LOCUS       NM_133706               1333 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus transmembrane protein 97 (Tmem97), mRNA.
ACCESSION   NM_133706 XM_489868
VERSION     NM_133706.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1333)
  AUTHORS   Hong,V.M., Rade,A.D., Yan,S.M., Bhaskara,A., Yousuf,M.S., Chen,M.,
            Martin,S.F., Liebl,D.J., Price,T.J. and Kolber,B.J.
  TITLE     Loss of Sigma-2 Receptor/TMEM97 Is Associated with Neuropathic
            Injury-Induced Depression-Like Behaviors in Female Mice
  JOURNAL   eNeuro 11 (7) (2024)
   PUBMED   38866499
  REMARK    GeneRIF: Loss of Sigma-2 Receptor/TMEM97 Is Associated with
            Neuropathic Injury-Induced Depression-Like Behaviors in Female
            Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1333)
  AUTHORS   Li,J., Shen,H. and Guo,L.W.
  TITLE     Transmembrane protein TMEM97 and epigenetic reader BAHCC1
            constitute an axis that supports pro-inflammatory cytokine
            expression
  JOURNAL   Cell Signal 116, 111069 (2024)
   PUBMED   38290642
  REMARK    GeneRIF: Transmembrane protein TMEM97 and epigenetic reader BAHCC1
            constitute an axis that supports pro-inflammatory cytokine
            expression.
REFERENCE   3  (bases 1 to 1333)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1333)
  AUTHORS   Yousuf,M.S., Sahn,J.J., Yang,H., David,E.T., Shiers,S., Mancilla
            Moreno,M., Iketem,J., Royer,D.M., Garcia,C.D., Zhang,J., Hong,V.M.,
            Mian,S.M., Ahmad,A., Kolber,B.J., Liebl,D.J., Martin,S.F. and
            Price,T.J.
  TITLE     Highly specific sigma2R/TMEM97 ligand FEM-1689 alleviates
            neuropathic pain and inhibits the integrated stress response
  JOURNAL   Proc Natl Acad Sci U S A 120 (52), e2306090120 (2023)
   PUBMED   38117854
REFERENCE   5  (bases 1 to 1333)
  AUTHORS   Wang,H., Peng,Z., Li,Y., Sahn,J.J., Hodges,T.R., Chou,T.H., Liu,Q.,
            Zhou,X., Jiao,S., Porciatti,V., Liebl,D.J., Martin,S.F. and Wen,R.
  TITLE     sigma2R/TMEM97 in retinal ganglion cell degeneration
  JOURNAL   Sci Rep 12 (1), 20753 (2022)
   PUBMED   36456686
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1333)
  AUTHORS   Sahn,J.J., Mejia,G.L., Ray,P.R., Martin,S.F. and Price,T.J.
  TITLE     Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting
            Antineuropathic Pain Effects in Mice
  JOURNAL   ACS Chem Neurosci 8 (8), 1801-1811 (2017)
   PUBMED   28644012
  REMARK    GeneRIF: Study generated a series of sigma1R and sigma2R/Tmem97
            agonists and antagonists and tested them for efficacy in the mouse
            spared nerve injury model. Results show robust antineuropathic pain
            effects of sigma1R and sigma2R/Tmem97 ligands, demonstrate that
            sigma2R/Tmem97 is a novel neuropathic pain target, and identify
            sigma2R/Tmem97 agonist UKH-1114 as a lead molecule for further
            development.
REFERENCE   7  (bases 1 to 1333)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   8  (bases 1 to 1333)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 1333)
  AUTHORS   Mink,M., Fogelgren,B., Olszewski,K., Maroy,P. and Csiszar,K.
  TITLE     A novel human gene (SARM) at chromosome 17q11 encodes a protein
            with a SAM motif and structural similarity to
            Armadillo/beta-catenin that is conserved in mouse, Drosophila, and
            Caenorhabditis elegans
  JOURNAL   Genomics 74 (2), 234-244 (2001)
   PUBMED   11386760
REFERENCE   10 (bases 1 to 1333)
  AUTHORS   Nehls,M., Luno,K., Schorpp,M., Pfeifer,D., Krause,S.,
            Matysiak-Scholze,U., Dierbach,H. and Boehm,T.
