LOCUS       NM_172923               2443 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus transmembrane protein 266 (Tmem266), transcript
            variant 1, mRNA.
ACCESSION   NM_172923
VERSION     NM_172923.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2443)
  AUTHORS   Kawai T, Narita H, Konno K, Akter S, Andriani RT, Iwasaki H,
            Nishikawa S, Yokoi N, Fukata Y, Fukata M, Wiriyasermkul P,
            Kongpracha P, Nagamori S, Takao K, Miyakawa T, Abe M, Sakimura K,
            Watanabe M, Nakagawa A and Okamura Y.
  TITLE     Insight into the function of a unique voltage-sensor protein
            (TMEM266) and its short form in mouse cerebellum
  JOURNAL   Biochem J 479 (11), 1127-1145 (2022)
   PUBMED   35574701
REFERENCE   2  (bases 1 to 2443)
  AUTHORS   Kim IH, Hevezi P, Varga C, Pathak MM, Hong L, Ta D, Tran CT,
            Zlotnik A, Soltesz I and Tombola F.
  TITLE     Evidence for functional diversity between the voltage-gated proton
            channel Hv1 and its closest related protein HVRP1
  JOURNAL   PLoS One 9 (8), e105926 (2014)
   PUBMED   25165868
  REMARK    GeneRIF: Results identified HVRP1, a voltage sensing
            domains-containing protein primarily expressed in the central
            nervous system with high expression in cerebellar tissues
            particularly in the granule layer.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC068128.1, AK036040.1 and CT025532.15.
            
            [WARNING] On May 19, 2023 this sequence was replaced by
            NM_172923.5.
            
            On Nov 4, 2017 this sequence version replaced NM_172923.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036040.1, SRR1660817.278913.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BC068128.1         1-36
            37-1332             AK036040.1         1-1296
            1333-1333           CT025532.15        123716-123716
            1334-2443           AK036040.1         1298-2407
FEATURES             Location/Qualifiers
     source          1..2443
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..2443
                     /gene="Tmem266"
                     /gene_synonym="9630029F15; HVRP1"
                     /note="transmembrane protein 266"
                     /db_xref="GeneID:244886"
                     /db_xref="MGI:MGI:2142980"
     exon            1..88
                     /gene="Tmem266"
                     /gene_synonym="9630029F15; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            89..222
                     /gene="Tmem266"
                     /gene_synonym="9630029F15; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1801
                     /gene="Tmem266"
                     /gene_synonym="9630029F15; HVRP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein C15orf27 homolog; Hv1 related
                     protein 1"
                     /codon_start=1
                     /product="transmembrane protein 266 isoform 1"
                     /protein_id="NP_766511.1"
                     /db_xref="CCDS:CCDS23203.1"
                     /db_xref="GeneID:244886"
                     /db_xref="MGI:MGI:2142980"
                     /translation="MALVTSFNMANPQPAIEGGISEVEIISQQVDEETKSIAPVQLVN
                     FAYRDLPLAAVDLSTGGSQLLSNLDEEYQREGSDWLKPCCGKRAAVWQVFLLSASLNS
                     FLVACVILVVILLTLELLIDTKLLQFSNAFQFAGVIHWISLVILSVFFSETVLRIVVL
                     GIWDYIENKIEVFDGAVIILSLAPMVASTVANGPRSPWDAISLIIMFRIWRVKRVIDA
                     YVLPVKLEMEMVTQQYEKAKAIQDEQLERLTQICQEQGFEIRQLRAHLAQQDLDLAAE
                     REAALQAPHVLSQPRSRYKVVEAGTWAEETAAESIVEELRPSQEATVKDDMNSYISQY
                     YNGPSSDSGAPEPAVCVVTTAAIDIHQPNVPSDLFSVDLPLKLSGNSTCASATSETTS
                     HSTCGSVTRAQSASSQTLGSSTDCSTPREELLPSKPRSSPLPLLLPPQQLVAEATVQD
                     LMSSLSKDPCPSHKALDPAPLAQPTPLGSVQTSPELEHRVSLFNQKNQEALPVLQINP
                     VIHLQPTAGLEEKFRSLESKEPKLHTVPEA"
     exon            223..411
                     /gene="Tmem266"
                     /gene_synonym="9630029F15; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..566
                     /gene="Tmem266"
