LOCUS       NM_001033321            2923 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus transmembrane protein 231 (Tmem231), transcript
            variant 1, mRNA.
ACCESSION   NM_001033321 XM_134593
VERSION     NM_001033321.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2923)
  AUTHORS   Abrams,S.R. and Reiter,J.F.
  TITLE     Ciliary Hedgehog signaling regulates cell survival to build the
            facial midline
  JOURNAL   Elife 10, e68558 (2021)
   PUBMED   34672258
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2923)
  AUTHORS   Roberson,E.C., Dowdle,W.E., Ozanturk,A., Garcia-Gonzalo,F.R.,
            Li,C., Halbritter,J., Elkhartoufi,N., Porath,J.D., Cope,H.,
            Ashley-Koch,A., Gregory,S., Thomas,S., Sayer,J.A., Saunier,S.,
            Otto,E.A., Katsanis,N., Davis,E.E., Attie-Bitach,T.,
            Hildebrandt,F., Leroux,M.R. and Reiter,J.F.
  TITLE     TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes
            the ciliary transition zone
  JOURNAL   J Cell Biol 209 (1), 129-142 (2015)
   PUBMED   25869670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY031259.1, BC100402.1 and AU254458.1.
            
            On Oct 26, 2017 this sequence version replaced NM_001033321.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155425.1, BC100402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BY031259.1         2-39
            39-2494             BC100402.1         1-2456
            2495-2767           BC100402.1         2459-2731
            2768-2923           AU254458.1         1-156
FEATURES             Location/Qualifiers
     source          1..2923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 58.15 cM"
     gene            1..2923
                     /gene="Tmem231"
                     /gene_synonym="4932417I16Rik; Gm178"
                     /note="transmembrane protein 231"
                     /db_xref="GeneID:234740"
                     /db_xref="MGI:MGI:2685024"
     exon            1..186
                     /gene="Tmem231"
                     /gene_synonym="4932417I16Rik; Gm178"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..995
                     /gene="Tmem231"
                     /gene_synonym="4932417I16Rik; Gm178"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 231 isoform 1"
                     /protein_id="NP_001028493.1"
                     /db_xref="CCDS:CCDS52676.1"
                     /db_xref="GeneID:234740"
                     /db_xref="MGI:MGI:2685024"
                     /translation="MALYHLFSHPIERAYRAGLCSKAALFLLLTTALTYIPPLLVAFR
                     SHGFWLKRSSYEEQPNVRFQHQVLLVALLGPEPEAFLAWSTFPTFNRLQGAHLRVPLV
                     SSREEDRNQDGKMDVLYFKLELPLQPTEHVLGVQLILTFSYQLHRMSTFEMQSMAFLQ
                     SSFAVPGSQLYVNGDLRLQQKQPLSYRGLDIRYNVSVINGTSPFAQDYDLTHIVAAYQ
                     ERNVTTVLSDPNPIWLVGRAAEAPFVIHAVIRYPTEVISYQPGFWEMIKFAWIQYVSI
                     LLIFLWVFERIKIFVFQNQVVTSIPVAVPQGEIRKEHLS"
     exon            187..356
                     /gene="Tmem231"
                     /gene_synonym="4932417I16Rik; Gm178"
                     /inference="alignment:Splign:2.1.0"
     exon            357..485
                     /gene="Tmem231"
                     /gene_synonym="4932417I16Rik; Gm178"
                     /inference="alignment:Splign:2.1.0"
     exon            486..629
                     /gene="Tmem231"
                     /gene_synonym="4932417I16Rik; Gm178"
                     /inference="alignment:Splign:2.1.0"
     exon            630..711
                     /gene="Tmem231"
                     /gene_synonym="4932417I16Rik; Gm178"
                     /inference="alignment:Splign:2.1.0"
     exon            712..817
                     /gene="Tmem231"
                     /gene_synonym="4932417I16Rik; Gm178"
                     /inference="alignment:Splign:2.1.0"
     exon            818..2920
                     /gene="Tmem231"
                     /gene_synonym="4932417I16Rik; Gm178"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2897..2902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem231"
