LOCUS       NM_026239               1979 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus transmembrane protein 35A (Tmem35a), mRNA.
ACCESSION   NM_026239
VERSION     NM_026239.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1979)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1979)
  AUTHORS   Khasabov,S.G., Rogness,V.M., Beeson,M.B., Vulchanova,L., Yuan,L.L.,
            Simone,D.A. and Tran,P.V.
  TITLE     The nAChR Chaperone TMEM35a (NACHO) Contributes to the Development
            of Hyperalgesia in Mice
  JOURNAL   Neuroscience 457, 74-87 (2021)
   PUBMED   33422618
  REMARK    GeneRIF: The nAChR Chaperone TMEM35a (NACHO) Contributes to the
            Development of Hyperalgesia in Mice.
REFERENCE   3  (bases 1 to 1979)
  AUTHORS   Knowland,D., Gu,S., Eckert,W.A. 3rd, Dawe,G.B., Matta,J.A.,
            Limberis,J., Wickenden,A.D., Bhattacharya,A. and Bredt,D.S.
  TITLE     Functional alpha6beta4 acetylcholine receptor expression enables
            pharmacological testing of nicotinic agonists with analgesic
            properties
  JOURNAL   J Clin Invest 130 (11), 6158-6170 (2020)
   PUBMED   33074244
REFERENCE   4  (bases 1 to 1979)
  AUTHORS   Kweon,H.J., Gu,S., Witham,E., Dhara,M., Yu,H., Mandon,E.D.,
            Jawhari,A. and Bredt,D.S.
  TITLE     NACHO Engages N-Glycosylation ER Chaperone Pathways for alpha7
            Nicotinic Receptor Assembly
  JOURNAL   Cell Rep 32 (6), 108025 (2020)
   PUBMED   32783947
  REMARK    GeneRIF: NACHO Engages N-Glycosylation ER Chaperone Pathways for
            alpha7 Nicotinic Receptor Assembly.
REFERENCE   5  (bases 1 to 1979)
  AUTHORS   Dhara,M., Matta,J.A., Lei,M., Knowland,D., Yu,H., Gu,S. and
            Bredt,D.S.
  TITLE     Polyamine regulation of ion channel assembly and implications for
            nicotinic acetylcholine receptor pharmacology
  JOURNAL   Nat Commun 11 (1), 2799 (2020)
   PUBMED   32493979
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1979)
  AUTHORS   Matta,J.A., Gu,S., Davini,W.B., Lord,B., Siuda,E.R.,
            Harrington,A.W. and Bredt,D.S.
  TITLE     NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout
            the Brain
  JOURNAL   Cell Rep 19 (4), 688-696 (2017)
   PUBMED   28445721
REFERENCE   7  (bases 1 to 1979)
  AUTHORS   Kennedy,B.C., Dimova,J.G., Dakoji,S., Yuan,L.L., Gewirtz,J.C. and
            Tran,P.V.
  TITLE     Deletion of novel protein TMEM35 alters stress-related functions
            and impairs long-term memory in mice
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 311 (1), R166-R178 (2016)
   PUBMED   27170659
  REMARK    GeneRIF: Pathway analysis of differentially expressed synaptic
            proteins in tmem35 KO hippocampus implicated molecular networks
            associated with specific cellular and behavioral functions,
            including decreased long-term potentiation, and increased startle
            reactivity
REFERENCE   8  (bases 1 to 1979)
  AUTHORS   Gu,S., Matta,J.A., Lord,B., Harrington,A.W., Sutton,S.W.,
            Davini,W.B. and Bredt,D.S.
  TITLE     Brain alpha7 Nicotinic Acetylcholine Receptor Assembly Requires
            NACHO
  JOURNAL   Neuron 89 (5), 948-955 (2016)
   PUBMED   26875622
REFERENCE   9  (bases 1 to 1979)
  AUTHORS   Chambers,D., Wilson,L.J., Alfonsi,F., Hunter,E., Saxena,U.,
            Blanc,E. and Lumsden,A.
  TITLE     Rhombomere-specific analysis reveals the repertoire of genetic cues
            expressed across the developing hindbrain
  JOURNAL   Neural Dev 4, 6 (2009)
   PUBMED   19208226
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1979)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC042623.1.
