LOCUS       NM_001013028            3778 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transmembrane protein 263 (Tmem263), mRNA.
ACCESSION   NM_001013028 XM_618794
VERSION     NM_001013028.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3778)
  AUTHORS   Sarver,D.C., Garcia-Diaz,J., Saqib,M., Riddle,R.C. and Wong,G.W.
  TITLE     Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and
            impairs skeletal acquisition
  JOURNAL   Elife 12, 90949 (2024)
   PUBMED   38241182
  REMARK    GeneRIF: Tmem263 deletion disrupts the GH/IGF-1 axis and causes
            dwarfism and impairs skeletal acquisition.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ093458.1, AK142035.1, BC086492.1 and BB687697.1.
            
            On Apr 23, 2009 this sequence version replaced NM_001013028.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ093861.1, BC086492.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                CJ093458.1         1-58
            59-148              CJ093458.1         60-149
            149-2015            AK142035.1         2-1868
            2016-3617           BC086492.1         1880-3481
            3618-3778           BB687697.1         241-401
FEATURES             Location/Qualifiers
     source          1..3778
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 41.63 cM"
     gene            1..3778
                     /gene="Tmem263"
                     /note="transmembrane protein 263"
                     /db_xref="GeneID:103266"
                     /db_xref="MGI:MGI:2143652"
     exon            1..371
                     /gene="Tmem263"
                     /inference="alignment:Splign:2.1.0"
     exon            372..438
                     /gene="Tmem263"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..725
                     /gene="Tmem263"
                     /note="UPF0444 transmembrane protein C12orf23 homolog"
                     /codon_start=1
                     /product="transmembrane protein 263"
                     /protein_id="NP_001013046.1"
                     /db_xref="CCDS:CCDS24087.1"
                     /db_xref="GeneID:103266"
                     /db_xref="MGI:MGI:2143652"
                     /translation="MNQADKNQEIPSYLSDEPPEGSMKDHPQQQPGMLSRVTGGIFSV
                     TKGAVGATIGGVAWIGGKSLEVTKTAVTTVPSMGIGLVKGGVSAVAGGVTAVGSAVVN
                     KVPLSGKKKDKSD"
     exon            439..3778
                     /gene="Tmem263"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3595..3600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem263"
                     /note="hexamer: AATAAA"
     polyA_site      3617
                     /gene="Tmem263"
                     /note="major polyA site"
     regulatory      3646..3651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem263"
                     /note="hexamer: AATAAA"
     polyA_site      3669
                     /gene="Tmem263"
ORIGIN      
        1 ggggctgctg ggagggctgc gcgcgccgag cgaccggtgg gcgcgggagg tgggggggcg
       61 gagggccggg ggcgcgagtg cgcgtgcgcg tcggaacccg aggcgcggga ggaggcggga
      121 gctccggagg ctgcggaggg ggcgggtcgc gtcaggcgcc acgtccgcag ccagaagccg
      181 ccgctgccgc cgccgccgcc tcgcaccgac ctcgcaccga gagtcttccg acttctgagc
      241 cggagaagag catctaggtc gcgtaagcca ctcccgggcc gcatcagggc ctctgctgcc
      301 ccggccgctt ctgctgttct ccgtgccacc gctccctccg cccggccgca gctcccggcc
      361 tcgaccccgc ggtgatcatg aatcaggcag ataaaaatca agaaattcca tcttacctta
      421 gtgatgaacc cccagaaggg tcaatgaaag atcacccgca gcagcagcca ggaatgttgt
      481 ctcgtgtgac tggaggtatc ttcagtgtta caaagggagc tgttggtgcc accattggtg
      541 gtgtggcttg gattggtgga aagagtctgg aagtgaccaa aacagctgtt acaactgtgc
      601 cttccatggg aatagggctg gtgaaaggag gcgtgtctgc tgtggctgga ggtgtgacag
      661 ctgttgggtc tgcagttgta aacaaagtgc ccttatcagg aaagaagaaa gacaagtctg
