LOCUS       NM_144534               2398 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transmembrane protein 38A (Tmem38a), transcript
            variant 1, mRNA.
ACCESSION   NM_144534
VERSION     NM_144534.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2398)
  AUTHORS   Murakami,M., Toyama,Y., Yonekura,M., Ohba,T., Matsuzaki,Y.,
            Sawamura,D., Murakami,A.M., Nishi,M., Itagaki,S., Tomita,H. and
            Takeshima,H.
  TITLE     Decreased cardiac pacemaking and attenuated beta-adrenergic
            response in TRIC-A knockout mice
  JOURNAL   PLoS One 15 (12), e0244254 (2020)
   PUBMED   33347504
  REMARK    GeneRIF: Decreased cardiac pacemaking and attenuated
            beta-adrenergic response in TRIC-A knockout mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2398)
  AUTHORS   Zhou,X., Park,K.H., Yamazaki,D., Lin,P.H., Nishi,M., Ma,Z., Qiu,L.,
            Murayama,T., Zou,X., Takeshima,H., Zhou,J. and Ma,J.
  TITLE     TRIC-A Channel Maintains Store Calcium Handling by Interacting With
            Type 2 Ryanodine Receptor in Cardiac Muscle
  JOURNAL   Circ Res 126 (4), 417-435 (2020)
   PUBMED   31805819
  REMARK    GeneRIF: Data suggest a function for TRIC-A protein (TRIC-A) as an
            accessory protein that interacts with ryanodine receptor calcium
            release channel (RyR2) to modulate intracellular Ca2+ signaling.
REFERENCE   3  (bases 1 to 2398)
  AUTHORS   O'Brien,F., Eberhardt,D., Witschas,K., El-Ajouz,S., Iida,T.,
            Nishi,M., Takeshima,H., Sitsapesan,R. and Venturi,E.
  TITLE     Enhanced activity of multiple TRIC-B channels: an endoplasmic
            reticulum/sarcoplasmic reticulum mechanism to boost counterion
            currents
  JOURNAL   J Physiol 597 (10), 2691-2705 (2019)
   PUBMED   30907436
  REMARK    GeneRIF: The role of TRIC-A and TRIC-B channels in skeletal muscle
            sarcoplasmic reticulum channels is reported.
REFERENCE   4  (bases 1 to 2398)
  AUTHORS   Robson,M.I., de Las Heras,J.I., Czapiewski,R., Le Thanh,P.,
            Booth,D.G., Kelly,D.A., Webb,S., Kerr,A.R.W. and Schirmer,E.C.
  TITLE     Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane
            Proteins Enhances Repression of Critical Developmental Genes during
            Myogenesis
  JOURNAL   Mol Cell 62 (6), 834-847 (2016)
   PUBMED   27264872
  REMARK    GeneRIF: Three muscle-specific nuclear membrane proteins, NET39,
            Tmem38A, and WFS1, direct specific myogenic genes to the nuclear
            periphery to facilitate their repression during myogenesis.
REFERENCE   5  (bases 1 to 2398)
  AUTHORS   Zhou,X., Lin,P., Yamazaki,D., Park,K.H., Komazaki,S., Chen,S.R.,
            Takeshima,H. and Ma,J.
  TITLE     Trimeric intracellular cation channels and sarcoplasmic/endoplasmic
            reticulum calcium homeostasis
  JOURNAL   Circ Res 114 (4), 706-716 (2014)
   PUBMED   24526676
  REMARK    GeneRIF: TRIC-A and TRIC-B seem to have differential functions in
            Ca(2+) signaling in excitable and nonexcitable cells.
            Review article
            Erratum:[Circ Res. 2020 May 8;126(10):e119. doi:
            10.1161/RES.0000000000000350.. PMID: 32379571]
REFERENCE   6  (bases 1 to 2398)
  AUTHORS   Yamazaki,D., Tabara,Y., Kita,S., Hanada,H., Komazaki,S., Naitou,D.,
            Mishima,A., Nishi,M., Yamamura,H., Yamamoto,S., Kakizawa,S.,
            Miyachi,H., Yamamoto,S., Miyata,T., Kawano,Y., Kamide,K.,
            Ogihara,T., Hata,A., Umemura,S., Soma,M., Takahashi,N.,
            Imaizumi,Y., Miki,T., Iwamoto,T. and Takeshima,H.
  TITLE     TRIC-A channels in vascular smooth muscle contribute to blood
            pressure maintenance
  JOURNAL   Cell Metab 14 (2), 231-241 (2011)
   PUBMED   21803293
  REMARK    GeneRIF: TRIC-A channels contribute to maintaining blood pressure,
            while TRIC-A SNPs could provide biomarkers for constitutional
            diagnosis and personalized medical treatment of essential
            hypertension.
