LOCUS       NM_001110496            2924 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus transmembrane protein 87A (Tmem87a), transcript
            variant 2, mRNA.
ACCESSION   NM_001110496
VERSION     NM_001110496.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2924)
  AUTHORS   Kang,H., Han,A.R., Zhang,A., Jeong,H., Koh,W., Lee,J.M., Lee,H.,
            Jo,H.Y., Maria-Solano,M.A., Bhalla,M., Kwon,J., Roh,W.S., Yang,J.,
            An,H.J., Choi,S., Kim,H.M. and Lee,C.J.
  TITLE     GolpHCat (TMEM87A), a unique voltage-dependent cation channel in
            Golgi apparatus, contributes to Golgi-pH maintenance and
            hippocampus-dependent memory
  JOURNAL   Nat Commun 15 (1), 5830 (2024)
   PUBMED   38992057
  REMARK    GeneRIF: GolpHCat (TMEM87A), a unique voltage-dependent cation
            channel in Golgi apparatus, contributes to Golgi-pH maintenance and
            hippocampus-dependent memory.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2924)
  AUTHORS   Chakrabarti,S., Klich,J.D., Khallaf,M.A., Hulme,A.J.,
            Sanchez-Carranza,O., Baran,Z.M., Rossi,A., Huang,A.T., Pohl,T.,
            Fleischer,R., Furst,C., Hammes,A., Begay,V., Hornberg,H.,
            Finol-Urdaneta,R.K., Poole,K., Dottori,M. and Lewin,G.R.
  TITLE     Touch sensation requires the mechanically gated ion channel ELKIN1
  JOURNAL   Science 383 (6686), 992-998 (2024)
   PUBMED   38422143
  REMARK    GeneRIF: Touch sensation requires the mechanically gated ion
            channel ELKIN1.
REFERENCE   3  (bases 1 to 2924)
  AUTHORS   Huang,T. and Krimm,R.F.
  TITLE     BDNF and NT4 play interchangeable roles in gustatory development
  JOURNAL   Dev Biol 386 (2), 308-320 (2014)
   PUBMED   24378336
REFERENCE   4  (bases 1 to 2924)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY149198.1, AK044591.1 and AL844608.18.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004047.1, AK044591.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BY149198.1         1-47
            48-1911             AK044591.1         2-1865
            1912-2924           AL844608.18        155242-156254       c
FEATURES             Location/Qualifiers
     source          1..2924
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.31 cM"
     gene            1..2924
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /note="transmembrane protein 87A"
                     /db_xref="GeneID:211499"
                     /db_xref="MGI:MGI:2441844"
     exon            1..212
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1736
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; elkin1"
                     /codon_start=1
                     /product="transmembrane protein 87A isoform 2 precursor"
                     /protein_id="NP_001103966.1"
                     /db_xref="CCDS:CCDS50677.1"
                     /db_xref="GeneID:211499"
                     /db_xref="MGI:MGI:2441844"
                     /translation="MAVKMAVAAWLQVSPVIFLLLGAQPFPLSFLGAGPAPVFAADRS
                     KWHIPMPSGKGYFNFGKILFRNTTILLKFDGEPCDQSLNITWFLKSADCYNEIYNFKA
                     DEIESYLENLKGKKGLSGRYQTSSRLFQNCSELYKAQSFSGDFTHRLPLLGEKQEAKE
                     NATNVTFTGDKIAMHEPLQTWQDAPYIFIVHVGISSSKESPKENALSNLFTMTVEVKG
                     PYEYLTLEDYPLMIFFMVMCIVYVLFGVLWLAWSACYWRDLLRIQFWIGAVIFLGMFE
                     KAVFYAEFQNIRYKGESVQNALVLAELLSAVKRSLARTLVIIVSLGYGIVKPRLGVTL
                     HKVVVAGALYLLFSGMEGVLRVTGAQTDLASLAFIPLAFLDTALCWWIFISLTQTMKL
                     LKLRRNIVKLSLYRHFTNTLILAVAASIVFIIWTTMKFRIVTCQSDWRELWVDDAIWR
                     LLFSMILFVIMILWRPSANNQRFAFSPLSEEDEEDEQKEPMLKESFEGMKMRSTKQEP
                     NGTSKVNKAQEDDLKWVEENVPSSVTDVALPALLDSDEERMITHFERSKME"
     exon            213..273
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            274..359
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            360..473
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            474..527
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            528..572
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            573..690
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            691..752
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            753..936
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1036
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1130
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1199
