LOCUS       NM_001357385            2815 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus transmembrane protein 25 (Tmem25), transcript variant
            4, mRNA.
ACCESSION   NM_001357385
VERSION     NM_001357385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2815)
  AUTHORS   Bi,J., Wu,Z., Zhang,X., Zeng,T., Dai,W., Qiu,N., Xu,M., Qiao,Y.,
            Ke,L., Zhao,J., Cao,X., Lin,Q., Chen,X.L., Xie,L., Ouyang,Z.,
            Guo,J., Zheng,L., Ma,C., Guo,S., Chen,K., Mo,W., Fu,G., Zhao,T.J.
            and Wang,H.R.
  TITLE     TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal
            state to suppress triple-negative breast cancer progression
  JOURNAL   Nat Commun 14 (1), 2342 (2023)
   PUBMED   37095176
  REMARK    GeneRIF: TMEM25 inhibits monomeric EGFR-mediated STAT3 activation
            in basal state to suppress triple-negative breast cancer
            progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2815)
  AUTHORS   Zhang,H., Tian,X., Lu,X., Xu,D., Guo,Y., Dong,Z., Li,Y., Ma,Y.,
            Chen,C., Yang,Y., Yang,M., Yang,Y., Liu,F., Zhou,R., He,M., Xiao,F.
            and Wang,X.
  TITLE     TMEM25 modulates neuronal excitability and NMDA receptor subunit
            NR2B degradation
  JOURNAL   J Clin Invest 129 (9), 3864-3876 (2019)
   PUBMED   31424425
  REMARK    GeneRIF: These results provide some insights into TMEM25 biology in
            the brain and the functional relationship between TMEM25 and
            epilepsy.
REFERENCE   3  (bases 1 to 2815)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human TMEM25 and mouse
            Tmem25 genes in silico
  JOURNAL   Oncol Rep 12 (2), 429-433 (2004)
   PUBMED   15254712
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142113.2.
            
            Transcript Variant: This variant (4) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (b) is
            shorter at the N-terminus compared to isoform a. Variants 2, 3, and
            4 all encode the same isoform (b).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3839571.1,
                                           ERR3363660.2164217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-584               AC142113.2         173847-174430       c
            585-896             AC142113.2         173304-173615       c
            897-1187            AC142113.2         171507-171797       c
            1188-1319           AC142113.2         171179-171310       c
            1320-1350           AC142113.2         170865-170895       c
            1351-1451           AC142113.2         170593-170693       c
            1452-1538           AC142113.2         170374-170460       c
            1539-2815           AC142113.2         168955-170231       c
FEATURES             Location/Qualifiers
     source          1..2815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..2815
                     /gene="Tmem25"
                     /gene_synonym="0610039J01Rik"
                     /note="transmembrane protein 25"
                     /db_xref="GeneID:71687"
                     /db_xref="MGI:MGI:1918937"
     exon            1..584
                     /gene="Tmem25"
                     /gene_synonym="0610039J01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             515..1612
                     /gene="Tmem25"
                     /gene_synonym="0610039J01Rik"
                     /note="isoform b precursor is encoded by transcript
                     variant 4"
                     /codon_start=1
                     /product="transmembrane protein 25 isoform b precursor"
                     /protein_id="NP_001344314.1"
                     /db_xref="CCDS:CCDS23120.1"
                     /db_xref="GeneID:71687"
                     /db_xref="MGI:MGI:1918937"
                     /translation="MELPLSQATLRHTLLLLPALLSSGQGELAPQIDGQTWAERALRE
                     NEHHAFTCRVAGGSATPRLAWYLDGQLQEATTSRLLSVGGDAFSGGTSTFTVTAQRSQ
                     HELNCSLQDPGSGRPANASVILNVQFKPEIAQVGAKYQEAQGPGLLVVLFALVRANPP
                     ANVTWIDQDGPVTVNASDFLVLDAQNYPWLTNHTVQLQLRSLAHNLSVVATNDVGVTS
                     ASLPAPGLLATRIEVPLLGIVVAGGLALGTLVGFSTLVACLVCRKEKKTKGPSRRPSL
                     ISSDSNNLKLNNVRLPRENMSLPSNLQLNDLTPDLRGKATERPMAQHSSRPELLEAEP
                     GGLLTSRGFIRLPMLGYIYRVSSVSSDEIWL"
     exon            585..896
                     /gene="Tmem25"
                     /gene_synonym="0610039J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1187
                     /gene="Tmem25"
                     /gene_synonym="0610039J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1319
