LOCUS       NM_025439               1460 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane protein 9 (Tmem9), transcript variant 2,
            mRNA.
ACCESSION   NM_025439
VERSION     NM_025439.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1460)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1460)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1460)
  AUTHORS   Jung,Y.S., Stratton,S.A., Lee,S.H., Kim,M.J., Jun,S., Zhang,J.,
            Zheng,B., Cervantes,C.L., Cha,J.H., Barton,M.C. and Park,J.I.
  TITLE     TMEM9-v-ATPase Activates Wnt/beta-Catenin Signaling Via APC
            Lysosomal Degradation for Liver Regeneration and Tumorigenesis
  JOURNAL   Hepatology 73 (2), 776-794 (2021)
   PUBMED   32380568
  REMARK    GeneRIF: TMEM9-v-ATPase Activates Wnt/beta-Catenin Signaling Via
            APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
REFERENCE   4  (bases 1 to 1460)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1460)
  AUTHORS   Jung,Y.S., Jun,S., Kim,M.J., Lee,S.H., Suh,H.N., Lien,E.M.,
            Jung,H.Y., Lee,S., Zhang,J., Yang,J.I., Ji,H., Wu,J.Y., Wang,W.,
            Miller,R.K., Chen,J., McCrea,P.D., Kopetz,S. and Park,J.I.
  TITLE     TMEM9 promotes intestinal tumorigenesis through
            vacuolar-ATPase-activated Wnt/beta-catenin signalling
  JOURNAL   Nat Cell Biol 20 (12), 1421-1433 (2018)
   PUBMED   30374053
REFERENCE   6  (bases 1 to 1460)
  AUTHORS   Van Dyck,F., Braem,C.V., Chen,Z., Declercq,J., Deckers,R.,
            Kim,B.M., Ito,S., Wu,M.K., Cohen,D.E., Dewerchin,M., Derua,R.,
            Waelkens,E., Fiette,L., Roebroek,A., Schuit,F., Van de Ven,W.J. and
            Shivdasani,R.A.
  TITLE     Loss of the PlagL2 transcription factor affects lacteal uptake of
            chylomicrons
  JOURNAL   Cell Metab 6 (5), 406-413 (2007)
   PUBMED   17983586
REFERENCE   7  (bases 1 to 1460)
  AUTHORS   Kveine,M., Tenstad,E., Dosen,G., Funderud,S. and Rian,E.
  TITLE     Characterization of the novel human transmembrane protein 9 (TMEM9)
            that localizes to lysosomes and late endosomes
  JOURNAL   Biochem Biophys Res Commun 297 (4), 912-917 (2002)
   PUBMED   12359240
REFERENCE   8  (bases 1 to 1460)
  AUTHORS   Kochilas,L.K., Li,J., Jin,F., Buck,C.A. and Epstein,J.A.
  TITLE     p57Kip2 expression is enhanced during mid-cardiac murine
            development and is restricted to trabecular myocardium
  JOURNAL   Pediatr Res 45 (5 Pt 1), 635-642 (1999)
   PUBMED   10231856
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA460035.1, AC108813.8 and AC124375.5.
