LOCUS       NM_001289485            2679 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transmembrane protein 232 (Tmem232), transcript
            variant 1, mRNA.
ACCESSION   NM_001289485
VERSION     NM_001289485.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2679)
  AUTHORS   Han,J., Cai,X., Qin,S., Zhang,Z., Wu,Y., Shi,Y., Deng,T., Chen,B.,
            Liu,L., Qian,H., Fang,W. and Xiao,F.
  TITLE     TMEM232 promotes the inflammatory response in atopic dermatitis via
            the nuclear factor-kappaB and signal transducer and activator of
            transcription 3 signalling pathways
  JOURNAL   Br J Dermatol 189 (2), 195-209 (2023)
   PUBMED   36928730
  REMARK    GeneRIF: TMEM232 promotes the inflammatory response in atopic
            dermatitis via the nuclear factor-kappaB and signal transducer and
            activator of transcription 3 signalling pathways.
            Erratum:[Br J Dermatol. 2023 Oct 25;189(5):e83-e87. doi:
            10.1093/bjd/ljad346.. PMID: 37742065]
REFERENCE   2  (bases 1 to 2679)
  AUTHORS   He,X., Mu,W., Wang,Z., Xu,K., Yin,Y., Lu,G., Chan,W.Y., Liu,H.,
            Lv,Y. and Liu,S.
  TITLE     Deficiency of the Tmem232 Gene Causes Male Infertility with
            Morphological Abnormalities of the Sperm Flagellum in Mice
  JOURNAL   Cells 12 (12), 1614 (2023)
   PUBMED   37371084
  REMARK    GeneRIF: Deficiency of the Tmem232 Gene Causes Male Infertility
            with Morphological Abnormalities of the Sperm Flagellum in Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2679)
  AUTHORS   Markiewicz-Potoczny,M., Lobanova,A., Loeb,A.M., Kirak,O.,
            Olbrich,T., Ruiz,S. and Lazzerini Denchi,E.
  TITLE     TRF2-mediated telomere protection is dispensable in pluripotent
            stem cells
  JOURNAL   Nature 589 (7840), 110-115 (2021)
   PUBMED   33239785
REFERENCE   4  (bases 1 to 2679)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB618060.1, CT030729.8, BC150885.1 and BX638107.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 3
            encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF338469.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BB618060.1         2-74
            74-158              CT030729.8         92419-92503         c
            159-2495            BC150885.1         36-2372
            2496-2679           BX638107.1         1-184               c
FEATURES             Location/Qualifiers
     source          1..2679
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 34.9 cM"
     gene            1..2679
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /note="transmembrane protein 232"
                     /db_xref="GeneID:381107"
                     /db_xref="MGI:MGI:2685786"
     exon            1..73
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            74..158
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            159..265
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            266..400
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..2309
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /note="isoform a is encoded by transcript variant 1;
                     testis-specific protein 13"
                     /codon_start=1
                     /product="transmembrane protein 232 isoform a"
                     /protein_id="NP_001276414.1"
                     /db_xref="CCDS:CCDS28940.1"
                     /db_xref="GeneID:381107"
                     /db_xref="MGI:MGI:2685786"
                     /translation="MKAYKPPVVNKFGVISSTYHEELLKSIFESSNRRKSQKPKPSFS
                     ISKEFILRFNHTDNPAEEEELLEQARRLIVRSKRKLGLKTLGSGKHVHLPTAWAEVIY
                     LAQCKGEIQDEALNMLHASLDHVSFDHDQLPALFFLAESVLYRLCCDAFMKGYLYSVE
                     IKLVKIGYLIFLRLFVFFLHGHLESFKQHLLRLQPYLYALHFSEPSYYKYPNIISNVQ
                     FILKTSEIICKRELHSEPFVESPDETEDPYSDLNHLQLNKRGYEVNHLLWHSVAAWSC
                     VQNNRPQLTEVLEHLLFYKTQLQTKCWLDSALALMVLGEAAKLDMACLKTLMDLVTDF
                     LENILSAQNQEENYNIYDTSWASEIVFTYTTIIAEVCLYAATSDLRKTALIGFCACKS
                     PQQGISLTDKSEELPELDGASILTLLKYFSSRISDNCEKVIWIGYYGIVYNLVKMSWE
                     LQGEQDQDGLRNMIWQTLQKIKDYEQDPRIRCALVIAQAELNGPSDPFCTKATPNSGE
                     EVFSKYIGWRIATTLSRLFFPSLDVAPPKTPVEVDLPRKHTIRERQPAKKRVLRFILK
                     DHSSVVEVSMTPYPNFFTKADKKLEEIIDHHWQKDMEARKREEEAYKAQNQKDKEEKE
