LOCUS       NM_178577                875 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transmembrane protein 205 (Tmem205), transcript
            variant 2, mRNA.
ACCESSION   NM_178577
VERSION     NM_178577.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 875)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   2  (bases 1 to 875)
  AUTHORS   Inoue,S., Sano,H. and Ohta,M.
  TITLE     Growth suppression of Escherichia coli by induction of expression
            of mammalian genes with transmembrane or ATPase domains
  JOURNAL   Biochem Biophys Res Commun 268 (2), 553-561 (2000)
   PUBMED   10679242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY790291.1 and CD775257.1.
            
            [WARNING] On Aug 6, 2024 this sequence was replaced by NM_178577.6.
            
            On Dec 7, 2011 this sequence version replaced NM_178577.4.
            
            Transcript Variant: This variant (2) uses a different splice site
            in the 5' end, which results in the use of a downstream start
            codon, compared to variant 1. The resulting protein (isoform 2) is
            shorter when it is compared to isoform 1. Variants 2-5 encode the
            same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010787.1, BF532759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               BY790291.1         2-340
            340-875             CD775257.1         1-536               c
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.92 cM"
     gene            1..875
                     /gene="Tmem205"
                     /note="transmembrane protein 205"
                     /db_xref="GeneID:235043"
                     /db_xref="MGI:MGI:3045495"
     exon            1..244
                     /gene="Tmem205"
                     /inference="alignment:Splign:2.1.0"
     exon            245..353
                     /gene="Tmem205"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..823
                     /gene="Tmem205"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="transmembrane protein 205 isoform 2"
                     /protein_id="NP_848692.2"
                     /db_xref="CCDS:CCDS22913.1"
                     /db_xref="GeneID:235043"
                     /db_xref="MGI:MGI:3045495"
                     /translation="MEKGEDPGSLIKVIHLLVLSGAWGMQVWVTFISGFLLFRSLPRH
                     TFGLVQSKVFPVYFHVSLGCAFINLCILAPQRAWIHLTLWEVSQLSLLLLSLTLATIN
                     ARWLEARTTAVMRALQSIEKERGLGTEVPGNFQGPDPYRQLRDKDPKYSALRRKFYHY
                     HGLSSLCNLGCLLSNGLCLVGLALGLRSL"
     exon            354..517
                     /gene="Tmem205"
                     /inference="alignment:Splign:2.1.0"
     exon            518..858
                     /gene="Tmem205"
                     /inference="alignment:Splign:2.1.0"
     regulatory      841..846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem205"
                     /note="hexamer: AATAAA"
     polyA_site      858
                     /gene="Tmem205"
                     /note="major polyA site"
ORIGIN      
        1 atcttcggtg agactggatg aagtccggag aggcgagatg gccagttgat tcccgcaagc
       61 caactgggca atccctaagt gggagagtcc agaggagtga gagctgtgat ctcattggct
      121 ctggctggga ggtggggcga ggcctgcggg gcggaagaaa acctgggaaa tctcaggcaa
      181 gccggagctg cactggagct gccacggttc ttggtcccta cgcctgagct cgtgtgctcc
      241 aacgggctgc agaatggaaa aaggagagga cccgggaagt ctgattaaag tcatccactt
      301 gctggtcttg tctggtgcct ggggcatgca ggtgtgggtg acctttatct caggcttcct
      361 gctttttcgg agcctcccgc ggcacacatt tggactggtg cagagcaagg tcttcccagt
      421 ctattttcac gtctccttgg gctgtgcctt catcaacctc tgcatcttgg caccacagcg
      481 agcctggatt cacctcacac tgtgggaagt cagtcagctt tccctgctgc ttctgagcct
      541 cacactggcc accatcaatg ctcgctggct tgaggctcgc accacggctg tcatgcgggc
      601 cctgcagagc atagagaaag agcggggcct ggggacagag gtgccaggca acttccaggg
      661 ccctgatccc taccgccagc tgcgggacaa ggaccccaag tacagtgctc tacgccggaa
      721 gttctaccac taccatggcc tgtcttccct ctgcaacctg gggtgcctgc tgagcaatgg
      781 gctctgcctt gtgggccttg ccctgggact caggagcctc taacacagac cctgtgtgtc
      841 aataaatgct tctttggaaa aaaaaaaaaa aaaaa
//
