LOCUS       NM_001369260            6882 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus transmembrane protein 245 (Tmem245), transcript
            variant 2, mRNA.
ACCESSION   NM_001369260 XM_006537925
VERSION     NM_001369260.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6882)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   2  (bases 1 to 6882)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX470220.11 and AL929577.9.
            
            On Mar 29, 2019 this sequence version replaced XM_006537925.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.6268.1,
                                           SRR10223971.4705.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-585               BX470220.11        13746-14330         c
            586-703             BX470220.11        4763-4880           c
            704-805             BX470220.11        3270-3371           c
            806-922             AL929577.9         143988-144104       c
            923-1159            AL929577.9         142790-143026       c
            1160-1329           AL929577.9         141150-141319       c
            1330-1353           AL929577.9         140198-140221       c
            1354-1458           AL929577.9         134513-134617       c
            1459-1541           AL929577.9         129859-129941       c
            1542-1632           AL929577.9         127968-128058       c
            1633-1731           AL929577.9         124026-124124       c
            1732-1863           AL929577.9         121729-121860       c
            1864-1986           AL929577.9         117117-117239       c
            1987-2132           AL929577.9         116837-116982       c
            2133-2233           AL929577.9         108611-108711       c
            2234-2408           AL929577.9         106346-106520       c
            2409-2603           AL929577.9         103829-104023       c
            2604-6882           AL929577.9         93825-98103         c
FEATURES             Location/Qualifiers
     source          1..6882
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 31.66 cM"
     gene            1..6882
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /note="transmembrane protein 245"
                     /db_xref="GeneID:242474"
                     /db_xref="MGI:MGI:2445107"
     exon            1..585
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..2649
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     likely ortholog of H. sapiens chromosome 9 open reading
                     frame 5 (C9orf5); transmembrane 245"
                     /codon_start=1
                     /product="transmembrane protein 245 isoform 2"
                     /protein_id="NP_001356189.1"
                     /db_xref="CCDS:CCDS89746.1"
                     /db_xref="GeneID:242474"
                     /db_xref="MGI:MGI:2445107"
                     /translation="MADRGGPAEAPSPRGSPRPESRAPRTVGPGETPRTAALALRFDK
                     PIKQAFYNTGAVLFVCLCCGAAVLVYFILEAFLRPLLWAVLCGTFLHPFKSSLTRLGR
                     LWLRRLHRAHTPIVLAALLLPLCFADYGVEALGEQALRRRRLLLLLGAGGPLLYGLYC
                     LGSYLGVQVLLAHAGALICRGLDYFSSLWIWTLVVGYVLMVSFKWNASTQRYLRAVSI
                     PVWMILLFHIASLAGSWRIPVFLVIVFLMSVGTLYEKQNEKESAGAELPGQVISMAAS
                     TLANLAISITGYESSTEDQPSDPPTEPTDKGEPPPALSASSSSSSRSSPSSPSPTLGR
                     QRPEMGTFLRKKKTSDIYFVSLVWAIIAVQLWLNLWIVQLLPVPVAVWIIKKLVIHFG
                     VVGFLEKRCHAWWQVIECFLKERQEALAPWPIIGLGKFLLKVDSKLWHWLNKKMIIWL
                     EKMLDKIISIFIIFLLVIGTLLLALLLTAKVHQESVHMIEVTSSLINETLANHPEWAN
                     WLPEAQVVQRALNSAANNVYQYGREWITHKLHKILGDKVNNTAVIEKQVLELWDRLYH