                     KIHFQEIMKQRERKLNKQTKPYEIILSEKESGSEKKCGFFELKPSTAPNAK"
     exon            401..512
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            513..618
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            619..776
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            777..876
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1034
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1189
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1313
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1566
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1745
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1978
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2072
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2673
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2654..2659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /note="hexamer: AATAAA"
     polyA_site      2673
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /note="major polyA site"
ORIGIN      
        1 agccagcggg ctccaagagc gacttacaca gcatccttag caaccagctg gagagcctgg
       61 cgggagcgct ggggaagata acttctcggc cactcttctg tcacccagca aggaagaaga
      121 aatagaaaga aagaaggctc catggatccg ccagaaagat aaatatcttc aagataaggt
      181 cttgggagct attggagccg gtgcagccac cttgcaggac agaagagaga atatagattc
      241 gacttcagac gaattcctct acagggtttt gatctgtaac tatgaaagct tataagccac
      301 ctgtggtcaa taagtttgga gtaatatctt ccacttatca tgaagaactc ctgaaatcta
      361 tttttgaaag ttcaaacaga agaaagagtc aaaaaccaaa gccatcattt tcaatttcca
      421 aagaattcat attgagattc aaccacacag ataatccagc agaggaggaa gaactgttgg
      481 aacaagccag gagactcatc gtcaggtcta agaggaagtt gggcctcaag acactgggct
      541 ctgggaagca tgtgcatctt ccgaccgcat gggctgaggt catctatctg gctcagtgca
      601 aaggggagat ccaagatgaa gctttaaata tgctccacgc ctccttggac catgtctcct
      661 ttgatcacga tcagcttcct gccctgtttt ttctcgcgga atccgtttta tatcgactct
      721 gttgcgatgc attcatgaag ggatatttat attcagttga gataaaactg gtgaagattg
      781 gctatttgat cttcttacgg ctttttgtat tcttcctgca tggtcactta gaaagcttta
      841 aacaacattt gcttaggctg cagccatatt tatacgcact tcatttctcg gaaccgtcct
      901 actacaagta tccgaacatc atctccaacg tgcagttcat cctgaaaaca tcggaaatta
      961 tctgtaaaag agagcttcat tctgaaccat tcgtggaaag cccagatgaa actgaggatc
     1021 catattctga cctgaatcat ttgcagctga ataagagggg ctacgaagtc aaccacctgc
     1081 tctggcacag tgtggccgcc tggtcctgcg ttcagaacaa tcgtcctcag ctcaccgaag
     1141 tgctggaaca cctcctcttc tacaaaacgc agcttcagac gaaatgctgg ttggattcag
     1201 ccctggcttt gatggtcctg ggggaagctg ctaagctgga catggcctgc ttgaaaacac
     1261 tgatggacct agtgacagat ttccttgaga acatcttgtc tgctcagaac caggaagaga
     1321 actataatat atatgatact tcctgggcct cagagattgt attcacatat acaacaatta
     1381 ttgcagaagt ctgtctgtat gcagctacct ctgacctgag gaaaacagct ttgattgggt
     1441 tctgtgcctg taaaagtccg cagcaaggta tttccctcac agacaagtct gaagagctgc
     1501 cagagttgga tggcgcaagc attttaactc ttctgaagta tttctcttcc agaatctctg
     1561 ataactgtga gaaggtgatc tggattggat actatggcat agtgtataac ctggtgaaga
     1621 tgtcatggga acttcagggt gagcaggatc aggatggact tagaaacatg atatggcaaa
     1681 cactgcaaaa gataaaggat tatgagcaag acccacggat ccgatgtgca ttagttatag
     1741 cccaggccga attaaatggc ccatctgacc ctttctgcac aaaggccaca ccaaactcag
     1801 gagaagaagt tttctccaag tacatcgggt ggagaatcgc tactactctc tccagactct
     1861 ttttcccctc tctcgatgtt gcccctccaa agacgccagt ggaagtggac ctgccaagaa
     1921 aacacaccat cagagaacgc cagcctgcaa aaaagagagt tctgcgcttt atcttgaagg
     1981 atcattcttc tgtggtagaa gtttccatga ctccgtatcc aaatttcttc accaaggcag
     2041 ataagaaatt ggaagaaatc attgatcatc attggcagaa agatatggag gcccgaaagc
     2101 gagaagagga agcatataag gcccaaaatc agaaggacaa ggaggaaaag gagaagattc
     2161 actttcaaga aattatgaag caaagagaac ggaaactgaa caaacaaacc aaaccctatg
     2221 aaataattct gtcagaaaaa gaaagtggct cagaaaagaa atgtgggttc ttcgagctga
     2281 aacccagcac cgcaccaaat gctaagtgaa ctcggtgtag aagagttttc ttagagtcag
     2341 tctgcagcca tttttaaaaa ggagttgcta ttttggcacc cattagtagt cacagcatag
     2401 tcttaaatta atagtcaact cttcttcaca ttaggtgaag tagtttttcc agctacaccc
     2461 attcttccct cagcggctct ccccttgttc gaggatcgct ctttcaacca ctctcagcac
     2521 tgatattctc tgcaccatga gaagaatgtg aaatgaagtc tgatcatcaa gtcagaacat
     2581 gagggggtgg taagaatttt tctttagagt gtgaatgaac atggggttga gtccctagaa
     2641 tcacttctat ttgaataaag aaattaggat ggcaaaaaa
//