REFERENCE   7  (bases 1 to 2398)
  AUTHORS   Zhao,X., Yamazaki,D., Park,K.H., Komazaki,S., Tjondrokoesoemo,A.,
            Nishi,M., Lin,P., Hirata,Y., Brotto,M., Takeshima,H. and Ma,J.
  TITLE     Ca2+ overload and sarcoplasmic reticulum instability in tric-a null
            skeletal muscle
  JOURNAL   J Biol Chem 285 (48), 37370-37376 (2010)
   PUBMED   20858894
  REMARK    GeneRIF: Absence of TRIC-A leads to instability of Ca(2+) movement
            across the sarcoplasmic reticulum membrane.
REFERENCE   8  (bases 1 to 2398)
  AUTHORS   Yamazaki,D., Yamazaki,T. and Takeshima,H.
  TITLE     New molecular components supporting ryanodine receptor-mediated
            Ca(2+) release: roles of junctophilin and TRIC channel in embryonic
            cardiomyocytes
  JOURNAL   Pharmacol Ther 121 (3), 265-272 (2009)
   PUBMED   19095005
  REMARK    Review article
REFERENCE   9  (bases 1 to 2398)
  AUTHORS   Bleunven,C., Treves,S., Jinyu,X., Leo,E., Ronjat,M., De Waard,M.,
            Kern,G., Flucher,B.E. and Zorzato,F.
  TITLE     SRP-27 is a novel component of the supramolecular signalling
            complex involved in skeletal muscle excitation-contraction coupling
  JOURNAL   Biochem J 411 (2), 343-349 (2008)
   PUBMED   18035970
REFERENCE   10 (bases 1 to 2398)
  AUTHORS   Yazawa,M., Ferrante,C., Feng,J., Mio,K., Ogura,T., Zhang,M.,
            Lin,P.H., Pan,Z., Komazaki,S., Kato,K., Nishi,M., Zhao,X.,
            Weisleder,N., Sato,C., Ma,J. and Takeshima,H.
  TITLE     TRIC channels are essential for Ca2+ handling in intracellular
            stores
  JOURNAL   Nature 448 (7149), 78-82 (2007)
   PUBMED   17611541
  REMARK    GeneRIF: TRIC channels are likely to act as counter-ion channels
            that function in synchronization with Ca2+ release from
            intracellular stores
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU707844.1, BC014728.1, AK165818.1, AC182435.3 and EF988666.1.
            
            On Oct 25, 2017 this sequence version replaced NM_144534.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024788.1, EF988666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               BU707844.1         152-418
            268-1382            BC014728.1         1-1115
            1383-1641           AK165818.1         1163-1421
            1642-1696           AC182435.3         32776-32830
            1697-2369           AK165818.1         1479-2151
            2370-2398           EF988666.1         2125-2153
FEATURES             Location/Qualifiers
     source          1..2398
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 35.08 cM"
     gene            1..2398
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /note="transmembrane protein 38A"
                     /db_xref="GeneID:74166"
                     /db_xref="MGI:MGI:1921416"
     exon            1..405
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1178
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     trimeric intracellular cation channel type A;
                     mitsugumin-33A; 27 kDa sarcoplasmic reticulum protein"
                     /codon_start=1
                     /product="trimeric intracellular cation channel type A
                     isoform 1"
                     /protein_id="NP_653117.1"
                     /db_xref="CCDS:CCDS22417.1"
                     /db_xref="GeneID:74166"
                     /db_xref="MGI:MGI:1921416"
                     /translation="MDLMSALSLGELALSFSRVPLFPVFDLSYFIVSIIYLKYEPGAV
                     ELSRRHPVASWLCAMLHCFGSYILADLLLGEPIIDYFSNSSSILLASGVWYLIFFCPL
                     DLFYKCVCFLPVKLIFVAMKEVVRVRKIAVGIHHAHHHYHHGWFIMIATGWVKGSGVA
                     LLSNVEQLLRGVWKPETNEILHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFVFTM
                     FMVSCKVFLTATHSHSSPFDILEGYICPVLFGATWGGDHHHDNHGAPHGMGLGTQHSG
                     LPAKAKEELGEGSRKKKTKKAD"
     exon            406..562
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /inference="alignment:Splign:2.1.0"
