A.R.,
            Young,F., MacLaren,R.E. and Jackson,I.J.
  TITLE     The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is
            required for eye size specification
  JOURNAL   PLoS Genet 16 (4), e1008583 (2020)
   PUBMED   32236127
  REMARK    GeneRIF: findings highlight the importance of the interplay between
            TMEM98 and MYRF in determining the size of the eye
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1442)
  AUTHORS   van der Wal,T., Lambooij,J.P. and van Amerongen,R.
  TITLE     TMEM98 is a negative regulator of FRAT mediated Wnt/ss-catenin
            signalling
  JOURNAL   PLoS One 15 (1), e0227435 (2020)
   PUBMED   31961879
  REMARK    GeneRIF: TMEM98 reduces FRAT2 protein levels and, accordingly,
            inhibits the FRAT2-mediated induction of ss-catenin/TCF signalling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1442)
  AUTHORS   Cross,S.H., Mckie,L., Keighren,M., West,K., Thaung,C., Davey,T.,
            Soares,D.C., Sanchez-Pulido,L. and Jackson,I.J.
  TITLE     Missense Mutations in the Human Nanophthalmos Gene TMEM98 Cause
            Retinal Defects in the Mouse
  JOURNAL   Invest Ophthalmol Vis Sci 60 (8), 2875-2887 (2019)
   PUBMED   31266059
REFERENCE   6  (bases 1 to 1442)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1442)
  AUTHORS   Huang,H., Teng,P., Du,J., Meng,J., Hu,X., Tang,T., Zhang,Z.,
            Qi,Y.B. and Qiu,M.
  TITLE     Interactive Repression of MYRF Self-Cleavage and Activity in
            Oligodendrocyte Differentiation by TMEM98 Protein
  JOURNAL   J Neurosci 38 (46), 9829-9839 (2018)
   PUBMED   30249802
  REMARK    GeneRIF: TMEM98 membrane protein physically interacts with MYRF in
            the endoplasmic reticulum and subsequently blocks its
            self-cleavage.
REFERENCE   8  (bases 1 to 1442)
  AUTHORS   Fu,W., Cheng,Y., Zhang,Y., Mo,X., Li,T., Liu,Y., Wang,P., Pan,W.,
            Chen,Y., Xue,Y., Ma,D., Zhang,Y. and Han,W.
  TITLE     The Secreted Form of Transmembrane Protein 98 Promotes the
            Differentiation of T Helper 1 Cells
  JOURNAL   J Interferon Cytokine Res 35 (9), 720-733 (2015)
   PUBMED   25946230
REFERENCE   9  (bases 1 to 1442)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1442)
  AUTHORS   Thaung,C., West,K., Clark,B.J., McKie,L., Morgan,J.E., Arnold,K.,
            Nolan,P.M., Peters,J., Hunter,A.J., Brown,S.D., Jackson,I.J. and
            Cross,S.H.
  TITLE     Novel ENU-induced eye mutations in the mouse: models for human eye
            disease
  JOURNAL   Hum Mol Genet 11 (7), 755-767 (2002)
   PUBMED   11929848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB872316.1 and AK148132.1.
