LOCUS       NM_001037812            1853 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus transmembrane protein 237 (Tmem237), transcript
            variant 2, mRNA.
ACCESSION   NM_001037812 XM_355201 XM_893795 XM_901044 XM_901060 XM_901064
            XM_909142 XM_921139 XM_921149 XM_921172 XM_921181
VERSION     NM_001037812.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1853)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1853)
  AUTHORS   Chen,T., Wang,L., Chen,C., Li,R., Zhu,N., Liu,R., Niu,Y., Xiao,Z.,
            Liu,H., Liu,Q. and Tu,K.
  TITLE     HIF-1alpha-activated TMEM237 promotes hepatocellular carcinoma
            progression via the NPHP1/Pyk2/ERK pathway
  JOURNAL   Cell Mol Life Sci 80 (5), 120 (2023)
   PUBMED   37041420
  REMARK    GeneRIF: HIF-1alpha-activated TMEM237 promotes hepatocellular
            carcinoma progression via the NPHP1/Pyk2/ERK pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1853)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1853)
  AUTHORS   Huang,L., Szymanska,K., Jensen,V.L., Janecke,A.R., Innes,A.M.,
            Davis,E.E., Frosk,P., Li,C., Willer,J.R., Chodirker,B.N.,
            Greenberg,C.R., McLeod,D.R., Bernier,F.P., Chudley,A.E., Muller,T.,
            Shboul,M., Logan,C.V., Loucks,C.M., Beaulieu,C.L., Bowie,R.V.,
            Bell,S.M., Adkins,J., Zuniga,F.I., Ross,K.D., Wang,J., Ban,M.R.,
            Becker,C., Nurnberg,P., Douglas,S., Craft,C.M., Akimenko,M.A.,
            Hegele,R.A., Ober,C., Utermann,G., Bolz,H.J., Bulman,D.E.,
            Katsanis,N., Blacque,O.E., Doherty,D., Parboosingh,J.S.,
            Leroux,M.R., Johnson,C.A. and Boycott,K.M.
  TITLE     TMEM237 is mutated in individuals with a Joubert syndrome related
            disorder and expands the role of the TMEM family at the ciliary
            transition zone
  JOURNAL   Am J Hum Genet 89 (6), 713-730 (2011)
   PUBMED   22152675
REFERENCE   5  (bases 1 to 1853)
  AUTHORS   Zuniga,F.I. and Craft,C.M.
  TITLE     Deciphering the structure and function of Als2cr4 in the mouse
            retina
  JOURNAL   Invest Ophthalmol Vis Sci 51 (9), 4407-4415 (2010)
   PUBMED   20375344
  REMARK    GeneRIF: Als2cr4 may be involved in membrane transport between the
            photoreceptor inner and outer segments and may be a key component
            in maintaining the structural integrity of the outer segment
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK167733.1 and BM899705.1.
            
            On Mar 19, 2018 this sequence version replaced NM_001037812.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167733.1, AK170118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1823              AK167733.1         3-1825
            1824-1853           BM899705.1         1-30                c
FEATURES             Location/Qualifiers
     source          1..1853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 29.2 cM"
     gene            1..1853
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /note="transmembrane protein 237"
                     /db_xref="GeneID:381259"
                     /db_xref="MGI:MGI:2138365"
     exon            1..104
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1283
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /note="isoform 2 is encoded by transcript variant 2;
                     amyotrophic lateral sclerosis 2 chromosomal region
                     candidate gene 4 protein homolog; amyotrophic lateral
                     sclerosis 2 (juvenile) chromosome region, candidate 4"
                     /codon_start=1
                     /product="transmembrane protein 237 isoform 2"
                     /protein_id="NP_001032901.1"
                     /db_xref="CCDS:CCDS14984.1"
                     /db_xref="GeneID:381259"
                     /db_xref="MGI:MGI:2138365"
                     /translation="MGKKQVVSEPQRPPRALPPVPSAIQDDIPLSHPKKKKSRTKSSL
                     ATASSEGHAEPVVNRRAEGSEPPAAELKEHPEAPAPRRQKKIRPPPELETSLTERPSS
                     PSLLRNENGIDAEPREEAVIPKPRRKAKKTQPAEPQYASELGVEDEDILTDEQSTLEH
                     HSRFTAPTGVSQPVGKVFVEKSRRFQAADRSELIKTTENIDVSMDVKPSWTTRDVALS
