LOCUS       NM_029565               1562 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transmembrane protein 59 (Tmem59), mRNA.
ACCESSION   NM_029565 NM_019801
VERSION     NM_029565.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1562)
  AUTHORS   Zhou,H., Wang,J. and Wen,T.
  TITLE     The molecular neural mechanism underlying the acceleration of brain
            aging due to Dcf1 deficiency
  JOURNAL   Mol Cell Neurosci 126, 103884 (2023)
   PUBMED   37506857
  REMARK    GeneRIF: The molecular neural mechanism underlying the acceleration
            of brain aging due to Dcf1 deficiency.
REFERENCE   2  (bases 1 to 1562)
  AUTHORS   Ma,Z., Li,W., Zhuang,L., Wen,T., Wang,P., Yu,H., Liu,Y. and Yu,Y.
  TITLE     TMEM59 ablation leads to loss of olfactory sensory neurons and
            impairs olfactory functions via interaction with inflammation
  JOURNAL   Brain Behav Immun 111, 151-168 (2023)
   PUBMED   37061103
REFERENCE   3  (bases 1 to 1562)
  AUTHORS   Meng,J., Han,L., Zheng,N., Wang,T., Xu,H., Jiang,Y., Wang,Z.,
            Liu,Z., Zheng,Q., Zhang,X., Luo,H., Can,D., Lu,J., Xu,H. and
            Zhang,Y.W.
  TITLE     Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and
            Leads to Autism-Like Behaviors in Mice
  JOURNAL   J Neurosci 42 (25), 4958-4979 (2022)
   PUBMED   35606143
  REMARK    GeneRIF: Microglial Tmem59 Deficiency Impairs Phagocytosis of
            Synapse and Leads to Autism-Like Behaviors in Mice.
REFERENCE   4  (bases 1 to 1562)
  AUTHORS   Lin,R., Zhou,H., Diao,X., Wang,J., Feng,R. and Wen,T.
  TITLE     A preliminary study on abnormal brain function and autistic
            behavior in mice caused by dcf1 deletion
  JOURNAL   Biochem Biophys Res Commun 579, 29-34 (2021)
   PUBMED   34583192
  REMARK    GeneRIF: A preliminary study on abnormal brain function and
            autistic behavior in mice caused by dcf1 deletion.
REFERENCE   5  (bases 1 to 1562)
  AUTHORS   Li,W.H., Gan,L.H., Ma,F.F., Feng,R.L., Wang,J., Li,Y.H., Sun,Y.Y.,
            Wang,Y.J., Diao,X., Qian,F.Y. and Wen,T.Q.
  TITLE     Deletion of Dcf1 Reduces Amyloid-beta Aggregation and Mitigates
            Memory Deficits
  JOURNAL   J Alzheimers Dis 81 (3), 1181-1194 (2021)
   PUBMED   33896839
  REMARK    GeneRIF: Deletion of Dcf1 Reduces Amyloid-beta Aggregation and
            Mitigates Memory Deficits.
REFERENCE   6  (bases 1 to 1562)
  AUTHORS   Li,X., Feng,R., Huang,C., Wang,H., Wang,J., Zhang,Z., Yan,H. and
            Wen,T.
  TITLE     MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates
            neural stem cell morphogenesis
  JOURNAL   RNA Biol 9 (3), 292-301 (2012)
   PUBMED   22336716
  REMARK    GeneRIF: MicroRNA-351 regulates TMEM 59 (DCF1) expression and
            mediates neural stem cell morphogenesis.
REFERENCE   7  (bases 1 to 1562)
  AUTHORS   Zhang,L., Ju,X., Cheng,Y., Guo,X. and Wen,T.
  TITLE     Identifying Tmem59 related gene regulatory network of mouse neural
            stem cell from a compendium of expression profiles
  JOURNAL   BMC Syst Biol 5, 152 (2011)
   PUBMED   21955788
  REMARK    GeneRIF: The expression of tmem59 is an important factor
            contributing to Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1562)
  AUTHORS   Wang,L., Wang,J., Wu,Y., Wu,J., Pang,S., Pan,R. and Wen,T.
