LOCUS       NM_178745               3865 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane protein 229B (Tmem229b), transcript
            variant 1, mRNA.
ACCESSION   NM_178745
VERSION     NM_178745.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3865)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3865)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3865)
  AUTHORS   Zhao,S., Lu,L., Liu,Q., Chen,J., Yuan,Q., Qiu,S. and Wang,X.
  TITLE     MiR-505 promotes M2 polarization in choroidal neovascularization
            model mice by targeting transmembrane protein 229B
  JOURNAL   Scand J Immunol 90 (6), e12832 (2019)
   PUBMED   31544253
  REMARK    GeneRIF: Our data have uncovered the critical contribution of
            miR-505 in AMD, which is predominantly mediated by downregulation
            of TMEM229B.
REFERENCE   4  (bases 1 to 3865)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC066067.1 and BC057677.1.
            
            On Jul 13, 2018 this sequence version replaced NM_178745.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066067.1, CA885219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2160              BC066067.1         1-2160
            2161-3865           BC057677.1         1952-3656
FEATURES             Location/Qualifiers
     source          1..3865
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 35.51 cM"
     gene            1..3865
                     /gene="Tmem229b"
                     /gene_synonym="6330442E10Rik; 9830138K24"
                     /note="transmembrane protein 229B"
                     /db_xref="GeneID:268567"
                     /db_xref="MGI:MGI:2444389"
     exon            1..305
                     /gene="Tmem229b"
                     /gene_synonym="6330442E10Rik; 9830138K24"
                     /inference="alignment:Splign:2.1.0"
     exon            306..486
                     /gene="Tmem229b"
                     /gene_synonym="6330442E10Rik; 9830138K24"
                     /inference="alignment:Splign:2.1.0"
     exon            487..3865
                     /gene="Tmem229b"
                     /gene_synonym="6330442E10Rik; 9830138K24"
                     /inference="alignment:Splign:2.1.0"
     CDS             505..1008
                     /gene="Tmem229b"
                     /gene_synonym="6330442E10Rik; 9830138K24"
                     /codon_start=1
                     /product="transmembrane protein 229B"
                     /protein_id="NP_848860.1"
                     /db_xref="CCDS:CCDS26005.1"
                     /db_xref="GeneID:268567"
                     /db_xref="MGI:MGI:2444389"
                     /translation="MASAEPLTALSRWYLYAIHGYFCEVMFTAAWEFVVNFNWKFPGV
                     TSVWALFIYGTSILIVERMYLRLRGRCPLLVRCVIYTLWTYLWEFTTGFILRQFNACP
                     WDYSQFDFDFMGLITLEYAVPWFCGALIMEQFIIRNTLRLRFDKDAEPGEPASPPALA
                     NGHVKTD"
     regulatory      3840..3845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem229b"
                     /gene_synonym="6330442E10Rik; 9830138K24"
                     /note="hexamer: AATATA"
     polyA_site      3865
                     /gene="Tmem229b"
                     /gene_synonym="6330442E10Rik; 9830138K24"
                     /note="major polyA site"
ORIGIN      
        1 gtggggcagc agcggctgca gctacccggg ccccgcgccg ccccggcggc cgcggacact
       61 ggatgcggga atagtcgcgg gcgggtggcg tgggggagtc tcgtccggtc actcggcgcg
      121 gggggagccg gagcgccggg cgtgggggca gggaacaggc ggcgcaggag agcgccccga
      181 gtcccggcgc ggaggaggag cgggagccag cccgtgagac cgcgctcctg gccgcacctg
      241 cgtcgggcag acggccgccc gaccctgcct tgccttgccc taccctcgtc cccggccccg
      301 caccgagaca catgaaagcc atccttcagc cagtcaagaa ttaactgagc actggggtga
      361 atgcttatct acattgctga gaatggcgtc aaggtccagt ctgataccaa gacgaggtta
      421 aattgggaca gagctgcaca gtgatcctga tgtctgttcc cagctacgca gtcaagactg
      481 tgataagagg tcccagttgt taccatggct tctgccgagc ccctgacagc gctgtctcgt
      541 tggtacctat atgctatcca cggctacttc tgcgaggtga tgtttacagc ggcctgggag
