LOCUS       NM_001360185            2356 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transmembrane protein 232 (Tmem232), transcript
            variant 4, mRNA.
ACCESSION   NM_001360185 XM_006524491
VERSION     NM_001360185.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2356)
  AUTHORS   Han,J., Cai,X., Qin,S., Zhang,Z., Wu,Y., Shi,Y., Deng,T., Chen,B.,
            Liu,L., Qian,H., Fang,W. and Xiao,F.
  TITLE     TMEM232 promotes the inflammatory response in atopic dermatitis via
            the nuclear factor-kappaB and signal transducer and activator of
            transcription 3 signalling pathways
  JOURNAL   Br J Dermatol 189 (2), 195-209 (2023)
   PUBMED   36928730
  REMARK    GeneRIF: TMEM232 promotes the inflammatory response in atopic
            dermatitis via the nuclear factor-kappaB and signal transducer and
            activator of transcription 3 signalling pathways.
            Erratum:[Br J Dermatol. 2023 Oct 25;189(5):e83-e87. doi:
            10.1093/bjd/ljad346.. PMID: 37742065]
REFERENCE   2  (bases 1 to 2356)
  AUTHORS   He,X., Mu,W., Wang,Z., Xu,K., Yin,Y., Lu,G., Chan,W.Y., Liu,H.,
            Lv,Y. and Liu,S.
  TITLE     Deficiency of the Tmem232 Gene Causes Male Infertility with
            Morphological Abnormalities of the Sperm Flagellum in Mice
  JOURNAL   Cells 12 (12), 1614 (2023)
   PUBMED   37371084
  REMARK    GeneRIF: Deficiency of the Tmem232 Gene Causes Male Infertility
            with Morphological Abnormalities of the Sperm Flagellum in Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2356)
  AUTHORS   Markiewicz-Potoczny,M., Lobanova,A., Loeb,A.M., Kirak,O.,
            Olbrich,T., Ruiz,S. and Lazzerini Denchi,E.
  TITLE     TRF2-mediated telomere protection is dispensable in pluripotent
            stem cells
  JOURNAL   Nature 589 (7840), 110-115 (2021)
   PUBMED   33239785
REFERENCE   4  (bases 1 to 2356)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030729.8, AC154457.2 and AC154821.2.
            
            On Jan 30, 2018 this sequence version replaced XM_006524491.3.
            
            Transcript Variant: This variant (4) lacks alternate exons in the
            5' UTR, lacks a portion of the 5' coding region, and initiates
            translation at an alternate start codon, compared to variant 1. The
            encoded isoform (c) has a distinct N-terminus and is shorter than
            isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF338468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                CT030729.8         64047-64129         c
            84-195              CT030729.8         40544-40655         c
            196-301             CT030729.8         39936-40041         c
            302-459             CT030729.8         38449-38606         c
            460-559             CT030729.8         32441-32540         c
            560-717             CT030729.8         30690-30847         c
            718-872             CT030729.8         4361-4515           c
            873-996             AC154457.2         119310-119433       c
            997-1249            AC154457.2         113826-114078       c
            1250-1428           AC154457.2         85875-86053         c
            1429-1661           AC154457.2         65469-65701         c
            1662-1755           AC154821.2         88596-88689         c
            1756-2356           AC154821.2         79397-79997         c
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 34.9 cM"
     gene            1..2356
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /note="transmembrane protein 232"
                     /db_xref="GeneID:381107"
                     /db_xref="MGI:MGI:2685786"
     exon            1..83
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1992
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /note="isoform c is encoded by transcript variant 4;
                     testis-specific protein 13"
                     /codon_start=1
                     /product="transmembrane protein 232 isoform c"
                     /protein_id="NP_001347114.1"
                     /db_xref="CCDS:CCDS89135.1"
                     /db_xref="GeneID:381107"
                     /db_xref="MGI:MGI:2685786"
                     /translation="MTSKKWPSFSISKEFILRFNHTDNPAEEEELLEQARRLIVRSKR
                     KLGLKTLGSGKHVHLPTAWAEVIYLAQCKGEIQDEALNMLHASLDHVSFDHDQLPALF
                     FLAESVLYRLCCDAFMKGYLYSVEIKLVKIGYLIFLRLFVFFLHGHLESFKQHLLRLQ
                     PYLYALHFSEPSYYKYPNIISNVQFILKTSEIICKRELHSEPFVESPDETEDPYSDLN
