LOCUS       NM_026919                428 bp    mRNA    linear   ROD 15-DEC-2024
DEFINITION  Mus musculus transmembrane protein 258 (Tmem258), transcript
            variant 1, mRNA.
ACCESSION   NM_026919 XM_622862 XM_903259 XM_981060
VERSION     NM_026919.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 428)
  AUTHORS   Ramirez,A.S., Kowal,J. and Locher,K.P.
  TITLE     Cryo-electron microscopy structures of human
            oligosaccharyltransferase complexes OST-A and OST-B
  JOURNAL   Science 366 (6471), 1372-1375 (2019)
   PUBMED   31831667
REFERENCE   2  (bases 1 to 428)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   3  (bases 1 to 428)
  AUTHORS   Graham,D.B., Lefkovith,A., Deelen,P., de Klein,N., Varma,M.,
            Boroughs,A., Desch,A.N., Ng,A.C.Y., Guzman,G., Schenone,M.,
            Petersen,C.P., Bhan,A.K., Rivas,M.A., Daly,M.J., Carr,S.A.,
            Wijmenga,C. and Xavier,R.J.
  TITLE     TMEM258 Is a Component of the Oligosaccharyltransferase Complex
            Controlling ER Stress and Intestinal Inflammation
  JOURNAL   Cell Rep 17 (11), 2955-2965 (2016)
   PUBMED   27974209
  REMARK    GeneRIF: we identify TMEM258 within this locus as a central
            regulator of intestinal inflammation. Strikingly, Tmem258
            haploinsufficient mice exhibit severe intestinal inflammation in a
            model of colitis.
REFERENCE   4  (bases 1 to 428)
  AUTHORS   Emoto,M., Miki,M., Sarker,A.H., Nakamura,T., Seki,Y., Seki,S. and
            Ikeda,S.
  TITLE     Structure and transcription promoter activity of mouse flap
            endonuclease 1 gene: alternative splicing and bidirectional
            promoter
  JOURNAL   Gene 357 (1), 47-54 (2005)
   PUBMED   15967598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB568308.1, AK007351.1 and AV456553.1.
            
            On or before Jul 22, 2009 this sequence version replaced
            XM_981060.2, XM_903259.3, XM_622862.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV456553.1, AU016310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BB568308.1         1-16
            17-409              AK007351.1         2-394
            410-428             AV456553.1         381-399
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.54 cM"
     gene            1..428
                     /gene="Tmem258"
                     /gene_synonym="1810006K21Rik"
                     /note="transmembrane protein 258"
                     /db_xref="GeneID:69038"
                     /db_xref="MGI:MGI:1916288"
     exon            1..63
                     /gene="Tmem258"
                     /gene_synonym="1810006K21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..300
                     /gene="Tmem258"
                     /gene_synonym="1810006K21Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0197 transmembrane protein C11orf10 homolog;
                     oligosaccharyl transferase subunit TMEM258;
                     dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit TMEM258"
                     /codon_start=1
                     /product="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit TMEM258 isoform 1"
                     /protein_id="NP_081195.1"
                     /db_xref="CCDS:CCDS50385.1"
                     /db_xref="GeneID:69038"
                     /db_xref="MGI:MGI:1916288"
                     /translation="MELEAMSRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTST
                     KYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYV"
     exon            64..173
                     /gene="Tmem258"
                     /gene_synonym="1810006K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            174..310
                     /gene="Tmem258"
                     /gene_synonym="1810006K21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            311..418
                     /gene="Tmem258"
                     /gene_synonym="1810006K21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      392..397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem258"
                     /gene_synonym="1810006K21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      412
                     /gene="Tmem258"
                     /gene_synonym="1810006K21Rik"
                     /note="major polyA site"
ORIGIN      
        1 ttgctcctgc cgacgtgttc ttccggtggc ggatcggtgg tttatcctgt gcggggcaaa
       61 atggagctcg aagccatgag taggtacacc agcccagtga acccggctgt cttccctcac
      121 ctgactgtgg tacttctggc catcggcatg ttcttcactg cctggttctt cgtttacgag
      181 gtcacctcta ccaagtacac acgcgatatt tacaaagagc tcctcatctc cttggtggcc
      241 tcactcttca tgggctttgg agtcctcttc ctcctgctct gggttggcat ctacgtataa
      301 gtctccaagg gtacccacca ggcagctcac caagtctctg cttttgtaaa ttaatttttt
      361 accattgcta cgtgtcccac ctgctgttta caataaaggc agatgtgtga caggcctgaa
      421 aaaaaaaa
//
