LOCUS       NM_025708               2888 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus transmembrane protein 186 (Tmem186), transcript
            variant 1, mRNA.
ACCESSION   NM_025708
VERSION     NM_025708.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2888)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115005.11.
            
            On Apr 18, 2018 this sequence version replaced NM_025708.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088656.1, AK014478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               AC115005.11        95309-95534
            227-2888            AC115005.11        96628-99289
FEATURES             Location/Qualifiers
     source          1..2888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 4.24 cM"
     gene            1..2888
                     /gene="Tmem186"
                     /gene_synonym="2810440M13Rik; 4432406C05Rik"
                     /note="transmembrane protein 186"
                     /db_xref="GeneID:66690"
                     /db_xref="MGI:MGI:1913940"
     exon            1..226
                     /gene="Tmem186"
                     /gene_synonym="2810440M13Rik; 4432406C05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..874
                     /gene="Tmem186"
                     /gene_synonym="2810440M13Rik; 4432406C05Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 186 isoform 1"
                     /protein_id="NP_079984.2"
                     /db_xref="CCDS:CCDS27940.1"
                     /db_xref="GeneID:66690"
                     /db_xref="MGI:MGI:1913940"
                     /translation="MAFLLRVVPRLQGPTAWRRPLQGLWCCSGQGDSKRWVGSRSPHS
                     REKSPGTETETFHTIYRFRAIRAIGFLSRLKLAQTAVTVVALPPGFYCYSQGLMTLSS
                     LCLLGGVASFALAMLCWMSHFFRRLVGILYVNESGTLLRVAHLTFWGWRQDTYCAVSD
                     MIPLSESQERVQDVFVRIQQYSGKQTFYLTLRYGRILDRERFAQVFGTLATLKNSK"
     exon            227..2888
                     /gene="Tmem186"
                     /gene_synonym="2810440M13Rik; 4432406C05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2722..2727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem186"
                     /gene_synonym="2810440M13Rik; 4432406C05Rik"
                     /note="hexamer: AATACA"
     regulatory      2736..2741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem186"
                     /gene_synonym="2810440M13Rik; 4432406C05Rik"
                     /note="hexamer: AATGAA"
     polyA_site      2742
                     /gene="Tmem186"
                     /gene_synonym="2810440M13Rik; 4432406C05Rik"
                     /note="major polyA site"
     polyA_site      2756
                     /gene="Tmem186"
                     /gene_synonym="2810440M13Rik; 4432406C05Rik"
ORIGIN      
        1 ggtccgctcc gagccctgga gttccaaggc accatgggaa gattccctaa tggttcacag
       61 aacaccggtg gcggttacaa aatttgaact acagttccca agccatagta attttttttt
      121 ttttttttga attagcgcat gcgggttttt aaccgcccgc gcatgcgccc ttcaactttc
      181 cggtgacaag tacagcgtgc gtcctgtagc aggcggcggg ctcatggctt tcctccttcg
      241 agtcgtgcca aggttgcagg ggcccactgc atggaggagg cctctacagg gactatggtg
      301 ctgctctggg cagggggatt ccaaaaggtg ggtggggagc aggtctcccc actcacggga