  TITLE     YAC/P1 contigs defining the location of 56 microsatellite markers
            and several genes across a 3.4-cM interval on mouse chromosome 11
  JOURNAL   Mamm Genome 6 (5), 321-331 (1995)
   PUBMED   7626882
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL591177.14.
            
            On Nov 17, 2006 this sequence version replaced NM_133706.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018156.1, AK155107.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AL591177.14        89661-89868         c
            209-353             AL591177.14        82619-82763         c
            354-1333            AL591177.14        80950-81929         c
FEATURES             Location/Qualifiers
     source          1..1333
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..1333
                     /gene="Tmem97"
                     /gene_synonym="1810014L12Rik; D11Bhm182e"
                     /note="transmembrane protein 97"
                     /db_xref="GeneID:69071"
                     /db_xref="MGI:MGI:1916321"
     exon            1..208
                     /gene="Tmem97"
                     /gene_synonym="1810014L12Rik; D11Bhm182e"
                     /inference="alignment:Splign:2.1.0"
     exon            209..353
                     /gene="Tmem97"
                     /gene_synonym="1810014L12Rik; D11Bhm182e"
                     /inference="alignment:Splign:2.1.0"
     exon            354..1333
                     /gene="Tmem97"
                     /gene_synonym="1810014L12Rik; D11Bhm182e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1306..1311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem97"
                     /gene_synonym="1810014L12Rik; D11Bhm182e"
                     /note="hexamer: AATAAA"
     polyA_site      1333
                     /gene="Tmem97"
                     /gene_synonym="1810014L12Rik; D11Bhm182e"
                     /note="major polyA site"
ORIGIN      
        1 cagctcgggc gcggggcttc taaccacgta gcaggcttct atcaccggct tgccagtcgt
       61 agcccaacgg acaggaggga acatgggggc cctggcagct aggcgctgtg tcgagtggct
      121 cttgggcctc tacttcgtct cgcacatccc catcacgctg ttcatcgacc tgcaggcggt
      181 gctgccgccc gaactatacc cgcaggagtt cagcaacctg ttgcggtggt actcaaagga
      241 gttcaaagac cctctgatgc aggagccccc agtgtggttc aagtccttcc tgctctgtga
      301 gcttgtgttc cagctgcctt tctttcccat tgcggcatat gccttcttca aaggaagctg
      361 ccggtggatc cgaatccctg caatcatcta tgcagctcac accataacga ctttaattcc
      421 aatcctctac acactcctgt ttgaggattt ctctaaagcc gttgctttca agggacaaag
      481 acccgagagt ttccgtgaac gactgaccct cgtaggtgtc tacgccccct atttaataat
      541 ccccctcata ctcctcctgt tcatgcttcg gaacccgtac tacaagtatg aggagaaaag
      601 aaagaaaaaa tagggacggc caccagcctg gtggggaaga ccccacagca cagttgcctt
      661 ttggacaaca caggaaaact gccccaaaca tgtttcagca gcatttgaaa caccaacagc
      721 agtgcataca aacaagacag tggtgggaga cgtgccaggc cttcaccttt cagcaggggt
      781 gtgaccaagt tacagcaaaa tggtgccaaa gcgctaccac agcactgcta aaaaggccag
      841 gtgggaagcc ggttagctcc tgacctggaa tgcacacacc tgaccaagtc ctcacctcga
      901 ccttgatagt caacaaatga gcagtatttt gtctctttag cactttttaa catggtttcc
      961 tgcccacacc tccacctctg ggagaaaaat atattatagc ctcacatgag tccaagccag
     1021 aaatgggtta cagggaagga aggtgcctcc atttctatct tgaacagata gcctgctctg
     1081 ggttattctg gtgctggttc tatgaacggc tctcatgtcc ctactctggc acctcacccc
     1141 actgggcttc ctagtacgca ggcttgtgag ggtgactgga ctgtccagtg tatgtctgct
     1201 gcttgttcca ctgactctac agaaacaaaa cccggtgggt gctagacagt gctggctctg
     1261 cttgcaagcc atgttgctgt ggttgttact tatgtgtctg gtccaaataa aggcagctgc
     1321 tgatttgttg tta
//
