LOCUS       NP_001028493             315 aa            linear   ROD 05-JUN-2024
DEFINITION  transmembrane protein 231 isoform 1 [Mus musculus].
ACCESSION   NP_001028493 XP_134593
VERSION     NP_001028493.1
DBSOURCE    REFSEQ: accession NM_001033321.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 315)
  AUTHORS   Abrams,S.R. and Reiter,J.F.
  TITLE     Ciliary Hedgehog signaling regulates cell survival to build the
            facial midline
  JOURNAL   Elife 10, e68558 (2021)
   PUBMED   34672258
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 315)
  AUTHORS   Roberson,E.C., Dowdle,W.E., Ozanturk,A., Garcia-Gonzalo,F.R.,
            Li,C., Halbritter,J., Elkhartoufi,N., Porath,J.D., Cope,H.,
            Ashley-Koch,A., Gregory,S., Thomas,S., Sayer,J.A., Saunier,S.,
            Otto,E.A., Katsanis,N., Davis,E.E., Attie-Bitach,T.,
            Hildebrandt,F., Leroux,M.R. and Reiter,J.F.
  TITLE     TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes
            the ciliary transition zone
  JOURNAL   J Cell Biol 209 (1), 129-142 (2015)
   PUBMED   25869670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY031259.1, BC100402.1 and AU254458.1.
            
            On Sep 16, 2005 this sequence version replaced XP_134593.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155425.1, BC100402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 58.15 cM"
     Protein         1..315
                     /product="transmembrane protein 231 isoform 1"
                     /calculated_mol_wt=36130
     Region          1..301
                     /region_name="TM231"
                     /note="Transmembrane protein 231; pfam10149"
                     /db_xref="CDD:462964"
     Site            23..43
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U284.1)"
     Site            194
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q3U284.1)"
     Site            199
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q3U284.1)"
     Site            221
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q3U284.1)"
     Site            262..282
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U284.1)"
     CDS             1..315
                     /gene="Tmem231"
                     /gene_synonym="4932417I16Rik; Gm178"
                     /coded_by="NM_001033321.2:48..995"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS52676.1"
                     /db_xref="GeneID:234740"
                     /db_xref="MGI:MGI:2685024"
ORIGIN      
        1 malyhlfshp ierayraglc skaalflllt taltyippll vafrshgfwl krssyeeqpn
       61 vrfqhqvllv allgpepeaf lawstfptfn rlqgahlrvp lvssreedrn qdgkmdvlyf
      121 klelplqpte hvlgvqlilt fsyqlhrmst femqsmaflq ssfavpgsql yvngdlrlqq
      181 kqplsyrgld irynvsving tspfaqdydl thivaayqer nvttvlsdpn piwlvgraae
      241 apfvihavir yptevisyqp gfwemikfaw iqyvsillif lwvferikif vfqnqvvtsi
      301 pvavpqgeir kehls
//