  TITLE     A novel function of dcf1 during the differentiation of neural stem
            cells in vitro
  JOURNAL   Cell Mol Neurobiol 28 (6), 887-894 (2008)
   PUBMED   18365309
  REMARK    GeneRIF: Overexpression of the dcf1 gene, the NSCs were maintained
            in undifferentiated status. After the dcf1 gene was silenced, cells
            tended to differentiate into neurons and astrocytes.
REFERENCE   9  (bases 1 to 1562)
  AUTHORS   Yang,L.T., Nichols,J.T., Yao,C., Manilay,J.O., Robey,E.A. and
            Weinmaster,G.
  TITLE     Fringe glycosyltransferases differentially modulate Notch1
            proteolysis induced by Delta1 and Jagged1
  JOURNAL   Mol Biol Cell 16 (2), 927-942 (2005)
   PUBMED   15574878
REFERENCE   10 (bases 1 to 1562)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB860994.1, AK145644.1 and BC058273.1.
            
            On Apr 22, 2009 this sequence version replaced NM_029565.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058273.1, AF116911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                BB860994.1         1-81
            82-1541             AK145644.1         3-1462
            1542-1562           BC058273.1         1457-1477
FEATURES             Location/Qualifiers
     source          1..1562
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.12 cM"
     gene            1..1562
                     /gene="Tmem59"
                     /gene_synonym="1110001M20Rik; 3110046P06Rik; D4Ertd20e;
                     MTDCF1; ORF18"
                     /note="transmembrane protein 59"
                     /db_xref="GeneID:56374"
                     /db_xref="MGI:MGI:1929278"
     exon            1..288
                     /gene="Tmem59"
                     /gene_synonym="1110001M20Rik; 3110046P06Rik; D4Ertd20e;
                     MTDCF1; ORF18"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1071
                     /gene="Tmem59"
                     /gene_synonym="1110001M20Rik; 3110046P06Rik; D4Ertd20e;
                     MTDCF1; ORF18"
                     /note="thymic dendritic cell-derived factor 1"
                     /codon_start=1
                     /product="transmembrane protein 59 precursor"
                     /protein_id="NP_083841.4"
                     /db_xref="CCDS:CCDS18432.1"
                     /db_xref="GeneID:56374"
                     /db_xref="MGI:MGI:1929278"
                     /translation="MAAPKGKLWVQAQLGLPPLLLLTMALAGGSGTAAAEAFDSVLGD
                     TASCHRACQLTYPLHTYPKEEELYACQRGCRLFSICQFVDDGLDLNRTKLECESACTE
                     AYSQPDEQYACHLGCQDQLPFAELRQEQLMSLMPRMHLLFPLTLVRSFWSDMMDSAQS
                     FITSSWTFYLQADDGKIVIFQSKPEIQYAPQLEQEPTNLRESSLSKMSYLQMRNSQAH
                     RNYLEEEESDGFLRCLSLNSGWILTTTLVLSVMVLLWICCAAVATAVEQYVPPEKLSI
                     YGDLEFMNEQKLSRYPAPSLVIVRSQTEEHEEAGPLPTKVNLAHSEI"
     exon            289..394
                     /gene="Tmem59"
                     /gene_synonym="1110001M20Rik; 3110046P06Rik; D4Ertd20e;
                     MTDCF1; ORF18"
                     /inference="alignment:Splign:2.1.0"
     exon            395..489
                     /gene="Tmem59"
                     /gene_synonym="1110001M20Rik; 3110046P06Rik; D4Ertd20e;
                     MTDCF1; ORF18"
                     /inference="alignment:Splign:2.1.0"
     exon            490..642
                     /gene="Tmem59"
                     /gene_synonym="1110001M20Rik; 3110046P06Rik; D4Ertd20e;
                     MTDCF1; ORF18"
                     /inference="alignment:Splign:2.1.0"
     exon            643..724
                     /gene="Tmem59"
                     /gene_synonym="1110001M20Rik; 3110046P06Rik; D4Ertd20e;
