LOCUS       NM_026436               1791 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane protein 86A (Tmem86a), mRNA.
ACCESSION   NM_026436
VERSION     NM_026436.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1791)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1791)
  AUTHORS   van Wouw,S.A.E., van den Berg,M., El Ouraoui,M., Meurs,A.,
            Kingma,J., Ottenhoff,R., Loix,M., Hoeksema,M.A., Prange,K.,
            Pasterkamp,G., Hendriks,J.J.A., Bogie,J.F.J., van Klinken,J.B.,
            Vaz,F.M., Jongejan,A., de Winther,M.P.J. and Zelcer,N.
  TITLE     Sterol-regulated transmembrane protein TMEM86a couples LXR
            signaling to regulation of lysoplasmalogens in macrophages
  JOURNAL   J Lipid Res 64 (2), 100325 (2023)
   PUBMED   36592658
  REMARK    GeneRIF: Sterol-regulated transmembrane protein TMEM86a couples LXR
            signaling to regulation of lysoplasmalogens in macrophages.
REFERENCE   3  (bases 1 to 1791)
  AUTHORS   Cho,Y.K., Yoon,Y.C., Im,H., Son,Y., Kim,M., Saha,A., Choi,C.,
            Lee,J., Lee,S., Kim,J.H., Kang,Y.P., Jung,Y.S., Ha,H.K.,
            Seong,J.K., Granneman,J.G., Kwon,S.W. and Lee,Y.H.
  TITLE     Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen
            homeostasis and protein kinase A-dependent energy metabolism
  JOURNAL   Nat Commun 13 (1), 4084 (2022)
   PUBMED   35835749
  REMARK    GeneRIF: Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen
            homeostasis and protein kinase A-dependent energy metabolism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1791)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   5  (bases 1 to 1791)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC113001.9.
            
            On Apr 29, 2007 this sequence version replaced NM_026436.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007864.1, BC056619.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC113001.9         118562-118723
            163-427             AC113001.9         120772-121036
            428-1791            AC113001.9         121335-122698
FEATURES             Location/Qualifiers
     source          1..1791
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.68 cM"
     gene            1..1791
                     /gene="Tmem86a"
                     /gene_synonym="1810054O13Rik"
                     /note="transmembrane protein 86A"
                     /db_xref="GeneID:67893"
                     /db_xref="MGI:MGI:1915143"
     exon            1..162
                     /gene="Tmem86a"
                     /gene_synonym="1810054O13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..867
                     /gene="Tmem86a"
                     /gene_synonym="1810054O13Rik"
                     /EC_number="3.3.2.2"
                     /note="lysoplasmalogenase-like protein TMEM86A"
                     /codon_start=1
                     /product="lysoplasmalogenase TMEM86A"
                     /protein_id="NP_080712.1"
                     /db_xref="CCDS:CCDS39966.1"
                     /db_xref="GeneID:67893"
                     /db_xref="MGI:MGI:1915143"
                     /translation="MVSPVTVVKSEGPKLVPFFKATCVYFVLWLPSSSPSWVSALIKC
                     LPIFCLWLFLLAHGVRFLLAHPSASLIFVGLVFSAVGDAFLIWQDHGYFEHGLLMFAV
                     AHILYAAAFGMRPLALRTGLVIGVLSGLCYALLYPGLSGAFTYLVGVYVALISFMGWR
                     AMAGLRLVGAAWRWTELAAGGGALLFILSDLTIALNKFCFPVPYSRALIMSTYYAAQM
                     LIALSAVESREPVGEDYRLSKAD"
     exon            163..427
                     /gene="Tmem86a"
                     /gene_synonym="1810054O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            428..1791
                     /gene="Tmem86a"
                     /gene_synonym="1810054O13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1774..1779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem86a"
                     /gene_synonym="1810054O13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1786
                     /gene="Tmem86a"
                     /gene_synonym="1810054O13Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtactctga gcgcccagcg cgcgggaggt attgtgcttc accccagctt tgttcggtcg
       61 tctgctcacc tggctctggg tgcgtcctgg tggtgcaacc cggagcgggt gccagcagcc
      121 gcagccgcag ccgccgccgc catggtgtct ccggtcactg tggtgaagag cgaaggaccc
      181 aaactggtgc ccttctttaa ggctacctgt gtgtattttg tgctctggct gccttcatcc
      241 agcccatcgt gggtcagcgc ccttatcaag tgcctgccca tcttttgcct ctggcttttt
      301 cttctggctc atggtgttcg gtttctgctg gctcacccca gtgcctccct catcttcgtg
      361 ggacttgtct tttctgctgt gggtgatgcc ttcctcatct ggcaggacca cggatacttt
      421 gaacatggtc tcctgatgtt tgccgtggca cacatcctct acgccgcggc ctttggcatg
      481 cggccactgg ctctgcggac aggcctggtg atcggagtgc tgtcaggcct gtgctatgcc
      541 ctgctctacc ctggcctgtc aggtgctttc acctacctgg tgggggtcta tgtggccctc
      601 atcagcttca tgggctggag agctatggca gggctgcggt tggttggggc agcctggcgg
      661 tggacagagc tggcggccgg cggtggtgct ctgctcttca tcctctcgga cctgaccatc
      721 gctctcaaca agttctgctt ccccgtgccc tactcccggg cactgatcat gtctacctac
      781 tatgctgctc agatgctcat tgccctgtca gctgtcgaga gccgagagcc agtgggagaa
      841 gactacagac tgagcaaggc cgactgaagg gactggggtc tgctcacctt tctcttgggg
      901 ctgggggccc agactttggg gtcatgcagg agctggacca gcaggcggct tctgggaaag
      961 gggcagtctt gaaggggggt aagctgaagg ggctcccagg aaagctggta gtccaggatg
     1021 acccggagag ctcaaagagg cagcctcaca tccctcacct gagtcagagg tagacatctc
     1081 ctcacctcat caggactgtc aaagccctcc tggaaggtgg tggtgctttt tgacccctct
     1141 ctttttatta gatgcaagag tgtgactctc tcttacgccc aggaccaatg gcagtgccag
     1201 gcccctccat tcccaccttt tctcttccaa gatgacccac gaatgaggag tcctgaaagc
     1261 tccttcccca ggctccctag ttgggaagac tggttgaagg tggagcctgg ttttctgtgt
     1321 ccaacctcgt tacttcagca gtcttttaag tggcaatggc tgtctctcca tggtagaagg
     1381 actgggttgg tctggaagct tgagggcacc aaggtttcag attggtcctt gttctctcac
     1441 aggccagctc aggcctcata ccatcacccc cagtctctgt ccccagggct agggtggacc
     1501 atgccaaagg aaggggccag tctccaacta tatgtctttg tcctactgtc tgcaaaagac
     1561 ttaaagttgc aggcctcaga gagctcctga ggggtgctta acccagctca gagctgcccc
     1621 cccaacccca gcacaccaac aatgctttct tccagctctg ggagtgagtt ctaaatgaca
     1681 ctttagggtc ttagacccaa agcacagtca atgcaagggg agcgaggatg gggtaactcc
     1741 atcctctact gcccatgtga aaaaataaaa taaaataaaa acctaagggc c
//
