LOCUS       NM_025464               1167 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus transmembrane protein 218 (Tmem218), transcript
            variant 2, mRNA.
ACCESSION   NM_025464
VERSION     NM_025464.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1167)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1167)
  AUTHORS   Vogel,P., Gelfman,C.M., Issa,T., Payne,B.J., Hansen,G.M.,
            Read,R.W., Jones,C., Pitcher,M.R., Ding,Z.M., DaCosta,C.M.,
            Shadoan,M.K., Vance,R.B. and Powell,D.R.
  TITLE     Nephronophthisis and retinal degeneration in tmem218-/- mice: a
            novel mouse model for Senior-Loken syndrome?
  JOURNAL   Vet Pathol 52 (3), 580-595 (2015)
   PUBMED   25161209
  REMARK    GeneRIF: tmem218-/- mice develop progressive cystic kidney disease
            and retinal degeneration, a model for Senior-Loken syndrome
REFERENCE   3  (bases 1 to 1167)
  AUTHORS   O'Shaughnessy,P.J., Abel,M., Charlton,H.M., Hu,B., Johnston,H. and
            Baker,P.J.
  TITLE     Altered expression of genes involved in regulation of vitamin A
            metabolism, solute transportation, and cytoskeletal function in the
            androgen-insensitive tfm mouse testis
  JOURNAL   Endocrinology 148 (6), 2914-2924 (2007)
   PUBMED   17332066
REFERENCE   4  (bases 1 to 1167)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154434.2, AW912288.1, AK003010.1 and BP772045.1.
            
            On Jun 29, 2015 this sequence version replaced NM_025464.2.
            
            Transcript Variant: This variant (2) uses an alternate splice
            junction at the 3' end of the first exon compared to variant 1. The
            resulting isoform (2) is shorter at the N-terminus compared to
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI873130.1, AK161115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC154434.2         44148-44168         c
            22-509              AW912288.1         1-488
            510-962             AK003010.1         397-849
            963-1167            BP772045.1         23-227              c
FEATURES             Location/Qualifiers
     source          1..1167
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.74 cM"
     gene            1..1167
                     /gene="Tmem218"
                     /gene_synonym="1810021J13Rik"
                     /note="transmembrane protein 218"
                     /db_xref="GeneID:66279"
                     /db_xref="MGI:MGI:1913529"
     exon            1..183
                     /gene="Tmem218"
                     /gene_synonym="1810021J13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            184..294
                     /gene="Tmem218"
                     /gene_synonym="1810021J13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..532
                     /gene="Tmem218"
                     /gene_synonym="1810021J13Rik"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="transmembrane protein 218 isoform 2"
                     /protein_id="NP_079740.1"
                     /db_xref="CCDS:CCDS22975.1"
                     /db_xref="GeneID:66279"
                     /db_xref="MGI:MGI:1913529"
                     /translation="MAGMVLGVGAGVFLLALIWVLVLLLCVLLSRASGIARFSIVFVF
                     LGALIITTVLLLFPRASEFPAPEGEMKIVDAFFIGRYVLLAFLSAVFLGGLFLLLTHH
                     LLEPIYAKPLRSC"
     exon            295..397
                     /gene="Tmem218"
                     /gene_synonym="1810021J13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            398..1147
                     /gene="Tmem218"
                     /gene_synonym="1810021J13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1078..1083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem218"
                     /gene_synonym="1810021J13Rik"
                     /note="hexamer: AATAAA"
     regulatory      1086..1091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem218"
                     /gene_synonym="1810021J13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1097
                     /gene="Tmem218"
                     /gene_synonym="1810021J13Rik"
                     /note="major polyA site"
     polyA_site      1145
                     /gene="Tmem218"
                     /gene_synonym="1810021J13Rik"
ORIGIN      
        1 cccttaagtg ctgaaagggc ggctttgatt ggtccatctt aaatttctta aatgagcccc
       61 tacttgtgat tcgtccaaag tagaccaaag cctggatgaa ggggacagag agcgaggggt
      121 gagtcctggt gaggaacctg agagccgggt gaggaccgga ggctggcccc agacgcctgg
      181 aaggatggct ggcatggtac ttggagtggg tgctggcgtg ttcctcctcg ctctgatctg
      241 ggtgctggtg ctgctgctgt gtgtgctgtt atccagagcc tctgggatag ctaggttctc
      301 catcgtcttt gtcttcctcg gagctctgat cattactaca gttctattgc ttttccctcg
      361 agccagtgaa ttcccagccc cagaaggaga aatgaagatt gtggacgcct ttttcatcgg
      421 ccgctatgtc ctgctggctt tcctcagtgc tgtctttctt ggaggcctct tcctgcttct
      481 tactcatcat ttgctggagc caatctatgc caaaccactg aggtcctgct gagcatagta
      541 acggaaacac gggacatgtt gacatcacgg atgagcgcaa aggcagtctg gagcctgacc
      601 accttcatgt cttcagacca gagggataac tatttgtcac taaggcaaac ctcctgagcc
      661 ctggcctcca gaaactcagt ggcaaagccg agtccatgga tgtaaattgt caccatcgag
      721 acaggtacag ctgtcttctc ggaacccata tgcaggattt ctgtctgttt tgaatgaaca
      781 gtagtaacag tgatctgctt tgggtacatt gttcaatcaa gctgtgggta gtagatttgg
      841 ggaaaaggag ttttgggctt tgttatccaa cagaagaagc cggccctttt taataacgta
      901 taaattataa gttctcagtt gagtatttgg aaccatttgg aagagagagg catacaaaca
      961 caaaattgct ttaatgagat agtatggaag atgcattagg cagcggttat tgaccattcc
     1021 ttatgtgcag ttccacagag ctctgtaaag acagtgtgtg gcccttgcct gaattctaat
     1081 aaagcaataa acagctacca aagggcttgc tcttcaagcc cctggctgca gctttgttat
     1141 gtttacaaaa aaaaaaaaaa aaaaaaa
//