                     SWFVKNVTHSGRHKGHKMHVSRQNSWLGDILDWQDIASFVHENIETFLSILESLWIVM
                     SRNVSLLFTTVTTLLTILFYSGTALLNFVLSLIIFLTTLFYLLSSSDEYYKPVKWVIS
                     LTPLSQPGPSSNIIGQSVEEAIRGVFDASLKMAGFYGLYTWLTHTIFGINIVFIPSAL
                     AAILGAVPFLGTYWAAVPAVLDLWLTQGLGCKAILLLVFHLLPTYFVDTAIYSDISGG
                     GHPYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNIYSAMLVSPTNSMPTPNQTPW
                     PAQTQRTFRDISEDLKSSVD"
     exon            586..703
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            704..805
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            806..922
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1159
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1329
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1353
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1458
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1541
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1632
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1731
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1863
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1986
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2132
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2233
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2408
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2603
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..6882
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5751..5756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /note="hexamer: AATAAA"
     regulatory      5763..5768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /note="hexamer: ATTACA"
     polyA_site      5774
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /note="major polyA site"
     polyA_site      5791
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
     regulatory      6060..6065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /note="hexamer: AATACA"
     polyA_site      6079
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
     regulatory      6810..6815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
                     /note="hexamer: AATACA"
     polyA_site      6841
                     /gene="Tmem245"
                     /gene_synonym="A630051L19Rik; D730040F13Rik"
ORIGIN      
        1 ggtccaggca gaggcgcgat ggccgaccgc ggcggccctg ctgaggcgcc cagcccgcgg
       61 ggctctcccc ggccagagtc ccgggccccg cgcacggtcg ggccgggcga gaccccgcgt
      121 accgcggcgc tggcgctgcg cttcgataag cccatcaagc aggctttcta caacacgggc
      181 gccgtgctgt tcgtgtgcct gtgctgcggc gccgcggtgc tcgtgtactt catcctcgag
      241 gccttcctgc ggccgctgct ctgggccgtg ctgtgcggca ctttcctgca cccgttcaag
      301 agctcgctca cgcgcctggg ccgcctgtgg ctgcggcgcc tgcaccgcgc gcacacgccc
      361 atcgtgctgg ccgcgctgct gctgccgctc tgcttcgccg actacggcgt ggaggcgctg
      421 ggcgagcagg cgctgcgccg ccgccgcctg ttgctgctgc tgggagcggg cggcccgctg
      481 ctctatgggc tctactgcct gggcagctac ctgggcgtgc aggtgctgct ggcgcacgcg
      541 ggcgcgctca tctgccgcgg cctcgactac ttcagcagcc tgtggatctg gacattggta
      601 gttggctacg tgctgatggt ttcattcaag tggaatgcaa gcactcaacg gtatttgaga
      661 gcagtttcga ttcctgtgtg gatgatactg ctttttcata tagcatcact ggctggctca
      721 tggagaattc cagtattcct ggttattgtt ttcctgatgt ctgtgggcac cctttatgaa
      781 aaacagaatg agaaggagtc ggctggggca gaattaccag gacaagtgat ctccatggca
      841 gcttctactc ttgcaaactt ggccatctcc atcactgggt atgagtccag cactgaagac
      901 cagccctctg accctccgac agagcccaca gacaagggag aaccccctcc agcattgtct
      961 gcttcttctt catcctcctc tcgttcctcg ccctcttctc cttcacctac tttgggcaga
     1021 cagaggcccg agatgggaac atttctcagg aagaagaaaa cgagtgacat ctacttcgtg
