LOCUS       NM_028053               2861 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transmembrane protein 38B (Tmem38b), mRNA.
ACCESSION   NM_028053
VERSION     NM_028053.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2861)
  AUTHORS   Ichimura,A., Miyazaki,Y., Nagatomo,H., Kawabe,T., Nakajima,N.,
            Kim,G.E., Tomizawa,M., Okamoto,N., Komazaki,S., Kakizawa,S.,
            Nishi,M. and Takeshima,H.
  TITLE     Atypical cell death and insufficient matrix organization in
            long-bone growth plates from Tric-b-knockout mice
  JOURNAL   Cell Death Dis 14 (12), 848 (2023)
   PUBMED   38123563
  REMARK    GeneRIF: Atypical cell death and insufficient matrix organization
            in long-bone growth plates from Tric-b-knockout mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2861)
  AUTHORS   Jovanovic,M., Mitra,A., Besio,R., Contento,B.M., Wong,K.W.,
            Derkyi,A., To,M., Forlino,A., Dale,R.K. and Marini,J.C.
  TITLE     Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts
            alters cell adhesion and mitochondrial function - A multi-omics
            study
  JOURNAL   Matrix Biol 121, 127-148 (2023)
   PUBMED   37348683
  REMARK    GeneRIF: Absence of TRIC-B from type XIV Osteogenesis Imperfecta
            osteoblasts alters cell adhesion and mitochondrial function - A
            multi-omics study.
REFERENCE   3  (bases 1 to 2861)
  AUTHORS   Besio,R., Contento,B.M., Garibaldi,N., Filibian,M., Sonntag,S.,
            Shmerling,D., Tonelli,F., Biggiogera,M., Brini,M., Salmaso,A.,
            Jovanovic,M., Marini,J.C., Rossi,A. and Forlino,A.
  TITLE     CaMKII inhibition due to TRIC-B loss-of-function dysregulates SMAD
            signaling in osteogenesis imperfecta
  JOURNAL   Matrix Biol 120, 43-59 (2023)
   PUBMED   37178987
  REMARK    GeneRIF: CaMKII inhibition due to TRIC-B loss-of-function
            dysregulates SMAD signaling in osteogenesis imperfecta.
REFERENCE   4  (bases 1 to 2861)
  AUTHORS   Murakami,M., Toyama,Y., Yonekura,M., Ohba,T., Matsuzaki,Y.,
            Sawamura,D., Murakami,A.M., Nishi,M., Itagaki,S., Tomita,H. and
            Takeshima,H.
  TITLE     Decreased cardiac pacemaking and attenuated beta-adrenergic
            response in TRIC-A knockout mice
  JOURNAL   PLoS One 15 (12), e0244254 (2020)
   PUBMED   33347504
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2861)
  AUTHORS   O'Brien,F., Eberhardt,D., Witschas,K., El-Ajouz,S., Iida,T.,
            Nishi,M., Takeshima,H., Sitsapesan,R. and Venturi,E.
  TITLE     Enhanced activity of multiple TRIC-B channels: an endoplasmic
            reticulum/sarcoplasmic reticulum mechanism to boost counterion
            currents
  JOURNAL   J Physiol 597 (10), 2691-2705 (2019)
   PUBMED   30907436
  REMARK    GeneRIF: The role of TRIC-A and TRIC-B channels in skeletal muscle
            sarcoplasmic reticulum channels is reported.
REFERENCE   6  (bases 1 to 2861)
  AUTHORS   Zhou,X., Lin,P., Yamazaki,D., Park,K.H., Komazaki,S., Chen,S.R.,
            Takeshima,H. and Ma,J.
  TITLE     Trimeric intracellular cation channels and sarcoplasmic/endoplasmic
            reticulum calcium homeostasis
  JOURNAL   Circ Res 114 (4), 706-716 (2014)
   PUBMED   24526676
  REMARK    GeneRIF: TRIC-A and TRIC-B seem to have differential functions in
            Ca(2+) signaling in excitable and nonexcitable cells.