                     /gene_synonym="9630029F15; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..640
                     /gene="Tmem266"
                     /gene_synonym="9630029F15; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            641..697
                     /gene="Tmem266"
                     /gene_synonym="9630029F15; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..836
                     /gene="Tmem266"
                     /gene_synonym="9630029F15; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..952
                     /gene="Tmem266"
                     /gene_synonym="9630029F15; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1142
                     /gene="Tmem266"
                     /gene_synonym="9630029F15; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1205
                     /gene="Tmem266"
                     /gene_synonym="9630029F15; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..2443
                     /gene="Tmem266"
                     /gene_synonym="9630029F15; HVRP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggtggggg ggcggagagg ggagccccgg gagcgggagc gcgggcccgg cgctgcagag
       61 cagagcgaat cctgagctcc ggcagcaggg tactctattt tcatgaatct tgtaaaagcc
      121 ccacttggaa atgctaagat cagacataag gacagctgag ccccactaga catcacgaaa
      181 agccatggct ttggttacat ctttcaacat ggccaatcca caacctgcca ttgaaggagg
      241 aatttctgaa gttgagatta tctcccaaca agtagacgaa gaaaccaaga gcattgctcc
      301 ggtgcagctg gtgaactttg cctatcggga cctgcccctg gctgccgtag acctctccac
      361 agggggctca cagctcctgt cgaatttgga cgaagagtac caaagagaag ggtctgactg
      421 gctgaagccg tgctgtggga agagagcagc cgtatggcag gtatttttgc tcagtgcaag
      481 tctcaacagt ttcctggtag cctgtgtaat attggtggtg atcctcctga ctctggagct
      541 tctcatagat acaaagcttc tccagttttc caatgctttc cagtttgctg gtgtcattca
      601 ctggatcagt ctggtcattc tctctgtgtt cttctcagag actgtcctac ggatcgtggt
      661 actggggatc tgggattaca tcgaaaacaa aatagaggtg tttgacgggg ctgtgatcat
      721 cctgtccttg gccccgatgg tggcgtccac tgtggctaac ggacccagga gcccctggga
      781 tgccatcagc ctcatcatca tgttccgaat ctggcgggtg aagagggtca ttgatgccta
      841 tgtcctgcca gtcaagttgg agatggagat ggtcacccag cagtatgaga aggccaaggc
      901 catccaagat gagcagctgg aaagactgac gcaaatctgt caggagcaag ggtttgagat
      961 ccggcagctg cgtgcgcacc tggcacagca ggacctggat ctggcagccg agcgggaggc
     1021 ggcgctgcag gccccacacg tgctcagcca gccacgcagc cgctacaagg tcgtagaggc
     1081 tggcacgtgg gccgaggaga cagcagccga gagcatcgtg gaagagctga ggccctctca
     1141 agaagccaca gtgaaagatg acatgaacag ctacatcagc caatactaca atgggcccag
     1201 cagtgacagt ggagccccag aaccagcagt atgtgtggtc actacagctg ccatagacat
     1261 ccaccagccc aatgtcccct cagacctctt ctcagtcgac ctgcctctga agctcagtgg
     1321 caacagcacc tgcgccagcg ccacctcgga gaccacctcc cactctacct gtggctcagt
     1381 caccagggcc cagagtgcca gcagccagac actgggttcc tccacagact gtagcacccc
     1441 ccgggaagag ctgctgccct ctaagcccag atcttctccc ctgccactgc ttctgccccc
     1501 tcagcagctg gtggcagagg ccacagtcca ggacctgatg tcctctctgt caaaggaccc
     1561 ctgcccatcc cataaggcct tggacccagc acccctggcc cagcctaccc cactgggctc
     1621 agtccagacc agccctgagc tggagcatag ggtgagtctg ttcaaccaga agaaccagga
     1681 ggctctccct gttcttcaga tcaaccctgt catccacttg cagcccacag cggggctgga
     1741 ggagaagttc agatctttgg aatccaaaga gccaaagttg catacagttc ctgaggccta
     1801 gagagcctac tggcttgttg agtgcaaaga ggggagacag ccatcttggt acttcaggac
     1861 cccagaggcc acccacggcc atacaagggg ctcaggatcc catctgatct cccacagggt
     1921 gctgtctgcc tccagggagg tgacgccagg cagaggccac atgcctcaga cctcagtcag
     1981 agtccagagc tggggcctcc ttttgcccta ctcaggagag ggtggtgctc ctggctgggg
     2041 ttttgggttt ttgttttatt tgttgtattg ttttgttttt taaaaccatt tttataaaaa
     2101 ccagcctatg gcccagcttc agcagggtag agtgtggggg ccagctcagc ctctttcgtt
     2161 gccttcgttc ctgatgccca ccccggattc tcggggacag cactgtgagc aggggctgca
     2221 cagcctcacc ccaagccgtc tttccagaaa tgctgaggga gccgccacaa ccacggagac
     2281 cacacccgag cctgtctcac ctgccattct ctcattccag catggacatt tccaagtctt
     2341 cacaggccat gaggggatgg atctggaagc gggaggggga tgggagggga gggacagcca
     2401 ttttatgacc ctggctttaa taataaaaac cagctgcact gag
//