     1081 tctcttgtgt gggccatcat tgctgtccag ctttggctga atctgtggat cgtacagctg
     1141 ctgccagtgc ctgttgcagt ctggatcatc aaaaagctcg tgatccactt tggagtggtg
     1201 ggcttcctgg agaaacgctg ccacgcatgg tggcaggtga ttgaatgctt cctgaaggag
     1261 cggcaggagg ctttggcacc ttggccgatt atcgggcttg gaaagttctt actaaaagtt
     1321 gatagcaagc tctggcactg gctaaataag aagatgatca tctggttgga gaagatgtta
     1381 gataaaatta ttagcatttt catcatattc ttgctagtca taggaaccct tcttttggcc
     1441 cttctcctga ctgcaaaggt acatcaggag agtgttcaca tgattgaagt cacaagtagt
     1501 ctgattaacg aaactctagc aaatcaccca gagtgggcaa attggcttcc tgaggctcag
     1561 gtggtccaaa gagctcttaa ttcagcagca aacaatgtgt accagtatgg acgggaatgg
     1621 ataactcaca agcttcacaa aattctagga gataaggtga acaatacggc tgtgattgaa
     1681 aagcaagttc tagaactgtg ggacagactg tatcactctt ggtttgttaa gaacgtgaca
     1741 cactctggaa ggcacaaagg gcacaagatg catgtgagcc gtcagaacag ctggctggga
     1801 gatattttgg actggcaaga tattgcctct ttcgttcatg agaacatcga gacttttctt
     1861 tcgatcctgg agtctctgtg gattgttatg agccggaacg tgagcctgct gttcaccaca
     1921 gtcaccaccc tgctgaccat cctcttctac agtggcactg cccttctcaa cttcgtgctg
     1981 tctctgataa ttttcctgac cacactgttt tatctgttaa gttccagtga tgagtactac
     2041 aagccagtga agtgggtgat cagcctgaca ccactttctc agccaggccc ttcctctaac
     2101 atcatcggcc agtctgtgga agaggcgatc agaggggtgt tcgatgcttc cctcaaaatg
     2161 gctggcttct atggactgta cacctggctg actcacacta tatttggcat caatattgtc
     2221 ttcataccat cagctttggc agcaatcctt ggagctgtgc catttctggg gacatattgg
     2281 gcagcagtac ctgccgttct agacctgtgg ctgacacaag ggctaggatg taaagccatc
     2341 ttgctcctgg tctttcatct cttgccaaca tacttcgtag acactgcaat ctactctgat
     2401 atatcaggag gaggccaccc ctacctgacc ggcttagcag tggctggtgg agcctactac
     2461 ctgggcctag aaggagcaat cattgggcct atccttctct gcatacttgt tgttgcttcc
     2521 aatatctaca gtgccatgct agtgagtcct acgaactcga tgcccacacc aaatcagacc
     2581 ccttggcctg ctcagactca gcggactttc cgtgacatct ctgaagatct gaaatcttca
     2641 gtagattgac ctggcttccc tgcagtgact tctggggagt ctcactttga cagtgagtcc
     2701 tgcgagcgtt ggcctctgct ctgtcagccg tgtctggcag gcaggggtac ccagaaaaga
     2761 agcagaagca gaacaccaag cgagagagaa cttgctctcg gccgcttcgc attttaaaac
     2821 acagcttgag agttgagaac tgtgtctgct cacagctcat gctaagacgg cttgaaagtc
     2881 gcagttcatg cactggtacc aaggcttgaa attgccctct ttgattatct gctgcagtgt
     2941 ttatttataa gttattttaa ggattctgga tgacctacta ttaagtgtat acccagtgta
     3001 atgctccttc tgctgtagga gtttagccct tgtcagcgag aaggttttcc ctgtggagta
     3061 tggttcagta agcagaaaag ggtaaagatg gctccctgtg ctgagaggag agaggatgca
     3121 ggaggagtgc agctcttcct ctcagccagg ttgccagatt tctataactc ttctgaccac
     3181 actgaaaaga tgccaactga gctgctatga atagtaacga tgtgacagat ccctgccgtc
     3241 agccttcctc tcttacctgc tttacaagca cagactgagg tgcagtggtc cctggctttg
     3301 tcatgtgtgc cctcagttag ttgcttagca gcagaatttc ttcttccact tagcaccgtg
     3361 ccttgtactc gggagtctag acgaatgctt gctgagttgg actataactt tgcacgtatc
     3421 tcagatatga cacaaccggc atagtgtttt atactttaca cagcctttgt gcacattact
     3481 ttacacacat ttcacatcag ctctcggagc tttgtactct ggggagtgtc accctggcgg
     3541 cgggggttgc ggggctaagc ttcaggacag cagcagtgca aagccaccaa gtgttgaaac
     3601 ttatctcctc cttctgatgt tacatctgca gaatgcattt cttatggctt tggcagtttc
     3661 ccagtcctgt tagcagaggt tctcatttat tcgatacatg tgaaagagtt gtcctgcttc
     3721 atgacgcagg acatggcgtc acttgagccc agctcctagt gttgagccct ttccagctgt
     3781 tgttccagct gttgttccag ctgtcctggg cagcagaagg ggttttgatt tgttttttga
     3841 aagcacttaa gactaaaatt tttcttaaaa cttcttacta actttataac ttgattgatt
     3901 aataaaaccc acacatgctg ggcggtggtg gcacacgcct ttaatcccag cacttgggag
