LOCUS       NM_172930               3431 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane protein 255A (Tmem255a), transcript
            variant 1, mRNA.
ACCESSION   NM_172930
VERSION     NM_172930.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3431)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3431)
  AUTHORS   Zhang,N.N., Zhang,T., Gao,W.Y., Wang,X., Wang,Z.B., Cai,J.Y.,
            Ma,Y., Li,C.R., Chen,X.C., Zeng,W.T., Hu,F., Li,J.M., Yang,Z.X.,
            Zhou,C.X. and Zhang,D.
  TITLE     Fam70A binds Wnt5a to regulate meiosis and quality of mouse oocytes
  JOURNAL   Cell Prolif 53 (6), e12825 (2020)
   PUBMED   32391621
  REMARK    GeneRIF: Fam70A regulates meiosis and quality of mouse oocytes
            through both canonical and non-canonical Wnt5a signalling pathways.
REFERENCE   3  (bases 1 to 3431)
  AUTHORS   Dong,B., Vold,S., Olvera-Jaramillo,C. and Chang,H.
  TITLE     Functional redundancy of frizzled 3 and frizzled 6 in planar cell
            polarity control of mouse hair follicles
  JOURNAL   Development 145 (19) (2018)
   PUBMED   30237242
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3431)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   5  (bases 1 to 3431)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (bases 1 to 3431)
  AUTHORS   Takase,H., Matsumoto,K., Yamadera,R., Kubota,Y., Otsu,A.,
            Suzuki,R., Ishitobi,H., Mochizuki,H., Kojima,T., Takano,S.,
            Uchida,K., Takahashi,S. and Ema,M.
  TITLE     Genome-wide identification of endothelial cell-enriched genes in
            the mouse embryo
  JOURNAL   Blood 120 (4), 914-923 (2012)
   PUBMED   22535667
REFERENCE   7  (bases 1 to 3431)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   8  (bases 1 to 3431)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   9  (bases 1 to 3431)
  AUTHORS   Gallardo,T.D., John,G.B., Shirley,L., Contreras,C.M., Akbay,E.A.,
            Haynie,J.M., Ward,S.E., Shidler,M.J. and Castrillon,D.H.
  TITLE     Genomewide discovery and classification of candidate ovarian
            fertility genes in the mouse
  JOURNAL   Genetics 177 (1), 179-194 (2007)
   PUBMED   17660561
  REMARK    GeneRIF: Transcripts highly enriched in ovary; gene identified as
            candidate female fertility factor.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY085502.1, BC062956.1, AK045375.1 and AV362114.1.
            
            On Jan 27, 2014 this sequence version replaced NM_172930.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062956.1, AK077178.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                BY085502.1         2-85
            85-1043             BC062956.1         1-959
            1044-1430           AK045375.1         1318-1704
            1431-3361           BC062956.1         1347-3277
            3362-3421           AK045375.1         3636-3695
            3422-3431           AV362114.1         256-265
FEATURES             Location/Qualifiers
     source          1..3431
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 22.46 cM"
     gene            1..3431
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /note="transmembrane protein 255A"
                     /db_xref="GeneID:245386"
                     /db_xref="MGI:MGI:3045722"
     exon            1..238
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1236
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM70A; family with sequence similarity 70, member
                     A"
                     /codon_start=1
                     /product="transmembrane protein 255A isoform 1"
                     /protein_id="NP_766518.3"
                     /db_xref="CCDS:CCDS30089.1"
                     /db_xref="GeneID:245386"
                     /db_xref="MGI:MGI:3045722"
                     /translation="MHQSLTQQRSSDMSLPDSMGAFNRRKRNSIYVTVTLLIVSMLIL
                     TVGLAATTRTQNVTVGGYYPGVILGFGSFLGIIGSNLIENKRQMLVASIVFISFGVIA
                     AFCCAIVDGVFAARHIDLKPLYANRCHYVPKTSQREAEEVITSSSKITPSTRALRNLT
                     QAVKEVNCPQLSRGLCTPRIRGNTCFCCDLYNCGNRVEITGGYYEYIDVSSCQDIIHL
                     YHLLWSATILNIVGLFLGIITAAVLGGFKDMNPTLPALNCSVENAHPTVSYYARPQVA
                     SYNTYYHSPPHLPPYSAYDFQHSGVFPSSPPSGLSDEQEPQSPSPSPSYMWSSSAPPR
                     YSPPYYPPFEKPPPYSP"
     exon            239..381
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /inference="alignment:Splign:2.1.0"
     exon            382..444
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /inference="alignment:Splign:2.1.0"
     exon            445..534
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /inference="alignment:Splign:2.1.0"
     exon            535..603
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /inference="alignment:Splign:2.1.0"
     exon            604..675
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /inference="alignment:Splign:2.1.0"
     exon            676..764
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /inference="alignment:Splign:2.1.0"
