LOCUS       NM_181401               4681 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transmembrane protein 64 (Tmem64), mRNA.
ACCESSION   NM_181401
VERSION     NM_181401.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4681)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4681)
  AUTHORS   Jeong,B.C., Kim,T.S., Kim,H.S., Lee,S.H. and Choi,Y.
  TITLE     Transmembrane protein 64 reciprocally regulates osteoblast and
            adipocyte differentiation by modulating Wnt/beta-catenin signaling
  JOURNAL   Bone 78, 165-173 (2015)
   PUBMED   25979161
  REMARK    GeneRIF: Tmem64 plays an important role in the regulation of
            mesenchymal lineage allocation by modulating Wnt/beta-catenin
            signaling
REFERENCE   3  (bases 1 to 4681)
  AUTHORS   Kim,H., Kim,T., Jeong,B.C., Cho,I.T., Han,D., Takegahara,N.,
            Negishi-Koga,T., Takayanagi,H., Lee,J.H., Sul,J.Y., Prasad,V.,
            Lee,S.H. and Choi,Y.
  TITLE     Tmem64 modulates calcium signaling during RANKL-mediated osteoclast
            differentiation
  JOURNAL   Cell Metab 17 (2), 249-260 (2013)
   PUBMED   23395171
  REMARK    GeneRIF: Tmem64 is a positive modulator of osteoclast
            differentiation via SERCA2-dependent Ca(2+) signaling.
REFERENCE   4  (bases 1 to 4681)
  AUTHORS   Roma,G., Cobellis,G., Claudiani,P., Maione,F., Cruz,P., Tripoli,G.,
            Sardiello,M., Peluso,I. and Stupka,E.
  TITLE     A novel view of the transcriptome revealed from gene trapping in
            mouse embryonic stem cells
  JOURNAL   Genome Res 17 (7), 1051-1060 (2007)
   PUBMED   17540781
REFERENCE   5  (bases 1 to 4681)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (bases 1 to 4681)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732571.8, AK035894.1 and AL929532.12.
            
            On Mar 21, 2009 this sequence version replaced NM_181401.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY147882.1, BC030341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               AL732571.8         19913-20226         c
            315-3164            AK035894.1         2-2851
            3165-3973           AL732571.8         1-809               c
            3974-4681           AL929532.12        2001-2708
FEATURES             Location/Qualifiers
     source          1..4681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 6.6 cM"
     gene            1..4681
                     /gene="Tmem64"
                     /gene_synonym="9630015D15Rik"
                     /note="transmembrane protein 64"
                     /db_xref="GeneID:100201"
                     /db_xref="MGI:MGI:2140359"
     exon            1..930
                     /gene="Tmem64"
                     /gene_synonym="9630015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1278
                     /gene="Tmem64"
                     /gene_synonym="9630015D15Rik"
                     /note="CG11367 gene product"
                     /codon_start=1
                     /product="transmembrane protein 64"
                     /protein_id="NP_852066.2"
                     /db_xref="CCDS:CCDS17983.1"
                     /db_xref="GeneID:100201"
                     /db_xref="MGI:MGI:2140359"
                     /translation="MRNPGGSLPHTLPRALQHAGRTGVVEQPGRWAPERTAGGDRSED
                     RLPRGGGASAAAAAAAAAASGALLGAYLERHGLPAASDLPAPAGALAGGPGSGGGVVV
                     GVAEVRNWRCCCLGSTCWCRSLVLVCVLAALCFASLALVRRYLQHLLLWVESLDSLLG
                     VLLFVVGFIVVSFPCGWGYIVLNVAAGYLYGFVLGMGLMVVGVLIGTFIAHVVCKRLL
