LOCUS       NP_080191                159 aa            linear   ROD 12-JUN-2025
DEFINITION  transmembrane protein 88 [Mus musculus].
ACCESSION   NP_080191
VERSION     NP_080191.3
DBSOURCE    REFSEQ: accession NM_025915.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 159)
  AUTHORS   Shen,S., Werner,T., Lukowski,S.W., Andersen,S., Sun,Y., Shim,W.J.,
            Mizikovsky,D., Kobayashi,S., Outhwaite,J., Chiu,H.S., Chen,X.,
            Chapman,G., Martin,E.M.M.A., Xia,D., Pham,D., Su,Z., Kim,D.,
            Yang,P., Tan,M.C., Sinniah,E., Zhao,Q., Negi,S., Redd,M.A.,
            Powell,J.E., Dunwoodie,S.L., Tam,P.P.L., Boden,M., Ho,J.W.K.,
            Nguyen,Q. and Palpant,N.J.
  TITLE     Atlas of multilineage stem cell differentiation reveals TMEM88 as a
            developmental regulator of blood pressure
  JOURNAL   Nat Commun 16 (1), 1356 (2025)
   PUBMED   39904980
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 159)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 159)
  AUTHORS   Li,L.Y., Yang,C.C., Li,S.W., Liu,Y.M., Li,H.D., Hu,S., Zhou,H.,
            Wang,J.L., Shen,H., Meng,X.M., Li,J. and Xu,T.
  TITLE     TMEM88 modulates the secretion of inflammatory factors by
            regulating YAP signaling pathway in alcoholic liver disease
  JOURNAL   Inflamm Res 69 (8), 789-800 (2020)
   PUBMED   32451556
  REMARK    GeneRIF: TMEM88 modulates the secretion of inflammatory factors by
            regulating YAP signaling pathway in alcoholic liver disease.
REFERENCE   4  (residues 1 to 159)
  AUTHORS   Santos,R., Kawauchi,S., Jacobs,R.E., Lopez-Burks,M.E., Choi,H.,
            Wikenheiser,J., Hallgrimsson,B., Jamniczky,H.A., Fraser,S.E.,
            Lander,A.D. and Calof,A.L.
  TITLE     Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals
            Multiple Determinants of Risk for Congenital Heart Defects
  JOURNAL   PLoS Biol 14 (9), e2000197 (2016)
   PUBMED   27606604
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 159)
  AUTHORS   Lee,H.J., Finkelstein,D., Li,X., Wu,D., Shi,D.L. and Zheng,J.J.
  TITLE     Identification of transmembrane protein 88 (TMEM88) as a
            dishevelled-binding protein
  JOURNAL   J Biol Chem 285 (53), 41549-41556 (2010)
   PUBMED   21044957
  REMARK    GeneRIF: TMEM88 associates with Dvl proteins and regulates Wnt
            signaling in a context-dependent manner
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161789.1 and AK045149.1.
            
            On Aug 1, 2009 this sequence version replaced NP_080191.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161789.1, AK045149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..159
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.6 cM"
     Protein         1..159
                     /product="transmembrane protein 88"
                     /calculated_mol_wt=17227
     Site            43..63
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D0N8.1)"
     Site            88..108
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D0N8.1)"
     CDS             1..159
                     /gene="Tmem88"
                     /gene_synonym="2600017H02Rik"
                     /coded_by="NM_025915.4:10..489"
                     /db_xref="CCDS:CCDS24894.1"
                     /db_xref="GeneID:67020"
                     /db_xref="MGI:MGI:1914270"
ORIGIN      
        1 maevpgaqrp vlaggpeprd pldcwacavl vtaqnllvav fnllllalvl gtillpavim
       61 lgfgflchsq flrsqaplct shlrdpgfta llvtgflllv pllvlalaty rrlclrlrla
      121 dclvpysral yrrrripqpk qipvspgsrs vptpgkvwv
//