            Review article
            Erratum:[Circ Res. 2020 May 8;126(10):e119. doi:
            10.1161/RES.0000000000000350.. PMID: 32379571]
REFERENCE   7  (bases 1 to 2861)
  AUTHORS   Venturi,E., Matyjaszkiewicz,A., Pitt,S.J., Tsaneva-Atanasova,K.,
            Nishi,M., Yamazaki,D., Takeshima,H. and Sitsapesan,R.
  TITLE     TRIC-B channels display labile gating: evidence from the TRIC-A
            knockout mouse model
  JOURNAL   Pflugers Arch 465 (8), 1135-1148 (2013)
   PUBMED   23467973
  REMARK    GeneRIF: Rapid transitions between TRIC-B sub-conductance states
            prevented development of reliable gating models.
REFERENCE   8  (bases 1 to 2861)
  AUTHORS   Tao,S., Yamazaki,D., Komazaki,S., Zhao,C., Iida,T., Kakizawa,S.,
            Imaizumi,Y. and Takeshima,H.
  TITLE     Facilitated hyperpolarization signaling in vascular smooth
            muscle-overexpressing TRIC-A channels
  JOURNAL   J Biol Chem 288 (22), 15581-15589 (2013)
   PUBMED   23592776
REFERENCE   9  (bases 1 to 2861)
  AUTHORS   Yamazaki,D., Komazaki,S., Nakanishi,H., Mishima,A., Nishi,M.,
            Yazawa,M., Yamazaki,T., Taguchi,R. and Takeshima,H.
  TITLE     Essential role of the TRIC-B channel in Ca2+ handling of alveolar
            epithelial cells and in perinatal lung maturation
  JOURNAL   Development 136 (14), 2355-2361 (2009)
   PUBMED   19515693
  REMARK    GeneRIF: TRIC-B-knockout neonates were cyanotic owing to
            respiratory failure and died shortly after birth. In mutant
            neonates, the deflated lungs exhibited severe histological defects,
            and alveolar type II epithelial cells displayed ultrastructural
            abnormalities.
REFERENCE   10 (bases 1 to 2861)
  AUTHORS   Yazawa,M., Ferrante,C., Feng,J., Mio,K., Ogura,T., Zhang,M.,
            Lin,P.H., Pan,Z., Komazaki,S., Kato,K., Nishi,M., Zhao,X.,
            Weisleder,N., Sato,C., Ma,J. and Takeshima,H.
  TITLE     TRIC channels are essential for Ca2+ handling in intracellular
            stores
  JOURNAL   Nature 448 (7149), 78-82 (2007)
   PUBMED   17611541
  REMARK    GeneRIF: TRIC channels are likely to act as counter-ion channels
            that function in synchronization with Ca2+ release from
            intracellular stores
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY138283.1, AK005479.1, AK136131.1 and AK150377.1.