                     MTDCF1; ORF18"
                     /inference="alignment:Splign:2.1.0"
     exon            725..806
                     /gene="Tmem59"
                     /gene_synonym="1110001M20Rik; 3110046P06Rik; D4Ertd20e;
                     MTDCF1; ORF18"
                     /inference="alignment:Splign:2.1.0"
     exon            807..915
                     /gene="Tmem59"
                     /gene_synonym="1110001M20Rik; 3110046P06Rik; D4Ertd20e;
                     MTDCF1; ORF18"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1544
                     /gene="Tmem59"
                     /gene_synonym="1110001M20Rik; 3110046P06Rik; D4Ertd20e;
                     MTDCF1; ORF18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1513..1518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem59"
                     /gene_synonym="1110001M20Rik; 3110046P06Rik; D4Ertd20e;
                     MTDCF1; ORF18"
                     /note="hexamer: ATTAAA"
     regulatory      1528..1533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem59"
                     /gene_synonym="1110001M20Rik; 3110046P06Rik; D4Ertd20e;
                     MTDCF1; ORF18"
                     /note="hexamer: AATAAT"
     polyA_site      1535
                     /gene="Tmem59"
                     /gene_synonym="1110001M20Rik; 3110046P06Rik; D4Ertd20e;
                     MTDCF1; ORF18"
                     /note="major polyA site"
     polyA_site      1544
                     /gene="Tmem59"
                     /gene_synonym="1110001M20Rik; 3110046P06Rik; D4Ertd20e;
                     MTDCF1; ORF18"
                     /note="major polyA site"
ORIGIN      
        1 gcgggccgga ggggcgggga aaggggctgg cccggaagaa ggagaaagcc tgaaaagaaa
       61 acagcaacaa ttcgagctgc tgtgacagag gggaacaaga tggcggcgcc aaaggggaag
      121 ctttgggtcc aggcccaact ggggctcccg ccgctgctgc tgttgactat ggcgctggcc
      181 ggaggctcgg ggactgcagc ggccgaagcc tttgactcgg tcctgggaga cacagcgtcc
      241 tgtcaccggg cctgtcagct gacctacccc ttgcacacct acccgaagga agaggagtta
      301 tacgcatgcc agagaggctg caggctgttt tcaatttgcc agtttgtgga tgatgggctt
      361 gatttaaatc ggaccaagct ggaatgtgaa tctgcgtgca cagaagcata ttcccaacct
      421 gatgagcagt atgcttgtca tcttggctgc caggatcagt tgccatttgc tgaactgaga
      481 caagaacaac tcatgtccct gatgccaaga atgcatctcc tcttccctct gactctggtg
      541 aggtcgttct ggagtgacat gatggactct gcacagagct tcataacctc ttcatggact
      601 ttttatcttc aagccgatga cggaaaaata gttatattcc agtctaagcc agaaattcag
      661 tatgcaccgc agttggagca ggagcctaca aacttgagag aatcatcttt aagcaaaatg
      721 tcctatctgc agatgagaaa ctcacaagca cacaggaact accttgaaga ggaagaaagc
      781 gatggctttt taagatgtct atctcttaac tctggatgga ttttaaccac aacccttgtc
      841 ctctcggtga tggtgttgct ctggatctgt tgtgcagctg ttgctacagc tgtagaacag
      901 tatgttcccc ctgagaagct gagtatctat ggtgacttgg aatttatgaa tgaacaaaag
      961 ctgagcagat acccagctcc ttctcttgtg attgttaggt ctcagactga agaacatgag
     1021 gaggcagggc ccctgcccac caaggtgaac cttgctcact cagaaatcta agctttttaa
     1081 aagagtcgtg gacacataaa cttccattcc tcatagagct ttttaagatg gtttcattgg
     1141 acataggcct taagaaatca ctataaaatg caaataaagt taccaaactc tgtgaagact
     1201 ttatttgctg tgactttacc tgtatttttc tagtcattta agatggacat tgggttgtat
     1261 ttttatttta ctaatatctg tagctactta gttagttgca ttggttttgg tttttttcct
     1321 ctcttcgcca aattctatga gctgatcatt gtggccccgc ccctgccatg ccccccgtca
     1381 gtcatctcac ttaataaccg aaaccttagg gtgtgatgct tctgcccgga aatggcctcc
     1441 aaactgtcct ctggattata gcagaaatgt tatttaatga cactacattt tcagttgtat
     1501 tgaattgaaa tcattaaaat ctatttgaat aattatgttc tgaaaaaaaa aaaaaaaaaa
     1561 aa
//