                     HLQLNKRGYEVNHLLWHSVAAWSCVQNNRPQLTEVLEHLLFYKTQLQTKCWLDSALAL
                     MVLGEAAKLDMACLKTLMDLVTDFLENILSAQNQEENYNIYDTSWASEIVFTYTTIIA
                     EVCLYAATSDLRKTALIGFCACKSPQQGISLTDKSEELPELDGASILTLLKYFSSRIS
                     DNCEKVIWIGYYGIVYNLVKMSWELQGEQDQDGLRNMIWQTLQKIKDYEQDPRIRCAL
                     VIAQAELNGPSDPFCTKATPNSGEEVFSKYIGWRIATTLSRLFFPSLDVAPPKTPVEV
                     DLPRKHTIRERQPAKKRVLRFILKDHSSVVEVSMTPYPNFFTKADKKLEEIIDHHWQK
                     DMEARKREEEAYKAQNQKDKEEKEKIHFQEIMKQRERKLNKQTKPYEIILSEKESGSE
                     KKCGFFELKPSTAPNAK"
     exon            84..195
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            196..301
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            302..459
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            460..559
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            560..717
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            718..872
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            873..996
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1249
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1428
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1661
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1755
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..2356
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2337..2342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /note="hexamer: AATAAA"
     polyA_site      2356
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /note="major polyA site"
ORIGIN      
        1 aaatgccaag gcaagccaat gccatacagc atagtcagcg aagactaaag tcagcaaaga
       61 ccagtgatga ccagcaaaaa atggccatca ttttcaattt ccaaagaatt catattgaga
      121 ttcaaccaca cagataatcc agcagaggag gaagaactgt tggaacaagc caggagactc
      181 atcgtcaggt ctaagaggaa gttgggcctc aagacactgg gctctgggaa gcatgtgcat
      241 cttccgaccg catgggctga ggtcatctat ctggctcagt gcaaagggga gatccaagat
      301 gaagctttaa atatgctcca cgcctccttg gaccatgtct cctttgatca cgatcagctt
      361 cctgccctgt tttttctcgc ggaatccgtt ttatatcgac tctgttgcga tgcattcatg
      421 aagggatatt tatattcagt tgagataaaa ctggtgaaga ttggctattt gatcttctta
      481 cggctttttg tattcttcct gcatggtcac ttagaaagct ttaaacaaca tttgcttagg
      541 ctgcagccat atttatacgc acttcatttc tcggaaccgt cctactacaa gtatccgaac
      601 atcatctcca acgtgcagtt catcctgaaa acatcggaaa ttatctgtaa aagagagctt
      661 cattctgaac cattcgtgga aagcccagat gaaactgagg atccatattc tgacctgaat
      721 catttgcagc tgaataagag gggctacgaa gtcaaccacc tgctctggca cagtgtggcc
      781 gcctggtcct gcgttcagaa caatcgtcct cagctcaccg aagtgctgga acacctcctc
      841 ttctacaaaa cgcagcttca gacgaaatgc tggttggatt cagccctggc tttgatggtc
      901 ctgggggaag ctgctaagct ggacatggcc tgcttgaaaa cactgatgga cctagtgaca
      961 gatttccttg agaacatctt gtctgctcag aaccaggaag agaactataa tatatatgat
     1021 acttcctggg cctcagagat tgtattcaca tatacaacaa ttattgcaga agtctgtctg
     1081 tatgcagcta cctctgacct gaggaaaaca gctttgattg ggttctgtgc ctgtaaaagt
     1141 ccgcagcaag gtatttccct cacagacaag tctgaagagc tgccagagtt ggatggcgca
     1201 agcattttaa ctcttctgaa gtatttctct tccagaatct ctgataactg tgagaaggtg
     1261 atctggattg gatactatgg catagtgtat aacctggtga agatgtcatg ggaacttcag
     1321 ggtgagcagg atcaggatgg acttagaaac atgatatggc aaacactgca aaagataaag
     1381 gattatgagc aagacccacg gatccgatgt gcattagtta tagcccaggc cgaattaaat
     1441 ggcccatctg accctttctg cacaaaggcc acaccaaact caggagaaga agttttctcc
     1501 aagtacatcg ggtggagaat cgctactact ctctccagac tctttttccc ctctctcgat
     1561 gttgcccctc caaagacgcc agtggaagtg gacctgccaa gaaaacacac catcagagaa
     1621 cgccagcctg caaaaaagag agttctgcgc tttatcttga aggatcattc ttctgtggta
     1681 gaagtttcca tgactccgta tccaaatttc ttcaccaagg cagataagaa attggaagaa
     1741 atcattgatc atcattggca gaaagatatg gaggcccgaa agcgagaaga ggaagcatat
     1801 aaggcccaaa atcagaagga caaggaggaa aaggagaaga ttcactttca agaaattatg
     1861 aagcaaagag aacggaaact gaacaaacaa accaaaccct atgaaataat tctgtcagaa
     1921 aaagaaagtg gctcagaaaa gaaatgtggg ttcttcgagc tgaaacccag caccgcacca
     1981 aatgctaagt gaactcggtg tagaagagtt ttcttagagt cagtctgcag ccatttttaa
     2041 aaaggagttg ctattttggc acccattagt agtcacagca tagtcttaaa ttaatagtca
     2101 actcttcttc acattaggtg aagtagtttt tccagctaca cccattcttc cctcagcggc
     2161 tctccccttg ttcgaggatc gctctttcaa ccactctcag cactgatatt ctctgcacca
     2221 tgagaagaat gtgaaatgaa gtctgatcat caagtcagaa catgaggggg tggtaagaat
     2281 ttttctttag agtgtgaatg aacatggggt tgagtcccta gaatcacttc tatttgaata
     2341 aagaaattag gatggc
//