            
            On Jul 4, 2018 this sequence version replaced NM_029537.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011208.1, AK148132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BB872316.1         2-51
            51-628              AK148132.1         1-578
            629-1442            AK148132.1         580-1393
FEATURES             Location/Qualifiers
     source          1..1442
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11"
     gene            1..1442
                     /gene="Tmem98"
                     /gene_synonym="6530411B15Rik; Rwhs"
                     /note="transmembrane protein 98"
                     /db_xref="GeneID:103743"
                     /db_xref="MGI:MGI:1923457"
     exon            1..94
                     /gene="Tmem98"
                     /gene_synonym="6530411B15Rik; Rwhs"
                     /inference="alignment:Splign:2.1.0"
     exon            95..278
                     /gene="Tmem98"
                     /gene_synonym="6530411B15Rik; Rwhs"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..828
                     /gene="Tmem98"
                     /gene_synonym="6530411B15Rik; Rwhs"
                     /codon_start=1
                     /product="transmembrane protein 98"
                     /protein_id="NP_083813.1"
                     /db_xref="CCDS:CCDS25135.1"
                     /db_xref="GeneID:103743"
                     /db_xref="MGI:MGI:1923457"
                     /translation="METVVIVAIGVLATIFLASFAALVVVCRQRYCRPRDLLQRYDSK
                     PIVDLIGAMETQSEPSELELDDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICH
                     TLTEKLVAMTMGSGAKMKTSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTT
                     ALLLSVSHLVLVTRNACHLTGGLDWIDQSLSAAEEHLEVLREAALASEPDKSLPNPEG
                     FLQEQSAI"
     exon            279..410
                     /gene="Tmem98"
                     /gene_synonym="6530411B15Rik; Rwhs"
                     /inference="alignment:Splign:2.1.0"
     exon            411..444
                     /gene="Tmem98"
                     /gene_synonym="6530411B15Rik; Rwhs"
                     /inference="alignment:Splign:2.1.0"
     exon            445..560
                     /gene="Tmem98"
                     /gene_synonym="6530411B15Rik; Rwhs"
                     /inference="alignment:Splign:2.1.0"
     exon            561..620
                     /gene="Tmem98"
                     /gene_synonym="6530411B15Rik; Rwhs"
                     /inference="alignment:Splign:2.1.0"
     exon            621..1442
                     /gene="Tmem98"
                     /gene_synonym="6530411B15Rik; Rwhs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1415..1420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem98"
                     /gene_synonym="6530411B15Rik; Rwhs"
                     /note="hexamer: AGTAAA"
     polyA_site      1442
                     /gene="Tmem98"
                     /gene_synonym="6530411B15Rik; Rwhs"
                     /note="major polyA site"
ORIGIN      
        1 ggcatgccct gctgctggcc gctgcgggca gcactcggac ttggccttgg ggggggatcg
       61 cggggagccg gcgtaccccg gagctgcaat tgagcttcca cctgctcaga ggatgtgagt
      121 ggactgaggc tgggagcccc tggaagcatg gagactgtgg tgatcgtcgc cataggtgtg
      181 ctggccacca ttttcctggc ctcatttgct gctttggtgg tggtctgtag gcagcgttac
      241 tgccggcctc gagacctact acagcgttat gattccaagc ccatcgtgga cctcattggt
      301 gctatggaga cgcagtctga accctccgag ctggagctgg atgatgtcgt catcaccaac
      361 ccccacatcg aggccatcct ggagaatgag gactggatcg aagatgcctc gggcctcatg
      421 tcccactgca tcgccatctt gaagatttgt cacactctga cagaaaaact cgttgccatg
      481 acaatgggtt ctggggccaa gatgaagacg tcagcaagtg tcagtgacat cattgtggtg
      541 gccaaacgga ttagccccag agtggacgac gtcgtgaagt caatgtaccc tccactggac
      601 cccaagctcc tggatgcacg gacaaccgcc ctgctgctgt ccgttagtca cttggtgcta
      661 gtgaccagga acgcctgcca tctaaccggg ggcctggact ggattgacca atcactgtct
      721 gccgctgagg agcacctgga agtccttcga gaggcagccc tggcttctga gccagataaa
      781 agcctcccca accctgaggg cttcctgcag gaacagtcgg ccatttaatc atctccgagg
      841 ccccatttcc gcccctgggc gagccttcta cttcctgtag atttagttgt tctctagagc
      901 tctgtcggcc agccctgggt gcagggtaaa gccgagagcc tcacgctgga caggctctgc
      961 tgcaatggca aacagtggct ggagagtggc agtgtaatcc cacagttagg ggagacgctg
     1021 tgtacctcta cagcagagcg cagaaagctg ccgggctcgc tgctacattt agttcattta
     1081 atgtttccaa gaaaatcgag ttgccctcta agaattgaga gacttcatat caaattagaa
     1141 tttccggctt ctgaaaatca aggcgtggca acatggacaa tcagaactaa gtggctaggt
     1201 cgagatagtc tcttcgggtg acccttgtgc tccccttgct aatttgtttg tgttcagtgc
     1261 tttggttcct gaagcatcag agctccccac ccccaccccg cttcccatgt atcttccgct
     1321 ttcccatttg tgttagaagc tgaggaaatg cgaagtcaat tgtttccttt ttatcactat
     1381 gcctgcaatt tcgctttaca accaccaggc gaatagtaaa cttgttcttc tgttttcctc
     1441 aa
//
