LOCUS       NM_001008973            2608 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transmembrane protein 232 (Tmem232), transcript
            variant 3, mRNA.
ACCESSION   NM_001008973 XM_355025
VERSION     NM_001008973.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2608)
  AUTHORS   Han,J., Cai,X., Qin,S., Zhang,Z., Wu,Y., Shi,Y., Deng,T., Chen,B.,
            Liu,L., Qian,H., Fang,W. and Xiao,F.
  TITLE     TMEM232 promotes the inflammatory response in atopic dermatitis via
            the nuclear factor-kappaB and signal transducer and activator of
            transcription 3 signalling pathways
  JOURNAL   Br J Dermatol 189 (2), 195-209 (2023)
   PUBMED   36928730
  REMARK    GeneRIF: TMEM232 promotes the inflammatory response in atopic
            dermatitis via the nuclear factor-kappaB and signal transducer and
            activator of transcription 3 signalling pathways.
            Erratum:[Br J Dermatol. 2023 Oct 25;189(5):e83-e87. doi:
            10.1093/bjd/ljad346.. PMID: 37742065]
REFERENCE   2  (bases 1 to 2608)
  AUTHORS   He,X., Mu,W., Wang,Z., Xu,K., Yin,Y., Lu,G., Chan,W.Y., Liu,H.,
            Lv,Y. and Liu,S.
  TITLE     Deficiency of the Tmem232 Gene Causes Male Infertility with
            Morphological Abnormalities of the Sperm Flagellum in Mice
  JOURNAL   Cells 12 (12), 1614 (2023)
   PUBMED   37371084
  REMARK    GeneRIF: Deficiency of the Tmem232 Gene Causes Male Infertility
            with Morphological Abnormalities of the Sperm Flagellum in Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2608)
  AUTHORS   Markiewicz-Potoczny,M., Lobanova,A., Loeb,A.M., Kirak,O.,
            Olbrich,T., Ruiz,S. and Lazzerini Denchi,E.
  TITLE     TRF2-mediated telomere protection is dispensable in pluripotent
            stem cells
  JOURNAL   Nature 589 (7840), 110-115 (2021)
   PUBMED   33239785
REFERENCE   4  (bases 1 to 2608)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB618060.1, AF338469.1, DV662151.1, BB538070.2 and CAAA01027226.1.
            
            On Aug 29, 2006 this sequence version replaced NM_001008973.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 3 encode the same protein
            (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150885.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-557               BB618060.1         2-558
            558-1500            AF338469.1         637-1579
            1501-1766           DV662151.1         461-726
            1767-2092           BB538070.2         345-670
            2093-2586           AF338469.1         2172-2665
            2587-2587           CAAA01027226.1     29184-29184         c
            2588-2608           AF338469.1         2667-2687
FEATURES             Location/Qualifiers
     source          1..2608
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 34.9 cM"
     gene            1..2608
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /note="transmembrane protein 232"
                     /db_xref="GeneID:381107"
                     /db_xref="MGI:MGI:2685786"
     exon            1..73
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            74..180
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            181..315
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..2224
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /note="isoform a is encoded by transcript variant 3;
                     testis-specific protein 13"
                     /codon_start=1
                     /product="transmembrane protein 232 isoform a"
                     /protein_id="NP_001008973.2"
                     /db_xref="CCDS:CCDS28940.1"
                     /db_xref="GeneID:381107"
                     /db_xref="MGI:MGI:2685786"
                     /translation="MKAYKPPVVNKFGVISSTYHEELLKSIFESSNRRKSQKPKPSFS
                     ISKEFILRFNHTDNPAEEEELLEQARRLIVRSKRKLGLKTLGSGKHVHLPTAWAEVIY
                     LAQCKGEIQDEALNMLHASLDHVSFDHDQLPALFFLAESVLYRLCCDAFMKGYLYSVE
                     IKLVKIGYLIFLRLFVFFLHGHLESFKQHLLRLQPYLYALHFSEPSYYKYPNIISNVQ
                     FILKTSEIICKRELHSEPFVESPDETEDPYSDLNHLQLNKRGYEVNHLLWHSVAAWSC
                     VQNNRPQLTEVLEHLLFYKTQLQTKCWLDSALALMVLGEAAKLDMACLKTLMDLVTDF
                     LENILSAQNQEENYNIYDTSWASEIVFTYTTIIAEVCLYAATSDLRKTALIGFCACKS
                     PQQGISLTDKSEELPELDGASILTLLKYFSSRISDNCEKVIWIGYYGIVYNLVKMSWE
                     LQGEQDQDGLRNMIWQTLQKIKDYEQDPRIRCALVIAQAELNGPSDPFCTKATPNSGE
                     EVFSKYIGWRIATTLSRLFFPSLDVAPPKTPVEVDLPRKHTIRERQPAKKRVLRFILK