            
            On Jun 19, 2003 this sequence version replaced NM_026239.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042623.1, BC050880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1979
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 56.06 cM"
     gene            1..1979
                     /gene="Tmem35a"
                     /gene_synonym="9030603L14Rik; NACHO; PMP52; Tmem35"
                     /note="transmembrane protein 35A"
                     /db_xref="GeneID:67564"
                     /db_xref="MGI:MGI:1914814"
     exon            1..405
                     /gene="Tmem35a"
                     /gene_synonym="9030603L14Rik; NACHO; PMP52; Tmem35"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..789
                     /gene="Tmem35a"
                     /gene_synonym="9030603L14Rik; NACHO; PMP52; Tmem35"
                     /note="peroxisomal membrane protein 52; transmembrane
                     protein 35"
                     /codon_start=1
                     /product="novel acetylcholine receptor chaperone"
                     /protein_id="NP_080515.1"
                     /db_xref="CCDS:CCDS30392.1"
                     /db_xref="GeneID:67564"
                     /db_xref="MGI:MGI:1914814"
                     /translation="MASPRTITIMALSVALGLFFVFMGTIKLTPRLSKDAYSEMKRAY
                     KSYVRALPLLKKMGINSILLRKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVL
                     FFHQLVGDPLKRYAHALVFGILLTCRLLIARKPEDRSSEKKALPESAEEQPSLYEKAP
                     QGKVKVS"
     exon            406..1918
                     /gene="Tmem35a"
                     /gene_synonym="9030603L14Rik; NACHO; PMP52; Tmem35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1896..1901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem35a"
                     /gene_synonym="9030603L14Rik; NACHO; PMP52; Tmem35"
                     /note="hexamer: AATAAA"
     polyA_site      1918
                     /gene="Tmem35a"
                     /gene_synonym="9030603L14Rik; NACHO; PMP52; Tmem35"
                     /note="major polyA site"
ORIGIN      
        1 gttggaagtt gccttctcac ttcagggctt cttttaactt tggcaaggca ccgtccttta
       61 cgcagggagg tgcaagcgta gggcattagg acccagcgat tgttgtagtg agagtcgttg
      121 aatctcgatc tctcaatttt tctctctagc tccctcctct ccctttgtca ttctctctgc
      181 tgcctccgca gcgtgcctct agctctccct gtgctaactg cctgcgcctt gacagccggg
      241 ctgcgcaaag cagagggatt agttgggacc tgccttggtg accccatggc atccccacga
      301 accataacta tcatggccct ctcagtggcc ctgggactct tctttgtttt catggggacc
      361 atcaagttga cccccaggct cagcaaggat gcctacagtg aaatgaaacg tgcttacaag
      421 agctacgttc gagcccttcc tctgctgaag aaaatgggca tcaattccat cctccttcgg
      481 aaaagtattg gtgctcttga agtggcctgt ggcattgtca tgaccctggt acccggtcgt
      541 cccaaagatg tggccaactt cttcctgctc ttgctggtgt tggctgtgct cttcttccac
      601 cagctggtgg gtgatcctct caaacgctac gcccatgctc tggtgtttgg aatcctgctc
      661 acctgccgcc tgctgattgc ccgcaagcct gaagacagat cttctgagaa gaaggccttg
      721 cctgagagtg cagaggagca accatccttg tatgagaagg ccccccaggg caaagtgaag
      781 gtgtcataaa aattggaagt acaaagaatg gaccttctag gcggttgctt ccttgacacc
      841 caagatgaca tcagtgtgtg tgcgtgtgtg tgtgtgtttt cctttgattg tttatcttgg
      901 gagtaaagag aaaaatacaa tctgtaagtt aattggcttg tgtacatcta taccctaaaa
      961 tgacctcccc acattgacat tcgtgtacca cctttaattc ctctggagca acactcacat
     1021 cttgctgcat gtacatgtat atggctacta ttgagttgta tttgtgagat ggactccagc
     1081 aagcatgtga ctgtgagatt atgtgtgggg caatgtattt aactgccgtg tgtgggtata
     1141 cacgtacttg tagaggaggc tctgatcttg aactaatcct gtgcaagtgt ccttcccttt
     1201 ataaattgat tccagataag aactgtctcc taaagagagt tgtttcctgg tggaaaacaa
     1261 atgacctagt ttgatccttc aagtgatgca gtgggagggg tcgccttgcc tttgtctgag
     1321 tacaagctat tgagctcttt agtaaccttt tactagacac agtcaacttt tgttttaagc
     1381 acaaagcagc cccactttac cattctcagt agccacccag gagctgaagt ttccccactg
     1441 cttccactga gggaccaggg attggtcctg gtacaagttt caatctccaa ccctagtggt
     1501 tttctgaaac ctgcaactgg atggagaagc tgtaggcagt atttatctgt atgaagagtt
     1561 ctctacacct attgattccc cacccaactt tgctaaagtt aacaactcca aaacaccccc
     1621 tagaaatgtc tactttacac ctcttcagcg ttccagaggg tggagtttag ctgggggagg
     1681 gacatttgac ttgggttagt tggattgacc agtatggaaa tttgcttttg tagttacata
     1741 ctgctgtttc tctttgttaa atgtgctttg atggttttaa tattgttgtg atggggaagg
     1801 gggtgggttt gtgtctaggg agagtgctta ctgtatttct tcagtgccat tgttcttggt
     1861 aattgatact tgtcttcttt tgctcattct ttcaaaataa agatttttga aatttggaaa
     1921 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
