LOCUS       NM_001284270            3737 bp    mRNA    linear   ROD 23-NOV-2023
DEFINITION  Mus musculus transmembrane protein 201 (Tmem201), transcript
            variant 3, mRNA.
ACCESSION   NM_001284270 XM_003945703 XM_003945704 XM_006536017 XM_011251196
VERSION     NM_001284270.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3737)
  AUTHORS   Fan J, Wang S, Lu X and Sun Z.
  TITLE     Transplantation of bone marrow cells from miR150 knockout mice
            improves senescence-associated humoral immune dysfunction and
            arterial stiffness
  JOURNAL   Metabolism 134, 155249 (2022)
   PUBMED   35792174
  REMARK    GeneRIF: Transplantation of bone marrow cells from miR150 knockout
            mice improves senescence-associated humoral immune dysfunction and
            arterial stiffness.
REFERENCE   2  (bases 1 to 3737)
  AUTHORS   Zhang Y, Kong Y, Guo H, Liu Y, Zang Y and Li J.
  TITLE     Inner nuclear membrane protein TMEM201 maintains endothelial cell
            migration and angiogenesis by interacting with the LINC complex
  JOURNAL   J Mol Cell Biol 14 (3) (2022)
   PUBMED   35311970
REFERENCE   3  (bases 1 to 3737)
  AUTHORS   Toan NK, Tai NC, Kim SA and Ahn SG.
  TITLE     Choline Acetyltransferase Induces the Functional Regeneration of
            the Salivary Gland in Aging SAMP1/Kl -/- Mice
  JOURNAL   Int J Mol Sci 22 (1), 404 (2021)
   PUBMED   33401680
  REMARK    GeneRIF: Choline Acetyltransferase Induces the Functional
            Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3737)
  AUTHORS   Shimizu A, Tani H, Takibuchi G, Ishikawa K, Sakurazawa R, Inoue T,
            Hashimoto T, Nakada K, Takenaga K and Hayashi JI.
  TITLE     Cytoplasmic transfer of heritable elements other than mtDNA from
            SAMP1 mice into mouse tumor cells suppresses their ability to form
            tumors in C57BL6 mice
  JOURNAL   Biochem Biophys Res Commun 493 (1), 252-257 (2017)
   PUBMED   28893537
  REMARK    GeneRIF: These observations suggest that tumor suppression was
            caused not by mtDNA with polymorphic mutations or infection of
            cytozoic bacteria but by hypothetical heritable cytoplasmic
            elements other than mtDNA from SAMP1 mice.
REFERENCE   5  (bases 1 to 3737)
  AUTHORS   Menghini P, Di Martino L, Lopetuso LR, Corridoni D, Webster JC, Xin
            W, Arseneau KO, Lam M, Pizarro TT and Cominelli F.
  TITLE     A novel model of colitis-associated cancer in SAMP1/YitFc mice with
            Crohn's disease-like ileitis
  JOURNAL   PLoS One 12 (3), e0174121 (2017)
   PUBMED   28301579
  REMARK    GeneRIF: data demonstrate a heightened susceptibility to colonic
            inflammation and tumorigenesis in AOM/DSS-treated SAMP mice with
            CD-like ileitis
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3737)
  AUTHORS   Khudoerkov,R.M., Sal'kov,V.N., Sal'nikova,O.V. and Sobolev,V.B.
  TITLE     [Morphological changes of neurons and neuroglial cells in the brain
            of senescence-accelerated prone 1 (SAMP1) mice]
  JOURNAL   Arkh Patol 76 (2), 22-25 (2014)
   PUBMED   25051721
  REMARK    GeneRIF: In the SAMP1 mice versus the SAMR1 ones, the glial index
            rose by 36% in layer III and by 24% in layer V. During simulation
            of physiological aging, the sizes of neuronal bodies were shown to
            be virtually unchanged in the cerebral cortex
REFERENCE   7  (bases 1 to 3737)
  AUTHORS   Aoyama Y, Kim TY, Yoshimoto T, Niimi K, Takahashi E and Itakura C.
  TITLE     Impaired motor function in senescence-accelerated mouse prone 1
            (SAMP1)
  JOURNAL   Brain Res 1515, 48-54 (2013)
   PUBMED   23583482
  REMARK    GeneRIF: At 2- and 4-months old, SAMP1 mice show motor-coordination
            dysfunction.
