LOCUS       NM_025486                762 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Mus musculus transmembrane protein 208 (Tmem208), transcript
            variant 3, mRNA.
ACCESSION   NM_025486
VERSION     NM_025486.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 762)
  AUTHORS   Dutta,D., Kanca,O., Shridharan,R.V., Marcogliese,P.C., Steger,B.,
            Morimoto,M., Frost,F.G., Macnamara,E., Wangler,M.F., Yamamoto,S.,
            Jenny,A., Adams,D., Malicdan,M.C. and Bellen,H.J.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Loss of the endoplasmic reticulum protein Tmem208 affects cell
            polarity, development, and viability
  JOURNAL   Proc Natl Acad Sci U S A 121 (9), e2322582121 (2024)
   PUBMED   38381787
  REMARK    GeneRIF: Loss of the endoplasmic reticulum protein Tmem208 affects
            cell polarity, development, and viability.
REFERENCE   2  (bases 1 to 762)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124584.5.
            
            On Mar 17, 2020 this sequence version replaced NM_025486.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002499.1, BC024608.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC124584.5         67005-67102         c
            99-194              AC124584.5         66333-66428         c
            195-254             AC124584.5         65250-65309         c
            255-391             AC124584.5         65021-65157         c
            392-476             AC124584.5         64787-64871         c
            477-762             AC124584.5         64422-64707         c
FEATURES             Location/Qualifiers
     source          1..762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..762
                     /gene="Tmem208"
                     /gene_synonym="1700006C06Rik; 2610030K20Rik; Hspc171"
                     /note="transmembrane protein 208"
                     /db_xref="GeneID:66320"
                     /db_xref="MGI:MGI:1913570"
     exon            1..98
                     /gene="Tmem208"
                     /gene_synonym="1700006C06Rik; 2610030K20Rik; Hspc171"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..614
                     /gene="Tmem208"
                     /gene_synonym="1700006C06Rik; 2610030K20Rik; Hspc171"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="transmembrane protein 208 isoform 3"
                     /protein_id="NP_079762.1"
                     /db_xref="CCDS:CCDS22599.1"
                     /db_xref="GeneID:66320"
                     /db_xref="MGI:MGI:1913570"
                     /translation="MAPKGKVGTRGKKQIFEENKETLKFYLRIILGANAIYCLVTLVF
                     FYSSASFWAWMALGFSLAVYGASYHSMSSMARASFSEDGSLMDGGMDLNMEQGMAEHL
                     KDVILLTAIVQVLSCFSLYIWSFWLLAPGRALYLLWVNVLGPWFTADSGAPAPELNEK
                     RQRRQERRQMKRL"
     exon            99..194
                     /gene="Tmem208"
                     /gene_synonym="1700006C06Rik; 2610030K20Rik; Hspc171"
                     /inference="alignment:Splign:2.1.0"
     exon            195..254
                     /gene="Tmem208"
                     /gene_synonym="1700006C06Rik; 2610030K20Rik; Hspc171"
                     /inference="alignment:Splign:2.1.0"
     exon            255..391
                     /gene="Tmem208"
                     /gene_synonym="1700006C06Rik; 2610030K20Rik; Hspc171"
                     /inference="alignment:Splign:2.1.0"
     exon            392..476
                     /gene="Tmem208"
                     /gene_synonym="1700006C06Rik; 2610030K20Rik; Hspc171"
                     /inference="alignment:Splign:2.1.0"
     exon            477..762
                     /gene="Tmem208"
                     /gene_synonym="1700006C06Rik; 2610030K20Rik; Hspc171"
                     /inference="alignment:Splign:2.1.0"
     regulatory      738..743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem208"
                     /gene_synonym="1700006C06Rik; 2610030K20Rik; Hspc171"
                     /note="hexamer: AATAAA"
     polyA_site      762
                     /gene="Tmem208"
                     /gene_synonym="1700006C06Rik; 2610030K20Rik; Hspc171"
                     /note="major polyA site"
ORIGIN      
        1 accggaagtg catgtgctgc cgatgtggtg tctactgact gcagttccag ttactcgccc
       61 ttgtttcagt ggctgggtgt ctgctgcgca ccatggcgcc caaaggaaaa gtgggtacca
      121 gagggaagaa acagatattt gaagagaaca aagaaactct caagttttac cttcggatca
      181 tactgggagc caacgccatc tactgccttg taaccttggt cttcttctat tcctctgcct
      241 cattctgggc ctggatggcc ctgggcttta gcttggccgt gtacggggcc agctaccact
      301 ctatgagctc gatggctcgg gcatccttct ctgaggatgg gtccttgatg gatggtggca
      361 tggacctcaa catggagcag ggcatggcag agcaccttaa ggatgtgatc ctactgacag
      421 ccattgttca ggtgctcagc tgtttctccc tctacatctg gtccttctgg cttctggctc
      481 caggccgggc cctttacctt ttgtgggtaa acgtgctggg cccctggttc acagcagaca
      541 gtggagcccc tgcaccagag ctcaatgaga aacgacaacg ccgacaggag cggcggcaga
      601 tgaaaaggtt atagcatcct taactgaggc tgtaggctgc tgggcactgg ttggctctgt
      661 tatgctgcgt ggccccatgc ctggagcagt gagggcctag tttaagggcc aaagcagcct
      721 ggattatagg atcactaaat aaatagtttc gaatgtggct aa
//