                     VHRAFRMVGLFSHGFLAGCAVWNTVVIYVLAGDQLSNVSNLLQQYKPLAYPFQSLLYL
                     LLALSTVSAFDRTDFAKISVAIRNFLALEPTALASFLYFTALILSLSQQMTSDRIHLY
                     EPSVNGSLWAAEAEEPILVPWIIVNLVVALLVGLSWLFLSYRPGMDLSEELMFFSDVD
                     EHPETGTKASP"
     exon            105..136
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /inference="alignment:Splign:2.1.0"
     exon            137..147
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /inference="alignment:Splign:2.1.0"
     exon            148..204
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /inference="alignment:Splign:2.1.0"
     exon            205..342
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /inference="alignment:Splign:2.1.0"
     exon            343..460
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /inference="alignment:Splign:2.1.0"
     exon            461..618
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /inference="alignment:Splign:2.1.0"
     exon            619..742
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /inference="alignment:Splign:2.1.0"
     exon            743..934
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1008
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1099
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1221
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1836
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1802..1807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /note="hexamer: AATAAA"
     regulatory      1813..1818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /note="hexamer: AATACA"
     polyA_site      1827
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
                     /note="major polyA site"
     polyA_site      1836
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4; Gm972"
ORIGIN      
        1 ggggcgggcc ggaccggggc ggggcgggcg gctgtggtgc cctgagctct gctgcggtcc
       61 ctggagacgt gatggggaag aagcaggtgg ttagcgagcc tcagcgtcct ccacgagcac
      121 tcccacctgt gccaagtgct atccaagacg atattccact tagtcatcct aagaaaaaga
      181 agtccagaac aaaaagctcg ctagctaccg cttcttcgga aggccatgct gagcccgttg
      241 ttaacaggag ggctgaaggc agtgagccac cagctgcaga actcaaggag cacccagaag
      301 ctcctgctcc aaggagacag aagaagataa gaccacctcc tgagttggag acttccctca
      361 ccgaaaggcc atcgagtcca tctctactac ggaacgaaaa cggcattgat gcggagcctc
      421 gtgaggaggc agtgattcca aaaccgagaa ggaaggcaaa gaaaacccag ccagctgagc
      481 cacagtatgc tagcgagcta ggggtggaag atgaagacat actcacagat gagcagagca
      541 ctctagaaca tcactctagg ttcacggcac ccaccggagt tagccagcct gttggcaaag
      601 tatttgtgga aaaaagccgg aggtttcagg cggcggaccg ttccgagttg ataaagacca
      661 cagaaaacat agatgtgtca atggacgtga agccatcttg gactacccga gatgtggcac
      721 tttctgtgca ccgagctttc aggatggtcg gtctgttctc tcatggcttc ttggctggct
      781 gtgctgtgtg gaatactgtt gtgatctacg ttcttgcagg agatcagctg tctaatgtct
      841 ccaaccttct gcagcagtac aagcccttgg cttatccctt ccagagcctt ctttacttgc
      901 ttttggctct aagtacagtt tcagcatttg ataggactga ctttgctaaa atatcagtag
      961 caatccggaa ctttttggcc ctggaaccaa cagctttagc ttcttttctg tattttactg
     1021 ctctaatact atctctgagt cagcaaatga caagtgacag aatccacctt tacgaacctt
     1081 ctgtcaatgg aagcctctgg gcagcagaag ctgaggaacc gattctcgtg ccatggatca
     1141 tagtgaatct ggtggtggct ctcctggttg gattatcctg gctctttctg tcttacagac
     1201 caggcatgga tcttagtgaa gagttaatgt tcttttctga tgtggacgag caccctgaga
     1261 caggaaccaa agcctctcca tagccgctcc ttccctgcag tggcgcctgc gctccccact
     1321 cgtgttttta agtgtatttt tataagatac atgtatttac aattgagctt ttgttacata
     1381 atgctgaaat gctactggag attatgaaaa atgtttcaat tttatctggt ccttatacca
     1441 aactaacatc tttattatta tcaccttagt gatacaggag ataatgagct aaaaaaaaat
     1501 aaaaataaaa taaaaaaaag caggtgatct gtttgtttcc tgttctctca aatttgctaa
     1561 atttataatt attatctaaa aagcaccaat gtagaaaagc cttaacttca gtgttataaa
     1621 atatacatca agttaaaatg taaatttaga aaatggggaa gatgggaaaa tgttttcatt
     1681 ttatattttt gatgtcttat tgaacatact gaagtatata atttgtgttt tctgaatctg
     1741 ctagctttgt gtatcatgta ataattatgt cgtcatttga attgaaagat gctttatagc
     1801 taataaaaca gaaatacatc tctttgacaa gctttaaaaa aaaaaaaaaa aaa
//
