LOCUS       NM_177102                908 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus transmembrane protein 91 (Tmem91), transcript variant
            1, mRNA.
ACCESSION   NM_177102
VERSION     NM_177102.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 908)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   2  (bases 1 to 908)
  AUTHORS   Sallman Almen,M., Bringeland,N., Fredriksson,R. and Schioth,H.B.
  TITLE     The dispanins: a novel gene family of ancient origin that contains
            14 human members
  JOURNAL   PLoS One 7 (2), e31961 (2012)
   PUBMED   22363774
REFERENCE   3  (bases 1 to 908)
  AUTHORS   Kalashnikova,E., Lorca,R.A., Kaur,I., Barisone,G.A., Li,B.,
            Ishimaru,T., Trimmer,J.S., Mohapatra,D.P. and Diaz,E.
  TITLE     SynDIG1: an activity-regulated, AMPA- receptor-interacting
            transmembrane protein that regulates excitatory synapse development
  JOURNAL   Neuron 65 (1), 80-93 (2010)
   PUBMED   20152115
REFERENCE   4  (bases 1 to 908)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK079312.1 and BC058996.1.
            
            On Feb 27, 2010 this sequence version replaced NM_177102.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058996.1, AK079312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AK079312.1         2-52
            52-908              BC058996.1         1-857
FEATURES             Location/Qualifiers
     source          1..908
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.97 cM"
     gene            1..908
                     /gene="Tmem91"
                     /gene_synonym="A830041P22Rik; DSPC3; SynDIG3"
                     /note="transmembrane protein 91"
                     /db_xref="GeneID:320208"
                     /db_xref="MGI:MGI:2443589"
     exon            1..131
                     /gene="Tmem91"
                     /gene_synonym="A830041P22Rik; DSPC3; SynDIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            132..367
                     /gene="Tmem91"
                     /gene_synonym="A830041P22Rik; DSPC3; SynDIG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..676
                     /gene="Tmem91"
                     /gene_synonym="A830041P22Rik; DSPC3; SynDIG3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synapse differentiation-induced protein 3; dispanin
                     subfamily C member 3"
                     /codon_start=1
                     /product="transmembrane protein 91 isoform 1"
                     /protein_id="NP_796076.1"
                     /db_xref="CCDS:CCDS39840.1"
                     /db_xref="GeneID:320208"
                     /db_xref="MGI:MGI:2443589"
                     /translation="MDNSSIQELQQPLLPSITCDLLAPRSEKPELGTPFPETAFAESP
                     RGWQLLLPPLPSVSAGLGEPETPDFEDTLSSDSDSDDDGGDRLSPLLPHDHLGLAVFS
                     VLCCFWPVGIAAFCLAHKTNKAWAKGDVQGAGAASRRAFLLGVLAVGLGLCTYAAALV
                     TLAAYLASRDPP"
     exon            368..517
                     /gene="Tmem91"
                     /gene_synonym="A830041P22Rik; DSPC3; SynDIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            518..877
                     /gene="Tmem91"
                     /gene_synonym="A830041P22Rik; DSPC3; SynDIG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      855..860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem91"
                     /gene_synonym="A830041P22Rik; DSPC3; SynDIG3"
                     /note="hexamer: ATTAAA"
     polyA_site      877
                     /gene="Tmem91"
                     /gene_synonym="A830041P22Rik; DSPC3; SynDIG3"
                     /note="major polyA site"
ORIGIN      
        1 ctccccagct cgctgcgggg ctggggcgca gagacccaag cgcagctcag cagcattcag
       61 accctgtacg gggtagcccg gacgcccgat ctctgggttc aggtttgccc atctctgggc
      121 ggcagggcaa gggccctcta ccacagcctc cacaaccatg gacaactcca gcatacagga
      181 actccagcaa cccttactgc caagcataac ctgtgacctc ctggctccca ggtctgagaa
      241 gccagagctg ggaaccccct tcccagaaac tgcctttgca gagtccccca gaggctggca
      301 gcttcttctc ccacctcttc cttcagtgag tgctggcctg ggggagcctg agacccctga
      361 ctttgaggac acattatcca gtgacagtga ctcagatgat gatgggggcg accggctctc
      421 tccacttctt ccccatgacc acctcggcct ggcggtattc tctgtgctgt gttgtttttg
      481 gcctgtgggc atcgctgcct tctgtctggc ccacaagacc aacaaggctt gggccaaggg
      541 ggacgtccaa ggggcagggg ctgcctcccg ccgagctttc ctgctggggg tccttgccgt
      601 ggggctgggc ctgtgcacat atgcagctgc cctggtgacc ttggctgcct accttgcctc
      661 ccgagacccg ccctagttgc ccttcagccc ccactgtgaa tgcagaggcc agaggaccat
      721 caaacccctg agcagaatgg atgatcttgg tgtacacagt ggtgacggag aggaccacat
      781 cgcccagaaa cgagtcagct ggaggccccc tctttttcct ggccacccct acccagaagg
      841 aagcaatgtg agaaattaaa gataccctga agccaaaaaa aaaaaaaaaa aaaaaaaaaa
      901 aaaaaaaa
//