            
            On May 13, 2009 this sequence version replaced NM_025439.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048017.1, AK154423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-604               CA460035.1         38-641
            605-899             AC108813.8         198465-198759
            900-1460            AC124375.5         90969-91529
FEATURES             Location/Qualifiers
     source          1..1460
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 59.51 cM"
     gene            1..1460
                     /gene="Tmem9"
                     /gene_synonym="1500015G18Rik"
                     /note="transmembrane protein 9"
                     /db_xref="GeneID:66241"
                     /db_xref="MGI:MGI:1913491"
     exon            1..62
                     /gene="Tmem9"
                     /gene_synonym="1500015G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            63..164
                     /gene="Tmem9"
                     /gene_synonym="1500015G18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..650
                     /gene="Tmem9"
                     /gene_synonym="1500015G18Rik"
                     /note="v-ATPase assembly regulator TMEM9;
                     proton-transporting V-type ATPase complex assembly
                     regulator TMEM9"
                     /codon_start=1
                     /product="proton-transporting V-type ATPase complex
                     assembly regulator TMEM9 precursor"
                     /protein_id="NP_079715.1"
                     /db_xref="CCDS:CCDS15323.1"
                     /db_xref="GeneID:66241"
                     /db_xref="MGI:MGI:1913491"
                     /translation="MKLLCLVAVVGCLLVPPAQANKSSEDIRCKCICPPYRNISGHIY
                     NQNVSQKDCNCLHVVEPMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGAL
                     LLYMAFLMLVDPLIRKPDAYTEQLHNEEENEDARTMATAAASIGGPRANTVLERVEGA
                     QQRWKLQVQEQRKTVFDRHKMLS"
     exon            165..256
                     /gene="Tmem9"
                     /gene_synonym="1500015G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            257..365
                     /gene="Tmem9"
                     /gene_synonym="1500015G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            366..497
                     /gene="Tmem9"
                     /gene_synonym="1500015G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            498..1460
                     /gene="Tmem9"
                     /gene_synonym="1500015G18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1437..1442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem9"
                     /gene_synonym="1500015G18Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1460
                     /gene="Tmem9"
                     /gene_synonym="1500015G18Rik"
                     /note="major polyA site"
ORIGIN      
        1 agccaataga tgctgaaggg gtggagcctg ctgatcagtg gcggctgcgg ctgagcttgc
       61 aggcatctag tcttgctggc tcagcaagcc cgataagcat gaagctgctg tgtttggtgg
      121 ctgtggtggg gtgcttgctg gtgcccccag ctcaagccaa caagagctct gaagatatcc
      181 ggtgcaaatg catctgtccg ccttacagaa acatcagcgg gcacatttac aaccagaatg
      241 tgtctcagaa ggactgcaac tgcctgcatg tggtggagcc catgccagtg cctggccacg
      301 atgtggaagc ctactgcctg ctctgcgagt gtaggtacga ggagcgtagc accacaacca
      361 tcaaggtcat tattgtcatc tacctgtctg tggtgggggc cctcttactc tacatggcct
      421 tcctgatgct ggtggacccg ctcatccgga agccagatgc ctatactgag cagctgcaca
      481 atgaagagga gaatgaggat gctcgcacca tggcaacagc cgctgcgtcc attggaggac
      541 cccgggcaaa cactgtcctg gagcgggtgg aaggcgctca gcagcggtgg aagctgcagg
      601 tgcaggagca gcggaagacg gtcttcgacc gacacaagat gctcagttag atggttgcca
      661 tgattgcatc agagacctgg gccatggcta ccagcttctg gggctcactg cagtcttccc
      721 tgggtcttcc cttcaaatgc ccatggcgtt tatccttctc cctctctaga aatgtactcg
      781 actgttataa cgagggagtg tgattgggtc tctgtaggtc tctggggggt agaggggagg
      841 ggagggaagg cagaagggaa cagagacatt tgaggtggcc acatgattgg gtggaattca
      901 tccctcctgt cttcaccatt cctcccagct ccacatctta aggatgctta cgggagacga
      961 agctgtgtca tcaagagctc agtgggtgcg aggaaagtat gatccagcgc tcagccttcg
     1021 ctctaggatg ctgtggtccc cattcccagt tcctccagtg ccagtacttt agcttggcct
     1081 agccccagtc tcaggaactg ttgtggtgcc cctgagccca cagtcatctc cagagtccac
     1141 ctggaagcct gttcccctct cctcggctcc tggtccacca gtgcatggca gtgcccatgc
     1201 atgccggcat attcagcagc tgtcacctta ctcccatccc aggaggccgt aaggcctccc
     1261 acctctcccc tgtgactgca gctgctgagc cataaagttg gaccatatga cacaaggcca
     1321 atggggaccg gagtaccatg gctcctgtcc ttggatggtc tcttgtccct gaatttcatt
     1381 gtatcatgca tggagagaaa tgtttgtctt tctgttgtct atacatcaaa gaagccatta
     1441 aattgtttta tttctcaaga
//