            
            On Apr 2, 2010 this sequence version replaced NM_028053.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150377.1, AK150892.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY138283.1         1-17
            18-1432             AK005479.1         1-1415
            1433-2184           AK136131.1         1183-1934
            2185-2861           AK150377.1         2163-2839
FEATURES             Location/Qualifiers
     source          1..2861
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 28.76 cM"
     gene            1..2861
                     /gene="Tmem38b"
                     /gene_synonym="1600017F22Rik; D4Ertd89e; mg33b; TRIC-B"
                     /note="transmembrane protein 38B"
                     /db_xref="GeneID:52076"
                     /db_xref="MGI:MGI:1098718"
     exon            1..176
                     /gene="Tmem38b"
                     /gene_synonym="1600017F22Rik; D4Ertd89e; mg33b; TRIC-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..943
                     /gene="Tmem38b"
                     /gene_synonym="1600017F22Rik; D4Ertd89e; mg33b; TRIC-B"
                     /note="Mitsugumin33B; TRICB; mitsugumin-33B"
                     /codon_start=1
                     /product="trimeric intracellular cation channel type B"
                     /protein_id="NP_082329.1"
                     /db_xref="CCDS:CCDS18193.1"
                     /db_xref="GeneID:52076"
                     /db_xref="MGI:MGI:1098718"
                     /translation="MEYPWDDLTLAFSRTSMFPFFDIAHYLVSVMALKQRPGAVAAAW
                     NNPLASWLSAMLHCFGGGILSCMLLAESPLKFLTNHTNILLASSIWYIVFFCPRDLVS
                     QGYSYQPIQFLAAGMKEVTRTWKIVGGVSDANSYYRNAWIVMIVVGWARGAGGAVVTA
                     CEQLLKGDWKPEGDEWLKMSFPCKITLLGSIMFTFQHTRHLAISKHDLMFLYTIFLVT
                     IKVTMMMTKDTAVTLTPFEDTLTRMLFGRRQQQQFSSSEKKTEVKPSSNGSASSASKR
                     GAEPSGGAKRHAKKED"
     exon            177..333
                     /gene="Tmem38b"
                     /gene_synonym="1600017F22Rik; D4Ertd89e; mg33b; TRIC-B"
                     /inference="alignment:Splign:2.1.0"
     exon            334..518
                     /gene="Tmem38b"
                     /gene_synonym="1600017F22Rik; D4Ertd89e; mg33b; TRIC-B"
                     /inference="alignment:Splign:2.1.0"
     exon            519..606
                     /gene="Tmem38b"
                     /gene_synonym="1600017F22Rik; D4Ertd89e; mg33b; TRIC-B"
                     /inference="alignment:Splign:2.1.0"
     exon            607..724
                     /gene="Tmem38b"
                     /gene_synonym="1600017F22Rik; D4Ertd89e; mg33b; TRIC-B"
                     /inference="alignment:Splign:2.1.0"
     exon            725..2861
                     /gene="Tmem38b"
                     /gene_synonym="1600017F22Rik; D4Ertd89e; mg33b; TRIC-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1417..1422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem38b"
                     /gene_synonym="1600017F22Rik; D4Ertd89e; mg33b; TRIC-B"
                     /note="hexamer: AATAAA"
     polyA_site      1435
                     /gene="Tmem38b"
                     /gene_synonym="1600017F22Rik; D4Ertd89e; mg33b; TRIC-B"
                     /note="major polyA site"
ORIGIN      
        1 accccctccg ccggagggga accggctgcc gcggctgctg gggccggcgg cgtcggtagt
       61 cgtcatggag tacccgtggg atgatctgac tctggccttt tcccgcacgt ccatgtttcc