      361 gaagtcacca ggcaccgaga ccgaaacatt ccatacaatc taccggttcc gagccatccg
      421 agcaattggg ttcctctcgc ggctgaagtt ggcccagaca gctgtgactg tggtggccct
      481 gcccccgggc ttctattgct actcacaagg cctcatgacc ctcagttcac tgtgccttct
      541 gggtggggtc gccagctttg ccctggccat gctctgttgg atgagccact tcttccggag
      601 actggtgggc atcctgtatg tgaacgagtc gggcaccctg ctccgagtgg cccacctgac
      661 cttctggggc tggcggcagg acacgtactg tgccgtgtca gacatgatac ccctgtcaga
      721 atcccaggaa cgggttcagg atgtgtttgt acgcatccag cagtacagtg gcaagcagac
      781 cttctacctc accttacgct atggccgaat cctggacagg gaacggttcg cacaagtgtt
      841 cggaactctg gccacactga agaacagcaa gtaggcctct catagccctc gttacacttg
      901 gattttagac agaaggccta ggacatggat gagacaaagc taataccagg gactgggctg
      961 gtgctcactt tgtagaatgc ttgtttagtg tgcaggatgt gaagccctgg gttcagaccc
     1021 tagcactgca tagaacaagg catggctatg cctgcctgta ctcagaactg gtgacacagg
     1081 caggtggaga aaaagttcaa ggttgttttg gcccaaaaag gaagctttag gaaaaagccc
     1141 ttagtggaac ataggacatc ccatcatata gtggcgagaa gtttctgtga agaggcagtt
     1201 gttggaggag tgctatgcca aggtcactaa ggcagaccgc tgctgtaaag ctgggaggca
     1261 ggagggttgg cagaggagca caggatgtgg ggtctgggga cttgggttct gctgagcctt
     1321 agctccttga caagtttctg aaccttgaat tgcattgtga gatggaaaac ccttctcatg
     1381 ggaacgggta tggctaggac tttgtgacag agctcttgcc tagcatgtat aaggtcctaa
     1441 gttccatccc cagcaccaca gaacaggcaa aaccagtgaa tactgagtgc tgtataaggt
     1501 acacagccca gagcttacaa catagagcaa ggcttctagg gtgccaatgg ggcccagcac
     1561 ttactcatgc tcaccagctg gacggccatg gctaaagccc agagtgaact tattttttcc
     1621 catcagcaag tcactgtaca ccaacagagg tagggacagc acccctgaga ctacattgat
     1681 ccctaggagg tccgggggtg ctcacacttg agagctttgt agtgtcatcg cagcagaggg
     1741 actgtgtcca agcaaaaatt catcatctaa aggacagtgc atatgctttt cataataaca
     1801 gcaaacactt gcttattagg taattgtacc tgcattaaaa ggaaagcagt cgtgattttt
     1861 gtaatttgtc taccagaatg ctttgctttg tagcttttta gtaatttctt tcctttaaga
     1921 atttttcttt taattatttg tgtgtttatc actgtgcata taaggagatt ggaggacaac
     1981 ttttccaagt tgcgttcctt ttagcatttg ggtcttgtgg gttaaattca ggttgtcagg
     2041 cttgacagca agcccctgca cgcactgagc catcctgctg gtcctctcta aagtaagcag
     2101 agcatgaaca caggtaacag tagactagac gtgccaaagt gtgtgtgtgt ggaggggtcc
     2161 caccacaggc ctacacaaag agctacaggc aacatgggaa ctctgagagc aggagtcttc
     2221 ctcaggggag ggcacaccca gtgtgaagtg ggcgaccctg aaaactggca catgcaagca
     2281 cagagtgagc cggccgtgtt tagaagcata tgcacggaca caacaatatt aaggagaaac
     2341 aggccacgaa cttgaaaggg caagggaagg tttggaggga ggaaagggaa gggggaagga
     2401 agtacatgta attctattgt aatctcaaaa aacccttaaa atgtgcatat cagattataa
     2461 ccattttcaa tgtcctggac atgtagcata tccttgcgtt tcgtagctgt cgatcgccgc
     2521 tggctagttc cagcacttca ctctcccaga taggatgtag gcacttaggc catagctgtc
     2581 cctgccttcg tcctctccac ctctgcctgt ttgtaggcat cagttaatct gtctgaattt
     2641 gttattctga catccatgaa gggaatcatg atatgtttcc tcctgtgctt cccagtgcta
     2701 acttggtggt gttcagagat taatacactt gagtcaatga aagtgtttgt gggttagttc
     2761 tttgtgactt gactctgggg tgcacttgaa tgtgaatgta tatgtatgct taccaactca
     2821 gcaggtcagt ggacatgatg ggctatctcc tccactcctc gatatgtgaa taacactgaa
     2881 gtaaacag
//
