LOCUS       NM_025339               1059 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane protein 42 (Tmem42), transcript variant
            1, mRNA.
ACCESSION   NM_025339
VERSION     NM_025339.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1059)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1059)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133650.4, AK012820.1 and BX515032.1.
            
            On Sep 19, 2009 this sequence version replaced NM_025339.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049583.1, AK002688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC133650.4         83718-83766
            50-931              AK012820.1         25-906
            932-1059            BX515032.1         209-336
FEATURES             Location/Qualifiers
     source          1..1059
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 73.52 cM"
     gene            1..1059
                     /gene="Tmem42"
                     /gene_synonym="0610027O18Rik; 4933429E06Rik; D9Ertd662e"
                     /note="transmembrane protein 42"
                     /db_xref="GeneID:66079"
                     /db_xref="MGI:MGI:1277176"
     exon            1..245
                     /gene="Tmem42"
                     /gene_synonym="0610027O18Rik; 4933429E06Rik; D9Ertd662e"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..527
                     /gene="Tmem42"
                     /gene_synonym="0610027O18Rik; 4933429E06Rik; D9Ertd662e"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 42 isoform 1"
                     /protein_id="NP_079615.1"
                     /db_xref="CCDS:CCDS23652.1"
                     /db_xref="GeneID:66079"
                     /db_xref="MGI:MGI:1277176"
                     /translation="MAAGPQSSGAAVSAAAYPDSPVELPARLQKGAMRRRFWGVFNCL
                     CAGAFGALAAAAAKLAFGSQVNIGLCVLGIVAMASANSLMWTFFSRGLSFSMSSAIAS
                     VTVTFSNILCSAILGYLLYGECQEILWWGGVFLILCGLTLIHRKFPPTWKESKEQ"
     exon            246..392
                     /gene="Tmem42"
                     /gene_synonym="0610027O18Rik; 4933429E06Rik; D9Ertd662e"
                     /inference="alignment:Splign:2.1.0"
     exon            393..1045
                     /gene="Tmem42"
                     /gene_synonym="0610027O18Rik; 4933429E06Rik; D9Ertd662e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1021..1026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem42"
                     /gene_synonym="0610027O18Rik; 4933429E06Rik; D9Ertd662e"
                     /note="hexamer: AATAAA"
     polyA_site      1045
                     /gene="Tmem42"
                     /gene_synonym="0610027O18Rik; 4933429E06Rik; D9Ertd662e"
                     /note="major polyA site"
ORIGIN      
        1 acggcgggtg gcggcgtgcg tggcagtcgg ccgtggcggg cgcagcgggc ctcatggcgg
       61 ccggtccgca gtcctcgggt gccgccgtgt ctgcggccgc ttaccctgac tcacccgtgg
      121 agttacccgc tcgcctacag aaaggcgcga tgcggcgccg cttctggggc gtgttcaact
      181 gtctgtgcgc cggggcgttc ggggctctgg ccgccgccgc cgccaagctg gccttcggga
      241 gccaggtcaa tattggctta tgtgtcttag gcatcgttgc catggcaagc gccaattctc
      301 tgatgtggac cttctttagc cggggcctca gtttctctat gtcttcagcc attgcatctg
      361 tcacagtgac tttctcgaac atactttgct cggccatctt aggctacctg ctgtatggag
      421 agtgccagga gatcttatgg tggggagggg tgttcctcat cctctgtggg ctcaccctga
      481 tccacaggaa gtttccaccc acctggaagg agagcaagga gcagtgaggc cagtcggtgg
      541 atagaccaga cccactgtaa agagaaccat gatacccagc caagggttga caagttgggc
      601 tgcttccagg gcggcctggg agtgcagccc ttaagtgtca gccacatgga gatggtggac
      661 cagccactgg cctctgacct cctcacagcc tggaaagtta aagcattagc tcctgtaagg
      721 ggaagctaac caccacagta tgaggcccaa gtccttcagt gttggtatag tgccttgatt
      781 cttgtgcacc agggaatatt ggaagactct gtgatcatgg gttacacagc aacatggcag
      841 gtacctgaaa aaaacaaaaa acatgtgatt agaatcctgc ccttcatgta ccccagcact
      901 ggcagttggc tttctgaaaa aacaaacaaa caaacaacaa aaaaaaaaca acttgatgtg
      961 tcatgcctca ggtggtccgt gatgcctatg aatccacagc aaaagaaggg aacgtgggct
     1021 aataaacact tgtaagctaa agctaaaaaa aaaaaaaaa
//