      121 cttttttgat atcgcccact acctggtgtc ggtgatggcg ctgaagcagc ggccaggagc
      181 agtggcggcg gcctggaata accccctggc tagctggctg agtgccatgc tccattgctt
      241 tggtggagga attttatcct gtatgctgct tgcagagtct ccattgaagt ttcttacaaa
      301 ccacactaat attttactgg catcttcaat ctggtatatt gtattctttt gccctcgtga
      361 cctagtttcc cagggttatt catatcaacc tattcagttc ctggctgcgg gaatgaagga
      421 agtgacccgg acgtggaaaa tagtaggcgg agtctcggat gctaatagct attacagaaa
      481 tgcctggata gtcatgatag ttgttggatg ggcccgaggt gcaggtggtg ctgtcgtcac
      541 agcttgtgaa cagttgttaa aaggagactg gaaaccagaa ggtgatgaat ggctgaagat
      601 gtccttccct tgcaagataa ccctgctggg gtcaattatg ttcaccttcc agcacaccag
      661 gcacctggcg atctcaaagc atgatctcat gttcctttac actatcttcc tcgtgaccat
      721 aaaggtaacc atgatgatga caaaggatac tgctgtgact ctcactccct ttgaggacac
      781 cctgactcgg atgctttttg gccggcggca gcagcagcag ttttcatcga gtgaaaagaa
      841 aactgaagtc aaaccgtctt ccaatggttc tgcctcaagt gcatcgaagc ggggagcaga
      901 gccttcgggt ggtgctaaga gacacgccaa gaaagaagac tgagggtcgc cctgggcgtc
      961 ggaggcagga ggaggagtta cttctctcag agtgtgcccg tggttctgtg aatgatgtga
     1021 gagagcgctt atgtgtaagg gtggaggaga caaaagagga agtgctttgg ttcagggaca
     1081 ccgctcgctc tgctggtcgt agctcttggg gtcacgagtg tatcatgtga atttattttt
     1141 ctggtgtaag agattctcat aattatttgg atagttttat attgataaaa gaataatttt
     1201 ttaaatgtta caaaaagttc acttgttact gcaaaattct aagaatttaa caaaaaattc
     1261 agtatttttt tttacctttt gaatgactat aattgtgttt taattctgca gaattaaact
     1321 tttacttcat atttccagta taattcctgt atatagaaga cgattcctat ttaattttga
     1381 acatggagaa cttttcctaa atacttttta acctaaaata aactaatagt gtacatttgg
     1441 tgtatacagt tatttatttt atatatcttg cacacattaa aaatacctga aattgtctac
     1501 agccatacca ccctgaacac gcccgatctt gtctgatctc tggagctaag cagggtcggg
     1561 cctggttagt acttggatgg gagaccgcct gggaataccg ggtgctgtag gcttgaaaaa
     1621 aaaaacctga aatttatttt agtttcaagt attatttttc attattttta atatgagtct
     1681 cagtttgaag tttatttctt gcccttgttt taaaaactac tttttcctta gaaaagcagg
     1741 gttacaattt gtgtgtattg ttttcttttt gcaacaggag tctcactctg tagcccaggc
     1801 tggccacaga ccttctacct cagcttccaa agtgctggga ttatgggtcc gggccaccgt
     1861 gccaggctag cggtgtagtt tttattgtta ataatcctgt ggttggaacc tgggctgttt
     1921 tgtgtcacca gctggagaga gatagtcttc acatgttgta tgtttctcct gactcagttg
     1981 gtctgaacag gctggtggca tgtctctgtg actgaacaaa aagtactgtc atggctgaaa
     2041 cggtgtcctg cacctcttcc ggcgatcatt gcttcacgag tttatttgac tgtctcttct
     2101 tgcaagtttg catttggtat ctctgctcaa tagatatgtg cgtgtatttc tagttttatc
     2161 tgaaatgaaa gttgttttcc tgtgaaaatg ctcagctctc ctgaggactg tcttcccaca
     2221 tttgatgtaa accacagaac ctaaccttat gtggcagact acttgactga gacaatacaa
     2281 cattaaacct gctgtctcgt ggacaaagta aaaagcaagc aagcaaacat actaagtgat
     2341 agattctatt tgctcgattt ggtgcataac tgccatgtta caacattaca gttctgtagg
     2401 atgactttca tcctaaggac gtgggcctgc cgtctgtgtt aggcattttt ggttggttaa
     2461 gaagcactta agtgatattc aatatataaa gttttccttt tttgtttttt ttttttgtgt
     2521 ttgttttgtt tttcagaaca gggtttttct atataatagc actgacggtt ccttttttaa
     2581 tttttagcaa acttgcacac ttgcagatac tttacttgat taagaaaaag attttgagtg
     2641 gcacttttga taacctacgt acgagaaaaa tgcttatttt tgatattgtg acaaaaaagc
     2701 actaaattgc attttctatt atatatttga caatctgtag ttaaaaactt tgcaaaatta
     2761 atatgttatt gaccagttct ggttttaact gtagttaaaa tggtaagaat cttgtttttc
     2821 atttgtatta aaaacaaatt cattaaaata agtattttag t
//
