LOCUS       NM_026837                999 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus transmembrane protein 53 (Tmem53), transcript variant
            2, mRNA.
ACCESSION   NM_026837
VERSION     NM_026837.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 999)
  AUTHORS   Guo,L., Iida,A., Bhavani,G.S., Gowrishankar,K., Wang,Z., Xue,J.Y.,
            Wang,J., Miyake,N., Matsumoto,N., Hasegawa,T., Iizuka,Y.,
            Matsuda,M., Nakashima,T., Takechi,M., Iseki,S., Yambe,S.,
            Nishimura,G., Koseki,H., Shukunami,C., Girisha,K.M. and Ikegawa,S.
  TITLE     Deficiency of TMEM53 causes a previously unknown sclerosing bone
            disorder by dysregulation of BMP-SMAD signaling
  JOURNAL   Nat Commun 12 (1), 2046 (2021)
   PUBMED   33824347
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 999)
  AUTHORS   Malik,P., Korfali,N., Srsen,V., Lazou,V., Batrakou,D.G.,
            Zuleger,N., Kavanagh,D.M., Wilkie,G.S., Goldberg,M.W. and
            Schirmer,E.C.
  TITLE     Cell-specific and lamin-dependent targeting of novel transmembrane
            proteins in the nuclear envelope
  JOURNAL   Cell Mol Life Sci 67 (8), 1353-1369 (2010)
   PUBMED   20091084
REFERENCE   3  (bases 1 to 999)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Tmem53 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671866.8, AK004164.1, AW049729.1 and AL844169.6.
            
            On Oct 23, 2013 this sequence version replaced NM_026837.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1,
            resulting in an isoform (b) that is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI248980.1, BG964943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AL671866.8         7780-7817           c
            39-959              AK004164.1         2-922
            960-993             AW049729.1         13-46               c
            994-999             AL844169.6         10816-10821
FEATURES             Location/Qualifiers
     source          1..999
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.43 cM"
     gene            1..999
                     /gene="Tmem53"
                     /gene_synonym="1110038M16Rik; 1500001P22Rik;
                     1700012A05Rik"
                     /note="transmembrane protein 53"
                     /db_xref="GeneID:68777"
                     /db_xref="MGI:MGI:1916027"
     exon            1..184
                     /gene="Tmem53"
                     /gene_synonym="1110038M16Rik; 1500001P22Rik;
                     1700012A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            185..300
                     /gene="Tmem53"
                     /gene_synonym="1110038M16Rik; 1500001P22Rik;
                     1700012A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            301..999
                     /gene="Tmem53"
                     /gene_synonym="1110038M16Rik; 1500001P22Rik;
                     1700012A05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      969..974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem53"
                     /gene_synonym="1110038M16Rik; 1500001P22Rik;
                     1700012A05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      993
                     /gene="Tmem53"
                     /gene_synonym="1110038M16Rik; 1500001P22Rik;
                     1700012A05Rik"
                     /note="major polyA site"
ORIGIN      
        1 cggggattgg acagcgctgg gcgtgggcgg ggaggggcgt ggcccggcgg cgtcccggcc
       61 ccgccgaggt gaaactgcgg gagttccggc gggaggcctg tgctgaagac ccgcaccttc
      121 accatggcct cggccgagct ggattacagc atcgagatcc cggatcagcc ctgctggagc
      181 cagaagaaca gacaaggtgg gaaggaagct gggaagcaac agcctgtggt gattctcttg
      241 ggctggggag gctgcaggga caagaacctg gccaagtata gtgctatcta ccacaaaagg
      301 ggctgcattg tgatccgata cacggccccc tggcacatgg tcttcttctc tgagtccttg
      361 ggcatccctt cacttcgcgt gatagcccag aaactgctgg agctcctctt tgactatgag
      421 attgagcggg agcctctgct cttccacgtc ttcagcaatg ccggcgtcat gctctaccgc
      481 tacgtgctgg agctcctaca gacccaccag cgcttccgcc atttgcatgt ggtgggcacc
      541 atctttgaca gtggtcctgg cgatagcaac ctgatagggg ccctgagggc tctggcaacc
      601 atcctggagc gccgacctgc ggtgctgcgc ctgttgctcc tggcagcatt tgccctggtg
      661 gtgatcctgt ttcacttcct gcttgctcca ttcactgccc tcttccacac ccacttctac
      721 gacaggctgc aggactcagg ctcctgctgg cctgaactct acctctactc tagagctgat
      781 aaggtggtct cggccaggga tgtggaacgt atggtagagg cacgcctggc tcaccaggtc
      841 atggtgcgtg gagtggactt tgtgtcatct gcgcatgtca gccacctccg agactatcct
      901 acttactata caagtctgtg tgttgacttc atgcataatt gtgtccaatg ctgaggtccc
      961 gctccggaaa taaacgccga cacctccctt caaccttta
//