      601 tttgtggtga attttaactg gaagttcccg ggggtcacga gcgtgtgggc cctcttcatc
      661 tatggcacct ccatcctgat cgtggagcgt atgtaccttc gtctgcgtgg ccgctgtcct
      721 cttctggtgc gctgcgtcat ctacactctc tggacttacc tgtgggaatt caccaccggc
      781 tttatcctac gccagttcaa cgcctgtccc tgggactact cccagttcga ctttgatttc
      841 atgggcctca ttaccctgga gtatgctgtg ccctggttct gcggggccct catcatggag
      901 cagtttatca tccgcaacac cctccgcctg cgctttgaca aggacgcaga gcctggggag
      961 cctgccagcc caccagccct ggccaatggc cacgtcaaga ccgactgagt cagaagatta
     1021 atgtgaggac ctgaagtctc tcataggacc ccatgaacag agaaagagag agaccaagct
     1081 gatgcagtta ccccttggtt cagcacaagc cctgccccca actgggtctt agctcagtag
     1141 ggcaaacata accacacatg gtgggcagtg ggatggtgtt ggggagttgg gcaacagaag
     1201 gactttgaga ctcatccgtg gctctcaaca catcctgggg actaggagct gggtggtgaa
     1261 caatcggaca ttgatggatg actttggaag cagcagaccc gtcctagcta agggacatga
     1321 actctggggc cacgggtgag aggcaaggtc tgagaaggcc ttggctgctg ttggggacca
     1381 ccaccccacc tgcccccagg cttcagctgg gctttggctg gttccattag gcaatattca
     1441 ggtgcttgct tgcaaccaat acctccccag gggcctctga gctgcagcct gagagagacc
     1501 aagtagccaa ctgggctgct tggtggcact ggtggtgtgc aaaggctggg aagacttcct
     1561 ttggctcctc tccttctccc tctcccaggg ccccacgctg ctcccttggc cttctggggg
     1621 cccctgtggt gctggattcc caccaacctt gggcttttgg aggtttcaat ccccgtgtgt
     1681 tcggtggtgt ttcccctttc tcttatgttc aaggtattta ccattagcag gcagcccttt
     1741 cctctgtgtc agtcaccata cccttctctg ctcccagctc cctatagaac acagcagtgg
     1801 ccagaggcac agctctgaag tggaccccac ctgccttgct gcagccttcc ctccaccttc
     1861 gtctgatgac tggggggtgc cctgtctccc tggcccaggg atagtagtct ggtgcccctt
     1921 ccctgcagag gtcctactga aaacgcatag tatccctata atgtacagcg aggcccagag
     1981 gtgtacagtg gatccacagc ggggggaaaa aaggcagagt tctaggtccc gtttgcccgt
     2041 atggtttatt atttcagcca gttaaccagt atggcttcct gtgagctaga ggagacccag
     2101 ggagaacaag acagatacag aagaccatgg aaggctcttt agaggccctt tcctggaaaa
     2161 agaacgaatc tcaccatagc ctcagctcag cagtcaaccc tcagggctgc tcttcctgca
     2221 actccccctg gccagctgat tccatgagct tgtttctcaa gcagtgttaa ccctgtcaca
     2281 ctcatgggcc ttgtcagctt ggttattgta actttatccc atgatgggtc cattgctggc
     2341 agtggacagg tgaaatctag gccccttctg atttttgtcc cccactcctt gagaagacgg
     2401 gaccatcaaa gagagtagca tcccatgagg ccaccctggg accctcaaag gttgcaatca
     2461 gcccttattt cttatagatc attttcttaa atgaccatac cacctgtgta tagtctctgg
     2521 atcgtgcaga cagcaccaag ccagggccag cagcagggct gtccttggct ggggcaaaga
     2581 ctggagacat aaccttctgt ggcatctttt cccagagtgt tctctgtcta gggtagaaag
     2641 ccaagtgttt ccctgggtag gcttctcaaa tcaccaaaca ccattctgtt gcggggggac
     2701 ttgttatata tacttgtaac gctttgggca ttacagggat tcaggtttcc aatgggagtg
     2761 gttgctttcc atctacaggt ggagaagatt ccttgttttc tccatttcca tattatctta
     2821 attatctgaa tcctaacgcc tctccaggcc acctcacacc tgtcttcaca actgaggtct
     2881 cccagcatta aggctccaat tctcaaccag aaaaggccat tgggtggccc ctaggtctca
     2941 gcgctccaga tgttgtcttg taggcattcc ctagtaccgt tttttcctca aagctctatt
     3001 aatcccatgt caggaggggt tcccagagca gatctgcatg cctggccata ctgagcattg
     3061 tgatctgctt tcctaggtcc cctgttgctc ctagggcccc tcataggcat agaaccccca
     3121 gccaagggaa gctacacctt aaggcctgac cacagaccta cagggtcaga tctcacggag
     3181 tgtagtttag atttcagctc ttgcttattg gctatcttca gggctccaac cccttagtgc
     3241 ttaggggctc aaaggttggg ggtaattaag cccttctgag cagtggggag tctgctggtt
     3301 gtttatggag ctgccctctg ctgttctgag cccaaggtag gagtttcaga tagtaagtat
     3361 gctgtcctgc atggttgagt tgctttggat gtctgctagg cttccagtac cctgtcccct
     3421 cctcatgctg gagagtcaca atggcctgtg cttattcaca gcaataatat atagggagcg
     3481 tctgtgagtc ccctttgtcc tgctccatca ctcttcatgg atctcccagg agactgctga
     3541 gtgggtcagt tacgtggaaa tctatttatg aagctctggg ctgtgcaaag tcttgtcgta
     3601 ggaggcaggt gagcagccca gccctgaagt atgaggaagg ccatgggagt gccttccacc
     3661 ctgaagccac ccttacctgg aggagctgta ggccccagct ttgtagcagg gcctatgaag
     3721 tggttaggac tgtcttccaa ctggacagct cttgagaaag gtacatgacc agtttgtaag
     3781 cccgttgcct gctatgtctc cgttagtctg tctctccctt ttcataactg tgcacataaa
     3841 atatactggt gtttgtgttc ctgga
//
