LOCUS       NM_001277860            1028 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus transmembrane protein 216 (Tmem216), transcript
            variant 1, mRNA.
ACCESSION   NM_001277860
VERSION     NM_001277860.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1028)
  AUTHORS   Wang,Y., Yao,H., Zhang,Y., Mu,N., Lu,T., Du,Z., Wu,Y., Li,X.,
            Su,M., Shao,M., Sun,X., Su,L. and Liu,X.
  TITLE     TMEM216 promotes primary ciliogenesis and Hedgehog signaling
            through the SUFU-GLI2/GLI3 axis
  JOURNAL   Sci Signal 17 (820), eabo0465 (2024)
   PUBMED   38261656
  REMARK    GeneRIF: TMEM216 promotes primary ciliogenesis and Hedgehog
            signaling through the SUFU-GLI2/GLI3 axis.
REFERENCE   2  (bases 1 to 1028)
  AUTHORS   Garcia-Gonzalo,F.R., Corbit,K.C., Sirerol-Piquer,M.S.,
            Ramaswami,G., Otto,E.A., Noriega,T.R., Seol,A.D., Robinson,J.F.,
            Bennett,C.L., Josifova,D.J., Garcia-Verdugo,J.M., Katsanis,N.,
            Hildebrandt,F. and Reiter,J.F.
  TITLE     A transition zone complex regulates mammalian ciliogenesis and
            ciliary membrane composition
  JOURNAL   Nat Genet 43 (8), 776-784 (2011)
   PUBMED   21725307
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1028)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DV063021.1, AC125093.4,
            AK013286.1 and BX633507.1.
            
            Summary: This gene encodes a transmembrane protein which is
            involved in regulation of signaling and trafficking of associated
            proteins. In humans, mutations in this gene are associated with
            ciliopathies including Joubert, Meckel and related syndromes.
            Alternative splicing of this gene results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Apr
            2013].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB182203.1, CB587275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DV063021.1         56-80
            26-51               AC125093.4         56082-56107
            52-997              AK013286.1         56-1001
            998-1028            BX633507.1         3-33                c
FEATURES             Location/Qualifiers
     source          1..1028
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.6 cM"
     gene            1..1028
                     /gene="Tmem216"
                     /gene_synonym="1110017C22Rik; 2810441K11Rik;
                     4921533J23Rik; A930021F15Rik"
                     /note="transmembrane protein 216"
                     /db_xref="GeneID:68642"
                     /db_xref="MGI:MGI:1920020"
     exon            1..51
                     /gene="Tmem216"
                     /gene_synonym="1110017C22Rik; 2810441K11Rik;
                     4921533J23Rik; A930021F15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..464
                     /gene="Tmem216"
                     /gene_synonym="1110017C22Rik; 2810441K11Rik;
                     4921533J23Rik; A930021F15Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thymus atrophy-related protein"
                     /codon_start=1
                     /product="transmembrane protein 216 isoform 1"
                     /protein_id="NP_001264789.1"
                     /db_xref="CCDS:CCDS70934.1"
                     /db_xref="GeneID:68642"
                     /db_xref="MGI:MGI:1920020"
                     /translation="MAPRDKRLSSTPLEVLFFLNGWYYATYFLLELLIFLYKGLLLPY
                     PTANLVLDVVMLLLYLGIEVIRLFFGTKGNLCQRKMPLGISVALTFPSAMMASYYLLL
                     QTYVLRLEAIMNSILLFFCGSELLLEMLTLATFSSMDRI"
     exon            52..153
                     /gene="Tmem216"
                     /gene_synonym="1110017C22Rik; 2810441K11Rik;
                     4921533J23Rik; A930021F15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            154..246
                     /gene="Tmem216"
                     /gene_synonym="1110017C22Rik; 2810441K11Rik;
                     4921533J23Rik; A930021F15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            247..448
                     /gene="Tmem216"
                     /gene_synonym="1110017C22Rik; 2810441K11Rik;
                     4921533J23Rik; A930021F15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            449..1028
                     /gene="Tmem216"
                     /gene_synonym="1110017C22Rik; 2810441K11Rik;
                     4921533J23Rik; A930021F15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1007..1012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem216"
                     /gene_synonym="1110017C22Rik; 2810441K11Rik;
                     4921533J23Rik; A930021F15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1026
                     /gene="Tmem216"
                     /gene_synonym="1110017C22Rik; 2810441K11Rik;
                     4921533J23Rik; A930021F15Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggcgctgca gtgtacgcag tttccatggg gactgaacat ggcgccgcga gataaaagat
       61 tgtcctcaac ccccctggaa gtcctgttct ttctgaatgg gtggtactat gctacctatt
      121 tcctgctgga gctccttatt ttcctgtaca aagggctcct gttgccgtac ccaacagcca
      181 acttagtcct ggatgtggtg atgctgctgc tctatcttgg cattgaagtc atacgattgt
      241 ttttcggtac aaagggaaac ctctgccagc gaaagatgcc ccttggcatt agtgtggcct
      301 tgaccttccc atccgctatg atggcttcct attacctgct gctgcagacc tacgtgctcc
      361 gcctagaagc tatcatgaac agtatcttgc tcttcttttg tggctcagag ctgctgcttg
      421 agatgctcac gctggccacc ttctccagca tggacaggat ctgaagtaca agaattccag
      481 ctggtgacaa cacatatcca tctggtactt cagccacact ggtgaaaagt ggtaggtcga
      541 gctaacctgg gaaaggtttg tgtggttttt cctcagtgcg gacatttggg cgctgagcac
      601 ctacctgagg ccagtggcac catctttaaa gcgggatcat cagcaggaga ctctttcctt
      661 ttgttgtagg gaggggcaag gctgtcccca tcttggtgtt tctaacagct tcctaatgat
      721 ctcaagttct cttctgtggt catcatggcc agagcacctt gtgtggacct tctagttttg
      781 tttggcttcc agcagaacct gagccacagc actctgtgca cgtacatctg tcctacatga
      841 ccatggagag cctcataatg gtgggctctt gggctgattc caatgtgtgt tctccacgct
      901 gctccacctg cccccatcct gctcaaagag atggtgatct agaacccatt tagtagttta
      961 tagtagtatt tttctattct gatcatgaag caaacacaaa atttttaata aaagtatttt
     1021 ctgataca
//
