LOCUS       NM_177175               3218 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus transmembrane protein 215 (Tmem215), transcript
            variant 1, mRNA.
ACCESSION   NM_177175
VERSION     NM_177175.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3218)
  AUTHORS   Liu,Y., Zheng,Q., He,G., Zhang,M., Yan,X., Yang,Z., Zhang,P.,
            Wang,L., Liu,J., Liang,L. and Han,H.
  TITLE     Transmembrane protein 215 promotes angiogenesis by maintaining
            endothelial cell survival
  JOURNAL   J Cell Physiol 234 (6), 9525-9534 (2019)
   PUBMED   30370660
  REMARK    GeneRIF: These results identified TMEM215 as a novel molecule
            involved in angiogenesis by regulating the survival of endothelial
            cells.
REFERENCE   2  (bases 1 to 3218)
  AUTHORS   Park,K.U., Randazzo,G., Jones,K.L. and Brzezinski,J.A. 4th.
  TITLE     Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar
            Interneurons in the Mouse Retina
  JOURNAL   Invest Ophthalmol Vis Sci 58 (2), 1137-1150 (2017)
   PUBMED   28199486
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044627.1 and CK617308.1.
            
            On Oct 2, 2009 this sequence version replaced NM_177175.3.
            
            Transcript Variant: This variant represents the longer transcript.
            Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044217.1, AK044627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1724              AK044627.1         3-1726
            1725-1915           CK617308.1         358-548
            1916-3218           AK044627.1         1918-3220
FEATURES             Location/Qualifiers
     source          1..3218
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 20.28 cM"
     gene            1..3218
                     /gene="Tmem215"
                     /gene_synonym="A930001M12Rik"
                     /note="transmembrane protein 215"
                     /db_xref="GeneID:320500"
                     /db_xref="MGI:MGI:2444167"
     exon            1..1425
                     /gene="Tmem215"
                     /gene_synonym="A930001M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..3218
                     /gene="Tmem215"
                     /gene_synonym="A930001M12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             1490..2197
                     /gene="Tmem215"
                     /gene_synonym="A930001M12Rik"
                     /codon_start=1
                     /product="transmembrane protein 215"
                     /protein_id="NP_796149.2"
                     /db_xref="CCDS:CCDS18046.1"
                     /db_xref="GeneID:320500"
                     /db_xref="MGI:MGI:2444167"
                     /translation="MRPDDINPRTGLVVALVSVFLVFGFMFTVSGMKGETLGNIPLLA
                     IGPAICLPGIAAIALARKTEGCTKWPENELLWVRKLPCFRKPKDKEVVELLRTPSDLE
                     SGKGSSDELAKKAGLRGKQLPQGPGEVPMASSVTTPTPTEEGECQSLVQSGRQEETSR
                     YLDGYCPSASSLAYSALDAKCSAWDRSDRPEPEDSIFFVPQDSIIVCSYKQNSPYDRY
                     CCYINQSQGRWDHETIV"
     regulatory      2797..2802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem215"
                     /gene_synonym="A930001M12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2830
                     /gene="Tmem215"
                     /gene_synonym="A930001M12Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggtctccat tgacttggat cctgccttac gtgctgagag cactataagc acacgatatg
       61 agcagaaaag agtacgtgta cctttctgtg cattttgaac aggaaccacg caccaaagcc
      121 ttgtgctagg aatttacgct tctgtagtcg tcatagcatt tgctcagaca tctgttgtta
      181 atagtctcct gatgactgat tctggtacac agggccagcc taggtggaga aggtctggtt
      241 gtcaacattc tttccaccaa gtcaagactt ggcatgaaag aacgtaattt tttgccttcc