     exon            765..927
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1071
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..3431
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1706..1711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /note="hexamer: AATACA"
     polyA_site      1733
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
     regulatory      3400..3405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /note="hexamer: AATAAA"
     polyA_site      3426
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /note="major polyA site"
ORIGIN      
        1 gagggggagg gagggggagg cggcacttgg gctgcagctc tcaacccgag gcagtcagtc
       61 cctctcagcg ctagggaaga ccgagagagg cagcggcaga gtaggatgct ctgcggggcg
      121 ccctgagcca ggggctcttg aagcagcttc ggggacaggg gcaactggac agctttcacc
      181 atgcatcagt ccctgactca gcagcggtcc agcgacatgt cccttcccga ttccatggga
      241 gccttcaata ggaggaagcg gaactccatc tacgtcaccg ttactttgct tattgtgtcc
      301 atgttaattc tcacggtggg ccttgctgcg actaccagga cccagaatgt gaccgtggga
      361 ggttattacc caggagttat tcttggcttt ggatcattcc ttgggatcat cgggtcaaac
      421 ctgattgaga acaagcggca gatgctggtg gcttctatcg tgtttatcag ctttggtgtg
      481 attgcagcat tttgttgtgc tatagttgat ggggtctttg ccgccagaca cattgatttg
      541 aaaccactct atgctaaccg gtgccactat gttcccaaga catcacagag ggaagctgag
      601 gaggtcataa cttcctcatc caaaattact ccttctacga gggctttgag gaaccttacc
      661 caggcagtta aagaggtgaa ctgccctcaa cttagccgtg gactttgcac acctcgcatc
      721 cggggcaaca cctgcttctg ctgtgacctc tacaactgtg gcaacagggt ggaaatcacc
      781 ggcggctact atgagtacat tgatgtcagc agctgccagg acatcatcca cctgtaccac
      841 ctactctggt ctgccaccat cctcaacatc gttggcctgt tcctgggtat cattactgct
      901 gcggtccttg ggggatttaa ggatatgaac cctactcttc cggcactgaa ctgctctgtt
      961 gaaaatgccc atccaactgt ttcttactat gcgcgtcccc aagtggcatc gtacaatacc
     1021 tactaccata gccctcctca tctgccaccg tattctgctt atgactttca gcattccggt
     1081 gtctttccat cctctcctcc ttctggactc tccgatgagc aggagcccca atcgccctct
     1141 ccttcaccca gctacatgtg gtcctccagt gcgccacccc gttattctcc accctactac
     1201 ccaccttttg aaaagccacc accttacagt ccttaaagag gaatacctgt cggctattga
     1261 gattattgtg gcttttgtat ttctgctcta gtggaagtgt gtaggttaca tctaaagtgt
     1321 gactcttcta catcaagttt tacaacagct tgccaagcta gggaaagata gggatgaagc
     1381 ttactcatta tcaaggaagg acaggattgg ctaggccaaa cctagtactt cgaagaaagc
     1441 aagttcacta agcagggctg gggagccagt ccagcaagaa gcatggcttc ttcagatacg
     1501 catttcctga tgctccgcct ctatacagta caagtgtggt tgccatctgt ttcactttaa
     1561 gtaaacgaca gcagtcctcg ggcccttggt agatgactat gatagcacct tggttgaatc
     1621 acctggtcta taggctctat ctttccctac aattgatgtc actcttagga aaatttcgta
     1681 gctgattggg ctacacagta gttccaatac agaaagttgt ggctttttgt ttgctcgtgt
     1741 ctggatattg aaaaaaaaaa gctgccaatc tctttactct gttctccaag tcgtgtaaaa
     1801 atggctgttg tgatcattca gcttttgtgg ctggtacctc ctaaggggaa aagtgcaaga
     1861 gtcccttctc ctgagtggtg agagaccatg accggctgat ggagaagcac ggaaatacag
     1921 agcaacatgt gtgctgtttt cggtagatct cagcatacat ctggcaactt aggagacagt
     1981 gttcctacta tatgttgcat tattacaaaa cacatttgct actggagata gacatcttac
     2041 agttgaaatt cagagtttaa aaatgctaga ttagattgga tcgtggtatg aattgttact
     2101 tatctttgtg actatttaat cttcagctat tgtgctttca ccccagcaaa ccgcacggtc
     2161 ctgcacccca ccactgaaaa ctcatctgta ttttaatgcc actgctctta ttggtccctt
     2221 ttttctgttg agatcaattg tgacagcatt caattcaaga ttatgaaaat gctacaatgc
     2281 catttcaagt cttcaagacc tcaaatatag ccaacttgac aaactcttaa gtgttacgca
     2341 tttaaaagtc caccgggcat agtgtggtag ttatatagtt gttttaatga tacagagctt
     2401 taaaccatca aactgttgag actctagcac ccatgccttc actccagcat gaacacattc
     2461 actgggattt tattttaacc tgagaaatgg tttaaaagaa gattgataat cctacacttg
     2521 tattatgtaa aagtacagga gctacagagg acgcctaatt agacagttct gcaaacacaa
     2581 gaacacacac tggaaacatt tccagcccat ttcgctgcct cccttctttg atggttggag
     2641 gcagcagacc aatgctggtg ctcccatcta ccttgtagac acctggtcat caagaatcac
     2701 caaggcacaa caagtgcact cactgttacg gtaaatgttt gcaaaacatt cagtttaact
     2761 ttcaatgtct cttatccagt cttcaaatcc aaaagactac aatcctttta tgttacacaa
     2821 aattactgtt attttttcag ttctgaacat attaaaattc tattgggctt caaaaaggac
     2881 taataatcaa ttgacttata gagataccta agggtttttt cttctcactt acactttacc
     2941 ccttgctgta gggaatgtgt gtattttaaa ggcaccatta caaagtatat cttttatgat
     3001 cacatttctt aaagtgttaa gattctatga ctcatttcta tgtatttttt ttactttaca
     3061 aaataacttg aaacagtata gattttgtaa cacttaattt gagcagcttt ttttttaatc
     3121 acattgaatt atatcaagtg catgctacct taggaaaaat tatatttgct gcttcactct
     3181 tctgcaaaac atttgctgta atgaaggaat ttgtatttcc aatgtatctt gacggcattt
     3241 tataacattt actgctttct tcctaattct gctctaaagt attgaacttg gcatgaaata
     3301 ttaaaatatt aattcaaaac ctgtataaaa tagatgttgc ttaaaatttg tatcactgcc
     3361 acgttggaaa cccagacagc ttttgtgatg tttcaaatta ataaaattat cttccctatc
     3421 cacttacagg t
//
