LOCUS       NM_153525               3619 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus transmembrane protein 41B (Tmem41b), mRNA.
ACCESSION   NM_153525
VERSION     NM_153525.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3619)
  AUTHORS   Carlini,M.J., Van Alstyne,M., Yang,H., Yadav,S., Shneider,N.A. and
            Pellizzoni,L.
  TITLE     Stasimon/Tmem41b is required for cell proliferation and adult mouse
            survival
  JOURNAL   Biochem Biophys Res Commun 712-713, 149923 (2024)
   PUBMED   38640735
  REMARK    GeneRIF: Stasimon/Tmem41b is required for cell proliferation and
            adult mouse survival.
REFERENCE   2  (bases 1 to 3619)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3619)
  AUTHORS   Sun,L., Zhao,C., Fu,Z., Fu,Y., Su,Z., Li,Y., Zhou,Y., Tan,Y.,
            Li,J., Xiang,Y., Nie,X., Zhang,J., Liu,F., Zhao,S., Xie,S. and
            Peng,G.
  TITLE     Genome-scale CRISPR screen identifies TMEM41B as a multi-function
            host factor required for coronavirus replication
  JOURNAL   PLoS Pathog 17 (12), e1010113 (2021)
   PUBMED   34871328
  REMARK    GeneRIF: Genome-scale CRISPR screen identifies TMEM41B as a
            multi-function host factor required for coronavirus replication.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3619)
  AUTHORS   Huang,D., Xu,B., Liu,L., Wu,L., Zhu,Y., Ghanbarpour,A., Wang,Y.,
            Chen,F.J., Lyu,J., Hu,Y., Kang,Y., Zhou,W., Wang,X., Ding,W.,
            Li,X., Jiang,Z., Chen,J., Zhang,X., Zhou,H., Li,J.Z., Guo,C.,
            Zheng,W., Zhang,X., Li,P., Melia,T., Reinisch,K. and Chen,X.W.
  TITLE     TMEM41B acts as an ER scramblase required for lipoprotein
            biogenesis and lipid homeostasis
  JOURNAL   Cell Metab 33 (8), 1655-1670 (2021)
   PUBMED   34015269
  REMARK    GeneRIF: TMEM41B acts as an ER scramblase required for lipoprotein
            biogenesis and lipid homeostasis.
REFERENCE   5  (bases 1 to 3619)
  AUTHORS   Simon,C.M., Van Alstyne,M., Lotti,F., Bianchetti,E., Tisdale,S.,
            Watterson,D.M., Mentis,G.Z. and Pellizzoni,L.
  TITLE     Stasimon Contributes to the Loss of Sensory Synapses and Motor
            Neuron Death in a Mouse Model of Spinal Muscular Atrophy
  JOURNAL   Cell Rep 29 (12), 3885-3901 (2019)
   PUBMED   31851921
  REMARK    GeneRIF: Stasimon Contributes to the Loss of Sensory Synapses and
            Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy.
REFERENCE   6  (bases 1 to 3619)
  AUTHORS   Van Alstyne,M., Lotti,F., Dal Mas,A., Area-Gomez,E. and
            Pellizzoni,L.
  TITLE     Stasimon/Tmem41b localizes to mitochondria-associated ER membranes
            and is essential for mouse embryonic development
  JOURNAL   Biochem Biophys Res Commun 506 (3), 463-470 (2018)
   PUBMED   30352685
  REMARK    GeneRIF: Stasimon is an essential gene for mouse embryonic
            development.
REFERENCE   7  (bases 1 to 3619)
  AUTHORS   Lotti,F., Imlach,W.L., Saieva,L., Beck,E.S., Hao le,T., Li,D.K.,
            Jiao,W., Mentis,G.Z., Beattie,C.E., McCabe,B.D. and Pellizzoni,L.
  TITLE     An SMN-dependent U12 splicing event essential for motor circuit
            function
  JOURNAL   Cell 151 (2), 440-454 (2012)
   PUBMED   23063131
  REMARK    GeneRIF: Defective U12 splicing and reduced mRNA levels of Stasimon
            (NP_705745) was observed in the motor circuit neurons of mice with
            spinal muscular atrophy.
REFERENCE   8  (bases 1 to 3619)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC140235.3.
