LOCUS       NP_083813                226 aa            linear   ROD 27-APR-2025
DEFINITION  transmembrane protein 98 [Mus musculus].
ACCESSION   NP_083813 XP_001001766
VERSION     NP_083813.1
DBSOURCE    REFSEQ: accession NM_029537.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 226)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 226)
  AUTHORS   Hassall,M.M., Javadiyan,S., Klebe,S., Awadalla,M.S., Sharma,S.,
            Qassim,A., White,M., Thomas,P.Q., Craig,J.E. and Siggs,O.M.
  TITLE     Phenotypic consequences of a nanophthalmos-associated TMEM98
            variant in human and mouse
  JOURNAL   Sci Rep 13 (1), 11017 (2023)
   PUBMED   37419942
  REMARK    GeneRIF: Phenotypic consequences of a nanophthalmos-associated
            TMEM98 variant in human and mouse.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 226)
  AUTHORS   Cross,S.H., Mckie,L., Hurd,T.W., Riley,S., Wills,J., Barnard,A.R.,
            Young,F., MacLaren,R.E. and Jackson,I.J.
  TITLE     The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is
            required for eye size specification
  JOURNAL   PLoS Genet 16 (4), e1008583 (2020)
   PUBMED   32236127
  REMARK    GeneRIF: findings highlight the importance of the interplay between
            TMEM98 and MYRF in determining the size of the eye
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 226)
  AUTHORS   van der Wal,T., Lambooij,J.P. and van Amerongen,R.
  TITLE     TMEM98 is a negative regulator of FRAT mediated Wnt/ss-catenin
            signalling
  JOURNAL   PLoS One 15 (1), e0227435 (2020)
   PUBMED   31961879
  REMARK    GeneRIF: TMEM98 reduces FRAT2 protein levels and, accordingly,
            inhibits the FRAT2-mediated induction of ss-catenin/TCF signalling.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 226)
  AUTHORS   Cross,S.H., Mckie,L., Keighren,M., West,K., Thaung,C., Davey,T.,
            Soares,D.C., Sanchez-Pulido,L. and Jackson,I.J.
  TITLE     Missense Mutations in the Human Nanophthalmos Gene TMEM98 Cause
            Retinal Defects in the Mouse
  JOURNAL   Invest Ophthalmol Vis Sci 60 (8), 2875-2887 (2019)
   PUBMED   31266059
REFERENCE   6  (residues 1 to 226)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 226)
  AUTHORS   Huang,H., Teng,P., Du,J., Meng,J., Hu,X., Tang,T., Zhang,Z.,
            Qi,Y.B. and Qiu,M.
  TITLE     Interactive Repression of MYRF Self-Cleavage and Activity in
            Oligodendrocyte Differentiation by TMEM98 Protein
  JOURNAL   J Neurosci 38 (46), 9829-9839 (2018)
   PUBMED   30249802
  REMARK    GeneRIF: TMEM98 membrane protein physically interacts with MYRF in
            the endoplasmic reticulum and subsequently blocks its
            self-cleavage.
REFERENCE   8  (residues 1 to 226)
  AUTHORS   Fu,W., Cheng,Y., Zhang,Y., Mo,X., Li,T., Liu,Y., Wang,P., Pan,W.,
            Chen,Y., Xue,Y., Ma,D., Zhang,Y. and Han,W.
  TITLE     The Secreted Form of Transmembrane Protein 98 Promotes the
            Differentiation of T Helper 1 Cells
  JOURNAL   J Interferon Cytokine Res 35 (9), 720-733 (2015)
   PUBMED   25946230
REFERENCE   9  (residues 1 to 226)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 226)
  AUTHORS   Thaung,C., West,K., Clark,B.J., McKie,L., Morgan,J.E., Arnold,K.,
            Nolan,P.M., Peters,J., Hunter,A.J., Brown,S.D., Jackson,I.J. and
            Cross,S.H.
  TITLE     Novel ENU-induced eye mutations in the mouse: models for human eye
            disease
  JOURNAL   Hum Mol Genet 11 (7), 755-767 (2002)
   PUBMED   11929848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB872316.1 and AK148132.1.
            
            On May 4, 2006 this sequence version replaced XP_001001766.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011208.1, AK148132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11"
     Protein         1..226
                     /product="transmembrane protein 98"
                     /calculated_mol_wt=24553
     Region          1..88
                     /region_name="Required for interaction with MYRF.
                     /evidence=ECO:0000269|PubMed:30249802"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91X86.1)"
     Site            4..24
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91X86.1)"
     Region          <48..152
                     /region_name="GCIP"
                     /note="Grap2 and cyclin-D-interacting; pfam13324"
                     /db_xref="CDD:463844"
     Region          207..226
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91X86.1)"
     CDS             1..226
                     /gene="Tmem98"
                     /gene_synonym="6530411B15Rik; Rwhs"
                     /coded_by="NM_029537.2:148..828"
                     /db_xref="CCDS:CCDS25135.1"
                     /db_xref="GeneID:103743"
                     /db_xref="MGI:MGI:1923457"
ORIGIN      
        1 metvvivaig vlatiflasf aalvvvcrqr ycrprdllqr ydskpivdli gametqseps
       61 elelddvvit nphieailen edwiedasgl mshciailki chtlteklva mtmgsgakmk
      121 tsasvsdiiv vakrisprvd dvvksmyppl dpklldartt alllsvshlv lvtrnachlt
      181 ggldwidqsl saaeehlevl reaalasepd kslpnpegfl qeqsai
//