REFERENCE   8  (bases 1 to 3737)
  AUTHORS   Borrego-Pinto J, Jegou T, Osorio DS, Aurade F, Gorjanacz M, Koch B,
            Mattaj IW and Gomes ER.
  TITLE     Samp1 is a component of TAN lines and is required for nuclear
            movement
  JOURNAL   J Cell Sci 125 (Pt 5), 1099-1105 (2012)
   PUBMED   22349700
  REMARK    GeneRIF: findings show that the nuclear envelope protein Samp1 is
            involved in nuclear movement during fibroblast polarization and
            migration
            GeneRIF: Nuclear envelope protein Samp1 (NET5) is involved in
            nuclear movement during fibroblast polarization and migration.
            Samp1 is part of the TAN lines complex that contain nesprin-2G and
            SUN2. Samp1 associates with SUN2 and lamin A/C.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ081115.1, AK086543.1, CD353644.1, CA316211.1, CD354653.1,
            CX562279.1, AK078532.1, AL626808.28 and BE987169.1.
            
            [WARNING] On Dec 6, 2023 this sequence was replaced by
            NM_001284270.2.
            
            On or before Feb 15, 2015 this sequence version replaced
            XM_011251196.1, XM_006536017.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (c).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078532.1, SRR17784646.1009176.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                CJ081115.1         2-25
            25-132              AK086543.1         2-109
            133-750             CD353644.1         1-618
            751-1140            CA316211.1         376-765
            1141-1625           CD354653.1         118-602
            1626-1879           CX562279.1         198-451
            1880-2124           AK078532.1         1808-2052
            2125-3687           AL626808.28        24260-25822         c
            3688-3737           BE987169.1         1-50                c
FEATURES             Location/Qualifiers
     source          1..3737
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 80.15 cM"
     gene            1..3737
                     /gene="Tmem201"
                     /gene_synonym="D4Ertd429e; Net5; Samp1"
                     /note="transmembrane protein 201"
                     /db_xref="GeneID:230917"
                     /db_xref="MGI:MGI:1196277"
     exon            1..234
                     /gene="Tmem201"
                     /gene_synonym="D4Ertd429e; Net5; Samp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2116
                     /gene="Tmem201"
                     /gene_synonym="D4Ertd429e; Net5; Samp1"
                     /note="isoform c is encoded by transcript variant 3;
                     spindle-associated membrane protein 1"
                     /codon_start=1
                     /product="transmembrane protein 201 isoform c"
                     /protein_id="NP_001271199.1"
                     /db_xref="CCDS:CCDS71523.1"
                     /db_xref="GeneID:230917"
                     /db_xref="MGI:MGI:1196277"
                     /translation="MEGVSALLASCPTAGLAGGLGVTACAAAGVVLYRIARRVKPTHT
                     MVNCWFCNHDTLVPYGNRNCWDCPHCEQYNGFQENGDYNKPIPAQYMEHLNHVVSSVP
                     SPRDPAQPQQWVSSQVLLCRRCSHHQTTKIKQLAAFTPREEGRYDEEIEVYRHHLEQM
                     YKLCRPCQAAVEYYIKHQNRQLRALLLSHQFRRREADQAHGQSFSSSAVKAPFQVILL
                     RALAFLACAFLLFTTLYGPSEPFTPGAALPPALPPGGNSSAASDNTTSQAEGWQQLLG