                     /gene_synonym="4932417I16Rik; Gm178"
                     /note="hexamer: ATTAAA"
     polyA_site      2916
                     /gene="Tmem231"
                     /gene_synonym="4932417I16Rik; Gm178"
                     /note="major polyA site"
ORIGIN      
        1 gcccgccgtc ggttgccgtg gagactcggc gctgcggccc tgcgctcatg gcgctgtacc
       61 atctcttctc tcacccaatc gagcgcgctt accgcgcggg gctctgctcc aaggccgcgc
      121 tcttcctgct gttgaccacc gcgctcacct acatcccccc gctgctggtg gccttccgga
      181 gccacgggtt ttggctgaag cggagcagct acgaggagca gccgaacgtg cgcttccagc
      241 accaagtgct gctcgtggct ctcctggggc cggagcctga agccttcctc gcctggagca
      301 cgttccccac cttcaaccgg ctgcaggggg ctcacctgcg cgtcccgctc gtgtcgtcca
      361 gagaagaaga ccggaaccag gatggaaaaa tggatgtgct gtactttaaa cttgaacttc
      421 ccctgcaacc cacagagcat gtcctcggtg tgcagctaat cctgaccttc tcctaccaac
      481 tgcacaggat gtcaacattc gagatgcaga gcatggcctt tctccagtcc tcctttgctg
      541 tccctgggtc acagttatat gtgaatggcg acctgaggct gcaacagaag cagccactga
      601 gctaccgtgg cctggacatc agatacaacg tgtccgtgat caatgggaca agtccttttg
      661 cccaggacta cgacctcacc cacattgttg ccgcctatca ggaaagaaat gttaccactg
      721 tcctcagtga ccccaacccg atctggctgg tgggcagagc cgctgaagct ccgttcgtga
      781 tccatgctgt catccgctat cccacggaag tcatttctta ccagccaggg ttctgggaga
      841 tgatcaagtt cgcctggatc cagtatgtca gcatcctgct gatcttcctc tgggtgtttg
      901 aaagaatcaa aatcttcgtg tttcagaacc aagtagtgac ctctatccct gtagccgtgc
      961 cccagggaga gatacggaaa gagcacttat cctgagaaga taccccgtca ggagcccgag
     1021 ggaccgcggc tacctcattc ctgtcttctg agacctgcca tcttacaaca tttctgcgaa
     1081 gagcccaccg gacactttca ggcctgcatg tttcacttca gagacaacgg tttttccagg
     1141 gctggactgc acaaaatcca cgccttcaaa gcaccgaggg aacccacaaa cactagtttg
     1201 tggaaaggtc tcagggtggc cggaggctgt gattttcgtt ttgttttgtt ttgtttctgg
     1261 ttttgctttg ctttgctttg ctttggcctt gaatttcagg gagacaatta ctgtgagttc
     1321 atacatcttt gaaagagccc cacctccggt caagcgaaga gtcttttgag ctgggacgcc
     1381 ctgcgcactc ctatctccta tcataagcta gccgctttct tagcctcccc aggggctctc
     1441 acaagaaaca cgcaagcccc gagtacattc tactcctagg tatctacaca gtgcccattc
     1501 agaactttga tttccagaac tgaagcctct taactggaga ccgaaagggg gcaggccagg
     1561 acctaaatac aagcggctca gaaccgcgtg cttgctggcg ggtaacttaa gggcaggagg
     1621 accagacacc tgccctcagg ctaataggtg ggggtctgtc atcagctcag ctgaacggcc
     1681 ctctgttcct ggtgcggctg gctctgtgcc ctgtttcttg ccctctgtct gtgcccctgg
     1741 gatggcggct ggagtcagaa gcgcctgctt cattcagtcc gtccgcctac cccctccctg
     1801 caccagggga ggatggtggg cttctaacaa ctggttcttt ctccctggct ctcacccaac
     1861 agcctggcca ctcctccttg atggccttcc ccctttctga aaggatgtgg gtgacagagg
     1921 ggttgttgtt ggcattggct tccactgcct gacaaccgca gggtttattt ggaggctgag
     1981 ctgaaaactc agttgttttg cagttccctt gattaaggaa cagagtactt aacagagggg
     2041 aggctctggg ggaaggcatg aggagggtga ggaaagaggc tgagcagagc atctaagcca
     2101 gcctggccat taaaggagtg acaagaagcc tagccagata gccctgtaat ctatagaggt
     2161 atgtatctac aaagacatct actctgcatc caaaactgtt atttggcccc gttccttccc
     2221 ctagcaagtg tgctctccta aaaaactctg ccacatcatt agccctgccc tgaaaggact
     2281 tccctacccc atcccccatg cctccaggtc taaccacaaa cactcctcac cacgtgcctc
     2341 agtttacctt ggagacatcc ttctgtcagg ctgagcaaag taagaatttt gaaaataaag
     2401 ctattttgag tattcaggga gaaaaactct ctggtactag tttctccgac ttaacacagc
     2461 tgattatgtg cctgagtggg gttttttttt ttttctgaag atatacatga aaaaaatggt
     2521 ctctgatttc aatttcaaaa aggttatgag atgtggctca gttggaagag cgcttgcctg
     2581 gcacacttgg agccctgtgt tccatcccca gctacacata aacctttatg gtggtgcaag
     2641 cctataaccc cggtgcattg tgggtggagg caggagcaga gaaattcagg atcatccttg
     2701 agttagagcc cagccgggga cacttgagac cctatctcaa taaaataagg aaatggggtt
     2761 ggggcatgat cagaagtata ttgtatggaa aaaagatagc aagacacaga aagatgacca
     2821 aagatacttt gcattaaatt aaactatcct gtgcaaaaat tgtactgaga actcaatgat
     2881 gttttataac tttctaatta aaatattcca aaagaacgtt aaa
//