                     TAWVAARIQNSDKLSAVIRVVEGGSGLKVVALARLTPIPFGLQNAVFSITDVPLPSYL
                     MASSAGLLPTQLLNSYLGTTLRTMEDVIAEQSLSGYFVFCLQIVISIGLMFYVVHRAQ
                     VELNAAIVACEMELKTSLVKGNQSDPSGSSFYNKRTLTFSGGGINIV"
     exon            931..1086
                     /gene="Tmem64"
                     /gene_synonym="9630015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..4681
                     /gene="Tmem64"
                     /gene_synonym="9630015D15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3246..3251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem64"
                     /gene_synonym="9630015D15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3269
                     /gene="Tmem64"
                     /gene_synonym="9630015D15Rik"
                     /note="major polyA site"
     regulatory      4658..4663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem64"
                     /gene_synonym="9630015D15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4664
                     /gene="Tmem64"
                     /gene_synonym="9630015D15Rik"
     polyA_site      4676
                     /gene="Tmem64"
                     /gene_synonym="9630015D15Rik"
ORIGIN      
        1 ccgcccttct ccggccgttc cctccccgcg agaggacgca gggagccgag gcctggcgtg
       61 cggggtgcca tggaaggccg caggcggggg gacgcggcgg gagtggagac actggccggc
      121 tgaggccgag gcatgcggaa ccccggtggg agcctgcccc acacgctgcc ccgggccttg
      181 cagcacgccg gtcggacggg agtcgtggag cagccgggcc gctgggcacc ggagcggaca
      241 gcgggagggg accgctcgga ggaccgcctt ccccgcgggg gcggggccag cgcggcggcg
      301 gctgctgctg cggcggcggc ctcgggcgcc ctgctcggcg cctatctgga gcgccacggt
      361 ctgcccgcgg cctcggactt gccggcgccg gccggggcgt tggcaggcgg ccccgggagc
      421 ggcggcggcg tggtggtcgg ggtggccgag gtgagaaact ggcgctgctg ctgcctcggc
      481 agcacctgtt ggtgccggag cctcgtgctg gtgtgcgtgc tggccgccct gtgcttcgct
      541 tccctggccc tggtccgccg ctacctgcag cacctcctgc tctgggtgga gagcctcgac
      601 tcgctgctcg gtgtcctgct cttcgtcgtg ggcttcatcg tggtctcctt cccctgcggt
      661 tggggctaca tcgtgcttaa tgtggcggcc ggctacctgt acggcttcgt gctaggcatg
      721 gggctcatgg tggtgggcgt cctcattggc acctttatcg ctcatgtggt ctgcaagcgg
      781 ctactcaccg cctgggtggc tgccaggatc cagaacagcg acaagctgag cgccgttatc
      841 cgcgtcgtgg agggaggaag cggcctgaag gtggtggcgc tggcccggct gactcccata
      901 ccttttgggc ttcagaatgc agtgttttcg attactgacg tccccttgcc cagctacctg
      961 atggcgtctt cagctgggct gctcccgact cagcttctga attcttactt gggaaccaca
     1021 ctacggacta tggaagatgt catcgcagaa caaagtctta gtggctattt tgtcttttgt
     1081 ttacagattg ttataagcat tggcctcatg ttttatgtag tccatcgcgc tcaagtggaa
     1141 ttgaatgcag ctattgtagc ttgtgagatg gaactgaaaa cctctctggt taaaggcaat
     1201 caatcggatc ccagtggctc ttccttctac aacaagagga ccctcacgtt ttctggaggt
     1261 ggaatcaata ttgtatgatt cttacaaact gtgattgttg agagcctagc gtgctgtcca
     1321 ggcctagcag tcacttacct gatggcagag acaagtgctg ttgtattatg gcacaaacaa
     1381 aactgactag tttttaaatt gcacaatttt ctaaaagcaa gaatcatttt ctgggtctgt
     1441 cagtgtaaat gtagatgcag ctctggctgc ccccccttgt tatacctgta atggcctata
     1501 ggtgtgcact ttagtgtttt tgaattattt tattgctggg acttatgaac agaaaaataa
     1561 cccaaatatt ttctttctgt ttagtatctt tatttataaa gcccatgaat agttgtgtgc
     1621 atctttaagg atgagtgaaa gtatagagtt cgcaatggct cttgttgtat gctctttgct
     1681 taggcattct ctccagaagg gtgaactgtt ttgtttaatg ttcacttgct tgtttcaagc
     1741 agaaaagctc tgctttgttt tccttgcttg taaggaaata gctgtatttc ggttgactgt
     1801 atgttatccg gcattatgtc actgtggtca tttacacctc tcggtacaag tgtaaaccct