            
            On May 1, 2007 this sequence version replaced NM_153525.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165226.1, AK029327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               AC140235.3         59736-60004
            270-387             AC140235.3         63193-63310
            388-516             AC140235.3         64849-64977
            517-610             AC140235.3         66484-66577
            611-715             AC140235.3         67152-67256
            716-854             AC140235.3         69233-69371
            855-3619            AC140235.3         71015-73779
FEATURES             Location/Qualifiers
     source          1..3619
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.69 cM"
     gene            1..3619
                     /gene="Tmem41b"
                     /gene_synonym="1500015G02Rik; 1500031M19Rik; D7Ertd70e;
                     D7Ertd743e"
                     /note="transmembrane protein 41B"
                     /db_xref="GeneID:233724"
                     /db_xref="MGI:MGI:1289225"
     exon            1..269
                     /gene="Tmem41b"
                     /gene_synonym="1500015G02Rik; 1500031M19Rik; D7Ertd70e;
                     D7Ertd743e"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1024
                     /gene="Tmem41b"
                     /gene_synonym="1500015G02Rik; 1500031M19Rik; D7Ertd70e;
                     D7Ertd743e"
                     /note="Stasimon; protein stasimon"
                     /codon_start=1
                     /product="transmembrane protein 41B"
                     /protein_id="NP_705745.3"
                     /db_xref="CCDS:CCDS21742.1"
                     /db_xref="GeneID:233724"
                     /db_xref="MGI:MGI:1289225"
                     /translation="MAKGRVADRSPTEMLHSTPAGDRAVRTQGSAAPGSKDHLNEKPC
                     AEAGSARTSLLILVSIFSCAAFVMFLVYKNFPQLSEEERVNMKVPRDMDDAKALGKVL
                     SKYKDTFYVQVLVAYFATYIFLQTFAIPGSIFLSILSGFLYPFPLALFLVCLCSGLGA
                     SFCYMLSYLVGRPVVYKYLTEKAVKWSQQVERHREHLINYIIFLRITPFLPNWFINIT
                     SPVINVPLKVFFIGTFLGVAPPSFVAIKAGTTLHQLTTAGEAVSWSSVFILMVLALLS
                     ILPAIFQKQLKQKFE"
     exon            270..387
                     /gene="Tmem41b"
                     /gene_synonym="1500015G02Rik; 1500031M19Rik; D7Ertd70e;
                     D7Ertd743e"
                     /inference="alignment:Splign:2.1.0"
     exon            388..516
                     /gene="Tmem41b"
                     /gene_synonym="1500015G02Rik; 1500031M19Rik; D7Ertd70e;
                     D7Ertd743e"
                     /inference="alignment:Splign:2.1.0"
     exon            517..610
                     /gene="Tmem41b"
                     /gene_synonym="1500015G02Rik; 1500031M19Rik; D7Ertd70e;
                     D7Ertd743e"
                     /inference="alignment:Splign:2.1.0"
     exon            611..715
                     /gene="Tmem41b"
                     /gene_synonym="1500015G02Rik; 1500031M19Rik; D7Ertd70e;
                     D7Ertd743e"
                     /inference="alignment:Splign:2.1.0"
     exon            716..854
                     /gene="Tmem41b"
                     /gene_synonym="1500015G02Rik; 1500031M19Rik; D7Ertd70e;
                     D7Ertd743e"
                     /inference="alignment:Splign:2.1.0"
     exon            855..3619
                     /gene="Tmem41b"
                     /gene_synonym="1500015G02Rik; 1500031M19Rik; D7Ertd70e;
                     D7Ertd743e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2296..2301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem41b"
                     /gene_synonym="1500015G02Rik; 1500031M19Rik; D7Ertd70e;
                     D7Ertd743e"
                     /note="hexamer: AATACA"
     polyA_site      2317
                     /gene="Tmem41b"
                     /gene_synonym="1500015G02Rik; 1500031M19Rik; D7Ertd70e;
                     D7Ertd743e"
                     /note="major polyA site"
     regulatory      3314..3319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem41b"
                     /gene_synonym="1500015G02Rik; 1500031M19Rik; D7Ertd70e;
                     D7Ertd743e"
                     /note="hexamer: AATAAA"
     polyA_site      3353
                     /gene="Tmem41b"
                     /gene_synonym="1500015G02Rik; 1500031M19Rik; D7Ertd70e;
                     D7Ertd743e"
ORIGIN      
        1 aagttttcga ggtcgtctca ggtgaggtgg tcgtgccgga agtagttgtg cctcgcgcct
