LOCUS       NM_026827                962 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transmembrane protein 219 (Tmem219), transcript
            variant 1, mRNA.
ACCESSION   NM_026827
VERSION     NM_026827.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 962)
  AUTHORS   D'Addio,F., Maestroni,A., Assi,E., Ben Nasr,M., Amabile,G.,
            Usuelli,V., Loretelli,C., Bertuzzi,F., Antonioli,B., Cardarelli,F.,
            El Essawy,B., Solini,A., Gerling,I.C., Bianchi,C., Becchi,G.,
            Mazzucchelli,S., Corradi,D., Fadini,G.P., Foschi,D., Markmann,J.F.,
            Orsi,E., Skrha,J. Jr., Camboni,M.G., Abdi,R., James Shapiro,A.M.,
            Folli,F., Ludvigsson,J., Del Prato,S., Zuccotti,G. and Fiorina,P.
  TITLE     The IGFBP3/TMEM219 pathway regulates beta cell homeostasis
  JOURNAL   Nat Commun 13 (1), 684 (2022)
   PUBMED   35115561
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 962)
  AUTHORS   Lee,C.M., He,C.H., Nour,A.M., Zhou,Y., Ma,B., Park,J.W., Kim,K.H.,
            Dela Cruz,C., Sharma,L., Nasr,M.L., Modis,Y., Lee,C.G. and
            Elias,J.A.
  TITLE     IL-13Ralpha2 uses TMEM219 in chitinase 3-like-1-induced signalling
            and effector responses
  JOURNAL   Nat Commun 7, 12752 (2016)
   PUBMED   27629921
  REMARK    Erratum:[Nat Commun. 2016 Nov 14;7:13541. doi:
            10.1038/ncomms13541.. PMID: 27841275]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 962)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY128578.1, AK004043.1 and BP769695.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023442.1, SRR11927932.3324731.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BY128578.1         1-54
            55-942              AK004043.1         15-902
            943-962             BP769695.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..962
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.25 cM"
     gene            1..962
                     /gene="Tmem219"
                     /gene_synonym="1110032O16Rik; 2900045G02Rik; IGFBP-3R"
                     /note="transmembrane protein 219"
                     /db_xref="GeneID:68742"
                     /db_xref="MGI:MGI:1915992"
     exon            1..55
                     /gene="Tmem219"
                     /gene_synonym="1110032O16Rik; 2900045G02Rik; IGFBP-3R"
                     /inference="alignment:Splign:2.1.0"
     exon            56..257
                     /gene="Tmem219"
                     /gene_synonym="1110032O16Rik; 2900045G02Rik; IGFBP-3R"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..815
                     /gene="Tmem219"
                     /gene_synonym="1110032O16Rik; 2900045G02Rik; IGFBP-3R"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; insulin-like growth factor-binding protein 3
                     receptor"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 3
                     receptor isoform 1 precursor"
                     /protein_id="NP_081103.1"
                     /db_xref="CCDS:CCDS40133.1"
                     /db_xref="GeneID:68742"
                     /db_xref="MGI:MGI:1915992"
                     /translation="MGSCQAGHNLHLCLAHHPPLVCATLILLLLGLSGLGLGGFLLTH
                     TTGLRSPDIPQDWVSFLRSFGQLSLCPMNETVTGTWQGPHVVGLLTTLNFGDGPDRNK
                     TQTFQAKIHGSQIGLTGSSAGESVLVTARVASGRTPGTCLYFSGVPKVLPSSQPPISC
                     SEEGVGNATLSPVMGEECVRVWSHERLVLTELLTSEELALCGSRVLGLGFFLVLLCGL
                     LCCTTAVCFHPRPEFHWSRTRL"
     exon            258..447
                     /gene="Tmem219"
                     /gene_synonym="1110032O16Rik; 2900045G02Rik; IGFBP-3R"
                     /inference="alignment:Splign:2.1.0"
     exon            448..677
                     /gene="Tmem219"
                     /gene_synonym="1110032O16Rik; 2900045G02Rik; IGFBP-3R"
                     /inference="alignment:Splign:2.1.0"
     exon            678..847
                     /gene="Tmem219"
                     /gene_synonym="1110032O16Rik; 2900045G02Rik; IGFBP-3R"
                     /inference="alignment:Splign:2.1.0"
     exon            848..944
                     /gene="Tmem219"
                     /gene_synonym="1110032O16Rik; 2900045G02Rik; IGFBP-3R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      925..930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem219"
                     /gene_synonym="1110032O16Rik; 2900045G02Rik; IGFBP-3R"
                     /note="hexamer: AATAAA"
     polyA_site      943
                     /gene="Tmem219"
                     /gene_synonym="1110032O16Rik; 2900045G02Rik; IGFBP-3R"
                     /note="major polyA site"
ORIGIN      
        1 tccgccaagc cacccatgac gtcacggggc gccggcctct gctgggctgc aagcgcaggc
       61 accccacgga ggcccagacc cctctgctcc ccatgggcag ctgccaggca gggcacaact
      121 tgcatctctg tctggctcat cacccacctt tggtctgtgc cactttgatc ctgctgctcc
      181 ttggcctttc tggcctgggc cttggtggct tcctcctcac ccacacaact ggcctccgta
      241 gccctgacat tccccaggat tgggtttcct tcttgagatc ttttggccag ctaagtctgt
      301 gccccatgaa tgagacagtc acagggacgt ggcaagggcc tcacgtcgtc ggcttactga
      361 ccactttgaa cttcggagat ggtccagaca gaaacaaaac ccaaacattc caagccaaga
      421 tccatggtag tcagatagga ttgacagggt cctctgccgg agagtctgtc cttgtcacag
      481 ccagagtggc gtcaggaagg actccaggga cctgcctata ttttagtggt gttccaaaag
      541 tcctgccctc tagccaacca cctatatcct gctcagagga gggagttgga aatgctaccc
      601 tgagcccagt gatgggtgag gagtgtgtca gggtctggag ccacgagcgc cttgtgctca
      661 ccgagctcct tacttcagag gagctggctc tgtgtggcag cagagtgctg ggcttgggct
      721 tcttcctggt tctgctctgt ggcctcctct gctgtaccac tgcagtctgc ttccatccgc
      781 gcccagagtt ccactggtct agaacacggc tttgagggcg acagactgcg cctcactctg
      841 ctgtcaggta caggtcaagt tcttggggcc cacttctgag tttagaagac ctattacaaa
      901 aagtgaagaa ctagactgtg ggaaaataaa tggcttttga ctacaaaaaa aaaaaaaaaa
      961 aa
//