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1308
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1367
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1471
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1545
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1607
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1663
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1694
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..2924
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2903..2908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /note="hexamer: TATAAA"
     polyA_site      2921
                     /gene="Tmem87a"
                     /gene_synonym="A930025J12Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaagaaggcg gaactaccta gccggaagaa ggctcaatac tttgggtagg cgcttcatgg
       61 ctgtgaagat ggcggtggct gcgtggcttc aggtgtctcc tgttattttt cttcttttag
      121 gggcgcagcc gttcccatta tcgtttcttg gtgcaggtcc ggcacccgtg tttgctgcag
      181 atagatcgaa gtggcacatt ccgatgccgt cggggaaagg ttattttaat tttggaaaga
      241 ttcttttcag aaatactacc atcttactga aatttgatgg agagccttgt gaccagtctt
      301 taaatataac ctggtttctg aaaagtgctg attgctacaa tgaaatctac aatttcaagg
      361 cagatgaaat agagtcatac ttggaaaatc tcaagggaaa aaaaggcttg tctgggagat
      421 accaaacatc atcaagatta tttcagaact gtagtgaact ctataaagca cagagctttt
      481 ctggggattt tacacatcga cttcctcttt tgggagaaaa acaggaggct aaggagaatg
      541 caacaaatgt tacctttact ggagacaaaa ttgcaatgca tgaaccattg cagacttggc
      601 aagatgctcc atacattttt atcgtgcatg ttggcatctc gtcctcaaag gaatcaccaa
      661 aagaaaatgc actaagtaac ctttttacca tgactgttga agtaaagggt ccctatgaat
      721 accttactct tgaagactac ccactgatga tttttttcat ggtgatgtgt attgtgtacg
      781 tactatttgg tgttctctgg ctggcatggt ctgcttgcta ctggagagat ctcctgagaa
      841 ttcaattttg gattggtgct gtcatctttc ttggaatgtt tgagaaagct gtgttttatg
      901 cagaatttca gaatatccga tacaaaggag aatctgtcca gaatgccttg gtccttgcag
      961 agctgctctc agcagtaaag cgctcactgg ctcgaaccct ggtcatcata gtcagtctgg
     1021 gatacggcat agtcaagcct cgccttggag tcactcttca caaggttgtg gtggcagggg
     1081 cactttatct tttattctct ggcatggaag gagtcctcag agttacaggg gcccagactg
     1141 atcttgcttc cttggccttt atacccttgg ctttcctaga cactgccctg tgctggtgga
     1201 tattcattag cttaactcaa accatgaagc tattaaaact tcggaggaac attgtaaagc
     1261 tctctttgta ccgacatttc accaatacgc ttatcttggc agtggcagcg tctattgtgt
     1321 tcatcatctg gacgaccatg aagttcagaa tagtgacttg ccagtcggac tggcgagagc
     1381 tgtgggtaga tgatgccatt tggagattgc tgttttccat gatcctcttt gtcatcatga
     1441 ttctttggcg gccatcagca aataaccaga ggtttgcctt ctcaccgttg tcagaggaag
     1501 atgaggagga tgagcagaag gagccgatgc tgaaggaaag ctttgaagga atgaaaatga
     1561 gaagtaccaa gcaggaacca aatgggacta gtaaagtaaa caaagcacag gaagatgatt
     1621 tgaaatgggt agaagaaaat gtcccttctt ctgtgactga tgtagcactt ccggccttgc
     1681 tggactcaga cgaggaacga atgatcacac actttgaaag gtcaaagatg gagtaaataa
     1741 tgggaaactg ccatagaaga tggcttgtat cagggaagag acagcttgcg tgtcagtctt
     1801 ctgcactgct ccgtgggatt aaaggaggca atgacatctg ttcctgatct ctgtgcatgg
     1861 gagctgggga gaggtgtcag ccaaggagag cagcttactg aaacatatcc acgggatgag
     1921 aaaaacctac cggcttcttt acatcatcga caccctttcc ctcccaaccc catcaacagc
     1981 tgtttttgca agctacatgt tgtccctgaa ctttctattc cattgtttaa tctgtcaaac
     2041 taggaagttt aaagtttatg aaaggactgt gtcatttaca ccataatttg tcatctctag
     2101 gagcaactgc ctgtgatttt atttatttag gaagttggta atgggagaaa ttatcattta
     2161 tttttgagtt tcctgagaag tcaagattac atcttgcaga agtagtttgt ggggaatagg
     2221 cccttttgag ttaaggaact atagatctat cagtgaccaa gagggaatgg ggtgggcaga
     2281 aagcgagaga aacttacatg tgattcaaaa tcaagtgcaa ttttgtttac aaatggtgta
     2341 tattaaagat ttttctattt cagatgtgct ttaaagagaa atactaactc ttctgacatc
     2401 tgatattatg acacatccca ttgctggcaa tgtggtgcac actccaaaac ttttaagtac
     2461 catttagtca gcctccaagg gcagcattgc agtcacaggc catgcttggt ttcccttcat
     2521 gccattcttt gggattacac cagatgccaa gaggcactct gtgtacgtgc tgtgattatt
     2581 cgccctgcaa gagggattat catgcttcag aaggggagct tacagagagg ggacaggtcc
     2641 cgttgcttta caagcaggta ttcttgcatg aagtggtatg gaggccctag actgctgctg
     2701 ctgctttttt tttttttttt tttttttttt tttttttttt tacagattga gggttctagt
     2761 ttctgatgtt ggcttggaga cggcctataa catcaccagg gatgggttca cttgaagcac
     2821 tgtatttcag ttttgatcgt tttatccagt tttgccttcc ctaaattttt gttctacatg
     2881 aaaagttcat gccacttttt aatataaaaa ttttaacaaa acta
//