     exon            563..747
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /inference="alignment:Splign:2.1.0"
     exon            748..835
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /inference="alignment:Splign:2.1.0"
     exon            836..953
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /inference="alignment:Splign:2.1.0"
     exon            954..2376
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1499..1504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /note="hexamer: ATTATA"
     polyA_site      1531
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /note="major polyA site"
     regulatory      2352..2357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /note="hexamer: AATAAA"
     polyA_site      2376
                     /gene="Tmem38a"
                     /gene_synonym="1110001E17Rik; mg33a; SPR-27; TRIC-A"
                     /note="major polyA site"
ORIGIN      
        1 attctaacta cgcagatgtt taaggacaag attccctctt gtgtgtgctg gatgcagggg
       61 acagatcgcc tttttggctc tgttgaacga gttctgacgt ccctacggcc ccgcattttg
      121 ggctcccggc tgctaggagt cccccaccac ccctcctctc ccgaggggtg ggggcaggcg
      181 gggggcggtg cctggcagtg gggcgggctc agtggcgagg gagcattcgt cgggcagcgg
      241 ggcgcgggac gcacggggcc ggggaggcgc cctccatcgc catggacctg atgtcagcgc
      301 tgagcctggg cgagctagcg ctcagcttct cgcgggtgcc gctcttccct gttttcgacc
      361 tcagctactt catcgtctcc atcatctacc tgaagtatga gccaggagct gtggagctgt
      421 cccggcgcca ccctgtggcg tcctggctgt gtgccatgtt gcactgtttt gggagttaca
      481 tcctggccga cctgcttctt ggggagccca tcattgacta cttcagcaac agctccagta
      541 tcctgctggc ctctggagtg tggtacttga ttttcttctg tcccttggac ctcttctaca
      601 agtgtgtctg ctttctgccc gtaaaactca tctttgtggc tatgaaggag gtggtgaggg
      661 tccgaaagat cgctgtgggc atccatcacg cacaccacca ctaccaccac gggtggttca
      721 tcatgatcgc caccgggtgg gtcaaagggt ctggtgttgc cctcctgtcc aacgtggaac
      781 agttgcttcg aggtgtctgg aagccagaaa ctaatgagat cctgcacatg tccttcccca
      841 ccaaggccag tctgtatgga gccatcctgt tcaccttgca gcagactcgc tggctcccag
      901 tgtccaaggc cagcctcatt ttcgtcttca ccatgtttat ggtgtcatgt aaggtgttcc
      961 tgacagccac acactcccac agttctccat ttgatatcct ggagggttac atctgcccag
     1021 tgctgtttgg ggcaacttgg ggaggcgacc atcaccatga caaccatgga gcaccacatg
     1081 gcatgggact aggcacccag cactccggcc tgcctgccaa ggccaaggaa gagctgggcg
     1141 aaggatccag gaagaagaag accaagaaag cggattaggg gttggcccca ggaatccact
     1201 gcgtgcttgg tagaaggatg tggactcaaa gaaactcaga acttaggggc attcagggct
     1261 cagaccctcc cctccccccg ccctgctctc taccaccctc aacttcccca tctgcagttt
     1321 ggagccatca gcaattccaa gggctgatgt gggctaaatt agtgtggagg aattcaacag
     1381 atgtggaaaa ccctgccctc tgccagaccc ctcaaaaggt cacagccttt gggggcacac
     1441 agtctaggcc caaagccctg gctggtaggc tcttggtttt cattctgtgt tctgtctaat
     1501 tatatcttgt aactaaaaga atttaaagcc acatggagac tcaattatct agatcctctc
     1561 gagagccagg tgctggggtc ccatgtcctt ccgcactcag gacctcccta gaattttgtg
     1621 actcctgctg gacatcttta ggcaaatggc cttccttctc tgagccttct gtttctgttc
     1681 tgtagcatgg agaccccagg tcctcctgtg tacaaaaggg tctttataat ttcaagcagt
     1741 tgcttaagca gcgtgctagt gagaaggaga ctggagcagc atgaaggaca gtggcaggct
     1801 gcttggtatg taggccattt gtgtttgagg ccagaaggtc tcaccagata ctcagctgag
     1861 catgagcagg cacatttagg gcagactgct aacaggaggg gggcttgagt tcctaggtgc
     1921 ccacaggtaa gaggtgtggg tgcagagcag agggtccaag agccaacagc cttggttact
     1981 cacaattggg ctctgggtgt atcaggtgtc cctcatgcct gatcagcata gttcattcag
     2041 tcattcaaca aacacacaga tccacacatg ctcgctatac agtgtcatgc tgctcctctt
     2101 aggagcgagc cttatacagg ggaagggcca tggtcgccaa agtctccagg gcacctgaga
     2161 gaggtgagca tggggtcctg ctggtctcag gcttatgtga ggctcagatc tagttgaagt
     2221 acccagtgta gcccatttgt tgagaaaatg ctcctcataa ctttgcctgg aggtagggta
     2281 ggccctgagg ctggaagctc ccgagtttca tccccttgat gtcaatcaaa gctcagtgtg
     2341 agtgatcagc caataaatct ggtgcgagta aatcaaaaaa aaaaaaaaaa aaaaaaaa
//