      301 taattccttt cctctacctt aaacagacca ggtgaaggat cgcaaccaca tctaatcttc
      361 cctagagaca agagaaccct atattccgcg ggcagacact ggactgagac tagcaagaca
      421 gaagagtctt gtctcttgtc accggttggg cctgaccctc caaaccaaag tctgtcctgt
      481 gggctccctg aatgaagatc agaaccagaa gcccttcctc ctggctccag tgtggttgga
      541 accacgtctg tgggattgag tttccaagga tactttctgc caagtgcaaa gatgggagtc
      601 cagcggagga gactctggtg acttctaagc acaggcagga cccggaggcc tgaccttcgt
      661 gctcctaccg cctgggtgct ctcccgggac gctcaggtca ggcagaagca gcctgcgacc
      721 cagcttcttc gagggtatct tgcgcctggt ggagctgcct gggagaggca gaggcagaga
      781 cagtcctggg gaacctggtt gctgtcgggg caggggcatt tgctcaggaa atgtggaact
      841 ggccaagaga gtcagtctcc aacatcctct cacgttgtcg ccagagccct tagatcctga
      901 atttggaacc cagactagga cggtgcacca gctgccccgt gggcaaggag ctctgggctc
      961 cggtttatgg cagccgcacg gacaccggtc caagccaccc gcctgctgca ccgcgacgag
     1021 agccccccag cagcccgctt cccgcggccg ctgggctctg accccctcgc gcccccgcgc
     1081 gtccatctct gttcccagcg cggtgcaagt gatgtaaggc ggccaggctc gcgcgctttc
     1141 ctcctgcccg gacggagtcc tccctccccg ccggcagcgc cgcgcgccca ctccgatccg
     1201 ctgcgcccag gctccgcttc tagagctctg gctacctact cgcagcggct gggaaagacc
     1261 ctcctcctct aacccatctc cctcctcccc tcctcgtccc cccccccctc ctgtgcagtg
     1321 tcggtgggga aaaaccaggc ttggctctcg gaatccaaga agagaacaga gggacagccc
     1381 atacaaagct ttctggagac actgagaggt ggcaggagcc ttcagaaaaa aaagcaaaag
     1441 ggtactactc cctggctacc aggcagcccc aagctggatg gagtgaaaga tgcggcctga
     1501 tgacataaat ccgaggactg ggctggtggt ggccctggtc agtgttttcc tggtctttgg
     1561 tttcatgttc actgtctctg gcatgaaggg ggaaactctg gggaacatcc ctctgttggc
     1621 catcgggcca gccatctgcc taccaggcat cgccgccatt gctctggcca ggaaaaccga
     1681 aggctgcacc aagtggccag agaatgagct actctgggtc cgcaagttac cctgcttccg
     1741 gaagcccaag gacaaggaag tggtggaact cctgaggacc ccatcagacc tggagtcagg
     1801 caaagggagc tcggatgaac tggctaagaa ggcaggcctc agaggcaagc agctcccaca
     1861 gggaccaggt gaggtgccta tggccagctc cgttactacc cccactccta cagaggaagg
     1921 agaatgccag agtctagtcc agagtgggcg gcaggaagag acatccagat acctggatgg
     1981 ctattgcccc tcggccagtt ccctcgccta cagtgccttg gatgccaagt gctcagcctg
     2041 ggacagatct gaccgccctg agcccgagga cagcatcttc tttgtgcccc aggacagtat
     2101 catcgtttgc tcctacaagc aaaacagccc ctatgacaga tactgttgct acatcaacca
     2161 gagccaaggc aggtgggacc acgagacaat agtctgacct gttcatacaa gggtcccatg
     2221 ttgacagaca cattgctata ctcagctccc aaggaaagag aatctgtgct ccaacagcct
     2281 tcacactgtt agaaactggc acggtatgtg atgggggtgc agacctctgg tgcctgatac
     2341 tcatgtaaat aggcatgttg ggggcatagt ttagggaagt acggagaatt aaggacactg
     2401 ggaagagaca gtaaacagga agaaagttcc atttgcttct gaacaaatta aacaatgttg
     2461 attgctttgt aaaacagccc aaaaagtgct tgctgtcagg taaatctagg gagcgttagc
     2521 tgctaggggt caaatgatgc aggggctatt cacacagaaa ccggctgctt tgtgtttgaa
     2581 gaacatgaag gaaaattgta tgttccttta tatggtttgg tttttgtttt gctttgtttt
     2641 tttgcctgat gatagctttt cacacatggt aattgttgaa agacataaaa atcaagatag
     2701 aataggtgaa tcctcctgat atgggatggg ttttggagtg agggtagtta aaattgttga
     2761 aatgtataat tgaatcccga caagatcatg gtttcaaata aagtgttgat tatgctatgt
     2821 gaaacattaa tattttaggt ggtcatgtta cttcttaaag tcttcatttg agctgagtgg
     2881 ctgggacttt atctgaagtt tttaaaatat ttattcacac tgatgtattt ccttaccagg
     2941 tacaaaatgg cttgttgtga tatcgttaga ttaggatttc tttttatcag tttgtaagac
     3001 aaattttaca aagtacctcc agcatttctg ggaggcatgt actaggaatt actgtatccc
     3061 ttttaaagta tgagactaca agtcaatcca ttagtcctga gctctatgaa aactttgtat
     3121 gagacacatg gttaagcctt catttgtcat ttatacattt gttcaacagc gcccctcccc
     3181 caaccatgat gagaatgcaa tgaaacaaga gttaattt
//
