LOCUS       NP_001264789             141 aa            linear   ROD 27-APR-2025
DEFINITION  transmembrane protein 216 isoform 1 [Mus musculus].
ACCESSION   NP_001264789
VERSION     NP_001264789.1
DBSOURCE    REFSEQ: accession NM_001277860.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 141)
  AUTHORS   Wang,Y., Yao,H., Zhang,Y., Mu,N., Lu,T., Du,Z., Wu,Y., Li,X.,
            Su,M., Shao,M., Sun,X., Su,L. and Liu,X.
  TITLE     TMEM216 promotes primary ciliogenesis and Hedgehog signaling
            through the SUFU-GLI2/GLI3 axis
  JOURNAL   Sci Signal 17 (820), eabo0465 (2024)
   PUBMED   38261656
  REMARK    GeneRIF: TMEM216 promotes primary ciliogenesis and Hedgehog
            signaling through the SUFU-GLI2/GLI3 axis.
REFERENCE   2  (residues 1 to 141)
  AUTHORS   Garcia-Gonzalo,F.R., Corbit,K.C., Sirerol-Piquer,M.S.,
            Ramaswami,G., Otto,E.A., Noriega,T.R., Seol,A.D., Robinson,J.F.,
            Bennett,C.L., Josifova,D.J., Garcia-Verdugo,J.M., Katsanis,N.,
            Hildebrandt,F. and Reiter,J.F.
  TITLE     A transition zone complex regulates mammalian ciliogenesis and
            ciliary membrane composition
  JOURNAL   Nat Genet 43 (8), 776-784 (2011)
   PUBMED   21725307
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 141)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DV063021.1, AC125093.4,
            AK013286.1 and BX633507.1.
            
            Summary: This gene encodes a transmembrane protein which is
            involved in regulation of signaling and trafficking of associated
            proteins. In humans, mutations in this gene are associated with
            ciliopathies including Joubert, Meckel and related syndromes.
            Alternative splicing of this gene results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Apr
            2013].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB182203.1, CB587275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..141
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.6 cM"
     Protein         1..141
                     /product="transmembrane protein 216 isoform 1"
                     /note="thymus atrophy-related protein"
                     /calculated_mol_wt=16028
     Region          15..121
                     /region_name="Transmemb_17"
                     /note="Predicted membrane protein; pfam09799"
                     /db_xref="CDD:462907"
     Site            15..35
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQC4.2)"
     Site            49..69
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQC4.2)"
     Site            82..102
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQC4.2)"
     Site            115..135
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQC4.2)"
     CDS             1..141
                     /gene="Tmem216"
                     /gene_synonym="1110017C22Rik; 2810441K11Rik;
                     4921533J23Rik; A930021F15Rik"
                     /coded_by="NM_001277860.1:39..464"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS70934.1"
                     /db_xref="GeneID:68642"
                     /db_xref="MGI:MGI:1920020"
ORIGIN      
        1 maprdkrlss tplevlffln gwyyatyfll elliflykgl llpyptanlv ldvvmlllyl
       61 gievirlffg tkgnlcqrkm plgisvaltf psammasyyl llqtyvlrle aimnsillff
      121 cgsellleml tlatfssmdr i
//