                     DHSSVVEVSMTPYPNFFTKADKKLEEIIDHHWQKDMEARKREEEAYKAQNQKDKEEKE
                     KIHFQEIMKQRERKLNKQTKPYEIILSEKESGSEKKCGFFELKPSTAPNAK"
     exon            316..427
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            428..533
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            534..691
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            692..791
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            792..949
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1104
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1228
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1481
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1660
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1893
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1987
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2588
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2569..2574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /note="hexamer: AATAAA"
     polyA_site      2588
                     /gene="Tmem232"
                     /gene_synonym="E130009J12Rik; Gm940; Tes13-L; Tes13-S"
                     /note="major polyA site"
ORIGIN      
        1 agccagcggg ctccaagagc gacttacaca gcatccttag caaccagctg gagagcctgg
       61 cgggagcgct gggataaata tcttcaagat aaggtcttgg gagctattgg agccggtgca
      121 gccaccttgc aggacagaag agagaatata gattcgactt cagacgaatt cctctacagg
      181 gttttgatct gtaactatga aagcttataa gccacctgtg gtcaataagt ttggagtaat
      241 atcttccact tatcatgaag aactcctgaa atctattttt gaaagttcaa acagaagaaa
      301 gagtcaaaaa ccaaagccat cattttcaat ttccaaagaa ttcatattga gattcaacca
      361 cacagataat ccagcagagg aggaagaact gttggaacaa gccaggagac tcatcgtcag
      421 gtctaagagg aagttgggcc tcaagacact gggctctggg aagcatgtgc atcttccgac
      481 cgcatgggct gaggtcatct atctggctca gtgcaaaggg gagatccaag atgaagcttt
      541 aaatatgctc cacgcctcct tggaccatgt ctcctttgat cacgatcagc ttcctgccct
      601 gttttttctc gcggaatccg ttttatatcg actctgttgc gatgcattca tgaagggata
      661 tttatattca gttgagataa aactggtgaa gattggctat ttgatcttct tacggctttt
      721 tgtattcttc ctgcatggtc acttagaaag ctttaaacaa catttgctta ggctgcagcc
      781 atatttatac gcacttcatt tctcggaacc gtcctactac aagtatccga acatcatctc
      841 caacgtgcag ttcatcctga aaacatcgga aattatctgt aaaagagagc ttcattctga
      901 accattcgtg gaaagcccag atgaaactga ggatccatat tctgacctga atcatttgca
      961 gctgaataag aggggctacg aagtcaacca cctgctctgg cacagtgtgg ccgcctggtc
     1021 ctgcgttcag aacaatcgtc ctcagctcac cgaagtgctg gaacacctcc tcttctacaa
     1081 aacgcagctt cagacgaaat gctggttgga ttcagccctg gctttgatgg tcctggggga
     1141 agctgctaag ctggacatgg cctgcttgaa aacactgatg gacctagtga cagatttcct
     1201 tgagaacatc ttgtctgctc agaaccagga agagaactat aatatatatg atacttcctg
     1261 ggcctcagag attgtattca catatacaac aattattgca gaagtctgtc tgtatgcagc
     1321 tacctctgac ctgaggaaaa cagctttgat tgggttctgt gcctgtaaaa gtccgcagca
     1381 aggtatttcc ctcacagaca agtctgaaga gctgccagag ttggatggcg caagcatttt
     1441 aactcttctg aagtatttct cttccagaat ctctgataac tgtgagaagg tgatctggat
     1501 tggatactat ggcatagtgt ataacctggt gaagatgtca tgggaacttc agggtgagca
     1561 ggatcaggat ggacttagaa acatgatatg gcaaacactg caaaagataa aggattatga
     1621 gcaagaccca cggatccgat gtgcattagt tatagcccag gccgaattaa atggcccatc
     1681 tgaccctttc tgcacaaagg ccacaccaaa ctcaggagaa gaagttttct ccaagtacat
     1741 cgggtggaga atcgctacta ctctctccag actctttttc ccctctctcg atgttgcccc
     1801 tccaaagacg ccagtggaag tggacctgcc aagaaaacac accatcagag aacgccagcc
     1861 tgcaaaaaag agagttctgc gctttatctt gaaggatcat tcttctgtgg tagaagtttc
     1921 catgactccg tatccaaatt tcttcaccaa ggcagataag aaattggaag aaatcattga
     1981 tcatcattgg cagaaagata tggaggcccg aaagcgagaa gaggaagcat ataaggccca
     2041 aaatcagaag gacaaggagg aaaaggagaa gattcacttt caagaaatta tgaagcaaag
     2101 agaacggaaa ctgaacaaac aaaccaaacc ctatgaaata attctgtcag aaaaagaaag
     2161 tggctcagaa aagaaatgtg ggttcttcga gctgaaaccc agcaccgcac caaatgctaa
     2221 gtgaactcgg tgtagaagag ttttcttaga gtcagtctgc agccattttt aaaaaggagt
     2281 tgctattttg gcacccatta gtagtcacag catagtctta aattaatagt caactcttct
     2341 tcacattagg tgaagtagtt tttccagcta cacccattct tccctcagcg gctctcccct
     2401 tgttcgagga tcgctctttc aaccactctc agcactgata ttctctgcac catgagaaga
     2461 atgtgaaatg aagtctgatc atcaagtcag aacatgaggg ggtggtaaga atttttcttt
     2521 agagtgtgaa tgaacatggg gttgagtccc tagaatcact tctatttgaa taaagaaatt
     2581 aggatggcaa aaaaaaaaaa aaaaaaaa
//