       61 gggtgttgaa agaaagctgc gggaggagct ttagtcattc aagggggcgc ggcaccagta
      121 ggagctcttc gcggcccccg cagcagccat ggcgaaaggc agagtggctg atcgatcgcc
      181 caccgaaatg ttgcactcga ccccagccgg ggaccgggca gtgaggaccc agggttccgc
      241 cgcgcctggc agcaaagatc atctgaacga aaagccttgt gcagaagctg gatcagcaag
      301 aacatcactc cttatactgg tgtccatttt ttcatgtgca gcttttgtta tgtttttggt
      361 atataaaaat tttcctcagc ttagtgagga agagagggtg aatatgaagg ttccgagaga
      421 tatggatgac gccaaggctc taggaaaagt tctctccaaa tataaggata ccttttatgt
      481 acaagtattg gttgcttatt ttgctacata tatttttttg caaacatttg ctatcccagg
      541 ttccatattc ctcagtatac tctccgggtt cctttatccc ttcccacttg ccttattcct
      601 tgtttgtttg tgctccggac ttggtgcctc attctgctac atgctctcct acttagttgg
      661 aagacccgtt gtatacaaat acctaacaga gaaggcagtg aaatggtcac agcaggtaga
      721 gcgtcacaga gaacatctta ttaactacat tatatttttg aggatcacac cgtttcttcc
      781 taattggttt attaatatta catctcctgt gataaatgta ccattgaaag tgttttttat
      841 tggcactttt ctaggtgttg cacctccttc ttttgtagca atcaaggcag gaacaactct
      901 gcatcagctt acaacagcag gggaagctgt ttcctggagc tcggtattta ttctgatggt
      961 tttggccctt ctttctatcc tgccagccat cttccaaaaa caactaaagc agaagtttga
     1021 gtgaaaagac atggcttttc ctttaccacc gccatcactc ctgccaccac cactgtcatc
     1081 tcaggattag caggtgtatt catgttacgt ttggacatca cctcttcagt cactgaaaga
     1141 aggacttgta aagtaaaata gcccatgaga gagaatgcac atatgggaga acagaagttg
     1201 gggccctatg agaagtgctg tcacctgcac ctgacctgtg agagtcactg ttccagggtt
     1261 agctctgaga catcactcat tgtcttggtt tggaattctt actctaaatg attcatttga
     1321 agtgttttcc tcttacatct gactaatgac taaaatcgtg aactcaggta cagtggaaca
     1381 tacttaaaac tccagctgcc cgggaggcta aggctagctg tgaaagtcac aagacaccct
     1441 gtattaaagt aaaataagga acagtgaaga taaaataaaa taaaaattca gagcacaaac
     1501 caaatacttg aagcaaaaat gagttttcat tttctttctc ttttcagaca gcactttcca
     1561 taggccagtg tatgtagcaa tgatgggtta tttaagtttt ccttggaaat ttgtatcatg
     1621 gattagtcca ataatttgaa ttctggccag tctgttttca tccttttttc taggttttgc
     1681 agtatttcca ccatacatat agaaaaggag aattatatat ctgtatcata ttggtgttga
     1741 taatgtatat taagataatg atattttgtt acagtgtctt tattatctca aagggggttc
     1801 taaagtaaat actcaaagca tatacttttt agacattatt ttatactgaa acaactgaca
     1861 gtaggtagga cattactgat taaatctagt ttatttgttc caatgactgt aaaatttgcc
     1921 tcatagattg tctggtcatt aaagaatgta ttgtaattac ctttcatgca tgatacatct
     1981 gcgattgctc tgttgccttt cctctgatga cctccttggg gcagcacttg attggtacac
     2041 tttgccaact gtaaagcttc tactttctca ccttgacatg gtgactggtg tctcccattt
     2101 cttggagcct ccctttggct gcttttgttc cctgccagga cagacccatg taaagcacta
     2161 agatctccgt tggtatgttg aacacttgct ttagtggagt gggagtcctt gtgtcttcaa
     2221 agtctgatca tctcaaagcc tgtttctcct gcaaagtgtg gactaatcct tctctgtcgc
     2281 agtattaatg ttacaaatac aaggaagata atactgatca atattgtatc tgtcttctgt
     2341 ccttttgtgt taaattgtta tgttgtctta ttgaccagag actgagtgat aaagctttta
     2401 ttatttttac aaatgagtta aacacataga tgtttaggac aaagtctact aatatttatg
     2461 tgatattatt tatgtgatat atatatatca ttgaagtcag tcatgtaaca tgcttgtaat
     2521 tccatgactt gggaagtaga gtttcatgtt taactttggc tacatagtga gtttgatgca
     2581 acaatctggg ctatataaga acctgtctca aaaaatacat gtatatatta attcatacaa
     2641 attttcagca ggcctctaaa gctcacattt tggagaagca ctgctgtttc tttgggttgt
     2701 tatggtgctt actctatgct gagagtgttc tctccatcct ctagtgcatg gactctttcc
     2761 ctttgctatg ttttttccta tactcaacag gagctaccac tttagttgga tgttttcttc
     2821 tcccagtaga gagtaaccat tgtgttaaca ttttaccctt ggctgtcaag aaagaacttg
     2881 gaccaagcat tgtgactaat taatgcccag tgcttggaag gccgaagcag aaggataagg
     2941 agcttgtgga cagcttgcgt tgcctgaggc cttgtctcag gcaaaaaaat ctcagcagta
     3001 gattgtaccc cacaatcacc tgtatgccac ctgtgttcat tgagcacaga cttgatataa
     3061 tgacaaatgt aagtcgtcca agattgaaac actccctatc ttcggtgcca gagatcccag
     3121 ggccttgcac cctaggattt aagcctgacc acagccataa gagatttcct agtaatccca
     3181 acaaaacatc ctattgtaat ggaaaggcaa gcaggctaac taggcataca ctgacaaaga
     3241 cagtttcctt cttagttacg actatttatt tcctggagct ttgttacttt gaatctaata
     3301 tatccatgat cttaataaat gtaaactagc tgggtggtga ttttttttaa ttaccatttt
     3361 ttatgaagcc ttttatttct tagaactata tgtaagtcta ttagaagtgt ttcaaaataa
     3421 gattaaagat cagtatatgg ggtgctggag agatgggtca gtggttaaga ccaccactgc
     3481 tcttccagag gacccaggtt catttcccag cacccacatg gcagctcaca cttgtctgta
     3541 actccagttc cagggtttct gataccctca catacatgta atgaacataa ataaaaacac
     3601 atttcatatt ttaaaaacc
//
