LOCUS       NM_001285815            1103 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus transmembrane protein 53 (Tmem53), transcript variant
            5, mRNA.
ACCESSION   NM_001285815
VERSION     NM_001285815.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1103)
  AUTHORS   Guo,L., Iida,A., Bhavani,G.S., Gowrishankar,K., Wang,Z., Xue,J.Y.,
            Wang,J., Miyake,N., Matsumoto,N., Hasegawa,T., Iizuka,Y.,
            Matsuda,M., Nakashima,T., Takechi,M., Iseki,S., Yambe,S.,
            Nishimura,G., Koseki,H., Shukunami,C., Girisha,K.M. and Ikegawa,S.
  TITLE     Deficiency of TMEM53 causes a previously unknown sclerosing bone
            disorder by dysregulation of BMP-SMAD signaling
  JOURNAL   Nat Commun 12 (1), 2046 (2021)
   PUBMED   33824347
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1103)
  AUTHORS   Malik,P., Korfali,N., Srsen,V., Lazou,V., Batrakou,D.G.,
            Zuleger,N., Kavanagh,D.M., Wilkie,G.S., Goldberg,M.W. and
            Schirmer,E.C.
  TITLE     Cell-specific and lamin-dependent targeting of novel transmembrane
            proteins in the nuclear envelope
  JOURNAL   Cell Mol Life Sci 67 (8), 1353-1369 (2010)
   PUBMED   20091084
REFERENCE   3  (bases 1 to 1103)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Tmem53 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671866.8, BE647557.1, AK004164.1, AW049729.1 and AL844169.6.
            
            Transcript Variant: This variant (5) differs in its 5' UTR and
            initiates translation at a downstream in-frame start codon,
            compared to variant 1. The encoded isoform (d) is shorter at the
            N-terminus, compared to isoform a. Both variants 5 and 6 encode
            isoform d.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR5189685.223996.1, AI006037.1
                                    [ECO:0000331]
            RNAseq introns       :: partial sample support SAMN00849386
                                    [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AL671866.8         7707-7817           c
            112-402             BE647557.1         1-291
            403-1063            AK004164.1         262-922
            1064-1097           AW049729.1         13-46               c
            1098-1103           AL844169.6         10816-10821
FEATURES             Location/Qualifiers
     source          1..1103
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.43 cM"
     gene            1..1103
                     /gene="Tmem53"
                     /gene_synonym="1110038M16Rik; 1500001P22Rik;
                     1700012A05Rik"
                     /note="transmembrane protein 53"
                     /db_xref="GeneID:68777"
                     /db_xref="MGI:MGI:1916027"
     exon            1..184
                     /gene="Tmem53"
                     /gene_synonym="1110038M16Rik; 1500001P22Rik;
                     1700012A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            185..288
                     /gene="Tmem53"
                     /gene_synonym="1110038M16Rik; 1500001P22Rik;
                     1700012A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            289..404
                     /gene="Tmem53"
                     /gene_synonym="1110038M16Rik; 1500001P22Rik;
                     1700012A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            405..1103
                     /gene="Tmem53"
                     /gene_synonym="1110038M16Rik; 1500001P22Rik;
                     1700012A05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..1058
                     /gene="Tmem53"
                     /gene_synonym="1110038M16Rik; 1500001P22Rik;
                     1700012A05Rik"
                     /note="isoform d is encoded by transcript variant 5;
                     nuclear envelope transmembrane protein 4"
                     /codon_start=1
                     /product="transmembrane protein 53 isoform d"
                     /protein_id="NP_001272744.1"
                     /db_xref="GeneID:68777"
                     /db_xref="MGI:MGI:1916027"
                     /translation="MVFFSESLGIPSLRVIAQKLLELLFDYEIEREPLLFHVFSNAGV
                     MLYRYVLELLQTHQRFRHLHVVGTIFDSGPGDSNLIGALRALATILERRPAVLRLLLL
                     AAFALVVILFHFLLAPFTALFHTHFYDRLQDSGSCWPELYLYSRADKVVSARDVERMV
                     EARLAHQVMVRGVDFVSSAHVSHLRDYPTYYTSLCVDFMHNCVQC"
     regulatory      1073..1078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem53"
                     /gene_synonym="1110038M16Rik; 1500001P22Rik;
                     1700012A05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1097
                     /gene="Tmem53"
                     /gene_synonym="1110038M16Rik; 1500001P22Rik;
                     1700012A05Rik"
                     /note="major polyA site"
ORIGIN      
        1 cggggattgg acagcgctgg gcgtgggcgg ggaggggcgt ggcccggcgg cgtcccggcc
       61 ccgccgaggt gaaactgcgg gagttccggc gggaggcctg tgctgaagac ccgcaccttc
      121 accatggcct cggccgagct ggattacagc atcgagatcc cggatcagcc ctgctggagc
      181 cagaaggttt ggattcctgg gggagcctct ggtcctcaga aaagccaagg gactcagcaa
      241 gcctagtcct gcccttctca gctcaccctg gcagtggtta acagaatgag aacagacaag
      301 gtgggaagga agctgggaag caacagcctg tggtgattct cttgggctgg ggaggctgca
      361 gggacaagaa cctggccaag tatagtgcta tctaccacaa aaggggctgc attgtgatcc
      421 gatacacggc cccctggcac atggtcttct tctctgagtc cttgggcatc ccttcacttc
      481 gcgtgatagc ccagaaactg ctggagctcc tctttgacta tgagattgag cgggagcctc
      541 tgctcttcca cgtcttcagc aatgccggcg tcatgctcta ccgctacgtg ctggagctcc
      601 tacagaccca ccagcgcttc cgccatttgc atgtggtggg caccatcttt gacagtggtc
      661 ctggcgatag caacctgata ggggccctga gggctctggc aaccatcctg gagcgccgac
      721 ctgcggtgct gcgcctgttg ctcctggcag catttgccct ggtggtgatc ctgtttcact
      781 tcctgcttgc tccattcact gccctcttcc acacccactt ctacgacagg ctgcaggact
      841 caggctcctg ctggcctgaa ctctacctct actctagagc tgataaggtg gtctcggcca
      901 gggatgtgga acgtatggta gaggcacgcc tggctcacca ggtcatggtg cgtggagtgg
      961 actttgtgtc atctgcgcat gtcagccacc tccgagacta tcctacttac tatacaagtc
     1021 tgtgtgttga cttcatgcat aattgtgtcc aatgctgagg tcccgctccg gaaataaacg
     1081 ccgacacctc ccttcaacct tta
//
