LOCUS       NM_001356354            3801 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus transmembrane protein 268 (Tmem268), transcript
            variant 2, mRNA.
ACCESSION   NM_001356354 XM_006537866
VERSION     NM_001356354.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3801)
  AUTHORS   Duan,M., Zhang,X., Lou,Y., Feng,J., Guo,P., Ye,S., Lv,P. and
            Chen,Y.
  TITLE     Deletion of Tmem268 in mice suppresses anti-infectious immune
            responses by downregulating CD11b signaling
  JOURNAL   EMBO Rep 25 (6), 2550-2570 (2024)
   PUBMED   38730209
  REMARK    GeneRIF: Deletion of Tmem268 in mice suppresses anti-infectious
            immune responses by downregulating CD11b signaling.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY067212.1, CJ046188.1, AK030466.1, AK031016.1, AK078066.1 and
            AI593215.1.
            
            [WARNING] On Mar 19, 2025 this sequence was replaced by
            NM_001356354.2.
            
            On Sep 30, 2017 this sequence version replaced XM_006537866.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030466.1, SRR11927932.1528511.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               BY067212.1         2-363
            363-746             CJ046188.1         241-624
            747-2481            AK030466.1         728-2462
            2482-3059           AK031016.1         2337-2914
            3060-3060           AK078066.1         1581-1581
            3061-3779           AK031016.1         2916-3634
            3780-3801           AI593215.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..3801
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 34.02 cM"
     gene            1..3801
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /note="transmembrane protein 268"
                     /db_xref="GeneID:230279"
                     /db_xref="MGI:MGI:1913920"
     exon            1..195
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            196..279
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..471
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..1391
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /note="transmembrane protein C9orf91 homolog"
                     /codon_start=1
                     /product="transmembrane protein 268"
                     /protein_id="NP_001343283.1"
                     /db_xref="CCDS:CCDS18261.1"
                     /db_xref="GeneID:230279"
                     /db_xref="MGI:MGI:1913920"
                     /translation="MACEPPTDPGGAAGPLPTSTLGCNILPQGNPPGWGQELHNGQVL
                     TVLRIDNTCAPISFDLGAAEEQLQAWGIQVPAEQYRNLAESALLEPQVRRYIIYNSRP
                     MRLAFAVVFYVLVWANIYSTSQMFALGNQWAGVLLATLAAFSLTLTLVLVFERQQRKA
                     NTNTDLRLVAANGALLRHRVLLGVTDTVEGCQSVIQLWFVYFDLENCVQFLSDHVQEM
                     KRSQESLLRSRLSQLCVVMETGVSPVVEGPEDLEDAPLLPSTPGPQERPLTQTELYQL
                     VPEAEPEEMARQLLAVFGGYYTRLLVTSRLPQSMGTRHMDSARIPCPCQLIEVHVLGT
                     GCCPFLAR"
     exon            472..581
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            582..689
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            690..839
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            840..950
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1031
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1211
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..3783
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3120..3125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /note="hexamer: AATAAA"
     polyA_site      3148
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
     regulatory      3761..3766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /note="hexamer: AATAAA"
     polyA_site      3783
                     /gene="Tmem268"
                     /gene_synonym="6330416G13Rik; bM230C2.2"
                     /note="major polyA site"
ORIGIN      
        1 gtccgcgctc ccgcgctcgg gggttggggc cgcggggcct gcgtgcgcgt ccctccgctc
       61 aggctcgggt gacctcttcc cgccccacgc gtcaggcgtg ggatctgcag ggcagggcgg
      121 gtgatttctg gggtaaagga accccaaggc cagagggcag agatcgggga gcctgctgcc
      181 caagcccgag gccagagcat cccagccttg tgcagctgtg cctgttgaaa tctggagaga
      241 aacagtgaag aagccagaag gttcagttcc tccctgaagg caagtggagg tgagacgctg
      301 ccccagcatg aactgcaccc ccagaaacag gaagtagaag ctagagcagc tgtctgtctg
