LOCUS       NM_027415               1729 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane protein 70 (Tmem70), transcript variant
            1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_027415
VERSION     NM_027415.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1729)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1729)
  AUTHORS   Kovalcikova,J., Vrbacky,M., Pecina,P., Tauchmannova,K., Nuskova,H.,
            Kaplanova,V., Brazdova,A., Alan,L., Elias,J., Cunatova,K.,
            Korinek,V., Sedlacek,R., Mracek,T. and Houstek,J.
  TITLE     TMEM70 facilitates biogenesis of mammalian ATP synthase by
            promoting subunit c incorporation into the rotor structure of the
            enzyme
  JOURNAL   FASEB J 33 (12), 14103-14117 (2019)
   PUBMED   31652072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            W91102.1 and AK003839.1.
            
            On Nov 9, 2006 this sequence version replaced NM_027415.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003839.1, AK008955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                W91102.1           1-16
            17-1729             AK003839.1         2-1714
FEATURES             Location/Qualifiers
     source          1..1729
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 5.1 cM"
     gene            1..1729
                     /gene="Tmem70"
                     /gene_synonym="1110020A09Rik; 2210416J16Rik"
                     /note="transmembrane protein 70"
                     /db_xref="GeneID:70397"
                     /db_xref="MGI:MGI:1915068"
     exon            1..315
                     /gene="Tmem70"
                     /gene_synonym="1110020A09Rik; 2210416J16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..879
                     /gene="Tmem70"
                     /gene_synonym="1110020A09Rik; 2210416J16Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein 70, mitochondrial"
                     /codon_start=1
                     /product="transmembrane protein 70, mitochondrial isoform
                     1"
                     /protein_id="NP_081691.2"
                     /db_xref="CCDS:CCDS56623.1"
                     /db_xref="GeneID:70397"
                     /db_xref="MGI:MGI:1915068"
                     /translation="MLLGLGGRWAAGLWPGRTRTTWCVAAALRGSGIAFWRAASLAEP
                     ERLRSGGHLALAESCGPPGRAQIPVCWEQCVRCFHTQVDKPENGRLIYTGNLARTIFG
                     VKCFSYSTSVVSLAFLPYLLSQNNMMFGSLPLQVLFYGVMGSFTVITPTLLHLLTKGY
                     VIRLYHEATSDTYRAVTYNVMLSETSTVFHQDDVTIPESAHIFTSFYAKTKSLLVNPA
                     LFLNPEDYNHLMGYDKPFTFDMEEVDEKKLHEGEK"
     exon            316..421
                     /gene="Tmem70"
                     /gene_synonym="1110020A09Rik; 2210416J16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            422..1729
                     /gene="Tmem70"
                     /gene_synonym="1110020A09Rik; 2210416J16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1250..1255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem70"
                     /gene_synonym="1110020A09Rik; 2210416J16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1271
                     /gene="Tmem70"
                     /gene_synonym="1110020A09Rik; 2210416J16Rik"
                     /note="major polyA site"
     regulatory      1608..1613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem70"
                     /gene_synonym="1110020A09Rik; 2210416J16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1652
                     /gene="Tmem70"
                     /gene_synonym="1110020A09Rik; 2210416J16Rik"
                     /note="major polyA site"
ORIGIN      
        1 gttccgttta aggggcggag cctcatcgct cttgtggggg ccactgtcga gcggagtcgc
       61 ttttgggtgt ccttggccgc agctggaaac tgacggccac cttctccaac tcgcagcatg
      121 ctgttggggt tgggcggccg gtgggcagcg ggcctatggc cgggccggac gaggacgacg
      181 tggtgtgtgg ccgccgcgct ccgaggttcc gggatcgctt tctggcgtgc ggcctcgcta
      241 gccgagccag agcggctccg gagcggcggg catctagcgc tagccgagtc ttgcgggcca
      301 cccgggcgag cgcagatacc tgtttgttgg gaacaatgtg tccgctgctt ccatacacaa
      361 gttgataagc cagaaaatgg caggctgatt tatactggaa acctggcccg aacgatattt
      421 ggtgtgaaat gtttctctta ttctacaagt gttgtcagcc ttgcattctt gccgtacctt
      481 ctctcacaaa ataacatgat gtttggaagt ctgcctttgc aagtcttatt ttacggagtc
      541 atgggaagct tcacagtgat cactcccacg ctgcttcacc ttcttacaaa aggctatgtc
      601 attcggttgt atcatgaagc cacaagtgac acttacagag ctgtcactta caatgttatg
      661 ctttcggaaa ccagcacagt gtttcaccaa gacgacgtga caattccaga gagcgcacat
      721 atattcacca gcttttatgc taaaacaaaa tcgctattag ttaatccagc actcttttta
      781 aaccctgaag actataacca tctaatgggt tatgacaaac cgttcacttt tgatatggaa
      841 gaagtcgatg aaaagaaact gcatgagggt gaaaaatgaa cctgttcttc atttgtgctt
      901 aaatgtcatg tattttcagg gtataataag attgccttta ttttgttatt gttagttaat
      961 gattgtagaa acaaaacaaa acaaacaaaa aagtgtaagg gctgaggaca cagcaattgg
     1021 cactgtgttt gctgatgtga ggccctagaa ttggccttca tagaagcagg atgcttttgt
     1081 acacttagaa tcccagcaca tgggacagcg aggtaggaag attagaaatc tgaggtcatc
     1141 cttggtaatg tagtaggttt gaggttagcc tggaccttgt cttaaaaaca gaagttgaaa
     1201 ctatcaagca gaatttctga aaaattttta catgacaatg ttcctatgta ataaaatatg
     1261 tttaaattaa atatgtaaaa tgtggatggt catgaatatt ctggtatatg tatggctaca
     1321 tttatttact tatattttgt ttttagacag aatcttacta tgtagaccag tctgaccttg
     1381 aattcataga aatctatctg cttctgtgtg tgccaccaca tctgagccat gtatggcggt
     1441 acatcagaac cggagcggtg gctcagtggt taagagcact ggctgttctt ccagaggtcc
     1501 tgagttcagt tcccagcaac cacatggtgg ctcacaacca tgaggggatc tgatgccctc
     1561 ttctcgtgtg tggatgtata tgcaggagag cactcataca ttaaataaat aaaggattaa
     1621 ggccttaaat aaattaaggc atgccaccat tacccagtat gtgtttgttt ggttttgggt
     1681 ttttgtttgt tttgttttta gtttttttaa ttattaaaat cttatgtgt
//