     3961 gcagaggcag gcggatttct gagtttgagg ccagtctggt ctgcagagtg agttccagga
     4021 cagccagggc tacacagaga aaccctgtct cagaaaacca aaataaataa ataaataaat
     4081 aaataaataa accccacaca tactgcagtg ccatctgact tgctatgtat agtatggctc
     4141 atgctggttt cctggttgta tcatgaatcc ttcaacatta tgacctgtta atccatcatc
     4201 tgttagatct gaccactaaa ccacttactc tgttctttaa taagttggtc atttgctcat
     4261 taatactttt cttgagcatt agtaaattct aggcaccatg ccaaggacca caggtggctg
     4321 tgggcgatga ctcccacgat ggcttctctc accttaaatg ccagccagat catgtaaatc
     4381 atactaaatc taaaattctt gcattaaaat ggttgaggag agaaaccaag tttttgtttt
     4441 taaactatat tgtgataagt ttataattag cacatgctca taagcagcaa atatacacag
     4501 tgagtttgta tacatctaca aattatgttg ctccagtgtg cttttagcca tgtaaaagca
     4561 aatttgcaaa aaactaagtt tgagctgatt catagttgtt ggtaggatag ttctcaattt
     4621 gaatgtgaat ttctagggga actctgagct ctaagtttag agcttcctaa attagtggta
     4681 atggtataag tctgtcctga aattttaaga gcagaagtcc cccaaaaact caaactaccc
     4741 cattgctaca gtgaatccag gaaggctgcc agttggaaaa acatcctagc atgtgtcagg
     4801 cacagggaag aggttttacg gaattttcct aggacagaga gagaatagat aacatgaggt
     4861 ggtaagagtc ttttagtccc taacataact taccttgaag agtttgcgta gaatttgacc
     4921 tgggaagaag agaatatata tggctggtgg ctggtttggt tttttgggtt ttttttgttg
     4981 ttgttgttgt tgttgttgct gttttttggt ttgtgatgtg tgtgtgtgtt catgtgcatg
     5041 tataggtaga ctttttggct actttattgg gttcttttac ctgcctctct tctccacccc
     5101 gatcccttgt aacccccaac actaggtcag tgaggaaagg ttagagggaa agggggcata
     5161 gatctctttg gactacttcc ttgtgattag ggatgtcaaa tttcctagag gaaagtccag
     5221 tcttcattgt caggacttct ccaaccagca gaccagcaaa ccagcaacac acacgcagca
     5281 gcaggaatca gcagcagcct ccacccccct cagggctctc agcagaccct cggattccaa
     5341 aggtaaacga ccttcagctg gcagaatcgt gcccctgccc accatgagac gagtcatagt
     5401 cagctgctgt ggacaatctg aagcagcccc atatcccacg cctggggtta aaactaaagc
     5461 ataatcacaa aacataactg gggtttttca tataagaaaa tttaaagcta acagagcact
     5521 agttagtctg tctttacagg gtctttactc ttcctttttg ttttattagc atttctttaa
     5581 aaatgcaact agatctttct acaactgctt gtcttgtagg attgtgtgat atatctgtaa
     5641 tatgctttat attataatat tcaaagaatt gcttcatctc actgaagaca tgtgagaggg
     5701 cattatcagt attaatttgt gcaggtgtcc tccaaacttc tgttatttcc aataaatgtg
     5761 caattacaga accagctttt cggaactcaa agcagttgca cattgggact gaatatgaat
     5821 cgtgtatggt gtgcaaactg tagtgttaga aattctgcaa aatggaacac atcatctgtc
     5881 tgccagattt catttccttt agcactccta ggactactcg gcaggtaatg aagtttggtt
     5941 atacagagaa taagtaaggc atttttttat ctcctcggct tgttgccaaa tcatagaaaa
     6001 aaaatttaaa ctttgattgt taacatggtg ggtttttttc atgaaatttt gaggcttcta
     6061 atacatttcc cattgataat tggtcaattt cttcatttcc ttgtgccaat agactgctca
     6121 acctgtatga gactgaatat gagtctcata ttcaaaaata caatggaaag tgtctatttc
     6181 tgattgccag ttgcggttgc acaaataaga ttaattctga gccatccgga acaaattcag
     6241 cagtttctat atacagaaca actctttctg catactgaga gtcagtaatt gttaagagat
     6301 tcagagaaat ctagcactag ggttgcatac agctctgact tttgaacgga atttcgtggg
     6361 ctttgggtca ctttgcttat tttgtccgac ttacagcctt ccattctcaa cttacttgca
     6421 tcaggataga atgtaggcgc ctcaggaact ggccttccct ttacaatact tgggagaatc
     6481 caattagttc tttttgtaaa ttgaagatgc ttgctttgga gatatttgtt aatttctccc
     6541 aaatagttgt tacatgcttt gcaaatcttc attgattaca catagtgaca taatctcagc
     6601 attagtaaaa ggcaccacaa ttttggctgt gtctgttact gataattcat atagtcttat
     6661 tctacctttt ataattaaat cagaaacctt ttctatatat gtaagttttt aactttttac
     6721 tttgtgtatt aagaaaatct atctataatt ctatcttccc tttgtataat gagccacgta
     6781 agagaatgag ttgatggcaa aaaaatgaaa atacaatcaa gcttaggctc tgtgtgatcc
     6841 acatatgcat cttgctgtga gtaaactctt tacttccact gt
//