                     LLPEHATEKLHEAWAFGQSHQTSIVAVGLLTCLLAMLLAGRIRLRRIDAFSTCLWALL
                     LGLHLAEHYLQAASPGWLDTLKFSTTSLCCLVGFTAAVATRKSTGPRRFRPRRYFSGD
                     SASLFPSSPSLAVPYPSVTSSPASLFIPTPPGFLPLTKQQLFRSPRRVSPSSLPGRLS
                     RALSLGTIPPLTRTDSGYLFSGSRPPSRVSPAGEVSLSDYFSLLSSSFPASPLPSPAP
                     SVASSVASSSGSLRHRRPLISPARLNLKGQKLLLFSSPGEAPNTPSSSEEFSPPNGSL
                     FIESPQLPQRNHTRDTKHTMEMRSMLARDSARSSHSIKKEDESSQSSTCVVDTTTKGC
                     SEETTPWKARVSPSLVRGLLAVSLAVNALFTSAYLYQSLR"
     exon            235..355
                     /gene="Tmem201"
                     /gene_synonym="D4Ertd429e; Net5; Samp1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..550
                     /gene="Tmem201"
                     /gene_synonym="D4Ertd429e; Net5; Samp1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..727
                     /gene="Tmem201"
                     /gene_synonym="D4Ertd429e; Net5; Samp1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..1077
                     /gene="Tmem201"
                     /gene_synonym="D4Ertd429e; Net5; Samp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1281
                     /gene="Tmem201"
                     /gene_synonym="D4Ertd429e; Net5; Samp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1514
                     /gene="Tmem201"
                     /gene_synonym="D4Ertd429e; Net5; Samp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1586
                     /gene="Tmem201"
                     /gene_synonym="D4Ertd429e; Net5; Samp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1880
                     /gene="Tmem201"
                     /gene_synonym="D4Ertd429e; Net5; Samp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2018
                     /gene="Tmem201"
                     /gene_synonym="D4Ertd429e; Net5; Samp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..3721
                     /gene="Tmem201"
                     /gene_synonym="D4Ertd429e; Net5; Samp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggggcggg ctcgcgccgg ctacaaagcg gcgaaggtca cggcgcgagc tggagcgcgc
       61 gggccgctgg gagtctcttt tgcggcccgc gccccttgcc caccgactcg gcccggaagc
      121 catggaggga gtgagcgcgc tgctggctag ctgccccacc gccggcctgg cgggcggcct
      181 cggggtcacg gcgtgcgctg ccgccggcgt ggtgctctac cggattgcgc ggagggtgaa
      241 gccaacacac acaatggtca actgctggtt ctgcaaccac gatacactgg tgccctatgg
      301 gaatcgcaac tgttgggact gtccccactg tgagcagtac aatggctttc aagagaatgg
      361 agactacaac aagccaatcc cagcacagta catggaacac ctgaaccacg tggtgagcag
      421 cgtgcccagt ccccgggacc ctgcacagcc acagcagtgg gtgagcagcc aggtcctgct
      481 gtgccgaagg tgcagccacc accagaccac caagatcaag cagctggctg ctttcacacc
      541 acgggaggag ggccgctacg atgaggagat tgaggtgtac cgccaccact tggagcagat
      601 gtacaagctg tgccgcccgt gccaggcggc cgtcgagtac tacatcaaac accagaaccg
      661 ccagctgcgt gccctgcttc tcagccacca gttccggcgt cgggaggctg accaggccca
      721 tgggcagagt ttcagttcct cggcagtgaa ggccccattc caggtcatcc tgctccgtgc
      781 cctggccttc ctggcctgtg ccttcttgtt gttcactaca ctgtatgggc ccagcgaacc
      841 cttcaccccg ggggctgcct tgcccccagc cctacctcct gggggcaaca gttctgcggc
      901 ctcggacaac accacttctc aggcggaggg ctggcagcag ctgctgggtc tattgcctga
      961 gcatgccaca gagaagctac atgaggcctg ggcctttggg cagagccacc agaccagcat
