LOCUS       NM_144936               1602 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane protein 45b (Tmem45b), mRNA.
ACCESSION   NM_144936
VERSION     NM_144936.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1602)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1602)
  AUTHORS   Tanioku,T., Nishibata,M., Tokinaga,Y., Konno,K., Watanabe,M.,
            Hemmi,H., Fukuda-Ohta,Y., Kaisho,T., Furue,H. and Kawamata,T.
  TITLE     Tmem45b is essential for inflammation- and tissue injury-induced
            mechanical pain hypersensitivity
  JOURNAL   Proc Natl Acad Sci U S A 119 (45), e2121989119 (2022)
   PUBMED   36322717
  REMARK    GeneRIF: Tmem45b is essential for inflammation- and tissue
            injury-induced mechanical pain hypersensitivity.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC026654.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026654.1, AK144325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1602
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 16.9 cM"
     gene            1..1602
                     /gene="Tmem45b"
                     /note="transmembrane protein 45b"
                     /db_xref="GeneID:235135"
                     /db_xref="MGI:MGI:2384574"
     exon            1..73
                     /gene="Tmem45b"
                     /inference="alignment:Splign:2.1.0"
     exon            74..273
                     /gene="Tmem45b"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..926
                     /gene="Tmem45b"
                     /codon_start=1
                     /product="transmembrane protein 45B"
                     /protein_id="NP_659185.1"
                     /db_xref="CCDS:CCDS22950.1"
                     /db_xref="GeneID:235135"
                     /db_xref="MGI:MGI:2384574"
                     /translation="MANFKGHALPGSFFLIVGLWWSVKYPLKYFHHKGLKNNRLSRQQ
                     ERIEIIEGAVKTLFAIIGILAEQFVPDGPHLHLYHENQWVKLMNWQHSTMYLFFGVSG
                     LMDMITYLYFHIVPLGLDRVVLAMAVFIEGFLFYFHVHNRPPLDQHIHSLLLFGLFGA
                     AVSISLEVILRDNIVLELFRTSLLILQGTWFWQIGFVLFPPFGRPEWDQKDMDNIMFI
                     TMCFCWHYLVALCIVAINYSLVYCFLTRVKRRAEGEIIGIQKLKSDHTYQSALLSGSD
                     EE"
     exon            274..483
                     /gene="Tmem45b"
                     /inference="alignment:Splign:2.1.0"
     exon            484..668
                     /gene="Tmem45b"
                     /inference="alignment:Splign:2.1.0"
     exon            669..814
                     /gene="Tmem45b"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1575
                     /gene="Tmem45b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1183..1188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem45b"
                     /note="hexamer: AATACA"
     polyA_site      1204
                     /gene="Tmem45b"
                     /note="major polyA site"
ORIGIN      
        1 tgcacctcct gggcacccgc ggtcacacgt gtgaccgaag ctggcaagtg gacacctctg
       61 aggctcggaa gaggcatcct ggaacagcga tggcaaactt caagggccat gctctcccag
      121 ggagcttctt tctaatagtg gggctgtggt ggtcagtgaa gtacccactg aagtactttc
      181 accacaaggg cttgaagaat aacagactga gccgtcagca ggagcgcatt gagatcattg
      241 aaggtgcagt gaagactctg tttgcaatca ttgggatcct ggcagagcag tttgttccag
      301 atggacctca cctgcacctc taccacgaga accaatgggt caagctgatg aattggcagc
      361 acagcaccat gtacctattc ttcggtgtct cgggactcat ggacatgatc acctaccttt
      421 acttccacat cgtgcccctg gggttagaca gagtggtttt ggctatggcc gtattcattg
      481 aaggttttct cttctacttc cacgttcaca accgccctcc cctggaccag cacatccact
      541 ccctgctgct gttcggtctt ttcggagcag ctgtcagcat ctctctggag gttatccttc
      601 gggataacat cgtgctggag ctcttccgaa ccagtctcct tatcttgcag ggaacctggt
      661 tctggcagat tggatttgtc ctgttcccgc catttggaag gccagaatgg gaccagaagg
      721 acatggacaa catcatgttc atcaccatgt gcttctgctg gcactacttg gttgctctct
      781 gcatcgtagc catcaactac tcccttgttt actgctttct gactcgggtg aagagacgtg
      841 cagaaggaga aatcattggg attcagaagc tgaagtctga tcacacttac cagtcagccc
      901 ttttgagtgg ctcggatgag gagtgacatc aagcatgggg gtgtggagac ctcacatcct
      961 ttttaaacaa cactggaaag gatgcagcct gtcccctgta cttcaaggct tgccttatgt
     1021 gctcctgtcc ctggtactcc aaggcttgcc ttatgtgctc ctgtccctgg tactccaagg
     1081 cttgccttat gtgctcctgt ccctggtact ccaaggcttg ccttatgtgc tcctagggct
     1141 ctatatgctg catccctcat ctactacaaa gctagaggct caaatacagg aaattagacc
     1201 tcaagtgttt tttatgcacc atgttattgg aatatttaag catagtttaa cttaaaatct
     1261 gtattagagt agtaacactg tccacacaga aaagtgaaca ccttccagaa gcaggcctgt
     1321 ccttatagag caatgactcg aagactctga attacactag gaagcgacca tgtggatgaa
     1381 gcaggccgga catcacgtgc tgcttctgat aacttgcccc tcttctctca atcaagcagg
     1441 tactttcttc tcagaaaagt accacaagtt agatggcgac aaatgtacca cattttctgt
     1501 atccattcct ctgttgaggg acatctgggt tctttccagc ttctggctat tataaataag
     1561 actgctatga acataaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