      721 attgaaagag aagtacactt gctctccaca gcatatgatg ccagtggcat tgaacagttc
      781 aattacagac tacaaccaag tcaaccgcta aactgctgtg ttgaaagtat tggtgactgg
      841 ctgcatctaa aacaagaaga gtccagtact accacagtgt ctgaaggctt ctcatcccta
      901 agttcagctt tttatctggt aaaatgttac acttgttcag ttgtaactga agatatggta
      961 tgtttaaata tttgctctaa gtctttcagt ttgactaaaa aatgtgaaag ttcaacttag
     1021 tagatgattt tacagttcca tgtgtacagt gtgccaggta acccacacga cccttacaaa
     1081 gggactcgaa ctacataaac tgtacctttg atgtgcctaa tagtttcaga tgtcttagtt
     1141 ttttataact atagtggttt aggccaagag gcattcttat ttaagctggc aaaaaagtag
     1201 caggaattca aaagtttaga agacaaatgt ttttatgata ctgttgtttt tttttttgtt
     1261 tgttttggtt agataagcat tctgtttgtt taatcattga tgccttacaa aagaaaacat
     1321 cttttctaat aatcttaaat atgtgcagtt cttataatta tcagtgaact ctttcaaagg
     1381 ttgtaaaatt agtttccctc ttaaaaatct caggagtatt gaggtaaagg agtttcctgg
     1441 tgtcagtggg taagagtgct tatcagctgt tgtgagtagt taacacgaaa tgtgctttag
     1501 tagttggatt catgctccca tccttaatac accccacagt atctatggaa catttcttag
     1561 ctcatcaaaa gctatgtggg aagtttcata ttgagaagga atacattttt ttttttgttt
     1621 tgttttgttt tttcgagaca gggtttctct gtgtagccct ggctgtcctg gaactcactt
     1681 tgtagatcag gctggcctcg aactcagaaa ttcacctgcc tctgcctccc gagtgctggg
     1741 attaaaggtg tgcaccacca cacccggcaa atattaattt ttaagttctt ataattatcc
     1801 tagtaaccta agataatcct tcatgcttat tctttcttta ggatgtctta aattattagt
     1861 agtaattcct ttaaaaatac aataaaatca accattaata tatgaggatt gactcttcaa
     1921 atgaatgaga tgggctctat acattggctt tgaatttaaa aaaaatagat aaatgctttc
     1981 aatgacgtat ttagggtttt tttttttttt ttttttttgt tgttgttgtt ttctttgaga
     2041 tggggtcttc taaagcccag gctggtcttg aactggatat gtagctgagg atattcttgc
     2101 gcttctaatt ctgcactcac ctcccaagtg ctgggcttaa ggcatgagat accatgcttg
     2161 ctttatgtga tgttggggat ggaacccagg gctgcatgca tagtaggcaa gtactgtacc
     2221 aactgagttg cattcgtagt gaaattcgtt catagcttta aaacatgttc tcttatagcc
     2281 ctttaaagca gctgtagaca taccatttct caagccagtt tcaggcaggg agttgaaggt
     2341 ttttgatatg gatggtaagt gtgttgtgtc ttaatgtgtt atcataacat attcattttc
     2401 acagaatgta actcagaagt tcatttcttt ttgtcttaat gcttagtttc atggaaattt
     2461 ataagtgaca tatatttggc atttatctta caatctaagc ctgaaaaaaa ttcttaattt
     2521 tctttatacc taaaactaga attctgtctt cattctgccc cttctaactc cctggagaga
     2581 ggaagggagt ggtgccttgg tgtaagtcaa aatgtagtgt tcctgagacc agaagaagat
     2641 cacctgaata tgtaggttca aatgtttgga actcttaaga ggattctatt agtaatgtgg
     2701 gccaacagtt gaataaaaat ataaatttaa aaagcactca taaataacag caggactgtc
     2761 aagcaaatct acagatgttc ttgaaacttt gtttatacaa aatttaaaat cactgaatta
     2821 aatttagaag gaattaaatg gtcatttatt tcatgcaata tcatttaaga gacatttgtt
     2881 gatacatttg gtgaaatgtg ttaacaaatg gtatttttaa agttccaaaa ttaatagacc
     2941 cattctcagt gatctaaata atggtattgg agaaattgat tcctgctatt tagaagaatt
     3001 tattgattca tatctggttt gtatttctaa cttagaggtt ctactatgct ttgtacttga
     3061 attagtctaa gtgtaggctt agtatactat atgcttgcat atttattttc aactttgctt
     3121 gtctttaaaa tcacttgagg aaaaatggct aattaatttc tgctacagaa aagccaactg
     3181 gtaaattttc tcaattgtct taaatgctaa agtataatgt ggttcagagg ggcttttacg
     3241 atagcagaga actgtacaaa tatacaggta gctgtagttc taactgaaat gaacttgcca
     3301 tttgatgatg tgtacagcta tatacctgag tcccttctag tttatgtaga ctagcaattt
     3361 gacctgttaa acaggactag tttactttgt tgtatacacc tggaggtatc tgttattcga
     3421 ctccattttt gagttttggc acagtgaaga taaatttgtg tgacccactt gaatgactga
     3481 tctaacaatg ttgatatgaa tattgtattt agtgaaatgt cagatgaaaa tacctgattg
     3541 aataatgcgg ggatttttgt attaaaggga tgggaaagaa cacctgaatc tgataataaa
     3601 ggactatgat ctacaaagat ggaatgtttc ataaagatct acagaaataa agggattttg
     3661 taaacaggat gatcttaaaa gttaagatta cacagttcag ggtgtgctgc agtaaatttt
     3721 tttggtgata ctttacaaac atgatatgga tgtagacaca acagtaaagt gcaaacac
//
