LOCUS       NP_766518                351 aa            linear   ROD 30-APR-2024
DEFINITION  transmembrane protein 255A isoform 1 [Mus musculus].
ACCESSION   NP_766518
VERSION     NP_766518.3
DBSOURCE    REFSEQ: accession NM_172930.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 351)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 351)
  AUTHORS   Zhang,N.N., Zhang,T., Gao,W.Y., Wang,X., Wang,Z.B., Cai,J.Y.,
            Ma,Y., Li,C.R., Chen,X.C., Zeng,W.T., Hu,F., Li,J.M., Yang,Z.X.,
            Zhou,C.X. and Zhang,D.
  TITLE     Fam70A binds Wnt5a to regulate meiosis and quality of mouse oocytes
  JOURNAL   Cell Prolif 53 (6), e12825 (2020)
   PUBMED   32391621
  REMARK    GeneRIF: Fam70A regulates meiosis and quality of mouse oocytes
            through both canonical and non-canonical Wnt5a signalling pathways.
REFERENCE   3  (residues 1 to 351)
  AUTHORS   Dong,B., Vold,S., Olvera-Jaramillo,C. and Chang,H.
  TITLE     Functional redundancy of frizzled 3 and frizzled 6 in planar cell
            polarity control of mouse hair follicles
  JOURNAL   Development 145 (19) (2018)
   PUBMED   30237242
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 351)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   5  (residues 1 to 351)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (residues 1 to 351)
  AUTHORS   Takase,H., Matsumoto,K., Yamadera,R., Kubota,Y., Otsu,A.,
            Suzuki,R., Ishitobi,H., Mochizuki,H., Kojima,T., Takano,S.,
            Uchida,K., Takahashi,S. and Ema,M.
  TITLE     Genome-wide identification of endothelial cell-enriched genes in
            the mouse embryo
  JOURNAL   Blood 120 (4), 914-923 (2012)
   PUBMED   22535667
REFERENCE   7  (residues 1 to 351)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   8  (residues 1 to 351)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   9  (residues 1 to 351)
  AUTHORS   Gallardo,T.D., John,G.B., Shirley,L., Contreras,C.M., Akbay,E.A.,
            Haynie,J.M., Ward,S.E., Shidler,M.J. and Castrillon,D.H.
  TITLE     Genomewide discovery and classification of candidate ovarian
            fertility genes in the mouse
  JOURNAL   Genetics 177 (1), 179-194 (2007)
   PUBMED   17660561
  REMARK    GeneRIF: Transcripts highly enriched in ovary; gene identified as
            candidate female fertility factor.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY085502.1, BC062956.1, AK045375.1 and AV362114.1.
            
            On Oct 24, 2009 this sequence version replaced NP_766518.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062956.1, AK077178.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 22.46 cM"
     Protein         1..351
                     /product="transmembrane protein 255A isoform 1"
                     /note="protein FAM70A; family with sequence similarity 70,
                     member A"
                     /calculated_mol_wt=38502
     Region          7..348
                     /region_name="FAM70"
                     /note="FAM70 protein; pfam14967"
                     /db_xref="CDD:464411"
     Site            30..50
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHW5.1)"
     Site            57..77
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHW5.1)"
     Site            89..109
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHW5.1)"
     Site            226..246
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHW5.1)"
     Region          302..331
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHW5.1)"
     CDS             1..351
                     /gene="Tmem255a"
                     /gene_synonym="4933417N17; 6430550H21Rik; Fam70a"
                     /coded_by="NM_172930.4:181..1236"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS30089.1"
                     /db_xref="GeneID:245386"
                     /db_xref="MGI:MGI:3045722"
ORIGIN      
        1 mhqsltqqrs sdmslpdsmg afnrrkrnsi yvtvtllivs mliltvglaa ttrtqnvtvg
       61 gyypgvilgf gsflgiigsn lienkrqmlv asivfisfgv iaafccaivd gvfaarhidl
      121 kplyanrchy vpktsqreae evitssskit pstralrnlt qavkevncpq lsrglctpri
      181 rgntcfccdl yncgnrveit ggyyeyidvs scqdiihlyh llwsatilni vglflgiita
      241 avlggfkdmn ptlpalncsv enahptvsyy arpqvasynt yyhspphlpp ysaydfqhsg
      301 vfpssppsgl sdeqepqsps pspsymwsss apprysppyy ppfekpppys p
//