     1021 tgtggcagtg ggcctgctca cctgcctgct ggccatgctg ctggctggcc gtatcaggct
     1081 ccggcggatc gatgccttct ccacctgcct ctgggccctg ctgctggggc tgcacctggc
     1141 agagcattat ctacaggctg cctcacccgg ctggctagac acactcaagt tcagtaccac
     1201 gtccctgtgc tgcctggtgg gcttcaccgc agctgtggct acgaggaaat cgacaggccc
     1261 acggaggttc cggccccgaa ggtacttctc cggagactct gccagccttt ttccttccag
     1321 ccccagcctg gctgtgccct acccaagtgt cacatcctcg ccagcatccc tgttcatccc
     1381 caccccacct ggcttcctgc ctctcaccaa gcagcagctg ttccgatctc cccgtcgggt
     1441 ctccccctcc tcactgccag gccgcctcag tcgggccctc tcgctgggaa ccatacctcc
     1501 tctgacccgg actgactcag gatacctgtt cagcgggagc cggccaccgt ctcgggtgtc
     1561 tccagcaggg gaggtttctc tttcagatta cttttctctg ctgtccagca gcttccctgc
     1621 ttctcccctc ccttccccag caccttccgt ggccagctcc gtggcctcca gctctggctc
     1681 cttgcgccac cgcaggcccc tcatcagccc tgcacggctc aacctgaaag gacagaaact
     1741 gctgctgttc tcatcccctg gggaagcacc aaataccccc agcagctcag aggagttctc
     1801 gccacccaac ggcagcctct tcattgagtc tccccagctg ccacagagga atcacactcg
     1861 ggacacaaag cacaccatgg agatgaggtc gatgctggcc agagacagcg cccgcagtag
     1921 ccactccatc aagaaagagg acgagtcgtc tcagtcctcc acctgcgtcg tagacaccac
     1981 caccaaaggg tgctcagagg agaccactcc ctggaaagct cgtgtcagtc cctccctggt
     2041 ccggggcctc ctggctgtga gtttggcagt caatgctctc ttcacctcgg cctacctgta
     2101 ccagagcctg cgctgacctc cgagtgccct tcccgagggc agtgccaggt gcatgctgct
     2161 tccgacactg gcgctgagat ccctccccga ggggctctgt ctctgccttg acctcctggg
     2221 tcaagtccct gacctcagga tacctgctgt ccacccaaca gactgcaaac atcaactgtg
     2281 tttggtgctg acactctgaa cccaaaacca gggatctctg acaggcttgc ctggccccag
     2341 ggacactact gctactgtag ctgtggcagg gaccaaccag gctgcctgtg cccgtctgct
     2401 gcctccgaga caccagaggt ctgctgcaga gccccaccaa gaaccaagat gaagaaagcc
     2461 cctgagagat gcacatggag cctggatcac ttcatcctca cacctgttcc ctccagaggg
     2521 cccggctccc tgcatcaggc agcagccgcc catctcgccc caactgttgg ctccaggcag
     2581 ggctgggcag cagggagcct gggactgaac aataaaccca tgatctcctg cctcacacac
     2641 ctgtttgtga ctttcccagc aagtagctct gttaccctga gaacaccaga gctccccttg
     2701 tctccctctc tctctcatcc agggtccctg cctgacccac cagttgctcg tgagctgcac
     2761 agttcagatg agactggacc ctcccttact tactcctgag ccctgctctc ctctcctcca
     2821 tcctgtccca atctgtgtcc cccttgacct gtggctccag gccatcggca ttggtgccta
     2881 cgtgtccagc cactgcctgc tgagggcact gcaggcttgc tggagcacgc tggagcacat
     2941 cctgtcccat gagggaggag gaggagcgtt ggcctaacac tggctgtttc gatagtgtgg
     3001 gggctacatg tgcctgtagg ggtcaggcct tggccctgtg tgcgtgtgag cctgtgtgtg
     3061 tatgagtgtg tgtgtgagtg tgtgtgtgtg tgtgtgtgtg tgtatgtgta tttgtattat
     3121 acccctgggg attcttgtgg gggaggggca tggggaaggg aagggtcttc actgtcattc
     3181 agggataaaa tttaacttta tttttctaca catctgttgc caggtgaggc acgtgctttg
     3241 aagcagatgc cttcagccct ccctgctggg aggtggtctc tcaagctctg ggtgctttta
     3301 gtactttttt ttttttttaa ctgtagggaa gcagccctga ccttacctct ccactcctgt
     3361 cccgggagct ctcaatgcta tcctggattg cctcgtacca gtcagaggtc aggactccat
     3421 gagtccagct gccacaaagg gttcagcttg gaggtgacac ctctttggtc tacatttgta
     3481 caatggatgc atcaagtttc taaattttat ttcctgccta aagaaaccaa attgtccctc
     3541 agcatccttg tctccagccc tgaggaaaca cctaaagaga agcaatggct cctcccagca
     3601 gggcagcctg gcaccctgcg cacccaggag ggccttttat gttttgattc atatataaac
     3661 acgatgttat ttttctttac aaaagcaaaa aaataaaaac cgtaccaacc tttgacttgt
     3721 aaaaaaaaaa aaaaaaa
//