     1861 acattgtggg actgaagtgc tcttaagacc ccttttattt tcactgtgta agatgcaaag
     1921 tgaaagggac attatttagc aggtggctca caagtcgagc ccgcattctt attcgattat
     1981 attgatttct cccattagac ctcatccaag ggctgtccga tagcaactct taccaaacca
     2041 tttccccctt ttatattaat aattaggctt tgaaataagc ttattgttcc tataaaatgg
     2101 tgggcttacc atctctgacg tcattcaggt ggccttgttt agtcaaaacg ccttgttaaa
     2161 aagaaacgag ctttaaaatc atgtttatag tttcagttaa aaaaaatata tatatgtccc
     2221 catagctttc agctttaaaa ctataaacat taacaaaaat cccacattcg tgctgtctgc
     2281 tgcattattg ctgttttgtt tggggctttg gtgttccttt tccctgacaa gactcaggaa
     2341 ttctgaaatg tgaaattgtc tcaatccttt atcttgtagc atgtgtgttt gctaacagca
     2401 cttaggactt agcatacaat aatccaacat gattcgtatg gcgtgcactc atttatcagc
     2461 tttattttta aaatagttta attgcaaact taatgatgag ttaattttga tgcaaataga
     2521 ttgtagttga tacggtaacg ttttctgtta aggacttcac ttttctatga ctgttccaac
     2581 ctatcagagc tctctccgct gccttttgct ggcagtaaaa cctttgccct gggtactgct
     2641 gacatccaga gaaatcccgc gcaagcagat ttttctagtc ttaaccccag agaagagttt
     2701 gattgtgttc acacacgagg tttttgccca gttcaggtgg ctttccttcc cctgctgatg
     2761 cgtaaatccc tctgcctctg agtagcagta gaagaccaga gtaactggga cgaaaggcac
     2821 ctggtctaca gtgcatgcct ggcctccaga cctttgttat cggtagaaaa acaactatac
     2881 atactgagtc cttactgtct gtttagttaa gtttcagtta gtttaaccat cccaataaaa
     2941 gaaatatttg atttatcctt tttagtacaa cttggcaaca tttttcttgt gtttctcatt
     3001 ggctattttt cgttaaagga atctttattt gagatcatta ttttcatgct tgctttacaa
     3061 ttcatgtatt ttgaagtgca ttatatttac ttagcatttg taacttgaat gacttcacca
     3121 aatgaatacc ttttggtaat ttgtaataac ttcttccaaa tgttaacact ttccctggta
     3181 attgtattac atatgtaaag acaaaagaaa tacttttctg tattctgcca atcataattt
     3241 tatataataa atcatcaact tttataatag tatggattga caatttctaa agtactaatg
     3301 tagcaatgct ttttctttct ttagtattcc caaggtacca ggaaacagca cttcattatt
     3361 gccatgttat ttgataggtg catctggtgg ctggtggctg ggttatattt atattcactg
     3421 taatctgtgc agcagagctg tatcatgttc actgtctcta atcctgtacc ctgggcttac
     3481 aacagcagaa gttctcaagc agtgctctgg acacatattg cctccagcca tatgtattca
     3541 agaaatgcat attcatagaa atgaaacatg gtgtccttac attggttaac tacagtctaa
     3601 agttgcttta tattcattta gagtccacct agttttcaat ctggttaaag ttttgttcta
     3661 ttttttctaa gattgccact ttgacaagtt tgcattacct ctttttaaaa ccatgtttat
     3721 atttactgtg ctctcatgtc atttttattt gatcatctga tttgtgaata attgaaatct
     3781 gtactcttgg tgaaaaaatc atgttatcaa gtctcattgt tggaatgttc attttcagtt
     3841 tatattcaga agtgaatgga tattttcaga gtcagccata ctcacccttg aagcactgta
     3901 cccagctgct agtgtcccac agtggctttc cccaatgccc atacagtgtc cccttgggga
     3961 aactgtggaa ttcagtttgt ttgccctcac tgtaaacaaa ctaaatggtt gaggcgcaca
     4021 cagcatcaca cctgttaacc tgtggtggta ctcttcctgg ggaagttaca tgacttacat
     4081 tgttgtctgt gaggctgatc tttccagttc ttgaaagctg ctgggtgtgt gccacattgg
     4141 tgcaaataga tccttcctgt gtggcagatg agtgccattc acagaaaagg agaattgaag
     4201 agaaaaagag gtttattgtg aagccagata actgtaactg ggttggtggc cttggtgctg
     4261 agattatgtt gcagctgaag gctcctccca ggctcggaat gatccatgta atatttattg
     4321 tctggatcct cagattagat gtttctggtt tctcttttaa taaggtattt aggatatata
     4381 tttttaaagt tcattgcttt aagctgaaaa gccatttaaa tggaggagag gaattgctct
     4441 tgtaggctat ttaaaactca ggagttcaaa taaactcaca aattgaacag acactgttga
     4501 ctttgcaact aagttatgac ctggtacgtc tgagctgcac agtgattgct gcagactgtt
     4561 ctcagaggtg gctgggattt acagtaccga attctaacag caaagcagtt ataatgtctt
     4621 gaaaattggt gtcccaaatc actcgtgtgc ctaagaaaat aaaaggaaat attttatgtt
     4681 t
//