                     /gene="Tmem25"
                     /gene_synonym="0610039J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1350
                     /gene="Tmem25"
                     /gene_synonym="0610039J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1451
                     /gene="Tmem25"
                     /gene_synonym="0610039J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1538
                     /gene="Tmem25"
                     /gene_synonym="0610039J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..2815
                     /gene="Tmem25"
                     /gene_synonym="0610039J01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2792..2797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem25"
                     /gene_synonym="0610039J01Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2815
                     /gene="Tmem25"
                     /gene_synonym="0610039J01Rik"
                     /note="major polyA site"
ORIGIN      
        1 cttgcagcgg actgcggtgc tcagccttct tgagcaattg ctggggctca ctctgggagg
       61 gagccaggtg agctgacccg aaagcaggat gctccagcga ccctcggatc cgcgacgctc
      121 tcttgctagg cccaagtcca cctgagcagc cgagattgga aaagcggtgc atggcgagat
      181 atgggaggga gagccaaggc cagcgaggag tgaaccgggt caagagaagg acgatcgttt
      241 gggggggaag gggaagggcg cctgtgcatg tctgtctgtc tgtctgtctg tctgtggtca
      301 tctactgtca gtgctggcct ctatgcccgc acagagacga agtgttgcca tagggtctct
      361 tcctttgggt cttgctgatt gtgtctattt gtgccggtgt cttggccact gtgggccagt
      421 ctacatcagt gcatggtaaa ttattgcagg aattgttagg cctacatggc tggtactctt
      481 ctctcagcag cctggaggcc ggtccctgat caccatggaa ttgcctctaa gccaagctac
      541 cctccggcac acactgctgc tccttcctgc cctcttaagt tcaggtcaag gggagctggc
      601 gccgcaaatt gatggtcaga cctgggctga gagagcgctt agggagaatg agcaccatgc
      661 cttcacctgt cgggttgcag gaggttctgc cactccccga ttagcctggt acctggatgg
      721 acagctacag gaggccacca cctcccgact gctgagtgtg ggtggggacg ccttctctgg
      781 aggaaccagc actttcactg ttactgccca gcgctcccaa catgagctta actgctccct
      841 gcaggaccca gggagtggcc ggccagccaa tgcctctgtc atcctcaatg tgcaattcaa
      901 accagagatt gcccaggttg gagccaaata ccaggaagct cagggcccag gccttctggt
      961 tgtcctgttt gccctggtgc gggccaaccc acctgccaat gtcacctgga ttgaccagga
     1021 tgggccagtg actgtcaatg cctctgactt cctggtgctg gatgctcaga actatccctg
     1081 gctcaccaac cacactgtgc agctgcagct ccggagcttg gcacacaacc tctcggtggt
     1141 ggccaccaat gacgtgggtg tcactagcgc ttcccttcca gctccagggc tcctggccac
     1201 acggatagaa gtgccactgc tgggcatcgt tgtggctgga ggacttgcct tgggcactct
     1261 agtggggttc agtaccttgg tggcctgcct ggtctgcagg aaagagaaga aaacaaaagg
     1321 cccctcccgg cgtccttctc tgatatctag tgactccaat aacctgaaac tgaataatgt
     1381 gcgcctgcca cgggagaaca tgtccctccc atccaacctt cagctcaatg acctcactcc
     1441 agatctcaga gggaaagcaa cagagcggcc aatggctcag catagcagcc gtccagagct
     1501 tctagaagcc gagcctggtg gcctcctcac cagccgaggt ttcatccgtc tcccgatgtt
     1561 gggctacatc taccgtgtgt ccagtgtaag cagtgatgag atttggctct gagcttgatg
     1621 gtgaggcatg aggcccaggt ggcctgtgga ctccccagag tgcccaccct ggtgtctcct
     1681 tcaagctttc ctctgcctgt ccctgttgtg accatgaaga aaccatgtca ctgccatctg
     1741 gcctgcctgg caaggatacc ctgtgggtca tgcatgtgta tttctttgca ctctaacctg
     1801 caaggcatgg gtacccttgg cagacccctg gtcggaacta gccccttgca ctcactgagt
     1861 ttggggccct gcatgtgata acctggtcca ggcacacaga accctggcca ggtgcgttca
     1921 ggtgtcaccc aacatctaag agatgggcct attatatgtc ctaccttagt atcctctgca
     1981 ccttgtgcac ataggcagag agatgcctat gtgggggaca ggagggtccc tgcacaactc
     2041 agatgtcctt cctatgctat gcagctttgt tccctcaggg aaaacttagc ccctgctcta
     2101 tgtatacaac caaactgccc tttgctcagg aaccagcccc ttgcccaggg acctggccaa
     2161 gcacaaataa gtcccttttg ctgcatatct ttctaccctt ttgtccccac ctcctcttgg
     2221 gtatcatcgg tcatacccta gaccttcttc actgggcatt agacccccca ttggttgggg
     2281 cctgcaggtg ccagcttttg atgttagcac aagatgagca agaagaggtg accggtgggc
     2341 tggctcccag gacgacatgt agctctgcat cgttttgtac aagtgtctgc attttaagca
     2401 cattccccgg aagggaggaa ggcccagggc cttcctgggt tccccatgtt cggccttccg
     2461 caattcactg tgagtgttct gagcactgag gattggtggt tgccctctct gcatgtctct
     2521 cccaccatgc agcctcattc tccaccgagc ctggctgccc catcctattc tttaggggat
     2581 ggtcacagtt gggtatataa tccaacaggg ccagaagctt taggggggac agagaaagca
     2641 ggagcccact gagctccgaa gagctaatac tttttaaaaa gcaacctgaa aacgactggc
     2701 gaccatcaga gtgcggcgtc tattctccct tcttcgtatc ttgttttgta atttttctca
     2761 tgttactggt tagggcagtt gctacacaca cagtaaactc ctttgaccaa agaaa
//