      361 ccatggcttg tgagcctccc acagatcctg gtggggcagc tggtcccctg cccacctcta
      421 cccttggctg caacatcctg cctcagggga accctcctgg ctgggggcaa gagctacaca
      481 atggccaggt cctcacagtc ctccggatcg acaatacctg tgcacctatc tcctttgacc
      541 tgggagctgc agaagagcaa ctgcaggcct ggggcattca ggtccctgct gagcagtaca
      601 ggaacttggc tgagagtgcc cttttggaac ctcaagtgag gaggtacatc atctacaact
      661 ccaggcccat gaggctggcc tttgctgtgg tgttctacgt gttggtgtgg gccaacatct
      721 actccaccag ccaaatgttt gccctgggca accagtgggc aggcgtgctg cttgcgaccc
      781 tggctgcttt cagcctgacc ctgacccttg tgctggtctt tgagaggcag cagaggaagg
      841 ccaacactaa cacagacctg aggctggtgg ccgccaatgg agcccttctg cgacaccgtg
      901 tgctgctggg ggtgacagac acagtggagg gatgccagag tgtgatccag ctctggtttg
      961 tctacttcga tctggagaac tgtgtgcagt ttttgtccga ccatgttcaa gagatgaaga
     1021 ggagccaaga gtccttgctg agaagcagat tgagccagct gtgcgttgtc atggagactg
     1081 gagtgagccc tgtggtggaa gggcccgagg atttggagga tgctcccctc ctgcccagca
     1141 ctcctggtcc tcaggagagg ccactcacac agactgaact ctatcagctt gttccagagg
     1201 ctgagccgga ggagatggcc cggcagctac tggcagtgtt tggtggctac tacacccggc
     1261 tcctggtgac ctctcggctc cctcagtcaa tgggaacgcg acacatggac tctgcaagga
     1321 tcccatgccc ctgccagctc atagaagtac acgttctggg cacaggatgt tgcccgttcc
     1381 tggctaggtg acctagggat ggagatgttc ctcttcctcc aagactgaga agtgggggag
     1441 gagtcaggag cccagcatgg gaaacagcga gctcagatga ggccagcatt tgggaacact
     1501 ttagcgagtc tcagtcatgt aggccttggg gtcaccaagc gcacaccaga tgccttcttg
     1561 gcatcacatg ctcgcctggc cttgctgaat ctggtggatg agctggagtt acttgggctt
     1621 gtggcctgcg tggagggtcc tttctgttgc ctgaaaatcc ctagagaact acagcaggct
     1681 ccacagggca agtccctgac ttttggagtc agaaggtgag actgaggctc ttagaggatg
     1741 ctgctccctc agcattgcct caggctgccg atgtcacagt cctacctgct tccagtggga
     1801 gggaagattc tcagcagggt gagctagctt gtgagctaca gtactgtctg ggattgttgt
     1861 ctcttagcac tcaggttata gaggaccagg gttggaggac aggggagagg aggagtcaaa
     1921 aagccgatgc ccgtcaacac ggcgctggaa aagaagaccc tgttggcctc agactgtctt
     1981 tgtgtggcaa cacgctttct tgagatgtga ttctgtcctg ctgagcagca gcggtgtttt
     2041 cagacactaa cattgttctg gaatgacatg tgatcagaca ctctgagctt gtgtgaagaa
     2101 ctcagagact ttcccaaagt ttgaagactg tccacagccc tatgcccaaa gccctggtct
     2161 ggtgtgaagg tcttactcaa aaaccaacct ttgtggtttt tgtccccgac aaatcatcat
     2221 tataagttgg aactcttcct tgaactggca tatgtattca ttcctgttgg actcttattc
     2281 ctcctcaaaa ccccgctctc catatccttc ctgctgttct ttgtctcatt gaaatcccct
     2341 tatggatatt ttatgttatt ccacgtttct cctgtacata cctctttttc tgtcaagact
     2401 gtaaactcct caaggcccaa cattgtaccc atcttccttt tgtgaatgac ctggacttgc
     2461 taagaaaaaa gaaaaaggtc tgaaaagtcc catggattgg ttgccttacc cgctccactg
     2521 gttttggcaa atgcttctgg caaacatggt tgagtgataa gacccaggtc accatggacc
     2581 tgagatctgg ccttgagctg catcacttta cttgtatgtg caccctccga ttgcccatct
     2641 cgacgggctg gatggttttg gtaatttcca gctgcttgtg ctgtttgtta ttcttaactt
     2701 ctgtgcacaa agtgctccct ggaccccaag ctgaggtgtc cctggtggga gccttcagag
     2761 ggagcaccgg cctgagctgg taacctggat tcttgctgcc cacctgccat ctctggccgg
     2821 ggctgtaagt gaccatggct gagtgcacaa attgattctc agtgtgtcca ctgactcctt
     2881 tatagggtga tgcagtggac cggaaccgcg caactcagga gatttttctg ggggagacaa
     2941 gtcctacctc ttgtgttctg tgtccagaat ggaagcgtcc cccagccgtg tgccagggaa
     3001 gccttcctca gtgggatcgt tcactgtctt ttgagccacg ggaaatgtca ctgtgaagtt
     3061 gatccaggga agcctgtgct tgtccttggg tcacaggact cttgagcgta gggatgggaa
     3121 ataaaactgt ttggtgagtg atggagcagc ttgctcgtgg aggcgtggtg tggtccttcg
     3181 acattctccc tgcctactgg atgggactta tggggtgagc ccacagtgga cgtttctttg
     3241 tgtgtgcctc agtttcctcc ctttgtaaaa tccacatgtc tcacctgctt cacaaggttg
     3301 ccaggaggct gatccatcca gcatttatgt taaaaaatat tatttttaat catatctctc
     3361 tgcacgtgag ttctgggaat taaacttagg ttcatgctct taccatctct acagcccagt
     3421 gctcgctcct aggtcttaag tttcgatacc catcagaggc aggagccatg gacacactgc
     3481 tgccatgcag ataggagcgt tcaaggccaa gtcctgcctg ccatcttgtc tctgtcccac
     3541 cagtcaccag ggaggagaac tcgtgcctgg aagatgtttc agactgaatg gaaacaacct
     3601 ccagtgcttg caacaccaag tcacgagctg gagcaggaac tcgataacct gctgccgttt
     3661 ctcttctaaa ttcttgccgt ctggtataca gtaggtgctc atatgtgttt gactcttgtc
     3721 tcatgttcaa ttgttccagc acctcagggg tgtgtataca aataaagagt tgtcaaatct
     3781 caaaaaaaaa aaaaaaaaaa a
//
